JPH07148189A - 体内脊柱埋め込み管 - Google Patents

体内脊柱埋め込み管

Info

Publication number
JPH07148189A
JPH07148189A JP6179134A JP17913494A JPH07148189A JP H07148189 A JPH07148189 A JP H07148189A JP 6179134 A JP6179134 A JP 6179134A JP 17913494 A JP17913494 A JP 17913494A JP H07148189 A JPH07148189 A JP H07148189A
Authority
JP
Japan
Prior art keywords
tube
tube according
implantable
peripheral wall
implant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6179134A
Other languages
English (en)
Other versions
JP2558438B2 (ja
Inventor
Jean Godefroy
ジャン ゴデフロイ
Claude Laville
クロード ラビル
Raymond Roy-Camille
レーモン ロイ−カミーユ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Advanced Technical Fabrication SA
Original Assignee
Advanced Technical Fabrication SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Technical Fabrication SA filed Critical Advanced Technical Fabrication SA
Publication of JPH07148189A publication Critical patent/JPH07148189A/ja
Application granted granted Critical
Publication of JP2558438B2 publication Critical patent/JP2558438B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
    • A61F2/446—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages having a circular or elliptical cross-section substantially parallel to the axis of the spine, e.g. cylinders or frustocones
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A—HUMAN NECESSITIES
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2/4603—Special tools for implanting artificial joints for insertion or extraction of endoprosthetic joints or of accessories thereof
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    • A61F2/02—Prostheses implantable into the body
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30317—The prosthesis having different structural features at different locations within the same prosthesis
    • A61F2002/30327—The prosthesis having different structural features at different locations within the same prosthesis differing in diameter
    • A—HUMAN NECESSITIES
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    • A61F2/02—Prostheses implantable into the body
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    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30537—Special structural features of bone or joint prostheses not otherwise provided for adjustable
    • A61F2002/30538—Special structural features of bone or joint prostheses not otherwise provided for adjustable for adjusting angular orientation
    • A61F2002/3054—Special structural features of bone or joint prostheses not otherwise provided for adjustable for adjusting angular orientation about a connection axis or implantation axis for selecting any one of a plurality of radial orientations between two modular parts, e.g. Morse taper connections, at discrete positions, angular positions or continuous positions
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0073—Quadric-shaped
    • A61F2230/0076—Quadric-shaped ellipsoidal or ovoid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0039—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
    • A61F2250/0097—Visible markings, e.g. indicia

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  • Veterinary Medicine (AREA)
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  • Prostheses (AREA)
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Abstract

(57)【要約】 【目的】 本発明は、嵌め込み中の神経損傷の危険性が
低減され、埋め込み管の脊椎間での回転に対抗する良好
な位置及び固定と、機械的剛性の増加と、良好な骨の接
着とを提供する新しい体内埋め込み管の構造の画定を目
的とする。 【構成】 本発明の中空管状の埋め込み管は、第１の端
で開口し略円形状の断面の外面を有する周囲壁により画
成される内部空洞よりなる。２つの側面は固く、上及び
底面は連通孔を有する。環状外部リブは、隣接する２つ
の脊椎の間に埋め込み管が挿入されるとき、埋め込み管
の逆行する動きと回転を防止する。埋め込み管は、嵌め
込み前に埋め込み管に挿入された骨の組織片によって２
つの脊椎を共に固定し融合する。

