JPH0720033A - Detector and detection method for material coagulation change - Google Patents

Abstract

(57) [Summary] [Purpose] To detect changes in solidification of liquid substances easily and accurately. [Structure] An annular groove 2 is provided on the surface of a support 1 to support the support 1.
A pair of piezoelectric bodies 3 and 4 and a voltage sensor 5 are attached to the back surface of the. A liquid substance is loaded in the annular groove 2, an AC voltage is applied to the piezoelectric bodies 3 and 4, and the solidification change of the liquid substance is known from the modulation output of the piezoelectric sensor 5 caused by the transport movement of the liquid substance.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a detector and method for detecting a change in solidification of a substance from a liquid to a solid due to a chemical reaction or physical change of a liquid substance.

[0002]

2. Description of the Related Art For example, in the conventional measurement of blood coagulation time, a blood coagulation activator is added to plasma and the change with time of light transmittance is measured to obtain the coagulation time.

Further, a feedback circuit for simply exciting the piezoelectric plate is constituted by an amplifier, and a liquid is loaded on the piezoelectric plate to change the amplitude of the oscillation circuit due to the change of solidification and the mode of the piezoelectric body and the generated sound wave. Some measure the change in frequency to determine the change in coagulation.

[0004]

However, in the above-mentioned conventional example, when measuring the transmittance of light, the optical system including the light source is large and optical adjustment is difficult, the apparatus becomes expensive, and the substance that does not transmit light is used. Not available for.

Further, when the amplitude and frequency of the piezoelectric plate are measured, only the relative value can be obtained because the amplitude and frequency depend on the load volume of the liquid. Furthermore, with the evaporation of liquid, the analysis of this factor is extremely difficult.

The object of the present invention is to solve the above-mentioned problems,
An object of the present invention is to provide a light-weight and small-sized detector for a coagulation change and a detection method capable of easily and accurately measuring a coagulation change and a coagulation time.

[0007]

SUMMARY OF THE INVENTION In order to achieve the above-mentioned object, a detector of a substance coagulation change according to the present invention is provided with a groove for extending a liquid substance and an annular traveling wave which is transmitted to the liquid substance. And a piezoelectric sensor for detecting an annular traveling wave.

In the method for detecting a change in substance coagulation according to the present invention, a liquid substance is extended in a groove of a support, alternating voltages having different phases are applied to a piezoelectric substance to cause a transport motion of the liquid substance,
It is characterized in that the change in solidification of the liquid substance is detected by detecting the modulation output from the piezoelectric sensor generated by this.

[0009]

The detector of the substance coagulation change having the above structure is
A fluid substance is loaded into the groove, a transport motion is generated in the liquid substance by the piezoelectric body, and a change in the solidification of the liquid substance is detected from the modulation output of the piezoelectric sensor.

In addition, in the method of detecting the change in substance coagulation, the liquid substance is loaded in the groove of the support, and the transport movement of the liquid substance caused by the AC voltage applied to the piezoelectric body is detected by the piezoelectric sensor.

[0011]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described in detail based on the illustrated embodiments. FIG. 1 is a plan view of this embodiment, and FIG. 2 is a sectional view.
An annular groove 2 is provided on the surface of a flat disc-shaped support 1. Further, as shown in the bottom view of FIG. 3, on the back surface of the support 1, a pair of piezoelectric bodies 3 and 4 having a length of a condition for generating an annular traveling wave, and the traveling wave generated are detected. The piezoelectric element 5 and the grounding plate 6 are attached.

Electrodes 7, 8 and 9 as input / output terminals are connected to the piezoelectric bodies 3 and 4 and the piezoelectric element 5, respectively, and signal sources 10 and 11 are connected to the electrodes 7 and 8 and electrode 9 is connected to the electrodes 9. A monitor 12 including an ammeter is connected.

In such a structure, the liquid for a sample is put in the annular groove 2 of the support 1 and alternating voltages having different phases are applied to the pair of piezoelectric bodies 3 and 4. As a result, transport movement occurs in the liquid, the piezoelectric sensor 5 detects the amplitude modulation signal, and the result is displayed on the monitor 12. After that, when the liquid gradually solidifies and the relative flexibility of the liquid changes, the degree of amplitude modulation gradually decreases, and when the solidification is complete, the modulation signal disappears and a standing wave signal is detected to detect the solidification change of the substance. To be done.

FIG. 4 shows a piezoelectric obtained by the monitor 12 immediately after the blood is loaded on the annular groove 2 as a subject and a 5 volt sine wave whose phase is shifted by 90 ° is input to the pair of piezoelectric bodies 3 and 4. The waveform of the output of the sensor 5 is shown. This waveform shows that the output amplitude is modulated by the transport movement of blood.

FIG. 5 shows the piezoelectric sensor 5 immediately after blood coagulation.
The waveform of the output of is shown. It can be seen that there is no amplitude modulation because the transport movement is stopped by the coagulation of blood. When the time required for blood coagulation in this case was measured, it was 6.1 seconds.

If an inexpensive PZT or the like is used for the piezoelectric bodies 3 and 4, the main body of the detecting portion can be disposable, and particularly when blood is the subject, hygienic measurement without the risk of infection can be performed. It is possible, and when an adhesive, an ultraviolet curable resin, or the like is an object to be inspected, it is possible to prevent impurities from being mixed in, and it is possible to use it repeatedly if a hard material is used.

Further, by making the groove 2 annular, continuous transport motion of the liquid is generated, the output from the piezoelectric sensor 5 becomes a waveform with amplitude modulation, and the length of the wavelength of the envelope is the groove. It is an integral multiple of the length of the circumference at the width center of 2. Since the amplitude of this envelope disappears when the liquid is solidified, the solidification change can be measured more reliably than when the liquid is simply loaded on the piezoelectric plate.

The present invention can be applied not only to changes in solidification but also to changes in density, viscosity, etc., which represent the degree of flexibility of a substance. However, it can be applied.

When the support 1 does not require any particular strength, the support 1 is used as a detector of the present detector by considering the shapes of the piezoelectric bodies 3 and 4 and the electrodes 7 and 8 on the surfaces thereof. It is also possible to remove it from the configuration.

[0020]

As described above, in the detector and the method for detecting a change in solidification of a substance according to the present invention, a voltage is applied to the piezoelectric body and the transport motion of the liquid is detected by the piezoelectric sensor, so that the size and weight are reduced. Coagulation changes can be measured easily and accurately.

[Brief description of drawings]

FIG. 1 is a plan view of the present embodiment.

FIG. 2 is a sectional view taken along line AA of FIG.

FIG. 3 is a rear view.

FIG. 4 is a waveform diagram of a piezoelectric sensor output.

FIG. 5 is a waveform diagram of a piezoelectric sensor output.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Support 2 Annular groove 3, 4 Piezoelectric body 5 Piezoelectric sensor 7, 8, 9 Electrode 10, 11 Signal source 12 Monitor

Claims (2)

[Claims] 1. A substance coagulation, comprising: a groove for extending a liquid substance; a piezoelectric body for generating an annular traveling wave and transmitting the same to the liquid substance; and a piezoelectric sensor for detecting the annular traveling wave. Change detector. 2. A liquid substance is extended in a groove of a support, alternating voltages having different phases are applied to the piezoelectric substance, a transport motion is caused in the liquid substance, and a modulation output from the piezoelectric sensor generated thereby is detected. The method for detecting a change in the coagulation of a substance is characterized by knowing the change in the coagulation of the liquid substance.