JPH0717821A - Dental composite resin and production thereof - Google Patents
Dental composite resin and production thereofInfo
- Publication number
- JPH0717821A JPH0717821A JP5192949A JP19294993A JPH0717821A JP H0717821 A JPH0717821 A JP H0717821A JP 5192949 A JP5192949 A JP 5192949A JP 19294993 A JP19294993 A JP 19294993A JP H0717821 A JPH0717821 A JP H0717821A
- Authority
- JP
- Japan
- Prior art keywords
- glass filler
- composite resin
- dental composite
- glass
- bacteria
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000011350 dental composite resin Substances 0.000 title claims abstract description 35
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 239000011521 glass Substances 0.000 claims abstract description 77
- 239000000945 filler Substances 0.000 claims abstract description 72
- 239000000057 synthetic resin Substances 0.000 claims abstract description 24
- 229920003002 synthetic resin Polymers 0.000 claims abstract description 24
- 239000013543 active substance Substances 0.000 claims abstract description 16
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 230000000844 anti-bacterial effect Effects 0.000 claims description 16
- 239000002245 particle Substances 0.000 claims description 9
- 229910004298 SiO 2 Inorganic materials 0.000 claims description 4
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical group [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 claims description 4
- 238000009826 distribution Methods 0.000 claims description 4
- 230000001788 irregular Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000377 silicon dioxide Substances 0.000 claims description 4
- 230000008878 coupling Effects 0.000 claims description 3
- 238000010168 coupling process Methods 0.000 claims description 3
- 238000005859 coupling reaction Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims description 2
- 229910000077 silane Inorganic materials 0.000 claims description 2
- 230000000379 polymerizing effect Effects 0.000 claims 2
- 208000002925 dental caries Diseases 0.000 abstract description 14
- 230000000845 anti-microbial effect Effects 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 description 42
- 238000010586 diagram Methods 0.000 description 14
- 230000001580 bacterial effect Effects 0.000 description 12
- 150000002500 ions Chemical class 0.000 description 7
- 241000894007 species Species 0.000 description 7
- 210000000214 mouth Anatomy 0.000 description 6
- 238000006116 polymerization reaction Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 239000000178 monomer Substances 0.000 description 5
- 239000000872 buffer Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- XDLMVUHYZWKMMD-UHFFFAOYSA-N 3-trimethoxysilylpropyl 2-methylprop-2-enoate Chemical compound CO[Si](OC)(OC)CCCOC(=O)C(C)=C XDLMVUHYZWKMMD-UHFFFAOYSA-N 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000006087 Silane Coupling Agent Substances 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000005498 polishing Methods 0.000 description 2
- 239000003505 polymerization initiator Substances 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- MZGMQAMKOBOIDR-UHFFFAOYSA-N 2-[2-(2-hydroxyethoxy)ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCO MZGMQAMKOBOIDR-UHFFFAOYSA-N 0.000 description 1
- HWSSEYVMGDIFMH-UHFFFAOYSA-N 2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCOC(=O)C(C)=C HWSSEYVMGDIFMH-UHFFFAOYSA-N 0.000 description 1
- 229910000497 Amalgam Inorganic materials 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- AMFGWXWBFGVCKG-UHFFFAOYSA-N Panavia opaque Chemical compound C1=CC(OCC(O)COC(=O)C(=C)C)=CC=C1C(C)(C)C1=CC=C(OCC(O)COC(=O)C(C)=C)C=C1 AMFGWXWBFGVCKG-UHFFFAOYSA-N 0.000 description 1
- 208000004509 Tooth Discoloration Diseases 0.000 description 1
- 206010044032 Tooth discolouration Diseases 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
- 239000000805 composite resin Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000007822 coupling agent Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- -1 ethoxy-3-methacryloxypropoxy Chemical group 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 239000011256 inorganic filler Substances 0.000 description 1
- 229910003475 inorganic filler Inorganic materials 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 229910052755 nonmetal Inorganic materials 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 239000003469 silicate cement Substances 0.000 description 1
- 238000003980 solgel method Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
Landscapes
- Dental Preparations (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】この発明は、歯科用コンポジット
レジンに関する。この歯科用コンポジットレジンは、特
に歯冠修復又は歯の欠損部や虫歯で生じた空隙を埋める
充填修復に好適に用いられる。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dental composite resin. This dental composite resin is particularly suitable for use in restoration of crowns or filling restoration for filling voids generated in tooth defects or tooth decay.