Description

【発明の詳細な説明】
【０００１】
【産業上の利用分野】本発明は、一定の平円形の空間を
確保するよう隣接する２つの脊柱の対向する面内に予め
形成された溝に挿入されるべきプラグを形成するよう設
計された脊柱固定用の中空管状の体内埋め込み管に関す
る。
【０００２】
【従来の技術】この種の中空管状の体内埋め込み管は、
例えば、米国特許出願第４ ５０１２６９号明細書に記
載されている。この挿入管は、少なくとも第１の端で開
口する周囲壁により画成される内部空洞と、挿入管の外
部と内部とを連通させ、脊椎と埋め込み管内に挿入され
た海綿状の骨の組織片との直接的な接触を可能にさせる
上部及び底部の開口部とよりなる。これにより、体内脊
椎接合が行われる。
【０００３】国際特許出願第８９ １２４３１号明細書
には、その側面に亘って孔が分布する円筒形のケージ
と、かかるケージを適当な場所にねじ込むための外部螺
旋状ねじとよりなる別の装置が記載されている。これら
の装置は、孔の大きさが必然的に制限され、また、回転
に対する固定は不充分であるので、２つの順次の脊椎を
共に接合するために有効ではないことが分かっている。
【０００４】欧州特許第０ ３０７ ２４１号明細書に
は、並列管状のケージの形で他の埋め込み管が記載され
ている。この種のケージの長手方向のエッジは、隣接す
る脊椎の間に埋め込み管を挿入する間に脊髄又は脊髄神
経の付け根を痛める。他の従来技術の埋め込み管は、ケ
ージの２つのエッジを結合する４本の柱により画成され
た円筒状のケージの形であり、この柱は脊椎の対向する
面に平行に配置される。この種の埋め込み管は、特に、
その構造の機械的剛性が不十分であるため、背骨の正常
な湾曲を回復させるには効果がない。
【０００５】
【発明が解決しようとする課題】本発明の課題は、嵌め
込み中の神経損傷の危険性が極めて著しく低減され、脊
椎の間で埋め込み管の回転に対抗する良好な位置及び良
好な固定と、機械的剛性の増加と、隣接する２つの脊椎
の融合を促進する良好な骨の接着とを提供する新しい体
内埋め込み管の構造を画定することである。
【０００６】本発明の解決する他の課題は、腰椎の正常
な湾曲を回復させるよう埋め込み管を特定の形状に形成
して脊椎間の角度を矯正することである。
【０００７】
【課題を解決するための手段】上記及びその他の目的を
達成するために、本発明の体内埋め込み管は、その周囲
壁が、 − 略円形状の断面の外面と、 − ２つの固い側面と、そこに連通孔を有する上面及び
底面と、 − 逆行する動きを防止する少なくとも一の環状外部リ
ブとよりなる。
【０００８】本発明の望ましい一実施例によれば、周囲
壁は、埋め込み管の長手方向の軸周りの回転に対抗する
ために脊椎の骨に固定されるよう適合された少なくとも
一の回転防止外部レリーフを更に有する。周囲壁は、長
手方向の両端の先端が切られた略直円錐台状或いは卵形
状のいずれかであることが望ましく、その大きい方の底
はその第１の端の面よりなり、その小さいほうの底は第
２の端の面よりなる。
【０００９】本発明の有利な一実施例は、側面がその外
側に平面部を含み、環状外部リブを含まない。
【００１０】
【実施例】本発明の他の目的、特徴及び利点は、以下に
添付図面を参照して本発明の特定の実施例を説明するこ
とにより明らかになる。図面を参照するに、本発明の体
内埋め込み管は、例えば、長手方向の軸Ｉ−Ｉを有し、
金属又は固い材料より作られる中空の管状部材であり、
少なくとも第１の端３で開口する周囲壁２により画成さ
れる内部空洞１よりなる。
【００１１】周囲壁２は略円形状の断面の外面４を有す
