JPH07258071A - Granular agent for skin and use thereof - Google Patents

Abstract

PURPOSE:To obtain a granular agent for skin having high safety, excellent handleability and beautiful appearance, by sticking fine powder to the surface of a granular material consisting essentially of an oily substance. CONSTITUTION:This granular agent for skin comprises a granular material containing an oil selected from fats and oils, wax, fatty acids and paraffins and fine powder (e.g. crystal cellulose or talc) having 0.01-500mum particle diameter stuck to the surface of the granular material. The granular agent for skin is further mixed with an oil-soluble substance, a surfactant, water and/or a water-soluble substance. The attachment of the fine powder to the granular material of the oily substance is carried out by a general method for sprinkling the fine powder while rolling the granular material. Although the granular agent for skin can be readily applied to the skin and is in a soft state, the surface of the granules has no greasiness. Consequently, the granules are not mutually stuck and not attached to a container and an inner wall of a machine in a production process. The granular agent for skin is suitably useful for a cosmetic, a quasi-drug, a medicine for external use, etc.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a granular dermatological agent having fine powder adhered to the surface of a granular material mainly composed of an oily substance, and a cream, ointment, emulsion or lotion containing the same. More specifically, the present invention relates to a granular dermatological agent having high stability and excellent handleability, and at the same time having a beautiful appearance, and a cream, ointment, emulsion or lotion containing the same.
The granular dermatological agent of the present invention can be suitably used as a cosmetic, a quasi drug, an external drug.

[0002]

2. Description of the Related Art As a granular cosmetic or drug, a capsule-shaped cosmetic or drug encapsulated in a film of gelatin or calcium alginate is known. Capsules are currently mainly used as an internal medicine. When these capsules are used as an application agent to apply to the skin, the capsules are not easily absorbed by the skin and remain on the skin, or when the capsules are crushed by applying force on the skin, they are applied due to the pressure applied. It is not very applicable as a skin agent, such as the contents popping out.
In addition, since the surface of the capsule is sticky, it sticks to the inner wall of the container in which the capsule is contained, or the capsules stick to each other, so that the individual capsules cannot be taken out from the container in the required amount. It was bad and had the drawback of becoming dirty in appearance. Further, the capsule has a disadvantage that the thickness of the capsule portion becomes thicker due to its structure and the amount of contents actually contained in the capsule is significantly smaller than the outer diameter of the capsule.

For the purpose of eliminating the above-mentioned drawbacks, the present inventor has already proposed a method for producing a particulate solid oil and fat product without a coating (Japanese Patent Laid-Open No. 3-146595).

However, according to the method disclosed in JP-A-3-146595, a soft particulate solid fat and oil product that can be used as a skin agent such as a cosmetic, a quasi drug or an external drug, is prepared in the same manner as a capsule. However, the particles are sticky and tend to stick to the inner wall of the container containing the particles or to stick to each other, which is not convenient.

In order to prevent the particles from sticking to each other, a spherical oil / fat dispersion formulation to be used as a cosmetic or the like by dispersing it in a water-soluble gel has been proposed (Japanese Patent Laid-Open No. Hei 5 (1993) -58).
179283). However, even this dispersion formulation must always be used in a state of being dispersed in a water-soluble gel such as xanthan gum or sodium acrylate, which is not satisfactory in terms of usability. Further, a product in which an active ingredient is suspended in a polymer gel aqueous solution has a problem in taking it out from a container. That is, when filled in a soft container such as a tube, it is easy to extrude and take out, but when extruding, the particulate matter near the wall surface is deformed,
It becomes damaged and becomes messy. In addition, when a dropper is used for taking out, there is no deformation or damage, but it is difficult to take out exactly the target amount of the granular material.

An object of the present invention is to provide a granular dermatological agent which solves the above problems all at once. That is, even though the active ingredient is soft enough to be easily applied to the skin, it does not have a film such as a capsule that does not easily disappear when applied, and there is no stickiness of individual particles. Is to provide a formulation that does not stick to the inner wall of the container or stick to each other.

