JPH07242551A - Agent for inhibiting accumulation of body fat - Google Patents

Agent for inhibiting accumulation of body fat

Info

Publication number
JPH07242551A
JPH07242551A JP3727794A JP3727794A JPH07242551A JP H07242551 A JPH07242551 A JP H07242551A JP 3727794 A JP3727794 A JP 3727794A JP 3727794 A JP3727794 A JP 3727794A JP H07242551 A JPH07242551 A JP H07242551A
Authority
JP
Japan
Prior art keywords
xylose
arabinose
body fat
fat
accumulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3727794A
Other languages
Japanese (ja)
Inventor
Toshihiko Asano
敏彦 浅野
Yasuyoshi Yoshimura
康美 吉村
Toshihito Kakiuchi
利仁 垣内
Kiyohiko Keyakida
清彦 欅田
Tsutomu Terachi
務 寺地
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to JP3727794A priority Critical patent/JPH07242551A/en
Publication of JPH07242551A publication Critical patent/JPH07242551A/en
Pending legal-status Critical Current

Links

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  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE:To provide a body fat-inhibiting-reducing agent containing D-xylose and L-arabinose as active ingredients, having actions to inhibit and reduce the accumulation of body fats, and useful for preventing health disorders such as obesity, hypertension and hyperlipemia. CONSTITUTION:A body fat-inhibiting.reducing agent contains D-xylose and L-arabinose as active ingredients. The D-xylose and the L-arabinose may be the crude extracts of the hydrolyzates of rice bran, wheat bran, bagasse, corn husk, cotton seed husk, etc., and when the D-xylose and the L-arabinose are mixed with each other and used, the mixing ratio of the D-xylose: L-arabinose is 50:50 to 99:1, especially 80:20 to 99:1.

Description

【発明の詳細な説明】Detailed Description of the Invention

【0001】[0001]

【産業上の利用分野】この発明は体脂肪蓄積抑制剤に関
するものであり、詳細にはD−キシロースおよび/また
はL−アラビノースを有効成分とする体脂肪蓄積抑制
剤、体脂肪減少剤に関するものである。
FIELD OF THE INVENTION The present invention relates to a body fat accumulation inhibitor, and more particularly to a body fat accumulation inhibitor and a body fat reducing agent containing D-xylose and / or L-arabinose as an active ingredient. is there.

【0002】[0002]

【従来の技術】肥満は、高血圧、耐糖能異常、高脂血症
などを合併しやすく、虚血性心疾患、脳卒中、糖尿病な
どの危険因子と考えられており、成人病予防の観点か
ら、肥満対策はきわめて重要である。肥満とは、単に体
重が多いことではなく、体構成成分の内、脂肪組織の占
める割合(体脂肪率)が正常以上に増加した状態として
定義されている。そして近年、皮下脂肪、内臓脂肪等の
体脂肪の蓄積について、皮下組織にたまる皮下脂肪型肥
満よりも、臓器の間にたまる内臓脂肪型肥満の方が高血
圧、高脂血症、糖尿病などの成人病を合併しやすいこと
も報告されている。[徳永勝人・他:日本内科学会誌8
1巻 95−99頁(1992年)。] この発明者等は皮下脂肪、内臓脂肪等の体脂肪に対する
各種薬剤の効果を検討した所、D−キシロースおよび/
またはL−アラビノースに、体脂肪の蓄積を抑制する作
用があるという新知見を得、さらに鋭意研究を進めた結
果、この発明を完成した。
BACKGROUND ART Obesity is easily associated with hypertension, impaired glucose tolerance, hyperlipidemia, etc., and is considered to be a risk factor for ischemic heart disease, stroke, diabetes, etc. Countermeasures are extremely important. Obesity is defined as a state in which the proportion of adipose tissue (body fat percentage) in body components is increased more than normal, rather than simply being heavy. In recent years, with regard to the accumulation of body fat such as subcutaneous fat and visceral fat, visceral fat obesity that accumulates between organs is more common in adults with hypertension, hyperlipidemia, diabetes, etc. than subcutaneous fat obesity that accumulates in subcutaneous tissues. It is also reported that the disease is likely to be complicated. [Katsuhito Tokunaga et al .: Journal of the Japanese Society of Internal Medicine 8
Volume 1, pages 95-99 (1992). The present inventors have examined the effects of various drugs on body fat such as subcutaneous fat and visceral fat, and found that D-xylose and / or
Alternatively, the present invention has been completed as a result of further finding out that L-arabinose has an action of suppressing the accumulation of body fat, and further conducting earnest research.

