JPH07258068A - Bath agent composition - Google Patents

Abstract

PURPOSE:To obtain a bathing agent. composition containing alpha2-adrenergic suppressing medicine, capable of providing smoothness to skin and excellent in warm feeling of body. CONSTITUTION:This bathing agent composition contains >=0.005wt.%, preferably 0.01-20wt.% of a beta-adrenergic suppressing medicine selected from yohimbine, phentolamine and ergotamine and theirs salts, etc., and further, inorganic salts (e.g. sodium sulfate), an organic acid (e.g. succinic acid), a carboxylic acid salt (e.g. sodium hydrogen carbonate) and an oily component (e.g. glyceride myristate) are preferably blended therein. The moist feeling of skin and warm feeling of body are further enhanced by combinedly using these ingredients. The concentration of the beta-adrenergic suppressing medicine used in bathing is preferably 0.01-200ppm. The bathing agent composition is used in an amount so as to provide 0.1-200ppm concentration of the p-adrenergic suppressing medicine at a time in bathing.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a bath preparation having a smooth feeling on the skin and an excellent warmth of the body.

[0002]

[Problems to be Solved by the Invention]

2. Description of the Related Art Bathing has various effects such as cleansing the body, warming not only limbs but also the core, and relaxing mentally, and is an essential activity in daily life. On the other hand, many people complain of the loss of oil content from the skin due to bathing, especially the bulkiness of the skin after bathing in the winter. And, in order to suppress the bulkiness of the skin after bathing, such a person usually uses various skin care products such as lotions and creams after bathing. However, when using a skin care product, labor is required for its application and the like, and it is difficult for an elderly person to apply the skin care product to every corner of the body. Therefore, an attempt has been made to prevent the skin from becoming bulky after bathing by adding an oil component to the bath agent, and the bath agent containing various inorganic salts, which are hot spring ingredients, as a main component is used for recovery from fatigue and warming. It has been developed for the purpose of improving the warm bath effect such as improving feeling.

[0003]

However, the bath sensation containing the above oil and hot spring ingredients does not always give the skin a smooth feeling and warmth, and further gives the skin a smooth feeling. A bath agent having an excellent warm feeling has been desired.

[0004]

[Means for Solving the Problems] Under these circumstances, the present inventors have conducted diligent studies, and as a result, a bath agent composition containing an α ₂ adrenergic inhibitor gives a smooth feeling to the skin, and The present invention has been completed by finding that the body has a warm feeling.

That is, the present invention provides a bath agent composition containing an α ₂ adrenergic inhibitor.

The α ₂ adrenergic inhibitor used in the present invention is not particularly limited, but yohimbine, phentolamine, phenoxybenzamine, trazoline, ergotamine, ergotoxin, dihydroergotamine, ergomethrin, methylergomethrin, dihydro. Examples thereof include ergotoxin, lauorcin, piperoxane, and pharmacologically acceptable salts thereof. Examples of the pharmaceutically acceptable salt include pharmaceutically acceptable acid addition salts, metal salts, ammonium salts, organic amine addition salts, amino acid addition salts and the like. In the present invention, one or two selected from the group consisting of yohimbine, phentolamine, ergotamine, and pharmacologically acceptable salts thereof.
It is preferable to use one or more species, and in this case, the salt is preferably a mesylate salt or a tartrate salt. The content of the α ₂ adrenergic inhibitor is 0.005% by weight based on the total amount of the composition.
(Hereinafter, simply indicated by “%”) or more, and particularly preferably 0.01 to 20%.

In the bath agent composition of the present invention, the above α
₂ By using an inorganic salt in combination with an adrenergic inhibitor, the effect of giving the skin a smooth feeling and the warmth of the body is further enhanced. As the inorganic salts used in the present invention, sodium chloride, sodium hydrogen carbonate, sodium carbonate, borax, sodium sulfate, sodium sulfide, sodium sesquicarbonate, sodium nitrate, sodium thiosulfate, sodium polyphosphate, sodium phosphate, calcium oxide,
Examples thereof include magnesium oxide, calcium carbonate, magnesium carbonate, potassium chloride and potassium sulfide. In the present invention, it is preferable to use sodium chloride, sodium hydrogen carbonate, sodium carbonate, sodium sulfate, sodium sesquicarbonate, magnesium oxide, calcium carbonate or magnesium carbonate among them. The content of the inorganic salt is preferably 5% or more, particularly 10% or more in the total amount of the composition, and the amount of the inorganic salt with respect to the α ₂ adrenergic inhibitor is 0.25 to 20,000 times by weight, particularly 0. The amount is preferably 0.5 to 10,000 times, more preferably 0.5 to 1,000 times.