[0007]

In order to solve the above problems, the present inventor has conducted various studies and found that when a fine powder is adhered to the entire surface of a granular material containing an oily substance as an active ingredient. The inventors have found that the above problems can be solved all at once, and have conducted further research to complete the present invention.

That is, the present invention relates to a granular dermatological agent comprising a granular material containing an oily substance and a fine powder adhered to the surface of the granular material.

Further, the present invention relates to cosmetics, quasi drugs, external medicines, etc., containing the above-mentioned granular dermatological agents, particularly creams, ointments, emulsions, lotions and the like.

The oily substance used in the present invention, of course, can maintain the granularity at 40 ° C. or less by itself,
As long as it can maintain the granularity at 40 ° C or less by mixing with other components (herein, the other components are also a concept that includes a hydrophobic substance), it can be used without distinction between liquid and solid. You can. Examples thereof include oils and fats, fatty acids, waxes and paraffins, but are not limited to these. That is, there is no problem as long as it is an oily substance (hydrophobic substance) used as a raw material for foods, food additives, cosmetics, quasi drugs, or pharmaceuticals. There is no shortage of enumerations if they are listed specifically, but the following is a list of only some of them.

For example, olive oil, corn oil, soybean oil, macadamian nut oil, cottonseed oil, jojoba oil, squalane, microcrystalline wax, liquid paraffin, isopropyl palmitate, cocoa butter, beef tallow, carnauba wax, beeswax, candelilla wax, stearin. Acid, palmitic acid, oleic acid, lanolin, sorbitan fatty acid, glycerin fatty acid, sucrose fatty acid, tocopherol, β-carotene, stearyl ascorbate and the like can be mentioned. These are used alone or as a mixture.

In the present invention, an oil-soluble substance which can be dissolved in the above oily substance can be contained. The oil-soluble substance is not particularly limited as long as it can be used while being retained in the oily substance, and is used in a wide range of fields including foods, medical products, cosmetics, health foods, seasonings and the like. Can be used by For example, oil-soluble vitamins, oil-soluble animal and plant extracts, substances exhibiting physiological activity, substances exhibiting a stabilizing action such as antioxidant action, fragrances, pigments, anti-inflammatory agents and antibacterial agents are exemplified. Not limited. These are used alone or as a mixture. When adding these oil-soluble substances, a surfactant may be used if necessary.

Further, the oily substance or the mixture of the oily substance and the oil-soluble substance used in the present invention may contain water and / or a water-soluble substance by adding a surfactant if necessary.

As the water-soluble substance, those used in a wide range of fields including foods, medical products, cosmetics, health foods, seasonings and the like can be used. For example, water-soluble vitamins, water-soluble animal and plant extracts, Examples thereof include, but are not limited to, substances exhibiting physiological activity, substances exhibiting stabilizing action such as antioxidant action, perfumes, pigments, anti-inflammatory agents and antibacterial agents.

As the surfactant, a nonionic surfactant which is usually used is preferably used, and specific examples thereof include sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyethylene glycol fatty acid ester and the like.

The granular material used in the present invention is, for example, the above-mentioned oily substance or an oil-soluble substance, a surfactant,
A composition or an emulsion containing at least one of water and a water-soluble substance is heated and melted, and dropped into an aqueous solvent having a temperature 5 to 50 ° C. lower than the melt to form a granular material. Particularly, it is preferable to drop a melt of the W / O type emulsion or a melt of two or more kinds having different melting points, preferably 20 ° C. or more, into the aqueous solvent. Examples of the aqueous solvent include ethanol aqueous solution, methanol aqueous solution, 2-propanol aqueous solution, and acetone aqueous solution. The method of dropping is not particularly limited, and there are methods such as dropping and ejecting using a nozzle.