【0003】[0003]

【発明の構成】この発明は、D−キシロースおよび/ま
たはL−アラビノースを有効成分とする体脂肪蓄積抑制
剤、体脂肪減少剤を提供する。
The present invention provides a body fat accumulation inhibitor and a body fat reducing agent containing D-xylose and / or L-arabinose as an active ingredient.

【0004】この発明で使用するD−キシロースおよび
L−アラビノースは粉末、液状、結晶あるいは顆粒のい
ずれであってもよいし、米ヌカ、小麦フスマ、バガス
(さとうきびのしぼりかす)、とうもろこし外皮、綿実
殻等の加水分解物のD−キシロースおよびL−アラビノ
ース粗抽出物であってもよい。D−キシロースとL−ア
ラビノースを混合して使用する場合、両者の混合割合は
一般的には限定はないが、工業的には、例えば上記粗抽
出物を使用する場合、D−キシロースとL−アラビノー
スの割合は50:50ないし99:1、好ましくは8
0:20ないし99:1の範囲が考えられる。
The D-xylose and L-arabinose used in the present invention may be in the form of powder, liquid, crystals or granules, rice bran, wheat bran, bagasse (squeeze of sugar cane), corn rind and cotton. It may be a D-xylose and L-arabinose crude extract of a hydrolyzate such as a nut shell. When D-xylose and L-arabinose are used as a mixture, the mixing ratio of both is generally not limited, but industrially, for example, when the above crude extract is used, D-xylose and L-arabinose are mixed. The ratio of arabinose is 50:50 to 99: 1, preferably 8
A range of 0:20 to 99: 1 is possible.

【0005】D−キシロースおよびL−アラビノースは
それぞれ単独あるいは両者を併用して体脂肪(皮下脂
肪、内臓脂肪)蓄積抑制剤として、体脂肪(皮下脂肪、
内臓脂肪)減少剤として使用することができる。これら
の用途で用いる場合には、例えばD−キシロース及び/
またはL−アラビノースの粉末、液状、結晶あるいは顆
粒をそのまま、あるいは水、エタノール、エチレングリ
コール、ポリエチレングリコール等の液状担体、澱粉、
セルロース、ポリアミド粉末等の固型担体等の無毒性担
体で希釈して、アンプル剤、顆粒剤、錠剤、丸剤、カプ
セル剤、シロップ剤等に常法にしたがって調製したもの
をD−キシロースおよび/またはL−アラビノースとし
て0.01g/kg以上投与するようにすればよい。
D-xylose and L-arabinose may be used alone or in combination of both as body fat (subcutaneous fat, visceral fat) accumulation suppressors.
It can be used as a visceral fat) reducing agent. When used for these purposes, for example, D-xylose and / or
Alternatively, L-arabinose powder, liquid, crystals or granules as they are, or liquid carrier such as water, ethanol, ethylene glycol, polyethylene glycol, starch,
D-xylose and / or an ampoule, a granule, a tablet, a pill, a capsule, a syrup and the like prepared by diluting with a non-toxic carrier such as a solid carrier such as cellulose and polyamide powder Alternatively, 0.01 g / kg or more of L-arabinose may be administered.

【0006】この発明の体脂肪蓄積抑制剤、体脂肪減少
剤は、上記のようにそれらを単独で人または動物に投与
することもできるが、一般の食品に添加して使用するこ
ともできる。例えば、D−キシロースおよび/またはL
−アラビノースを直接もしくは上記のような担体とを常
法に従って調製したものを各種食品、例えば清涼飲料
水、コーヒー、紅茶、果汁、牛乳、ジャム、あん、ゼリ
ー、菓子、コーンフレークなどの液状或いは固状の食
品、調味料、副食品等に添加して使用することもでき
る。
The body fat accumulation suppressor and body fat reducer of the present invention can be administered alone to humans or animals as described above, or can be used by adding them to general foods. For example, D-xylose and / or L
-Arabinose prepared directly or with a carrier as described above according to a conventional method for various foods, such as soft drinks, coffee, tea, fruit juice, milk, jam, bean jam, jelly, confectionery, corn flakes, etc. It can also be used by adding it to foods, seasonings, side foods, etc.