【０００２】[0002]
【従来の技術】一般に上記分野で用いられる歯科用充填
修復材料としては、臨床段階で成形する必要のあること
から、合成樹脂、シリケートセメント、アマルガム等が
知られており、特に環境を汚染しない合成樹脂が多用さ
れている。そして、合成樹脂のみでは、機械的強度及び
硬度に乏しいので、これに無機材料よりなるフィラーを
含有させている。2. Description of the Related Art Generally, as a dental filling / restoring material used in the above fields, synthetic resins, silicate cements, amalgams, etc. are known because they need to be molded at the clinical stage, and synthetic materials which do not pollute the environment are particularly known. Resin is often used. Since the synthetic resin alone is poor in mechanical strength and hardness, a filler made of an inorganic material is contained therein.
【０００３】[0003]
【発明が解決しようとする課題】しかし、上記のように
合成樹脂と無機フィラーよりなる歯科用コンポジットレ
ジンの場合、これを歯の修復部に充填後、時間の経過と
ともに口腔内の細菌が、歯科用コンポジットレジンと歯
牙との隙間に繁殖し、虫歯や歯の変色を促進するという
２次齲蝕を生じる。この発明の目的は、このような２次
齲蝕を防止しうる抗菌性に優れた歯科用コンポジットレ
ジンを提供することにある。However, in the case of the dental composite resin composed of the synthetic resin and the inorganic filler as described above, after filling the restorative part of the tooth with bacteria, the bacteria in the oral cavity may be absorbed with the passage of time. Propagates in the gap between the composite resin for teeth and teeth, causing secondary caries that promotes tooth decay and discoloration of teeth. An object of the present invention is to provide a dental composite resin having excellent antibacterial properties which can prevent such secondary caries.
【０００４】[0004]
【課題を解決するための手段】上記目的を達成するため
に、本発明歯科用コンポジットレジンは、図１に示すよ
うに、イオン化又はラジカル状態にされた抗菌性の活性
物質が注入されたガラスフィラー２の群と、このガラス
フィラーの周囲に存在し、ガラスフィラーを結合してい
る合成樹脂３よりなることを特徴とする。In order to achieve the above object, the dental composite resin of the present invention is, as shown in FIG. 1, a glass filler in which an antibacterial active substance in an ionized or radical state is injected. It is characterized in that it is composed of a group 2 and a synthetic resin 3 existing around the glass filler and binding the glass filler.
【０００５】この歯科用コンポジットレジンにおいて望
ましいのは、ガラスフィラーがシリカＳｉＯ2を主成分
とするもの、イオン化又はラジカル状態にされた抗菌性
の活性物質を銀イオンＡｇ+とするもの、並びにガラス
フィラーの群の粒度分布が、粒径０．１〜２０μの範囲
で分散し、不規則形状をなしているものである。In this dental composite resin, it is desirable that the glass filler contains silica SiO 2 as a main component, the ionized or radicalized antibacterial active substance is silver ion Ag +, and the glass filler. The particle size distribution of the group is dispersed in a particle size range of 0.1 to 20 μm and has an irregular shape.
【０００６】本発明歯科用コンポジットレジンの製造方
法は、イオン化又はラジカル状態にされた抗菌性の活性
物質をガラスフィラーに１０〜４００ＫＶの加速電圧で
注入し、そのガラスフィラーを合成樹脂原料とともに混
合した後、その原料を重合させることを特徴とする。In the method for producing a dental composite resin of the present invention, an antibacterial active substance in an ionized or radical state is injected into a glass filler at an accelerating voltage of 10 to 400 KV, and the glass filler is mixed with a synthetic resin raw material. After that, the raw material is polymerized.
【０００７】ガラスフィラーのガラスは、シリカガラス
に限らず、無アルカリホウ珪酸塩系ガラス等ガラス全般
が適用可能である。イオン化又はラジカル状態にされた
抗菌性の活性物質としては、Ａｇ+に限らず水銀Ｈｇ，
銅Ｃｕ，金Ａｕ等の他の重金属のイオンや非金属イオン
でも適用可能である。The glass of the glass filler is not limited to silica glass, but any glass such as alkali-free borosilicate glass can be applied. The antibacterial active substance in the ionized or radical state is not limited to Ag + , but mercury Hg,
Ions of other heavy metals such as copper Cu and gold Au and non-metal ions are also applicable.
【０００８】合成樹脂の原料としては、基材としてのモ
ノマー、硬化反応を開始させる重合開始剤、重合促進
剤、保存性をよくし且つ操作時間を維持するための重合
抑制剤等を適度に配合して用いられる。また、モノマー
とガラスフィラーとを化学的に結合させるために、シラ
ンカップリング剤などのカップリング剤が添加されるこ
ともある。これら原料をガラスフィラーとともに混合
し、歯の修復部に充填した後に化学重合反応や紫外線、
可視光線等の光重合反応によって硬化させ、ガラスフィ
ラー同士を結合させることにより、歯科用コンポジット
レジンとなって口腔内に固定される。As raw materials for the synthetic resin, a monomer as a base material, a polymerization initiator for initiating a curing reaction, a polymerization accelerator, a polymerization inhibitor for improving storage stability and maintaining operation time, and the like are appropriately blended. Used. In addition, a coupling agent such as a silane coupling agent may be added to chemically bond the monomer and the glass filler. These raw materials are mixed with a glass filler, and after filling the tooth restoration part, a chemical polymerization reaction or ultraviolet rays,
The composition is cured by a photopolymerization reaction such as visible light, and the glass fillers are bonded together to form a dental composite resin, which is fixed in the oral cavity.