The above-mentioned granules are in the vicinity of the body temperature of the human or animal using the dermatological agent of the present invention, specifically in the range of 40 ° C. or less, and are granulated while being easily crushed when lightly pressed with a finger. (For example, it disintegrates when 25 to 50 g (static load) is applied to each granular material having a diameter of 2.5 mm at 25 ° C.).

The particle size of the granular material is not particularly limited, but the lower limit is usually 0.2 mm, preferably 0.5 mm, more preferably 1.0 mm, and the upper limit is 10 mm, preferably 5 mm, more preferably 3 mm. .

There is no particular limitation on the shape of the granular material. For example, a spherical shape, a disk shape, a conical shape, an eggplant shape, or the like can be used.

The feature of the present invention resides in that the fine powder is adhered to the entire surface of the granular material of the oily substance thus obtained. The fine powder that can be used in the present invention can be used without particular limitation, whether it is lipophilic or hydrophilic, as long as it has high chemical stability and is safe for humans or animals. The fine powders satisfying these conditions can be enumerated specifically, but from the viewpoint of safety to humans or animals, and from the viewpoint of suppressing stickiness of the above-mentioned granules, the followings are particularly preferable. Is effective.

That is, talc, kaolin, mica, bentonite, calcium carbonate, calcium phosphate, boron nitride, titanium dioxide, white carbon, silica gel, crystalline cellulose, cellulose derivative, fatty acid calcium, fatty acid zinc, zinc oxide, fatty acid aluminum, glucose, etc. Monosaccharide, oligosaccharide, polysaccharide, cyclodextrin, hydroxyethyl starch, nylon powder, polystyrene powder, silk powder, polyvinyl alcohol, polyvinylpyrrolidone, chitosan, chitin, collagen, plasma protein, amino acid, RNA, DN
A etc. are mentioned. These are used alone or as a mixture.

Among them, talc, kaolin, mica, bentonite, silica gel, crystalline cellulose, fatty acid zinc, fatty acid calcium, fatty acid aluminum, monosaccharide,
Cyclodextrin, nylon powder, silk powder, polyvinylpyrrolidone, chitosan, collagen,
Plasma proteins, RNA and DNA are particularly preferred as they suppress stickiness particularly effectively.

The lower limit of the average diameter of the fine powder is 0.01 μ.
m, preferably 0.05 μm, more preferably 0.1
μm, most preferably 0.2 μm, with an upper limit of 50
0 μm, preferably 200 μm, more preferably 10 μm
It is 0 μm. A fine powder having a large diameter exceeding 500 μm gives a feeling of strangeness when applied to the skin. Further, the fine powder having a particle size of less than 0.01 μm is not suitable for production because it is scattered in the environment in the step of adhering to the surface of the above-mentioned granular material, or is significantly attached to the production apparatus due to static electricity.

The amount of the fine powder is appropriately selected depending on the particle size and composition of the granular material, but the lower limit is usually 0.1% by weight, preferably 1% by weight, more preferably 3% by weight based on the granular material. %, And the upper limit is 30% by weight, preferably 20% by weight, and more preferably 10% by weight.
In general, when the amount of the fine powder is less than 0.1% by weight, the effect of suppressing stickiness of the granular oily substance is often insufficient. In addition, even if the amount of adhesion exceeds 30% by weight, the effect of suppressing stickiness is often not further improved.

As a method for adhering the fine powder to the granular substance of an oily substance, for example, a method of sprinkling the fine powder while rolling the granular substance is generally used. The object can also be achieved by a method of vibrating the powder, a method of adding a granular material into the fine powder, or the like.

As a particularly preferred combination of the granular dermatological agent of the present invention, in the granules containing beeswax or olive oil or a mixture thereof as a main component, fine powders of crystalline cellulose, chitosan or DNA are candelilla wax or corn. Fine particles of mica or talc can be used for oils or granules containing a mixture of these as main ingredients, and granules containing carnauba wax or olive oil or a mixture of these for main ingredients of zinc stearate or aluminum stearate. An example is a combination of fine powders. Despite the above, generally, water and / or a water-soluble substance is emulsified as a granular material.
The granules obtained by melting the W / O type emulsion mixed and blended include cyclodextrin, maltose, glucose,
It is preferable to combine a fine powder of amino acid (glycine).