Further, in the bath agent composition of the present invention,
The combined use of the above-mentioned α ₂ adrenergic inhibitor with an organic acid and a carbonate further enhances the effect of giving the skin a smooth feeling and the warmth of the body. Examples of the organic acid used in the present invention include succinic acid, fumaric acid, malic acid, tartaric acid, citric acid and benzoic acid. These may be used alone or in combination of two or more. Examples of the carbonate used in the present invention include sodium hydrogen carbonate, sodium carbonate, potassium hydrogen carbonate, calcium carbonate, magnesium carbonate, sodium sesquiate carbonate and the like. These may be used alone or in combination of two or more. In the present invention, it is preferable to use sodium hydrogen carbonate, sodium carbonate, magnesium carbonate, sodium sesquicarbonate as the carbonate, and succinic acid and fumaric acid as the organic acid. The content of the carbonate is preferably 5 to 80%, particularly preferably 10 to 50% in the total amount of the composition. The content of organic acid is 1 of the carbonate.
It is preferably set to 0 to 300%, particularly 30 to 150%. Further, the compounding ratio of the carbonate and the α ₂ adrenergic inhibitor is such that the weight ratio of the carbonate to the α ₂ adrenergic inhibitor is 0.25 to 16,000 times, particularly 0.5 to 5,0.
It is preferably 00 times, more preferably 0.5 to 500 times.
In addition, when the organic acid and the carbonate are used together in the bath agent composition of the present invention, carbon dioxide generated in the bath water is dissolved in the bath water to obtain a blood circulation promoting effect by the dissolved carbon dioxide. It is preferable to add an acid component for making the bath water weakly acidic (preferably pH 5 to 7) in the bath agent composition, if necessary. Such an acid component is not particularly limited, but it is preferable to add the organic acid in excess.

Further, in the bath agent composition of the present invention,
By using an oily component in combination with the α ₂ adrenergic inhibitor, the effect of giving the skin a smooth feeling and the warmth of the body is further enhanced.

Examples of the oily component used in the present invention include oils and fats, waxes, hydrocarbons, higher fatty acids, higher alcohols, esters, essential oils and silicone oils. Examples of the oils and fats include natural oils and fats such as soybean oil, bran oil, jojoba oil, avocado oil, almond oil, olive oil, cacao oil, sesame oil, persic oil, castor oil, coconut oil, mink oil, beef fat, and pork fat. Hydrogenated natural oils and fats, hydrogenated oils obtained by hydrogenation, myristic acid glycerides, and synthetic triglycerides such as 2-ethylhexanoic acid triglyceride. Examples of waxes include carnauba wax, whale wax, beeswax, and lanolin. Examples of the hydrocarbons include liquid paraffin, petrolatum, paraffin microcrystalline wax, ceresin, squalane, blistane and the like. Examples of the higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, lanolinic acid and isostearic acid. Examples of higher alcohols include lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol and 2-hexyldecanol. As the esters, cetyl octanoate, triglyceride octanoate, myristyl lactate, cetyl lactate, isopropyl myristate,
Examples include myristyl myristate, octyldodecyl myristate, isopropyl palmitate, isopropyl adipate, butyl stearate, decyl oleate, cholesterol isostearate, POE sorbit fatty acid ester, and the like. As essential oils, peppermint oil, jasmine oil, show brain oil, cypress oil, spruce oil, ryu oil,
Turpentine oil, cinnamon oil, bergamot oil, tangerine oil, ginger oil, pine oil, lavender oil, bay oil, clove oil, hiba oil, rose oil, eucalyptus oil, lemon oil, thyme oil, peppermint oil, rose oil, sage. Examples thereof include oil, menthol, cineol, eugenol, citral, citronellal, borneol, linalool, geraniol, camphor, thymol, spilanthol, pinene, limonene, and terpene compounds. Examples of silicone oils include dimethylpolysiloxane. These oily components described above can be used alone or in combination of two or more. In the present invention, among these, myristic acid glyceride, 2-ethylhexanoic acid triglyceride, lanolin, liquid paraffin, petrolatum, paraffin microstarin wax, squalane, lauric acid, myristic acid, palmitic acid, linoleic acid, linolenic acid, isostearic acid , Cetyl alcohol, stearyl alcohol, oleyl alcohol, cholesterol, cetyl octanoate, triglyceride octanoate,
Isopropyl myristate, octyldodecyl myristate, cholesterol isostearate, POE sorbit fatty acid ester, peppermint oil, spruce oil, cinnamon oil,
Preference is given to using rose oil, menthol, cineole, eugenol, citral, citronellal, geraniol, pinene, limonene, dimethylpolysiloxane. The content of the oily component in the bath agent composition can be appropriately selected according to the dosage form (form) of the bath agent, and can usually be 0.1 to 95% in the total amount of the composition.
Further, the blending ratio of the oil component and the α ₂ adrenergic inhibitor is 0.005 to 19,000 times by weight of the blend amount of the oil component with respect to the α ₂ adrenergic inhibitor, and more preferably, 0.
The amount is preferably 005 to 9,500 times, more preferably 0.005 to 950 times.