【０００９】[0009]
【作用】ガラスフィラーは、前述の如く歯科用コンポジ
ットレジンの機械的強度及び硬度を確保するほか、活性
物質を長時間にわたって安定にイオンもしくはラジカル
状態に保持する。合成樹脂は、ガラスフィラー同士を結
合するとともに、所望形状の歯科用コンポジットレジン
に成形することを可能にする。そして、注入された抗菌
性の活性物質は、ガラス表面から徐々に口腔内に溶け出
して齲蝕関連菌の呼吸を阻害し、その増加を抑制する。The glass filler not only secures the mechanical strength and hardness of the dental composite resin as described above, but also stably holds the active substance in the ionic or radical state for a long time. The synthetic resin enables the glass fillers to be bonded together and can be molded into a dental composite resin having a desired shape. Then, the injected antibacterial active substance gradually dissolves from the glass surface into the oral cavity, inhibits the respiration of caries-related bacteria, and suppresses the increase.
【００１０】就中、ガラスフィラーがシリカＳｉＯ2を
主成分とするものであるとき、ガラスフィラーが口腔内
に溶け出さず、長期にわたって安定して上記機能を発揮
する。しかも歯科用コンポジットレジンとしての強度、
硬度、弾性率、熱膨張係数等の機械的性質が歯質に近い
ので、好適である。In particular, when the glass filler is mainly composed of silica SiO 2 , the glass filler does not melt into the oral cavity and stably exhibits the above function for a long period of time. Moreover, strength as a dental composite resin,
Mechanical properties such as hardness, modulus of elasticity, and coefficient of thermal expansion are similar to those of the tooth structure, which is preferable.
【００１１】また、活性物質が、銀イオンＡｇ+である
ときは微量で上記の抗菌作用を発揮する。さらにガラス
フィラーの群の粒度分布が、粒径０．１〜２０μの範囲
で広く分散し、不規則形状をなしているとき、歯科用コ
ンポジットレジン中のガラスフィラーの充填密度を高く
することができる。When the active substance is silver ion Ag + , the above-mentioned antibacterial action is exerted even in a small amount. Furthermore, when the particle size distribution of the group of glass fillers is widely dispersed within a particle size range of 0.1 to 20μ and has an irregular shape, the packing density of the glass filler in the dental composite resin can be increased. .
【００１２】製造過程において、活性物質をガラスフィ
ラーに１０〜４００ＫＶの加速電圧で注入すると、活性
物質の注入分布が、ガラスフィラーの表面から７５〜１
３００オングストロームの深さのところでピーク濃度と
なる。その結果、活性物質が表面から少しずつ溶け出
し、溶け出した分量が内部から補充される。従って、長
期にわたって安定して活性物質が口腔内に存在する。
尚、注入量は、５〜５００ｐｐｍ程度がよく、注入時間
で調整可能である。In the manufacturing process, when the active substance is injected into the glass filler at an acceleration voltage of 10 to 400 KV, the injection distribution of the active substance is 75 to 1 from the surface of the glass filler.
The peak concentration is reached at a depth of 300 Å. As a result, the active substance is gradually dissolved from the surface, and the dissolved amount is replenished from the inside. Therefore, the active substance is stably present in the oral cavity over a long period of time.
The injection amount is preferably about 5 to 500 ppm and can be adjusted by the injection time.
【００１３】[0013]
−実施例１− 図１に実施例の歯科用コンポジットレジンの構造を模式
的に示す。歯科用コンポジットレジン１は、銀イオンＡ
ｇ+（図示省略）が注入されたガラスフィラー２の群
と、このガラスフィラーの周囲に存在し、ガラスフィラ
ーを結合している合成樹脂３よりなる。（ガラスフィラ
ー２）／（合成樹脂３）重量比は、７０／３０である。-Example 1- The structure of the dental composite resin of an Example is typically shown in FIG. Dental composite resin 1 is silver ion A
It is composed of a group of glass fillers 2 into which g + (not shown) is injected, and a synthetic resin 3 existing around the glass fillers and binding the glass fillers. The (glass filler 2) / (synthetic resin 3) weight ratio is 70/30.
