JPH07215832A - Skin external preparation - Google Patents

Abstract

PURPOSE:To obtain a highly safe skin external preparation having excellent effect of improving roughness of skin. CONSTITUTION:This skin external preparation comprises at least one kind of natural humectant factor(NHF) ingredient and erythritol. In particular, the NHF ingredient consists of at least one kind selected from lactic acid, lactates, citrates, Na<+>, Ca<2+>, K<+>, PO4<3-> and Cl<->.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin external preparation, and more particularly to a skin external preparation having a high skin roughening improving effect.

[0002]

2. Description of the Related Art One of the major purposes of external preparations for skin such as cosmetics is to maintain a beautiful skin condition. To maintain beautiful skin,
It is important to prevent and improve the roughness of the skin, prepare the skin's furrows and cuticles, and smooth the turnover of epidermal cells. Traditionally, creams and milky lotions that replenish water and oil have been used as the skin care base. And various moisturizers have been added. In particular, natural moisturizing factor (NMF)
Since it was revealed that isturizing factor) plays an important role in moisturizing the skin, it has been incorporated into external skin preparations such as cosmetics.

[0003]

However, the natural moisturizing factor has a problem that the skin roughening improving effect is weak at a low concentration, and that when it is blended at a high concentration to sufficiently exert the effect, irritation to the skin occurs. there were. The present invention has been made in view of the above problems of the prior art, and an object thereof is to provide an external preparation for skin which has excellent effects of preventing and improving rough skin and has less skin trouble.

[0004]

Means for Solving the Problems As a result of intensive studies for achieving the above-mentioned object, the present inventors have found that not only the use of natural moisturizing factor in combination with erythritol improves skin roughening prevention and improvement effects, but also The inventors have found that the occurrence of irritation is small and have completed the present invention. That is, the external skin preparation according to claim 1 of the present invention is characterized by containing one or more natural moisturizing factor (NMF) components and erythritol.

The external preparation for skin according to claim 2 of the present invention is characterized in that in the external preparation for skin according to claim 1, lactic acid and / or lactate is added as a natural moisturizing factor (NMF) component. The external skin preparation according to claim 3 is the external skin preparation according to claim 1, which is a natural moisturizing factor (NM).
It is characterized in that citric acid and / or citrate is added as the component (F). The external preparation for skin according to claim 4 is the external preparation for skin according to claim 1, which is a natural moisturizing factor (NM).
F) as components Na ⁺ , Ca ²⁺ , Mg ²⁺ , K ⁺ , PO ₄ ^3-
Alternatively, at least one or more of Cl ⁻ is blended.

The structure of the present invention will be described in detail below. The natural moisturizing factor (hereinafter abbreviated as NMF) according to the present invention is a hydrophilic hygroscopic substance existing in keratin and is known to have a composition as shown in Table 1.

[Table 1] ─────────────────────────────────── (NMF component) (Composition) Amino acids 40% Pyrrolidonecarboxylic acid (PCA) 12 Lactate 12 Urea 7 NH ₃ , Uric acid, Glucosamine, Creatinine 1.5 Citrate 0.5 Na, Ca, Mg, K, PO ₄ , Cl 18.5 Sugar, organic acid, peptide Etc. 8.5 ────────────────────────────────────

The NMF used in the present invention includes the NMF components shown in Table 1, preferably lactic acid and / or lactate, citric acid and / or citrate, Na ⁺ , Ca ²⁺ , Mg. ²⁺ , K ⁺ , PO ₄ ³⁻ , Cl ⁻ ions, more preferably lactic acid and / or lactate,
Citric acid and / or citrate. The lactate and citrate are not particularly limited, and examples thereof include alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as calcium salt and magnesium salt, and ammonium salt. Further, as the ions, NaCl,
CaCl ₂ , KCl, Na ₃ PO ₄ , K ₂ HPO ₄ , H ₃ PO
_{4 In} addition to inorganic salts such as HCl, organic acid salts such as sodium acetate and potassium acetate can be added.