The granular dermatological agent of the present invention obtained in this manner has no stickiness, so that it hardly sticks to each other or to the inner wall of the container and has a beautiful appearance. Needless to say, the granular dermatological agent of the present invention can be used as it is as a cosmetic, a quasi drug, a drug, etc., but it is also used by blending it with an emulsion, cream, lotion, beauty essence, ointment, etc. It is also possible. Further, when the particle diameter of the granular material is not uniform, there is no stickiness, so that the particles having a uniform particle diameter can be easily selected using a standard sieve or the like.

The feature of the present invention resides in that the fine powder is adhered to the entire surface of the granular material containing the oily substance as a main component to suppress the stickiness of the granular material. In the present invention, the mechanism by which the fine powder suppresses the stickiness of the oily substance is not clear, but in the case of the lipophilic fine powder, the oil content causing stickiness leaching on the surface of the granules should be incorporated into the fine powder. Or in the case of hydrophilic fine powder, it is assumed that the fine powder prevents the oil content from leaching on the surface of the granular material, thereby suppressing stickiness. However, the mechanism of stickiness suppression cannot be completely explained only by the hydrophilicity and lipophilicity of the fine powder, and the lubricity of the adhered powder (the larger the slipperiness, the greater the stickiness suppression effect) and the powder It is presumed that the friction is reduced by covering the granular material to eliminate the unevenness, and the fluidity of the entire granular material is enhanced, which also contributes to the suppression of stickiness.

As a result, the granular skin preparation of the present invention does not become sticky or stick to each other or to the inner wall of the container, although it is in a soft state that can be easily applied to the skin. This does not need to be dispersed in a water-soluble gel or the like, and it can be used as a cosmetic or a medicine for external use in a granular form, and the handleability is remarkably improved. Also in the manufacturing process of the product, the work efficiency can be remarkably improved, for example, those having a uniform particle size can be easily selected with a sieve or the like. Further, the granular material is excellent in aesthetics. On the other hand, by including a liquid compound that is unstable at room temperature in the granular material of an oily substance, it becomes possible to stabilize the compound. By applying fine powder to the surface of such a granular material to eliminate stickiness and improve handleability, the use of compounds that are normally unstable to light and heat can be significantly expanded.

[0030]

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to the following examples. In the examples,% is% by weight unless otherwise specified.

Example 1 100 g of beeswax, 400 g of olive oil, and vitamin A3
g and Vitamin E 3 g were heated and melted at 70 ° C.
The melt was dropped into 80% by volume aqueous ethanol solution adjusted to 35 ° C. to form granules, which was taken out from the ethanol aqueous solution and dried at room temperature to obtain granules having a diameter of 3 mm. The obtained granules adhered to each other, had poor fluidity, and were sticky. 100 g of the granules were placed in a deep dish made of aluminum, and while vibrating the granules, 5 g of crystalline cellulose fine powder having an average particle diameter of 10 μm was sprinkled onto the granules to obtain a granular skin preparation.

The obtained granular dermatological agent was not sticky at room temperature, had fluidity, and did not stick to each other, and was easy to use. Furthermore, 45
No stickiness or adhesiveness was observed even after storage in a thermostat at 30 ° C for 30 days. When one granular dermatological agent stored at room temperature for 30 days was picked up with a spoon on the left palm and pressed with the right thumb, the particles easily disintegrated, that is, showed good disintegration property, and further disintegrated when the right thumb was moved. The granular dermatological agent was easily distracted, showed good dispersibility, and could be applied to the skin in its entirety without leaving any kind of film.