【００１４】ガラスフィラー２は、シリカＳｉＯ2１０
０重量％からなり、同組成のガラスを粉砕し、又はゾル
ゲル法もしくは気相法などで調製して種々の粒径のもの
を配合することによって、粒径０．１〜２０μの範囲で
広く分散し、不規則形状をなすように調製されたもので
ある。ガラスフィラー２には、Ａｇ+がガラス１０ｇに
対して１０〜１００ｐｐｍの濃度で表面から７５〜１３
００オングストロームの深さの位置に注入されている。The glass filler 2 is silica SiO 2 10
It is made up of 0% by weight and is widely dispersed in a particle size range of 0.1 to 20 by crushing glass having the same composition or prepared by a sol-gel method or a gas phase method and blending with particles having various particle sizes. However, it is prepared to have an irregular shape. The glass filler 2 contains Ag + at a concentration of 10 to 100 ppm with respect to 10 g of glass at 75 to 13 from the surface.
It is implanted at a depth of 00 Å.
【００１５】合成樹脂３は、下記の化学式で特定される
2,2-ヒ゛ス［4-(2-ヒト゛ロキシ-3-メタクリロキシフ゜ロホ゜キシ)フェニル］フ゜ロハ゜ン
（以下、Ｂｉｓ−ＧＭＡという）及びトリエチレンク゛リコールシ゛メタ
クリレート(n=3)（以下、ＴＥＤＭＡという）を主成分モノマ
ーとして化学的に重合されてなるものである。The synthetic resin 3 is specified by the following chemical formula.
The main components are 2,2-bis [4- (2-human ethoxy-3-methacryloxypropoxy) phenyl] propane (hereinafter referred to as Bis-GMA) and triethylene glycol methacrylate (n = 3) (hereinafter referred to as TEDMA). The monomer is chemically polymerized.
【００１６】[0016]
【化１】 [Chemical 1]
【化２】 これらモノマーを重合開始剤、重合促進剤、重合抑制剤
及びＡｇ+注入済みのガラスフィラーとともに混合し、
歯の修復部に充填した後に化学重合反応によって硬化さ
せ、ガラスフィラー同士を結合させることにより、歯科
用コンポジットレジンとなって口腔内に固定される。[Chemical 2] These monomers are mixed with a polymerization initiator, a polymerization accelerator, a polymerization inhibitor, and Ag + injected glass filler,
After filling the restorative part of the tooth, it is cured by a chemical polymerization reaction, and the glass fillers are bonded together to form a dental composite resin, which is fixed in the oral cavity.
【００１７】その結果、ガラスから溶け出したＡｇ+が
齲蝕関連菌の呼吸を阻害し、その増加を抑制する。しか
もＡｇ+は、使用中にガラスフィラーの内部から徐々に
表面に拡散移動してくるので、その抗菌作用が持続性を
有している。As a result, Ag + dissolved out of the glass inhibits the respiration of caries-related bacteria and suppresses the increase. Moreover, since Ag + gradually diffuses and moves from the inside of the glass filler to the surface during use, its antibacterial action is persistent.
【００１８】−実施例２− この例は、ガラスフィラーを合成樹脂で結合する前に、
予めガラスフィラーをシランカップリング処理すること
により、ガラスフィラーと合成樹脂との結合力を増した
ものである。Example 2-This example shows that before the glass filler is bonded with the synthetic resin,
The bonding force between the glass filler and the synthetic resin is increased by subjecting the glass filler to a silane coupling treatment in advance.
【００１９】すなわち、シランカップリング剤としてγ
-メタクリロキシフ゜ロヒ゜ルトリメトキシシラン（ＭＰＴＭＳ）を用い、次の
反応によりカップリング処理し、ガラスフィラーの表面
に炭素−炭素二重結合を存在させ、この二重結合とモノ
マーとを共重合させることにより、合成樹脂とガラスフ
ィラーとが強固に結合するようになるのである。That is, γ as a silane coupling agent
-By using methacryloxypropyltrimethoxysilane (MPTMS), a coupling treatment is carried out by the following reaction to cause a carbon-carbon double bond to exist on the surface of the glass filler, and by copolymerizing this double bond and a monomer. Thus, the synthetic resin and the glass filler are firmly bonded to each other.
【００２０】[0020]
【化３】 −実験例１− 実施例の歯科用コンポジットレジンの効果を確認するた
めに、種々の齲蝕関連菌を種々の条件下で発育させ、Ａ
ｇ+注入済みのガラスフィラーの存在が及ぼす影響を調
べた。以下、詳述する。[Chemical 3] -Experimental Example 1-In order to confirm the effect of the dental composite resin of Example, various caries-related bacteria were grown under various conditions, and A
The effect of the presence of g + injected glass filler was investigated. The details will be described below.