In the present invention, one or more of these NMF components can be blended. The amount of NMF used in the present invention is 0.01 to 3 based on the total amount of the skin external preparation.
0% by weight is preferable, and more preferably 0.01 to 20.
% By weight. If the amount is less than 0.01% by weight, the effect of the present invention is not sufficiently exhibited, and if the amount is more than 30% by weight, the effect corresponding to the increase in the amount of the compound cannot be expected.

Erythritol used in the present invention is also called meso-erythritol, and is a sugar alcohol of 4 carbon sugars contained in lichens, basidiomycetes, fruits and the like in the natural world.
The amount of erythritol used in the present invention is preferably 0.1 to 30% by weight, and more preferably 1 to 20% by weight, based on the total amount of the external preparation for skin. If it is less than 0.1% by weight, the effect of the present invention is not sufficiently exerted, and if it exceeds 30% by weight, the effect corresponding to the increase of the compounding amount cannot be expected.

In the external preparation for skin of the present invention, the combined use of NMF and erythritol synergistically improves the rough skin improving effect as compared with the case where they are used alone. The external preparation for skin of the present invention refers to cosmetics, pharmaceuticals, quasi drugs, etc. applied to the outer skin, and its dosage form is an aqueous solution-based, solubilized-based, emulsion-based, powder-based, oil-based, gel-based system. , An ointment system, a water-oil two-layer system, a water-oil-powder three-layer system, and the like.