【0007】[0007]

【発明の効果】この発明の体脂肪(皮下脂肪、内臓脂
肪)蓄積抑制剤、体脂肪(皮下脂肪、内臓脂肪)減少剤
を使用することにより、体脂肪とくに内臓脂肪の蓄積が
抑制され、また内臓脂肪の減少効果が顕著になり、肥
満、高血圧、高脂血症等の健康障害を予防することがで
きる。
The use of the body fat (subcutaneous fat, visceral fat) accumulation suppressor and body fat (subcutaneous fat, visceral fat) reducer of the present invention suppresses the accumulation of body fat, particularly visceral fat, and The visceral fat reducing effect becomes remarkable, and health disorders such as obesity, hypertension, and hyperlipidemia can be prevented.

【0008】次にこの発明の効果を試験例により説明す
る。 試験例 内臓脂肪蓄積に対するキシロースの効果(ラット):ラ
ット(ウイスター雄、6週令、体重約210g)を1群
4匹とし、計12匹使用した。飼料はCE−2(日本ク
レア(株))(組成は下に示す通り)を使用し、1群
(対照)には、CE−2に砂糖20%及びセルロース2
0%添加したものを与え、2群にはCE−2に砂糖20
%、セルロース10%、D−キシロース10%を添加し
たものを、3群にはCE−2に砂糖20%及びD−キシ
ロース20%を添加したものを与えて、10週間飼育し
た。飼育後屠殺・解剖し、副睾丸の周囲及び後腹膜の脂
肪をとりだし、重量を測定し、体重100g当りに補正
したものを脂肪率とした。結果は以下の通りである。
Next, the effects of the present invention will be described with reference to test examples. Test Example Effect of xylose on visceral fat accumulation (rat): Rats (male Wistar, 6-week-old, body weight: about 210 g) were used in groups of 4 and a total of 12 rats were used. CE-2 (CLEA Japan, Inc.) (composition as shown below) was used as the feed, and CE-2 had 20% sugar and 2 cellulose as a group (control).
0% added to the 2 groups CE-2 and sugar 20
%, Cellulose 10% and D-xylose 10% were added, and to group 3 were given CE-2 with 20% sugar and 20% D-xylose added, and were bred for 10 weeks. After rearing, the animals were slaughtered and dissected, and the fat around the epididymis and the retroperitoneum were taken out, weighed, and corrected for 100 g of body weight to obtain the fat percentage. The results are as follows.

【0009】内臓脂肪蓄積に対するキシロース摂取の効
果 ラットWistar♂、6週令(開始時体重 平均20
8g)、10週間飼育、n=4
Effect of xylose ingestion on visceral fat accumulation Rat Wistar♂, 6 weeks old
8g), raised for 10 weeks, n = 4

【表1】 [Table 1]

【0010】飼料組成: 水 分(%) 8.7 粗 蛋 白 質(%) 24.8 粗 脂 肪(%) 4.4 粗 繊 維(%) 3.5 粗 灰 分(%) 7.0 可溶性無窒素物(%) 51.6Feed composition: Water (%) 8.7 Crude protein (%) 24.8 Crude fat (%) 4.4 Crude fiber (%) 3.5 Crude ash (%) 7. 0 Soluble nitrogen-free (%) 51.6

Claims (2)

【特許請求の範囲】[Claims] 【請求項1】 D−キシロースおよび/またはL−アラ
ビノースを有効成分として含有する体脂肪蓄積抑制剤。
1. A body fat accumulation inhibitor containing D-xylose and / or L-arabinose as an active ingredient.
【請求項2】 D−キシロースおよび/またはL−アラ
ビノースを有効成分として含有する体脂肪減少剤。
2. A body fat reducing agent containing D-xylose and / or L-arabinose as an active ingredient.
JP3727794A 1994-03-08 1994-03-08 Agent for inhibiting accumulation of body fat Pending JPH07242551A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3727794A JPH07242551A (en) 1994-03-08 1994-03-08 Agent for inhibiting accumulation of body fat

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3727794A JPH07242551A (en) 1994-03-08 1994-03-08 Agent for inhibiting accumulation of body fat

Publications (1)

Publication Number Publication Date
JPH07242551A true JPH07242551A (en) 1995-09-19

Family

ID=12493200

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3727794A Pending JPH07242551A (en) 1994-03-08 1994-03-08 Agent for inhibiting accumulation of body fat