【００２１】イオン注入機（日新電機製）にて、実施例
１のガラスフィラーに１×１０-6Torrの真空中でＡｇ+
を注入した。注入時のイオンの加速電圧は、２０ＫＶ
で、Ａｇ+電流が１０μアンペア得られた。注入された
Ａｇ+の濃度は、ガラス１０ｇに対して約５０ｐｐｍ
で、ピーク濃度の深さは、１００オングストロームであ
る。Using an ion implanter (manufactured by Nissin Electric Co.), Ag + was added to the glass filler of Example 1 in a vacuum of 1 × 10 -6 Torr.
Was injected. Ion acceleration voltage during implantation is 20 KV
At 10 μAg + current was obtained. The concentration of injected Ag + is about 50ppm with respect to 10g of glass.
And the depth of the peak concentration is 100 Å.
【００２２】齲蝕関連菌として表１に示す菌種を準備し
た。このうち、Ｎｏ．３の菌は、特に齲蝕の原因となり
やすく、またＮｏ．５の菌は、合成樹脂に対して高い付
着性を有するものである。As the caries-related bacteria, the bacterial species shown in Table 1 were prepared. Of these, No. The bacterium No. 3 is particularly likely to cause dental caries, and also has a no. The bacterium No. 5 has high adhesiveness to the synthetic resin.
【００２３】[0023]
【表１】 表１に示された各菌をトリフ゜チケースソイフ゛ロス（Tripticase Soy
Broth）（ＢＢＬ社製）にて１×１０5-6個に調整し
て、これを菌液とした。そして、滅菌されたレテ゛ューストトラン
スホ゜ートフルイト゛Reduced Transport Fluid（以下、ＲＴＦ緩
衝液という。）１ｍｌ中に、菌液１００μｌとＡｇ+注
入済みのガラスフィラー０．１ｇとを分注し、３７℃の
嫌気的条件下にて各菌を個別に所定時間放置した。尚、
ＲＴＦ緩衝液は、細菌の発育を促進させることも阻害す
ることもない性質を有する。Ａｇ+注入済みのガラスフ
ィラーは、分注する直前に滅菌した。[Table 1] Each of the bacteria shown in Table 1 was added to the tripticase soy broth (Tripticase Soy).
Broth) (manufactured by BBL) was adjusted to 1 × 10 5-6 cells and used as a bacterial solution. Then, 100 μl of the bacterial solution and 0.1 g of Ag + injected glass filler were dispensed into 1 ml of sterilized Reduced Transport Fluid (hereinafter, referred to as RTF buffer solution), and anaerobic at 37 ° C. Each bacterium was left alone for a predetermined time under static conditions. still,
The RTF buffer has the property of neither promoting nor inhibiting the growth of bacteria. The glass filler injected with Ag + was sterilized immediately before dispensing.
【００２４】２、６又は１２時間の放置後、分注された
菌を寒天培地に移し、更に４日間放置した後、寒天培地
コロニー計算法により菌数を目視にて測定した。測定結
果を図２〜図８に示す。図２、図３、図４、図５、図
６、図７及び図８は、それぞれ使用菌種が表１のＮｏ．
１、Ｎｏ．２、Ｎｏ．３、Ｎｏ．４、Ｎｏ．５、Ｎｏ．
６及びＮｏ．７の場合の測定結果である。図中、縦軸は
菌数、横軸は分注してから寒天培地に移すまでの放置時
間である。After being left for 2, 6 or 12 hours, the dispensed bacteria were transferred to an agar medium and allowed to stand for 4 days, and then the number of bacteria was visually measured by an agar medium colony counting method. The measurement results are shown in FIGS. 2, FIG. 3, FIG. 4, FIG. 5, FIG. 6, FIG. 7, and FIG.
1, No. 2, No. 3, No. 4, No. 5, No.
6 and No. It is a measurement result in the case of 7. In the figure, the vertical axis represents the number of bacteria, and the horizontal axis represents the standing time from dispensing to transferring to the agar medium.
【００２５】比較のためにガラスフィラーをＲＴＦ緩衝
液に入れない以外は上記と同一条件で細菌を培養し（以
下、対照標準培養という）、菌数を測定した結果を菌種
毎にそれぞれ対応する図に示した。同じく比較のために
Ａｇ+イオンを注入していないガラスフィラーを用いた
以外は上記と同一条件で細菌を培養し、菌数を測定した
結果も菌種毎にそれぞれ対応する図に示した。図中、短
破線が本発明実施例、長破線が対照標準培養、点線が無
イオンガラスフィラーによる値である。また、図の打点
位置近傍の数字は、菌数をｍ×１０nとしたときのｍ値
である。For comparison, bacteria were cultured under the same conditions as described above except that glass filler was not added to the RTF buffer (hereinafter referred to as control standard culture), and the results of measuring the number of bacteria correspond to each bacterial species. As shown in the figure. Similarly, for comparison, the bacteria were cultured under the same conditions as above except that a glass filler into which Ag + ions were not injected was used, and the results of measuring the number of bacteria are also shown in the figures corresponding to each bacterial species. In the figure, the short broken line is the value of the example of the present invention, the long broken line is the value for the control culture, and the dotted line is the value for the nonionic glass filler. The numbers near the hitting point in the figure are m values when the number of bacteria is m × 10 n .
