JPH0733649A - Anticarious agent - Google Patents

Abstract

PURPOSE:To obtain an anticarious agent, having strong antimicrobial actions on Streptococcus mutans and capable of being blended in an oral composition, etc., capable of avoiding or preventing the dental caries. CONSTITUTION:This anticarious agent is composed of a biphenyl compound expressed by the formula (R is H or 1-8C linear or branched chainlike saturated hydrocarbon group). This compound has antimicrobial actions on Streptococcus mutans in a concentration-dependent manner, manifests effects at a low concentration and can be blended in an oral composition such as a tooth paste, a tooth powder, a tooth wash, a mouthwash or a troche and further a chewing gum, a candy, a thick malt syrup, etc.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to Streptococcus mutans which is a pathogenic bacterium that induces dental caries.
cus mutans, hereinafter abbreviated as S. mutans) to a biphenyl compound having strong antibacterial properties and growth inhibition.

[0002]

[Prior art]

As one of the prevention and prevention of caries, a method of eradicating caries-causing bacteria or preventing growth thereof has been conventionally known. For example, attempts have been made to use antibiotics such as penicillin and erythromycin, cell wall lytic enzymes that dissolve the cell wall of S. mutans, which is a causative bacterium, and bactericides such as cyclohexidine.

Further, as a caries preventive agent using a plant extract, an oral composition using an extract of Japanese nutmeg (Japanese Patent Laid-Open No. 59-134729), an extract of persimmon leaves, and fruits of Japanese quince (Japanese Patent Laid-Open No. 2-78609) and the like have been proposed.

Further, a method of using a synthetic fragrance having a specific carboxylic acid or lactone structure as an anti-caries agent (Japanese Patent Laid-Open No. 175423/1984) or a method of using magnolol or honokiol as a caries preventive agent (Japanese Patent Laid-Open No. Hei 9 (1999) -58,091) 1-15
No. 1512) has been proposed.

However, antibiotics have side effects, synthetic fragrances have a peculiar odor problem, and magnolol and honokiol have stability problems.

[0007]

DISCLOSURE OF THE INVENTION As a result of intensive studies made by the present inventors in view of the above circumstances, a specific biphenyl compound has a strong antibacterial action against S. mutans which is a cariogenic bacterium. I found a thing.

[0008] Therefore, an object of the present inventor is to provide a compound having a strong antibacterial action against S. mutans which is a cariogenic bacterium.

[0009]

Means for Solving the Problems That is, the present invention has the following general formula:

[0010]

[Chemical 2]

(Wherein R is a hydrogen atom or a linear or branched saturated hydrocarbon group having 1 to 8 carbon atoms) and relates to an anticaries agent comprising a biphenyl compound.

A part of the biphenyl compound used in the present invention includes known substances, and a method for synthesizing the same has been reported (Japan Chemical Journal Vol. 87, No. 6, p. 603,
1966). Also, compounds other than known compounds can be obtained by the same synthetic method.

The anti-caries agent of the present invention is, for example, a toothpaste,
It can be added to oral compositions such as toothpaste, toothpaste, mouthwash, troche, etc., chewing gum, candy, candy and the like.

The blending amount depends on the system used,
Although it cannot be generally stated, as is clear from the following examples, it may be equivalent to the existing substances of this type.

Next, S.
An example for clarifying the effect of antibacterial action against mutans will be shown.

[0016]

EXAMPLES The present invention will be described in more detail with reference to the following examples. In addition, unless otherwise specified, the percentage display in the following shows the percentage by volume. The names of the biphenyl compounds in the examples are abbreviated as follows depending on the difference in R in the general formula. Biphenyl compound 1
(R = CH ₃ ), biphenyl compound 2 (R = C
₂ H _5), biphenyl compounds _{3 (R = C 3 H 7} ), biphenyl compounds _{4 (R = iso-C 3} H 7), biphenyl compounds _{5 (R = C 8 H 17} ), biphenyl compounds 6 (R =
H). In addition, dehydrodioigenol and dehydrodicresol, which are biphenyl compounds having different structures, were used as controls.

[Test Method for Antibacterial Action] As a method for testing the antibacterial action against Streptococcus mutans, a paper disk method was used. The agar medium was mixed with the S. mutans culture solution that had been separately cultured in the same liquid medium (0.1 ml / 100 ml medium), and 10 ml was dispensed and solidified in a petri dish. A paper disk was placed in the center of the petri dish, and 50 μl of an absolute ethanol solution of the sample was dropped. After standing at 5 ° C. for 24 hours, it was cultured at 32 ° C. for 48 hours. The antibacterial activity was investigated by measuring the diameter of the inhibition circle formed around the paper disc. The sample concentrations used for measurement are 1.25, 0.625, 0.31.
3 and 0.156%.

[0018]

[Table 1]

From the results shown in Table 1, the biphenyl compound of the present invention has an antibacterial action against S. mutans in a concentration-dependent manner,
Moreover, it was found that it was effective at low concentrations.

[0020]

INDUSTRIAL APPLICABILITY As described above, according to the present invention, S.mu
Since it has a strong antibacterial action against tans, it is obvious to provide an anti-caries agent which can be incorporated into an oral composition for preventing or preventing dental caries and chewing gum, candy, candy and the like.

Claims (1)

[Claims] 1. An anticaries agent comprising a biphenyl compound represented by the following general formula. [Chemical 1] (However, R is a hydrogen atom or a linear or branched saturated hydrocarbon group having 1 to 8 carbon atoms)