る。この外面４は、２つの固い側面５及び６と、そこに
連通孔を有する上面７及び底面８とより形成される。例
えば、上面７は、そこに２つの連通孔９及び１０を有
し、底面８は、そこに連通孔１１及び１２を有する。周
囲壁２は、逆行する動きを防止する少なくとも一の環状
外部リブ、例えば、第１の端３の近くにリブ１３を更に
有する。
【００１２】図示する実施例において、埋め込み管は、
第１の端３の近くに第１の環状外部リブ１３と、第２の
端１５の近くに第２の環状外部リブ１４と、連通孔を含
まない周囲壁２の中間領域１７に中間環状外部リブ１６
とを有する。図６乃至９に示す実施例において、環状外
部リブ１３、１４及び１６は、直動及び回転の両方に関
する埋め込み管の軸方向の動きを防止するための歯をつ
けられることが望ましく、その歯が脊椎に固定されるよ
うになる。
【００１３】或いは、上記の例に対して、周囲壁２の外
面から突出する１以上の長手方向のリブを設けることが
可能である。しかしながら、これらの回転対抗手段は、
環状外部リブ上の歯よりも製造が難しい。全ての実施例
において、連通孔９、１０、１１及び１２は、長円状の
孔であることが有利であり、その長さは、埋め込み管の
長さの半分よりも僅かに短く、その幅は、埋め込み管の
径に実質的に一致する。
【００１４】本発明の埋め込み管は、１、２、或いは３
つのリブ、又は、より多数の環状外部リブにより構成し
得ることが理解されよう。特に、図３、５及び８を参照
して、各々の環状外部リブ１３、１４又は１６は、第２
の端１５に向かう方向で埋め込み管の動きを防止する非
対称性の鋸歯状の横方向断面を有することが望ましい。
【００１５】図１乃至３及び６乃至８の実施例におい
て、周囲壁２は、略直円錐台状の外形を有し、大きい方
の底は、第１の端３の面よりなり、小さい方の底は、第
２の端１５の面よりなる。この種の形状により、隣接す
る２つの脊椎間に適切な生理学的角度を回復させ、維持
することが可能である。図５に示す実施例において、周
囲壁２は、第１の端３に大きな底を形成し、第２の端１
５に小さな底を形成する長手方向の両端が先端を切られ
た略卵形状の外形を有する。
【００１６】この卵形状は、その間に埋め込み管が挿入
されるべき脊椎の解剖学的形状により良く適合するので
選ばれている。埋め込み管を挿入する前に、溝に適当な
長手方向の断面形状が与えられる。図示する実施例にお
いて、側面５及び６は、外側に外部リブを含まない。従
って、図４及び９により明瞭に示す如く、環状外部リブ
は、側面５又は６の両方で中断される。例えば、外側の
リブ１６は、上部に２箇所の中断部１８及び１９と、下
部に２箇所の中断部２０及び２１を含み、隣接する２つ
の脊椎の間に係合するとき、この中断部は埋め込み管の
回転を防止する。
【００１７】側面５及び６は、図１、４、６及び９に示
す如く、外側に平面部を有し、これにより、そこから埋
め込み管が作られる材料の量を少し減少させることが可
能である。この平面部は、夫々の側面の長さ全体を占め
る。周囲壁２は、その第２の端１５で横支承壁２２に接
続される。この横支承壁２２は、ねじ付軸孔２３を有す
るので、埋め込み管と位置を合わされた挿入具を軸穴に
嵌め込むことが可能である。
【００１８】横支承壁２２は、挿入具と埋め込み管とが
一緒に回転するよう拘束する外部レリーフ、例えば、直
径方向の溝又はスロット２４を更に有する。外部レリー
フは、長手方向の軸Ｉ−Ｉに関する埋め込み管の角度位
置を示す視覚的な手段を提供するような形状とされるこ
とが望ましい。直径方向の溝又はスロットの形の外部レ
リーフ構造は、角度位置の視覚的な提示手段を提供する