【００２６】図２〜図８に示されるように、対照標準培
養の場合や無イオンのガラスフィラーの場合よりもＡｇ
+イオン注入済みのガラスフィラーが、菌数を減少させ
ていることが明らかである。すなわち、Ａｇ+イオン注
入済みのガラスフィラーは、顕著な抗菌効果を発揮する
ことが判明した。従って、そのようなガラスフィラーを
合成樹脂で結合して歯科用コンポジットレジンとして利
用すれば、２次齲蝕を有効に防止し得るものである。As shown in FIGS. 2 to 8, the Ag content is higher than that in the case of the control standard culture or the case of the nonionic glass filler.
+ It is clear that ion-filled glass filler reduces the number of bacteria. That is, it has been found that the glass filler into which Ag + ions have been implanted exhibits a remarkable antibacterial effect. Therefore, if such a glass filler is combined with a synthetic resin and used as a dental composite resin, secondary caries can be effectively prevented.
【００２７】−実験例２− この例は、細菌発育に及ぼすガラスフィラー量の影響を
調べるための実験である。実験例１では、ＲＴＦ緩衝液
１ｍｌ中に、菌液１００μｌとＡｇ+注入済みのガラス
フィラー０．１ｇとを分注し、所定条件下での菌の発育
状況を観察したが、本例ではこのときのガラスフィラー
量を０．５ｇとする以外は実験例１と同一条件で菌の発
育状況を観察した。所定の放置時間経過後の菌数を測定
した結果を実験例１と同様に菌種毎に図９〜図１５に示
した。また、実験例１のガラスフィラー量０．１ｇによ
る培養及び対照標準培養もそれらの図に併記した。図
中、太点線がガラスフィラー０．５ｇ、細点線がガラス
フィラー０．１ｇ、破線が対照標準培養によるもので、
打点位置近傍の数字は、実験例１と同じ意味である。図
９〜図１５に示されるように、Ａｇ+を含むガラスフィ
ラー量が多い程に、すなわちＡｇ+濃度が高い程に抗菌
効果に優れることが判った。-Experimental Example 2-This example is an experiment for investigating the influence of the glass filler amount on the bacterial growth. In Experimental Example 1, 100 μl of the bacterial solution and 0.1 g of Ag + -injected glass filler were dispensed in 1 ml of the RTF buffer, and the growth of the bacteria under predetermined conditions was observed. The growth of the bacteria was observed under the same conditions as in Experimental Example 1 except that the glass filler amount was 0.5 g. Similar to Experimental Example 1, the results of measuring the number of bacteria after the passage of a predetermined standing time are shown in FIGS. 9 to 15 for each bacterial species. In addition, the culture with the glass filler amount of 0.1 g and the control standard culture of Experimental Example 1 are also shown in these figures. In the figure, the thick dotted line is the glass filler 0.5 g, the thin dotted line is the glass filler 0.1 g, and the broken line is the control standard culture.
The numbers in the vicinity of the hitting point have the same meaning as in Experimental Example 1. As shown in FIGS. 9 to 15, to the extent the amount of glass filler containing Ag + is large, i.e. it was found to be excellent in antibacterial effect to the extent Ag + concentration is high.
【００２８】−実験例３− この例は、実際にガラスフィラーを合成樹脂で結合した
歯科用コンポジットレジンの抗菌効果を直接調べるため
の実験である。実験例１では、ＲＴＦ緩衝液１ｍｌ中
に、菌液１００μｌとＡｇ+注入済みのガラスフィラー
０．１ｇとを分注し、所定条件下での菌の発育状況を観
察したが、本例ではこのときのガラスフィラー０．１ｇ
に代えて歯科用コンポジットレジン０．９０ｇを用いた
ことと、菌種を表１のＮｏ．４のみに限定したこと以外
は実験例１と同一条件で菌の発育状況を観察した。所定
の放置時間経過後の菌数を測定した結果を実験例１と同
様に図１６に示した。歯科用コンポジットレジンに用い
た合成樹脂及びガラスフィラーとの混合比は、実施例１
において既述の通りである。-Experimental Example 3-This example is an experiment for directly examining the antibacterial effect of the dental composite resin in which the glass filler is actually bonded with the synthetic resin. In Example 1, in RTF buffer 1 ml, aliquoted and glass filler 0.1g of bacterial solution 100μl and Ag + NOTE ON already minute, was observed the growth conditions of bacteria under predetermined conditions, in this example 0.1 g of glass filler at this time
The dental composite resin 0.90 g was used in place of the above, and the bacterial species was determined as No. 1 in Table 1. The growth of the bacteria was observed under the same conditions as in Experimental Example 1 except that the number was limited to 4. The results of measuring the number of bacteria after a predetermined standing time are shown in FIG. 16 as in Experimental Example 1. The mixing ratio of the synthetic resin and the glass filler used in the dental composite resin was the same as in Example 1.