If desired, the bath agent composition of the present invention may contain an oily component such as a partial acid or an emulsifier.
The dispersant / emulsifier has a function of preventing the oily component in the bath agent from floating on the water surface when the bath agent is dissolved in the bath water, and makes the bath water cloudy so that the transparency of the 0.01% aqueous solution is 40 cm.
Hereafter, it is preferably 20 cm or less, and a high-class image like a milk bath can be produced. Examples of such dispersion / emulsifiers include water-soluble polymer compounds and surfactants. Of these, water-soluble polymers include sodium alginate, propylene glycol alginate, gum arabic, xanthan gum, pectin, tragacanth, sodium carboxymethylcellulose, methylcellulose, carboxyvinyl polymer, polyethylene glycol, polyvinyl alcohol, polyvinylpyrrolidone, milk protein, soy protein, Examples include gelatin, egg protein, sodium caseinate, whey protein, and the like, gums such as gum arabic and xanthan gum, sodium caseinate, whey protein, and the like, and gums such as gum arabic and xanthan gum and sodium caseinate, whey protein. Water-soluble proteins such as

As the above-mentioned surfactant, any of anionic, cationic, nonionic, natural and synthetic surfactants can be used, but in consideration of skin irritation, a nonionic one is used. Preferably. Examples of the nonionic surfactant include glycerin fatty acid ester, propylene glycol fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, tetraoleic acid polyoxyethylene sorbit, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene. Examples thereof include glycol, polyoxyethylene polyoxypropylene alkyl ether, polyethylene glycol fatty acid ester, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, and polyglycerin fatty acid ester. These dispersion / emulsifiers can be used alone or in combination of two or more, and the blending amount thereof is preferably 5 to 100% with respect to the oily component.

The bath agent composition of the present invention may further contain the following known bath agent raw materials which are commonly used in bath agents, but the bath agent raw materials which can be blended are limited to the exemplified ones. There is no such thing. (A) Inorganic acids; boric acid, metasilicic acid, silicic acid anhydride and the like. (B) Herbal medicines: fennel, chamomile, ginkgo, psyllium, cinnamon, safflower, peony, ginger, iris, senkyu, touki, chimpi, soybean, valerian, juniper, spruce, peppermint, carrot, etc. (C) Dyes; yellow dye 4, blue dye 1, yellow dye (1), and other tar dyes specified in the Ordinance of the Ministry of Health and Welfare, dyes of Appendices I and II, chlorophyll, riboflavin, crocin,
Natural pigments recognized as food additives such as safflower and anthraquinone. (D) Vitamins; vitamin A, vitamin C, vitamin D, vitamin E and the like. (E) Fragrances (f) Others; sulfur, hot water, mineral sand, mica powder, neutral clay, rice bran, fungicides, preservatives, and other necessary components for formulation.