In addition to the above essential components, the external preparation for skin of the present invention
Other skin external preparations such as cosmetics and pharmaceuticals
The components may be blended within a range that does not impair the effects of the present invention.
it can. For example, powders of titanium dioxide, mica, talc, etc.
Powdered ingredients, avocado oil, corn oil, olive oil, na
Seed oil, evening primrose oil, castor oil, sunflower oil, tea seed oil, coconut oil
Menuka oil, jojoba oil, cocoa oil, coconut oil, squalene,
Squalane, beef tallow, owl, beeswax, candelilla
Wax, carnauba wax, whale wax, lanolin, silicone oil,
Liquid paraffin, ceresin, petrolatum, polyoxyethylene
Len (8 mol) oleyl alcohol ether, monoole
Oils such as glyceryl inate, capryl alcohol, laur
Ryl alcohol, myristyl alcohol, cetyl alcohol
Alcohol such as alcohol, cholesterol, phytostea
Sterols such as rolls, capric acid, lauric acid, millimeters
Stastic acid, palmitic acid, stearic acid, behenic acid,
Higher fats such as lanolin fatty acid, linoleic acid and linolenic acid
Acid, para-aminobenzoic acid, homomenthyl-7N-acetyl
Rualantranilate, butyl methoxybenzoyl meta
And di-paramethoxycinnamic acid-mono-2-ethylhexyl
Glyceryl sanate, amyl salicylate, octylcin
Purple such as namate and 2,4-dihydroxybenzophenone
External line absorbent, polyethylene glycol, glycerin, sodium
Rubitol, xylitol, maltitol, mucopolysaccharide,
Moisturizing hyaluronic acid, chondroitin sulfate, chitosan, etc.
Agent, methyl cellulose, ethyl cellulose, arabian moth
System, polyvinyl alcohol, montmorillonite, lavona
Thickeners such as ito, ethanol, 1,3-butylene glyco
Organic solvent such as alcohol, butylhydroxytoluene, tocov
Erol, antioxidants such as phytic acid, benzoic acid, sari
Cylic acid, sorbic acid, alkyloxy paraoxybenzoate
Ter (ethyl paraben, butyl paraben, etc.), hexac
Antibacterial preservatives such as lolofen, glycine, alanine, burr
, Leucine, serine, threonine, phenylalani
, Tyrosine, aspartic acid, asparagine, gluta
Amino acids such as min, taurine, arginine and histidine
And their alkali metal salts and hydrochlorides, acyl sarcosylates
Acids (eg lauroyl methyl sarcosine sodium
Etc.), organic acids such as glutathione, malic acid, tartaric acid, etc.
Tamine A and its derivatives, vitamin B₆Hydrochloride, Vitamin
B₆Tripalmitate, vitamin B₆Dioctanoe
G, vitamin B₂And its derivatives, vitamin B₁₂, Vita
Min B 1_FiveB vitamins such as and its derivatives, ascorbi
Acid, ascorbic acid sulfate (salt), ascorbi
Acid phosphate (salt), ascorbic acid dipalmite
Vitamin Cs, α-tocopherol, β-tocolate
Ferrol, γ-tocopherol, vitamin E acetate
Vitamin E nicotinate and other vitamin Es, vitamin
Bis such as vitamin D, vitamin H, pantothenic acid, and pantethine
Tamines, nicotinamide, benzyl nicotinate, γ
-Oryzanol, Allantoin, Glycyrrhizic acid
(Salt), glycyrrhetinic acid and its derivatives, hinokitio
, Muscidin, bisabolol, eucalyptol, chi
Mohr, inositol, saponins (saikosaponin,
Carrot saponin, loofah saponin, muclodisaponin
Etc.), pantothenyl ethyl ether, ethinyl estra
Various types of diol, cepharanthin, placenta extract, etc.
Drug, Rumex, Clara, Kouhone, Orange, Say
Ji, yarrow, mallow, senkyu, senbu
Re, thyme, spruce, spruce, perch, horsetail, hechi
Ma, horse chestnut, Yukinoshita, Arnica, lily, mugwort,
Organic of plants such as peony, aloe, gardenia, and mackerel
Solvent, alcohol, polyhydric alcohol, water, aqueous alcohol
Natural extract, pigment, sol monolaurate
Bitan, sorbitan monopalmitate, sesquiolein
Acid sorbitan, sorbitan trioleate, monolauri
Acid polyoxyethylene sorbitan, monostearic acid
Polyoxyethylene sorbitan, polyethylene glycol
Lumonooleate, polyoxyethylene alkyl ether
, Polyglycol diester, lauroyldiethanone
Luamide, fatty acid isopropanol amide, mulch
Tall hydroxy aliphatic ether, alkylated polysaccharide,
Non-ionic fields such as ruquil glucoside and sugar ester
Surface-active agent, stearyl trimethyl ammonium chloride
, Benzalkonium chloride, laurylamine oxide
Cationic surfactants such as sodium palmitate,
Sodium laurate, Sodium lauryl sulfate, Lau
Potassium rilsulfate, triethanolamine alkylsulfate
Ether, funnel oil, linear dodecyl benzene sulfate, po
Rioxyethylene hydrogenated castor oil maleic acid, acyl meth
Anionic surfactant such as lutarine, amphoteric surfactant
Agents, fragrances, purified water and the like can be added.

[0012]

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto.
In addition, the compounding amount is represented by weight% unless otherwise specified. [Rough skin prevention test] The back skin of a healthy man was treated with a 3% sodium dodecyl sulfate aqueous solution to prepare rough skin. After 2 hours, 20 μl of each sample aqueous solution was applied in an open manner.
This was repeated for 5 days, and on the 6th day, the state of rough skin was visually observed and scored according to the criteria in Table 1. The higher the score, the higher the effect of improving rough skin.

[0013]

[Table 1] ─────────────────────────────────── Scores Standards of scores ───── ────────────────────────────── 1 A wide range of horny layer dryness, swelling, and strong erythema are observed. 2 Dry, swelling and moderate erythema on the stratum corneum. 3 Dryness of the stratum corneum is observed, but no curling is observed. Weak erythema. 4 Dryness and turning of the stratum corneum are not observed, but some erythema is observed. 5 Dryness, swelling and erythema of the stratum corneum are not observed. ───────────────────────────────────

The test males were 10 in each group, and the skin roughening improving effect of each sample was judged based on the average value of the scores of 10 males. Judgment ◎: Average score is 4 or more ○: Average score is 3 or more and less than 4 Δ: Average score is 2 or more and less than 3 ×: Average score is less than 2

[0015]

[Table 2]

From Table 2, it is understood that the use of NMF (sodium lactate) or erythritol alone has a low skin roughening improving effect, but the system in which these are used together synergistically increases the skin roughening preventing effect.