Is as described above.
【００２９】図１６に示されるように、Ａｇ+イオン注
入済みのガラスフィラーを歯科用コンポジットレジンに
適用することにより、優れた抗菌効果を発揮することが
明らかとなった。尚、本例では歯科用コンポジットレジ
ン中のガラスフィラーと合成樹脂との混合比を７０／３
０としたが、ガラスフィラーがもっと少量であったり、
ガラスフィラー中のＡｇ+濃度が低くても、歯科用コン
ポジットレジンの表面を研磨等することにより、同等の
効果を発揮し得る。研磨すればガラスフィラーの露出面
積が増すので、表面上においてはＡｇ+濃度が高くなる
からである。As shown in FIG. 16, it was clarified that the application of the Ag + ion-implanted glass filler to the dental composite resin exerts an excellent antibacterial effect. In this example, the mixing ratio of the glass filler and the synthetic resin in the dental composite resin was 70/3.
Although it was set to 0, there is a smaller amount of glass filler,
Even if the Ag + concentration in the glass filler is low, the same effect can be exhibited by polishing the surface of the dental composite resin. This is because the exposed area of the glass filler is increased by polishing, so that the Ag + concentration is increased on the surface.
【００３０】[0030]
【発明の効果】以上のように、本発明歯科用コンポジッ
トレジンは、齲蝕の原因となる可能性の高い菌種及び合
成樹脂に付着し易い菌種を含む齲蝕関連菌全般に対し
て、優れた抗菌性を持つ。よって、２次齲蝕を未然に防
止することができる。INDUSTRIAL APPLICABILITY As described above, the dental composite resin of the present invention is excellent for all caries-related bacteria including bacterial species that are likely to cause dental caries and bacterial species that easily adhere to synthetic resins. Has antibacterial properties. Therefore, secondary caries can be prevented in advance.
【図１】実施例の歯科用コンポジットレジンの構造の模
式図。FIG. 1 is a schematic view of the structure of a dental composite resin of an example.
【図２】実験例１におけるＮｏ．１の菌数と放置時間と
の関係を示すグラフである。2 is a diagram illustrating No. 1 in Experimental example 1. FIG. It is a graph which shows the relationship between the number of bacteria of 1 and leaving time.
【図３】実験例１におけるＮｏ．２の菌数と放置時間と
の関係を示すグラフである。3 is a diagram illustrating No. 1 in Experimental Example 1. It is a graph which shows the relationship between the number of bacteria of 2 and leaving time.
【図４】実験例１におけるＮｏ．３の菌数と放置時間と
の関係を示すグラフである。4 is a diagram illustrating No. 1 in Experimental example 1. FIG. It is a graph which shows the relationship between the number of bacteria of 3 and leaving time.
【図５】実験例１におけるＮｏ．４の菌数と放置時間と
の関係を示すグラフである。5 is a diagram showing No. 1 in Experimental example 1. FIG. It is a graph which shows the relationship between the number of bacteria of 4 and leaving time.
【図６】実験例１におけるＮｏ．５の菌数と放置時間と
の関係を示すグラフである。6 is a diagram illustrating No. 1 in Experimental Example 1. It is a graph which shows the relationship between the number of bacteria of 5 and leaving time.
【図７】実験例１におけるＮｏ．６の菌数と放置時間と
の関係を示すグラフである。7 is a diagram illustrating No. 1 in Experimental Example 1. It is a graph which shows the relationship between the number of bacteria of 6 and leaving time.
【図８】実験例１におけるＮｏ．７の菌数と放置時間と
の関係を示すグラフである。8 is a diagram showing No. 1 in Experimental example 1. FIG. It is a graph which shows the relationship between the number of bacteria of 7 and leaving time.
【図９】実験例２におけるＮｏ．１の菌数と放置時間と
の関係を示すグラフである。9 is a diagram illustrating No. 1 in Experimental Example 2. It is a graph which shows the relationship between the number of bacteria of 1 and leaving time.