The bath agent composition of the present invention can be produced by adding the above-mentioned optional components to the above-mentioned essential components as necessary. The content of these optional components is 0 to 99% in the preparation. Further, an appropriate amount of water in the range of 0.01 to 90% is added to the bath agent composition of the present invention prepared as described above to increase the stability of the preparation or to emulsify the preparation. You can also Needless to say, the bath agent composition of the present invention can be made into various dosage forms such as powders, granules, tablets, and liquids in the same manner as known bath agents.

The bath agent composition of the present invention is used by putting it in bath water at the time of bathing.
₂ Adrenergic action inhibitor concentration is 0.01-200p
The amount is preferably pm. This concentration is 0.1
If it is less than ppm, the freshness of the skin and the warmth of the body cannot be provided, and if it exceeds 200 ppm, the effect of providing the smoothness of the skin and the warmth of the body is not further improved.

[0016]

The bath agent composition of the present invention gives a sufficient skin smoothness and warmth to the body.

[0017]

The present invention will be described in detail below with reference to examples, but the present invention is not limited to these examples. Examples 1 to 4 and Comparative Example 1 Liquid bath compositions having the compositions shown in Table 1 were prepared by a conventional method, and the skin smoothness and the warmth of the body (limbs) were examined by the following test methods. The results are shown in Table 1.

Smoothness of the skin: The bath agent composition in the amount shown in Table 1 is used in a bath filled with 150 l of hot water at 40 ° C. After 10 minutes from the pouring, the hot water is sufficiently stirred, and then each subject (n = 5) is bathed for 5 minutes. This bath is performed once a day for 3 consecutive days. The smoothness of the skin after bathing on the 3rd day was judged according to the following criteria and shown as the average score. 5 points: Very smooth. 4 points: Smooth and smooth. 3 points: Smooth. 2 points: A little smooth. 1 point: equivalent to Sarayu. Feeling of warmth of limbs: The feeling of warmth of the limbs after bathing for 3 days in each of the above-mentioned subjects was judged according to the following criteria, and shown as the average score. 5 points: Very warm. 4 points: Warm up well. 3 points: It gets warm. 2 points: A little warm. 1 point: equivalent to Sarayu.

[0019]

[Table 1]

[0020] From Table 1, bath compositions of Examples 1 to 4 was blended alpha ₂ adrenergic inhibitors, compared with bath composition of Comparative Example 1 without blending alpha ₂ adrenergic inhibitors, skin It can be seen that the effect of giving the smoothness and warmth of the body is excellent.

Examples 5 to 8 and Comparative Examples 2 to 3 Powdery bath agent compositions having the compositions shown in Table 2 were prepared by a conventional method, and the same test method as in Example 1 was used to measure the smoothness of the skin and the limbs. I investigated the feeling of warmth. The results are shown in Table 2.

[0022]

[Table 2]

[0023] From Table 2, in the bath agent composition containing inorganic salts, bath compositions of Examples 5-8 were blended alpha ₂ adrenergic inhibitors are comparative examples that do not blended alpha ₂ adrenergic inhibitors It can be seen that the effect of imparting smoothness to the skin and warmth of the limbs is more excellent than those of the bath agent compositions of a few.

Examples 9 to 12 and Comparative Example 4 Tablet-shaped bath agent compositions having the compositions shown in Table 3 were prepared by a conventional method, and the same test method as in Example 1 was used to test the smoothness of skin and warmth of limbs. I investigated the feeling. The results are shown in Table 3.

[0025]

[Table 3]

[0026] From Table 3, in the bath agent composition containing an organic acid and a carbonate, bath compositions of Examples 9-12 were blended alpha ₂ adrenergic inhibitors are the alpha ₂ adrenergic inhibitors It can be seen that the effect of imparting smoothness to the skin and warmth of the limbs is superior to that of the bath agent composition of Comparative Example 4 which is not blended.

Examples 13 to 16 and Comparative Example 5 Liquid bath compositions having the compositions shown in Table 4 were prepared by a conventional method, and the same test method as in Example 1 was used to test the smoothness of skin and warmth of limbs. I checked about. The results are shown in Table 4.