[0017]

[Table 3] ──────────────────────────────────── Sample 7 8 9 9 10 11 12 12 13 14 ─ ─────────────────────────────────── Sodium lactate 10 20 30 40 5 5 10 15 20 Erythritol − − − − 5 10 15 20 ──────────────────────────────────── Purified water Residue ────── ────────────────────────────── Rough skin prevention effect △ ○ △ × ○ ◎ ◎ ◎ ◎ ───────── ────────────────────────────

From Table 3, conventional NMF (sodium lactate) has an effect of improving rough skin at low concentrations, but its effect is weak, while high concentration causes erythema and the like, and rather tends to enhance rough skin. On the other hand, in the system using erythritol in combination, the rough skin improving effect is synergistically improved,
An excellent effect of improving rough skin was obtained with a low concentration of NMF.

[0019]

[Table 4] ──────────────────────────────────── Sample 15 16 17 18 18 19 20 21 22 22 ─ ─────────────────────────────────── (NMF) Na citrate Na 10 − − − − 5 − − NaCl − 10 − − − 5 − − KCl − − 10 − − − − 5 − Acetic acid Na − − − 10 − − − 5 5 ───────────────────────── ──────────── Erythritol − − − − 5 55 5 5 ───────────────────────────── ─────── Water residue ──────────────────────────────────── Skin roughening prevention effect △ △ △ △ ○ ○ ○ ○ ───────────────── ────────────────── from Table 4, in combination systems with various NMF component and erythritol will be appreciated that rough skin improvement effect increases.

[Actual Use Test by Replica Method] The skin surface morphology of the face of a healthy female panelist was replicated using a silicone resin replica method, and a microscope (1
7 times). Rough skin was evaluated based on the criteria shown in Table 5 based on the condition of the skin squeezing and the peeling state of the stratum corneum, and the panelists judged to have a score of 1 or 2 were 20 persons per group, and Table 6 is shown on the right half of the face. Lotion of Formulation Example 1 or Formulation 2 of Comparative Example 1 was applied to the left half for 2 days each.
It was applied twice. Two weeks later, a replica was taken again, and the condition of the skin was observed and evaluated in the same manner as above.

[0021]

[Table 5] ─────────────────────────────────── Scores Standards of scores ───── ────────────────────────────── 1 Skin clefts, disappearance of cuticles, and wide skin keratinization 2 skins Grooves and crusts are unclear, and horny layer is turned up. 3 Crusts and crusts are observed, but flat 4 Crusts, crusts are clear 5 Crusts, crusts are clear and regular ──── ───────────────────────────────

In each group, the rough skin improving effect was judged as follows. Judgment ○: The proportion of panelists who were evaluated as 4 or 5 is 75
% Or more △: The proportion of panelists evaluated as 4 or 5 is 25
% Or more and less than 75% x: The proportion of panelists evaluated as 4 or 5 is 25
The results are shown in Table 6.

[0023]

[Table 6] ─────────────────────────────────── Component Composition example 1 Composition example 2 Comparative example 1 ─ ────────────────────────────────── Sodium lactate 1.5 1.0 3.0 KCl − 1.0 − Erythritol 1.5 1.0 − ─── ──────────────────────────────── Propylene glycol 1.0 1.0 1.0 Citric acid 0.2 0.2 0.2 95% Ethanol 10.0 10.0 10.0 POE ( 20) Lauryl ether 0.5 0.5 0.5 Perfume Suitable quantity Suitable quantity Purified water Residual residue Residual residue ─────────────────────────────────── ─ Evaluation ○ ○ △ ─────────────────────────────────── As seen from Table 6, the present invention Such an external preparation for skin improves rough skin It is an excellent skin external preparation in the results.

When the external preparations for the skin of the following formulation examples 3 to 11 were prepared by a conventional method, they all had the effect of preventing and improving the rough skin, and were also capable of producing papules, comedones, blister, erythema and the like. It was a highly safe external preparation for skin.