一つの方法である。特に、この構造により、その間に埋
め込み管が挿入される隣接する２つの脊椎の対応する面
に上面７及び底面８が対向するよう、埋め込み管を２つ
の脊椎の間に位置決めすることが可能である。
【００１９】図３、４、５及び９は、隣接する２つの脊
椎２５及び２６の間に置かれた本発明の埋め込み管を示
す。挿入具を挿入する前に、患者の身体のいずれかの部
位から摘出された海綿状の骨の組織片１００が内部空洞
１００に挿入される。２つの脊椎の間に埋め込み管を挿
入する前に、矢印で背骨の長手方向の軸に示された適当
な断面の溝が夫々の脊椎に形成され、この２つの溝の組
み合わせは、その断面が埋め込み管の第２の端１５の寸
法に実質的に等しい実質的に円筒形のハウジングを形成
する。次いで、２つの脊椎２５及び２６は、適当な手段
によって離され、埋め込み管が２つの溝の中に軸の方向
に挿入され、その後、脊椎は自由にされる。埋め込み管
の直円錐台状の形状により、適切な角度の向きが脊椎２
５及び２６に分与され、腰椎の正常な湾曲のような正常
な形態学的角度が生じる。環状外部リブ１３、１４及び
１６は、埋め込み管の軸方向の平行移動を防止するよう
脊椎２５及び２６の骨に係合する。環状外部リブ及び長
手方向のリブの端１８乃至２１、即ち、歯は、埋め込み
管の長手方向の軸周りの回転を防止するよう骨を圧迫す
る。
【００２０】埋め込み管が嵌め込まれると、海綿状の骨
の組織片１００は、下方の脊椎２５と上方の脊椎２６の
骨組織と接触し、これらの脊椎は徐々に一体的に融合す
る。寸法の大きな連通孔９、１０、１１及び１２は、封
入された組織片と、２つの脊椎２５及び２６との間に良
好な接触を与えることにより、かかる融合に寄与する。
【００２１】本発明の埋め込み管の固い側面５及び６に
より、埋め込み管は、２つの脊椎２５及び２６の間の圧
縮負荷に耐え得るよう固定される。埋め込み管の略円形
状の断面により、２つの脊椎の間への埋め込み管の挿入
中に神経損傷の危険が回避される。本発明は、詳述した
実施例に限定されることはなく、特許請求の範囲の記載
の目的の範囲内であらゆる変形とその一般化を含む。
【図面の簡単な説明】
【図１】本発明の体内埋め込み管の第１実施例の斜め上
からの斜視図である。
【図２】図１に示す体内埋め込み管の平面図である。
【図３】２つの脊椎の間の位置にある図１の体内埋め込
み管を示す長手方向断面の側面図である。
【図４】図３の線Ａ−Ａによる横断面図である。
【図５】長手方向の両端の先端が切られた略卵形状の埋
め込み管を示す長手方向断面の側面図である。
【図６】本発明の体内埋め込み管の第２実施例の斜め上
からの斜視図である。
【図７】図６に示す体内埋め込み管の平面図である。
【図８】図６に示す埋め込み管の長手方向の断面図であ
る。
【図９】図６に示す埋め込み管の横方向の断面図であ
る。
【符号の説明】
１ 内部空洞 ２ 周囲壁 ３ 第１の端 ４ 外面 ５，６ 側面 ７，８ 上及び底面 ９，１０，１１，１２ 連通孔 １３，１４ 環状外部リブ １５ 第２の端 １６ 中間環状外部リブ １７ 中間領域 １８，１９，２０，２１ 中断部 ２２ 横支承壁 ２３ 軸孔 ２４ 外部レリーフ ２５，２６ 脊椎 １００ 海綿状の骨の組織片
───────────────────────────────────────────────────── フロントページの続き (72)発明者 ラビル クロード フランス国 75016 パリ アヴニュ・ド ゥ・ヴェルサイユ 206 (72)発明者 ロイ−カミーユ レーモン フランス国 75007 パリ リュ・ドゥ・ ブエノス−アイレス １