[0028]

[Table 4]

[0029] From Table 4, in the bath agent composition containing an oil component, bath compositions of Examples 13 to 16 was blended alpha ₂ adrenergic inhibitors are comparative examples that do not blended alpha ₂ adrenergic inhibitors It can be seen that the effect of imparting smoothness to the skin and warmth of the limbs is more excellent than that of the bath agent composition of No. 5.

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[Procedure amendment]

[Submission date] June 3, 1994

[Procedure Amendment 1]

[Document name to be amended] Statement

[Name of item to be corrected] 0002

[Correction method] Change

[Correction content]

[0002]

2. Description of the Related Art Bathing has various effects such as cleansing the body, warming not only limbs but also the core, and relaxing mentally, and is an essential activity in daily life. On the other hand, many people complain of the loss of oil content from the skin due to bathing, especially the bulkiness of the skin after bathing in the winter. And, in order to suppress the bulkiness of the skin after bathing, such a person usually uses various skin care products such as lotions and creams after bathing. However, when using a skin care product, labor is required for its application and the like, and it is difficult for an elderly person to apply the skin care product to every corner of the body. Therefore, an attempt has been made to prevent the skin from becoming bulky after bathing by adding an oil component to the bath agent, and the bath agent containing various inorganic salts, which are hot spring ingredients, as a main component is used for recovery from fatigue and warming. It has been developed for the purpose of improving the warm bath effect such as improving feeling.

[Procedure Amendment 2]

[Document name to be amended] Statement

[Correction target item name] 0010

[Correction method] Change

[Correction content]

Examples of the oily component used in the present invention include oils and fats, waxes, hydrocarbons, higher fatty acids, higher alcohols, esters, essential oils and silicone oils. Examples of the oils and fats include natural oils and fats such as soybean oil, bran oil, jojoba oil, avocado oil, almond oil, olive oil, cacao oil, sesame oil, persic oil, castor oil, coconut oil, mink oil, beef fat, and pork fat. Hydrogenated natural oils and fats, hydrogenated oils obtained by hydrogenation, myristic acid glycerides, and synthetic triglycerides such as 2-ethylhexanoic acid triglyceride. Examples of waxes include carnauba wax, whale wax, beeswax, and lanolin. Examples of the hydrocarbons include liquid paraffin, petrolatum, paraffin microcrystalline wax, ceresin, squalane, blistane and the like. Examples of the higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, lanolinic acid and isostearic acid. Examples of higher alcohols include lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol and 2-hexyldecanol. As the esters, cetyl octanoate, triglyceride octanoate, myristyl lactate, cetyl lactate, isopropyl myristate,
Examples include myristyl myristate, octyldodecyl myristate, isopropyl palmitate, isopropyl adipate, butyl stearate, decyl oleate, cholesterol isostearate, POE sorbit fatty acid ester, and the like. As essential oils, peppermint oil, jasmine oil, show brain oil, cypress oil, spruce oil, ryu oil,
Turpentine oil, cinnamon oil, bergamot oil, tangerine oil, ginger oil, pine oil, lavender oil, bay oil, clove oil, hiba oil, rose oil, eucalyptus oil, lemon oil, thyme oil, peppermint oil, rose oil, sage. Examples thereof include oil, menthol, cineol, eugenol, citral, citronellal, borneol, linalool, geraniol, camphor, thymol, spilanthol, pinene, limonene, and terpene compounds. Examples of silicone oils include dimethylpolysiloxane. These oily components described above can be used alone or in combination of two or more. In the present invention, among these, myristic acid glyceride, 2-ethylhexanoic acid triglyceride, lanolin, liquid paraffin, petrolatum, paraffin microcrystalline wax, squalane, lauric acid, myristic acid, palmitic acid, linoleic acid,
Linolenic acid, isostearic acid, cetyl alcohol, stearyl alcohol, oleyl alcohol, cholesterol, cetyl octanoate, triglyceride octanoate, isopropyl myristate, octyldodecyl myristate, cholesterol isostearate, POE sorbit fatty acid ester, peppermint oil, spruce oil, silica Preference is given to using skin oils, rose oils, menthol, cineole, eugenol, citral, citronellal, geraniol, pinene, limonene, dimethylpolysiloxane. The content of the oily component in the bath agent composition can be appropriately selected according to the dosage form (form) of the bath agent, and can usually be 0.1 to 95% in the total amount of the composition. In addition, the mixing ratio of the oil component and the α ₂ adrenergic inhibitor is 0.005 to 19,000 times, particularly 0.005 to 9,500 times the weight ratio of the oil component to the α ₂ adrenergic inhibitor. , 0.005-950
The amount is preferably doubled.