Formulation 3 Pack Kaolin 70.8 wt% Talc 23.0 Propylene glycol 5.0 Calcium acetate 0.01 Urea 0.5 Erythritol 0.3 KCl 0.1 Perfume Suitable amount

Formulation 4 Nourishing cream Stearic acid 2.0 wt% Stearyl alcohol 7.0 Reduced lanolin 2.0 Squalane 5.0 Octyldodecanol 6.0 Maltitol hydroxylauryl ether 3.0 Glyceryl monostearate 2.0 Antiseptic Agent Appropriate amount Perfume Appropriate amount Propylene glycol 5.0 Erythritol 10.0 Potassium lactate 0.5 Purified water Residual

Blending Example 5 Lip Treatment Candelilla Wax 9.0 wt% Solid Paraffin 8.0 Beeswax 5.0 Carnauba Wax 5.0 Lanolin 11.0 Castor Oil Residual Erythritol 18.0 NaCl 10.0 Isopropyl myristate 10.0 Fragrance Suitable amount Antioxidant Residue

Formulation Example 6 Emulsion stearic acid 2.0 wt% Cetanol 1.0 Vaseline 3.0 Lanolin alcohol 2.0 Liquid paraffin 8.0 Squalane 2.0 Escalol 507 2.0 Erythritol 10.0 HCl 0.5 Poly Oxyethylene (10) monooleate 2.5 Triethanolamine 1.0 Propylene glycol 5.0 Preservative A suitable amount Perfume Suitable amount Purified water Residual

Formulation Example 7 Emulsion stearic acid 2.0 wt% Cetanol 1.0 Vaseline 3.0 Lanolin alcohol 2.0 Liquid paraffin 8.0 Squalane 2.0 Escalol 507 2.0 Erythritol 1.5 Sodium lactate 0.5 KCl 0.1 Polyoxyethylene (10) monooleate 2.5 Triethanolamine 1.0 Propylene glycol 5.0 Preservative A suitable amount Perfume Suitable amount Purified water Residual

Formulation Example 8 Nourishing Cream Stearic Acid 2.0 wt% Stearyl Alcohol 7.0 Reduced Lanolin 2.0 Squalane 5.0 Octyldodecanol 6.0 Maltitol Hydroxylauryl Ether 3.0 Glyceryl Monostearate 2.0 Preservative Agent Amount Perfume Amount Propylene glycol 5.0 Erythritol 1.0 Lactic acid 0.3 Sodium citrate 0.5 Epsilon aminocaproic acid 0.3 Purified water Residual

Formulation 9 Pack Kaolin 65.0 wt% Talc 19.0 Propylene glycol 5.0 Calcium acetate 0.01 Urea 0.5 Erythritol 0.2 Perfume Suitable amount

Blending Example 10 Lip Treatment Candelilla Wax 9.0 wt% Solid Paraffin 8.0 Beeswax 5.0 Carnauba Wax 5.0 Lanolin 11.0 Castor Oil Residual Erythritol 20.0 Potassium Lactate 15.0 Sodium Citrate 10. 0 Isopropyl myristate 10.0 Fragrance Suitable amount Antioxidant Residual

[0033]

The external preparation for skin of the present invention is a highly safe external preparation for skin, which is excellent in improving and preventing skin roughness and does not cause papules, blisters, vesicles, erythema and the like.

Claims (4)

[Claims] 1. An external preparation for skin, comprising one or more natural moisturizing factor (NMF) components and erythritol. 2. The external preparation for skin according to claim 1, which contains lactic acid and / or lactate as a natural moisturizing factor (NMF) component. 3. The external skin preparation according to claim 1, wherein citric acid and / or citrate is added as a natural moisturizing factor (NMF) component. 4. The external preparation for skin according to claim 1, wherein Na ⁺ , Ca ²⁺ and Mg are used as natural moisturizing factor (NMF) components.
^An external preparation for skin, comprising at least one selected from ²⁺ , K ⁺ , PO ₄ ³⁻ or Cl ⁻ .