【図１０】実験例２におけるＮｏ．２の菌数と放置時間
との関係を示すグラフである。10 is a diagram illustrating No. 1 in Experimental Example 2. It is a graph which shows the relationship between the number of bacteria of 2 and leaving time.
【図１１】実験例２におけるＮｏ．３の菌数と放置時間
との関係を示すグラフである。11 is a diagram illustrating No. 1 in Experimental Example 2. It is a graph which shows the relationship between the number of bacteria of 3 and leaving time.
【図１２】実験例２におけるＮｏ．４の菌数と放置時間
との関係を示すグラフである。12 is a diagram illustrating No. 2 in Experimental Example 2. It is a graph which shows the relationship between the number of bacteria of 4 and leaving time.
【図１３】実験例２におけるＮｏ．５の菌数と放置時間
との関係を示すグラフである。13 is a diagram illustrating No. 1 in Experimental Example 2. It is a graph which shows the relationship between the number of bacteria of 5 and leaving time.
【図１４】実験例２におけるＮｏ．６の菌数と放置時間
との関係を示すグラフである。14 is a diagram illustrating No. 1 in Experimental Example 2. It is a graph which shows the relationship between the number of bacteria of 6 and leaving time.
【図１５】実験例２におけるＮｏ．７の菌数と放置時間
との関係を示すグラフである。15 is a diagram illustrating No. 1 in Experimental Example 2. It is a graph which shows the relationship between the number of bacteria of 7 and leaving time.
【図１６】実験例３における菌数と放置時間との関係を
示すグラフである。FIG. 16 is a graph showing the relationship between the number of bacteria and the standing time in Experimental Example 3.
１ 歯科用コンポジットレジン ２ ガラスフィラー ３ 合成樹脂 1 Dental composite resin 2 Glass filler 3 Synthetic resin
Claims (6)
性の活性物質が注入されたガラスフィラーの群と、この
ガラスフィラーの周囲に存在し、ガラスフィラーを結合
している合成樹脂よりなることを特徴とする歯科用コン
ポジットレジン。1. A group of glass fillers into which an antibacterial active substance in an ionized or radical state is injected, and a synthetic resin which is present around the glass fillers and which is bound to the glass fillers. Dental composite resin.
成分とするものである請求項１に記載の歯科用コンポジ
ットレジン。2. The dental composite resin according to claim 1, wherein the glass filler contains silica SiO 2 as a main component.
性の活性物質が、銀イオンＡｇ+である請求項１又は２
に記載の歯科用コンポジットレジン。3. The ionized or radicalized antibacterial active substance is silver ion Ag +.
The dental composite resin described in.
０．１〜２０μの範囲で分散し、不規則形状をなしてい
る請求項１〜３のいずれかに記載の歯科用コンポジット
レジン。4. The dental composite resin according to claim 1, wherein the particle size distribution of the glass filler group is dispersed in a particle size range of 0.1 to 20 μm to form an irregular shape.
性の活性物質をガラスフィラーに１０〜４００ＫＶの加
速電圧で注入し、そのガラスフィラーを合成樹脂原料と
ともに混合した後、その原料を重合させることを特徴と
する歯科用コンポジットレジンの製造方法。5. A method of injecting an ionized or radicalized antibacterial active substance into a glass filler at an accelerating voltage of 10 to 400 KV, mixing the glass filler with a synthetic resin raw material, and then polymerizing the raw material. A method for producing a characteristic dental composite resin.
にガラスフィラーをシランカップリング処理する請求項
５に記載の歯科用コンポジットレジンの製造方法。6. The method for producing a dental composite resin according to claim 5, wherein the glass filler is subjected to a silane coupling treatment after injecting the active substance and before polymerizing the synthetic resin raw material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5192949A JPH0717821A (en) | 1993-07-06 | 1993-07-06 | Dental composite resin and production thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5192949A JPH0717821A (en) | 1993-07-06 | 1993-07-06 | Dental composite resin and production thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0717821A true JPH0717821A (en) | 1995-01-20 |
Family
ID=16299701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5192949A Pending JPH0717821A (en) | 1993-07-06 | 1993-07-06 | Dental composite resin and production thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0717821A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6123925A (en) * | 1998-07-27 | 2000-09-26 | Healthshield Technologies L.L.C. | Antibiotic toothpaste |
| GB2459948A (en) * | 2008-05-07 | 2009-11-18 | Rocktron Ltd | A dry filler comprising glass beads coated with a microbiocide |
-
1993
- 1993-07-06 JP JP5192949A patent/JPH0717821A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6123925A (en) * | 1998-07-27 | 2000-09-26 | Healthshield Technologies L.L.C. | Antibiotic toothpaste |
| GB2459948A (en) * | 2008-05-07 | 2009-11-18 | Rocktron Ltd | A dry filler comprising glass beads coated with a microbiocide |
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