Claims (12)

    【特許請求の範囲】
  1. 【請求項１】 連通孔（９，１０，１１，１２）を有す
    る周囲壁（２）により画成される内部空洞（１）よりな
    る脊柱固定用の中空管状の体内埋め込み管であって、 該周囲壁（２）は、 − 略円形状の断面の外面（４）と、 − ２つの固い側面（５，６）と、そこに該連通孔
    （９，１０，１１，１２）を有する上面及び底面（７，
    ８）と、 − 逆行する動きを防止する少なくとも一の環状外部リ
    ブ（１３）とよりなることを特徴とする体内埋め込み
    管。
  2. 【請求項２】 前記周囲壁（２）は少なくとも一の回転
    防止外部レリーフをさらに有することを特徴とする請求
    項１記載の埋め込み管。
  3. 【請求項３】 前記周囲壁（２）は、長手方向の両端の
    先端が切られた略直円錐台状或いは卵形状であり、その
    大きい方の底はその第１の端（３）の面よりなることを
    特徴とする請求項１又は２記載の埋め込み管。
  4. 【請求項４】 前記周囲壁（２）は、その第１の端
    （３）及びその第２の端（１５）近くの夫々環状外部リ
    ブ（１３，１４）よりなることを特徴とする請求項１乃
    至３のうちいずれか１項記載の埋め込み管。
  5. 【請求項５】 貫通孔のない該壁の中間領域（１７）に
    中間環状外部リブ（１６）を更に有することを特徴とす
    る請求項４記載の埋め込み管。
  6. 【請求項６】 前記回転防止外部レリーフは、逆行する
    動きを防止する少なくとも一の前記環状外部リブ（１
    ３）から突出する少なくとも一の歯よりなることを特徴
    とする請求項２記載の埋め込み管。
  7. 【請求項７】 前記側面（５，６）は環状外部リブを有
    しないことを特徴とする請求項１乃至６のうちいずれか
    １項記載の埋め込み管。
  8. 【請求項８】 前記側面（５，６）はその外側に平面部
    を含むことを特徴とする請求項１乃至７のうちいずれか
    １項記載の埋め込み管。
  9. 【請求項９】 前記周囲壁（２）は、その第２の端（１
    ５）で横支承壁（２２）に接続されることを特徴とする
    請求項１乃至８のうちいずれか１項記載の埋め込み管。
  10. 【請求項１０】 前記横支承壁（２２）は、挿入具を取
    り付けるねじ付軸孔（２３）よりなることを特徴とする
    請求項９記載の埋め込み管。
  11. 【請求項１１】 前記横支承壁（２２）は、埋め込み管
    に対する挿入具の回転を防止する外部レリーフ（２４）
    を含むことを特徴とする請求項１０記載の埋め込み管。
  12. 【請求項１２】 前記外部レリーフ（２４）は、埋め込
    み管の長手方向の軸（Ｉ−Ｉ）周りの角度位置を視覚的
    に示す手段を構成するような形状とされていることを特
    徴とする請求項１１記載の埋め込み管。
JP6179134A 1993-08-06 1994-07-29 体内脊柱埋め込み管 Expired - Lifetime JP2558438B2 (ja)

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FR9309835A FR2708461B1 (fr) 1993-08-06 1993-08-06 Implant intersomatique pour colonne vertébrale.
FR9309835 1993-08-06

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JPH07148189A true JPH07148189A (ja) 1995-06-13
JP2558438B2 JP2558438B2 (ja) 1996-11-27

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DE69406216T2 (de) 1998-05-28
EP0637440A1 (fr) 1995-02-08
KR950005279A (ko) 1995-03-20
FR2708461B1 (fr) 1995-09-29
FR2708461A1 (fr) 1995-02-10
NZ264176A (en) 1996-10-28
JP2558438B2 (ja) 1996-11-27
AU6890094A (en) 1995-03-02
CA2128932A1 (fr) 1995-02-04
FI943640L (fi) 1995-02-07
EP0637440B1 (fr) 1997-10-15
CA2128932C (fr) 1998-08-25
US5683463A (en) 1997-11-04
ATE159167T1 (de) 1997-11-15
TW267932B (ja) 1996-01-11
DE69406216D1 (de) 1997-11-20
FI943640A7 (fi) 1995-02-07
FI943640A0 (fi) 1994-08-05
AU668654B2 (en) 1996-05-09

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