5 g of the obtained granular dermatological agent was mixed with 100 g of a previously prepared emulsion having the following composition to obtain an emulsion containing the granular dermatological agent. Emulsion composition: Cetanol 1.0%, Vaseline 2.0%,
Squalane 6.0%, beeswax 0.5%, dimethylpolysiloxane 2.0%, ethanol 5%, glycerin 4
%, 1,3-butylene glycol 4.0%, polyoxyethylene monooleate 1.0%, glycerol monostearate 1.0%, quince seed extract (containing 5%) 20%, water 53. 5%

Example 2 1 g of glycyrrhetinic acid stearic acid ester, 5 g of carnauba wax, 12 g of candelilla wax, 5 g of oleic acid,
9 with 50g jojoba oil and 50g corn oil
It was melted by heating to 0 ° C. The melt was dropped into 80% by volume ethanol aqueous solution adjusted to 30 ° C. to form granules, taken out from the ethanol aqueous solution, dried at room temperature, and had a diameter of about 1.5.
mm particles were obtained. The obtained granular material was sticky, had poor fluidity, and was troublesome to handle. 50 g of the granular material was placed in an aluminum deep dish, and while vibrating the granular material, talc fine powder 5 having an average particle diameter of 5 μm
A granular dermatological agent was obtained by sprinkling g and adhering it to the above-mentioned granular material.

The obtained granular dermatological agent was stored at room temperature (20 ° C.).
It was not sticky, had fluidity, and was easy to use without sticking to each other. When one particle of this drug was placed on the left forearm and pressed with the second finger of the right hand, it easily disintegrated. Furthermore, when the right finger was moved on the forearm as it was, the disintegrated granular material was easily distracted, and no foreign matter such as a film was observed.

The present granular material was applied between the fingers of the left hand of a patient who has atopic dermatitis between the fingers of each finger at a rate of 1 tablet per finger for 5 days and once each in the morning and evening. . When the left and right fingers were compared on the 6th day, the inflammation between the left fingers treated with the application was cured, but the inflammation between the right fingers not treated was exacerbated. From this, it is understood that the granular material of the present invention has an anti-inflammatory effect.

Further, 1 g of the obtained granular dermatological agent was kneaded and mixed into 100 g of a cream having the following composition to obtain a granular dermatological agent-containing cream having an anti-inflammatory effect. Cream composition: Microcrystalline Wax 9.0
%, Solid paraffin 2.0%, squalane 34.0%,
Beeswax 3.0%, Vaseline 5.0%, Reduced Lanolin 5
%, Hexadecyl adipate 10.0%, propylene glycol 5%, glyceryl monooleate 1.
0%, polyoxyethylene sorbitan monooleate 1.0%, water 24.5%, methylparaben 0.5
%

Example 3 1 g of dexamethasone palmitate ester was melted by heating to 70 ° C. together with 10 g of hydrogenated beef tallow (melting point 60 ° C.), 20 g of beeswax, 10 g of cocoa butter, 10 g of squalane, 100 g of soybean oil and 10 g of macadamia nut oil.
The melt was dropped into 80% by volume aqueous ethanol solution adjusted to 30 ° C. to give granules, which were taken out from the ethanol aqueous solution and dried at room temperature to obtain granules having a diameter of about 2 mm. The obtained granular material was sticky. 50 g of the granules,
5g of zinc stearate fine powder with an average particle diameter of 5μm was placed in an aluminum deep dish, which was shaken vigorously to attach zinc stearate, and nylon powder with an average particle diameter of 5μm (made by Toray Industries, Inc.) ) 5 g were sprinkled and adhered to obtain a granular skin preparation.

The obtained granular dermatological agent is not sticky at room temperature, has fluidity, is easy to use without sticking to each other, and has good disintegrating property and dispersibility. No residual film was observed when applied to the skin.