[Procedure 3]

[Document name to be amended] Statement

[Correction target item name] 0011

[Correction method] Change

[Correction content]

If desired, the bath agent composition of the present invention may contain a dispersion / emulsifier of an oily component.
The dispersant / emulsifier has a function of preventing the oily component in the bath agent from floating on the water surface when the bath agent is dissolved in the bath water, and makes the bath water cloudy so that the transparency of the 0.01% aqueous solution is 40 cm.
Hereafter, it is preferably 20 cm or less, and a high-class image like a milk bath can be produced. Examples of such dispersion / emulsifiers include water-soluble polymer compounds and surfactants. Of these, water-soluble polymers include sodium alginate, propylene glycol alginate, gum arabic, xanthan gum, pectin, tragacanth, sodium carboxymethylcellulose, methylcellulose, carboxyvinyl polymer, polyethylene glycol, polyvinyl alcohol, polyvinylpyrrolidone, milk protein, soy protein, Gelatin, egg protein, sodium caseinate, whey protein and the like can be mentioned. Among them, gums such as gum arabic and xanthan gum and water-soluble proteins such as casein sodium and whey protein are preferable.

[Procedure amendment 4]

[Document name to be amended] Statement

[Correction target item name] 0013

[Correction method] Change

[Correction content]

The bath agent composition of the present invention may further contain the following known bath agent raw materials which are commonly used in bath agents, but the bath agent raw materials which can be blended are limited to the exemplified ones. There is no such thing. (A) Inorganic acids; boric acid, metasilicic acid, silicic acid anhydride and the like. (B) Herbal medicines: fennel, chamomile, ginkgo, psyllium, cinnamon bark, safflower, peony, ginger, iris, senkyu, touki, chimpi, soybean, valerian, juniper, spruce, peppermint, carrot, etc. (C) Dyes; yellow dye 4, blue dye 1, yellow dye (1), and other tar dyes specified in the Ordinance of the Ministry of Health and Welfare, dyes of Appendices I and II, chlorophyll, riboflavin, crocin,
Natural pigments recognized as food additives such as safflower and anthraquinone. (D) Vitamins; vitamin A, vitamin C, vitamin D, vitamin E and the like. (E) Fragrances (f) Others; sulfur, hot water, mineral sand, mica powder, neutral clay, rice bran, fungicides, preservatives, and other necessary components for formulation.

[Procedure Amendment 5]

[Document name to be amended] Statement

[Name of item to be corrected] 0015

[Correction method] Change

[Correction content]

The bath agent composition of the present invention is used by putting it in bath water at the time of bathing.
₂ Adrenergic action inhibitor concentration is 0.01-200p
The amount is preferably pm. This concentration is 0.0
If it is less than 1 ppm, the freshness of the skin and the warmth of the body cannot be imparted, and if it exceeds 200 ppm, the effect of imparting the smoothness of the skin and the warmth of the body is not further improved.

[Procedure correction 6]

[Document name to be amended] Statement

[Correction target item name] 0017

[Correction method] Change

[Correction content]

[0017]

The present invention will be described in detail below with reference to examples, but the present invention is not limited to these examples. Examples 1 to 4 and Comparative Example 1 A liquid bath composition having a composition shown in Table 1 was prepared by a conventional method, and the skin smoothness and the warmth of the body (limbs) were examined by the following test methods. The results are shown in Table 1.

Claims (5)

[Claims] 1. A bath agent composition containing an α ₂ adrenergic inhibitor. 2. The α ₂ adrenergic inhibitor is selected from the group consisting of yohimbine, phentolamine, ergotamine, and pharmacologically acceptable salts thereof.
The bath agent composition described. 3. The method according to claim 1, further comprising an inorganic salt.
The bath agent composition described. 4. The bath agent composition according to claim 1, further comprising an organic acid and a carbonate. 5. The method according to claim 1, further comprising an oily component.
The bath agent composition described.