Country Status (1)

Country Link
JP (1) JPH07242551A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0923382A4 (en) * 1996-08-09 1999-12-22 Mannatech Inc Compositions of plant carbohydrates as dietary supplements
WO2001057230A1 (en) * 2000-02-01 2001-08-09 Unitika Ltd. Process for producing l-arabinose, l-arabinose-containing enzymatically processed products, diet foods, diabetic diet foods and fruit or vegetable juices and process for producing the same
WO2003024468A1 (en) * 2001-09-19 2003-03-27 Bioneer Corporation Substances extracted from corn which can inhibit the activities of amylase, pharmaceutical compositions and food additives containing the same extracts for treatment or prevention of obesity and diabetes mellitus, and processes for their preparations
US6548662B1 (en) 1999-01-14 2003-04-15 Sanwa Kosan Kabushiki Kaisha Method for purification of saccharide
US6929807B1 (en) 1996-08-09 2005-08-16 Mannatech, Inc. Compositions of plant carbohydrates as dietary supplements
JP2010532346A (en) * 2007-07-04 2010-10-07 ヒポキシ カンパニー リミテッド Compositions comprising starch or dietary fiber from Graminea plant for prevention and treatment of ischemic and brain degenerative diseases
US8071141B2 (en) 2000-12-12 2011-12-06 Kaneka Corporation Compositions for preventing or ameliorating multiple risk factor syndromes
CN102771687A (en) * 2011-05-10 2012-11-14 陈培豪 A metabolic conditioner containing L-arabinose and its production method
KR101231583B1 (en) * 2010-08-11 2013-02-08 이해수 Composition for Improving Obesity Using Effective Compounds Isolated from Wheat Bran

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7199104B2 (en) 1996-08-09 2007-04-03 Mannatech, Inc. Compositions of plant carbohydrates as dietary supplements
US7157431B2 (en) 1996-08-09 2007-01-02 Mannatech, Inc. Compositions of plant carbohydrates as dietary supplements
EP1172041A3 (en) * 1996-08-09 2002-08-07 Mannatech, Inc. Compositions of plant carbohydrates as dietary supplements
US7196064B2 (en) 1996-08-09 2007-03-27 Mannatech, Inc. Compositions of plant carbohydrates as dietary supplements
EP0923382A4 (en) * 1996-08-09 1999-12-22 Mannatech Inc Compositions of plant carbohydrates as dietary supplements
US6929807B1 (en) 1996-08-09 2005-08-16 Mannatech, Inc. Compositions of plant carbohydrates as dietary supplements
US7202220B2 (en) 1996-08-09 2007-04-10 Mannatech, Inc. Compositions of plant carbohydrates as dietary supplements
US6548662B1 (en) 1999-01-14 2003-04-15 Sanwa Kosan Kabushiki Kaisha Method for purification of saccharide
WO2001057230A1 (en) * 2000-02-01 2001-08-09 Unitika Ltd. Process for producing l-arabinose, l-arabinose-containing enzymatically processed products, diet foods, diabetic diet foods and fruit or vegetable juices and process for producing the same
US8071141B2 (en) 2000-12-12 2011-12-06 Kaneka Corporation Compositions for preventing or ameliorating multiple risk factor syndromes
KR20030025200A (en) * 2001-09-19 2003-03-28 (주)바이오니아 Substances extracted from corn which can inhibit the activities of amylase, pharmaceutical compositions and food additives containing the same extracts for treatment or prevention of obesity and diabetes mellitus, and processes for their preparation
WO2003024468A1 (en) * 2001-09-19 2003-03-27 Bioneer Corporation Substances extracted from corn which can inhibit the activities of amylase, pharmaceutical compositions and food additives containing the same extracts for treatment or prevention of obesity and diabetes mellitus, and processes for their preparations
JP2010532346A (en) * 2007-07-04 2010-10-07 ヒポキシ カンパニー リミテッド Compositions comprising starch or dietary fiber from Graminea plant for prevention and treatment of ischemic and brain degenerative diseases
KR101231583B1 (en) * 2010-08-11 2013-02-08 이해수 Composition for Improving Obesity Using Effective Compounds Isolated from Wheat Bran
CN102771687A (en) * 2011-05-10 2012-11-14 陈培豪 A metabolic conditioner containing L-arabinose and its production method

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