A granular skin preparation was applied to a patient who had stiffness in the finger joints due to rheumatoid arthritis at a rate of 1 tablet per finger before bedtime, and no stiffness was felt when waking up the next morning. It was

1 g of the obtained granular dermatological agent was mixed with 100 g of an ointment having the following composition to obtain a granular dermatological agent-containing ointment. Ointment composition: Stearic acid 8%, Stearyl alcohol 5%, Lanolin 45%, Glycerin monostearate 2
%, Water 40%

Example 4 1 g of sodium ascorbate, red pigment (red 10
6) 10 mg and 1 g of licorice extract were dissolved in 50 g of distilled water and heated to 75 ° C. 5 g of beeswax, 10 g of candelilla wax, and 5 of lanolin obtained by heating and melting this solution at 80 ° C.
g, 20 g of isopropyl palmitin, 50 g of cottonseed oil, 10 g of olive oil, 0.5 g of vitamin E and 1 g of sorbitan trioleate, and the mixture was stirred and emulsified using a homomixer. Immediately after emulsification, the mixture was injected into a 65% by volume aqueous ethanol solution adjusted to 40 ° C. from a nozzle to form granules, taken out from the ethanol aqueous solution, and dried at room temperature for 24 hours to obtain granules having a diameter of about 1.0 to 2.0 mm. Obtained. 50 g of the obtained granules are placed in an aluminum deep dish, and while vibrating the granules, the average particle diameter is 2.5.
5 g of talc fine powder of μm was sprinkled and adhered to the granular material, and further 4 g of polyvinylpyrrolidone fine powder having an average particle diameter of 32 μm or less was sprinkled and adhered thereon to obtain a granular skin preparation.

The obtained granular dermatological agent is not sticky at room temperature, has fluidity, is easy to use without sticking to each other, and has good disintegrating property and spreadability. Not only was no film or the like remained when it was applied to the skin, but it was a beautiful red color in appearance.

5 g of the obtained granular dermatological agent was added to 100 ml of a lotion having the composition shown below to obtain a lotion containing particles. Lotion composition: 1,3-butylene glycol 6%, glycerol 4%, oleyl alcohol 0.1%, polyoxyethylene sorbitan monolaurate 0.5
%, Polyoxyethylene lauryl alcohol ether 0.5%, ethanol 10%, lemon oil 1%, water 7
7.9%

Example 5 5 g of ibuprofen, which is a non-steroidal anti-inflammatory agent, 10 g of beeswax, 5 g of carnauba wax, 5 g of stearic acid,
Palmitic acid 5g, oleic acid 10g, olive oil 80
85 g with 10 g squalane and 20 g soybean oil
It was melted by heating to ℃. The melt was dropped into 80% by volume 2-propanol aqueous solution adjusted to 40 ° C., and the diameter was adjusted to about 2.0.
Granules of ~ 3.0 mm were obtained. 100 g of the obtained granules
In advance, it was crushed in a mortar to a diameter of 75 μm or less (2
Passed through a 00 mesh sieve) 7 g of β-cyclodextrin fine powder was added and adhered to obtain an anti-inflammatory skin agent.
The obtained anti-inflammatory skin agent showed no stickiness,
It showed good disintegration and dispersibility.

10 anti-inflammatory skin preparations (about 120 m
When g) was applied to the lower back of a patient who complained of muscular / fascial back pain, pain disappeared 15 minutes after application. Also, put this skin preparation in a glass bottle indoors,
When it was stored, even after 6 months, neither mutual adhesion of particles nor stickiness was observed, and it was stored well.

Example 6 10 g of beeswax, 5 g of candelilla wax, 5 g of paraffin (melting point 60 ° C.), 20 g of safflower oil, 30 g of olive oil, glycerin monostearate (HL)
B: 3.5) 0.5 g, sucrose stearate (HLB: 3) 0.5 g, licorice extract 1 g, red 102
It was heated and melted at 80 ° C. with 25 g of water colored in No.
The melt was injected from a nozzle into a 70% by volume aqueous ethanol solution adjusted to 40 ° C. to obtain colored granules having a diameter of 1.0 to 3.5 mm. To 50 g of the obtained granules, 4 g of polyvinylpyrrolidone fine powder pulverized in advance with a mortar to a diameter of 75 μm or less (passing through a 200 mesh sieve) was added and adhered to obtain a granular skin preparation. The obtained granular skin agent is
No stickiness was observed, and good disintegration and ductility were exhibited.

Further, the obtained particle size is about 1.0-3.
When the 5 mm granular dermatological agent was classified into particles having a diameter of 2.4 mm or more and less than 2.4 mm by using a standard 7.5 mesh sieve, the particles were made uniform in size and the appearance was also improved. .

Example 7 In the same procedure as in Example 6, the granular material 1 obtained in Example 1 was used.
The fine powder shown in Table 1 was added to 00 g to obtain a granular skin preparation. In the same manner as in Example 1, no stickiness was observed in any of the obtained granular dermatological agents, and good disintegration and ductility were exhibited. Table 1 shows the particle size and the addition amount of the fine powder.

[0050]

[Table 1]

[0051]

INDUSTRIAL APPLICABILITY The granular dermatological agent of the present invention has no stickiness on the surface of the particles in spite of being in a soft state which can be easily applied to the skin, and therefore the particles are used together or the inner wall of a machine in the process of manufacturing containers or products. Not only does it not stick to, etc., its handling and work efficiency are significantly improved, but it is also aesthetically superior.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical display location A61K 7/00 LK 9/50 J L 35/78 C 8217-4C 45/00 ABE ADZ 47 / 02 D 47/12 D 47/26 D 47/32 D 47/34 D 47/36 D 47/42 D 47/44 B

Claims (15)

[Claims] 1. A granular dermatological agent comprising a granular material containing an oily substance and a fine powder adhered to the surface of the granular material. 2. The fine powder is talc, kaolin, mica,
Bentonite, white carbon, boron nitride, titanium dioxide, calcium carbonate, calcium phosphate, silica gel, crystalline cellulose, cellulose derivative, fatty acid zinc,
Fatty acid calcium, fatty acid aluminum, zinc oxide, monosaccharide, oligosaccharide, polysaccharide, cyclodextrin, hydroxyethyl starch, nylon, polystyrene, silk, polyvinyl alcohol, polyvinylpyrrolidone, chitosan, chitin, collagen, DNA, RNA, plasma protein and The granular dermatological agent according to claim 1, which is one or more selected from the group consisting of amino acids. 3. The particle size of the fine powder is 0.01 to 500 μm.
The granular dermatological agent according to claim 1, which is m. 4. The granular dermatological preparation according to claim 1, wherein 0.1 to 30% by weight of the fine powder adheres to the granular material. 5. The granular dermatological preparation according to claim 1, wherein the oily substance is composed of one or more components selected from fats and oils, waxes, fatty acids and paraffins. 6. The granular dermatological agent according to claim 1, further comprising an oil-soluble substance. 7. The oil-soluble substance is composed of one or more components selected from the group consisting of hydrocarbons, fat-soluble vitamins, pigments, fragrances, anti-inflammatory agents, antibacterial agents and animal and plant extracts. The granular skin preparation described. 8. The granular dermatological preparation according to claim 1, wherein the component of the oily substance is composed of two or more substances having different melting points. 9. The granular dermatological preparation according to claim 6, wherein the components of the oily substance and the oil-soluble substance are composed of two or more substances having different melting points. 10. The granular dermatological agent according to claim 1, further comprising a surfactant and water and / or a water-soluble substance. 11. The granular dermatological agent according to claim 1, wherein the diameter of the granular material is 0.2 to 10 mm. 12. A cream comprising the granular dermatological agent according to claim 1, 6 or 10. 13. An ointment containing the granular dermatological agent according to claim 1, 6 or 10. 14. An emulsion containing the granular dermatological agent according to claim 1, 6 or 10. 15. A lotion containing the granular dermatological agent of claim 1, 6 or 10.