JPH07501056A - グアニジン含有ｈｉｖプロテアーゼ阻害剤 - Google Patents

グアニジン含有ｈｉｖプロテアーゼ阻害剤

Info

Publication number
JPH07501056A
JPH07501056A JP5508659A JP50865993A JPH07501056A JP H07501056 A JPH07501056 A JP H07501056A JP 5508659 A JP5508659 A JP 5508659A JP 50865993 A JP50865993 A JP 50865993A JP H07501056 A JPH07501056 A JP H07501056A
Authority
JP
Japan
Prior art keywords
alkyl
formula
amino
butyloxycarbonyl
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5508659A
Other languages
English (en)
Japanese (ja)
Inventor
グリーソン，ジョン・ジェラルド
ラム，ロバート・トーマス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of JPH07501056A publication Critical patent/JPH07501056A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP5508659A 1991-11-01 1992-10-30 グアニジン含有ｈｉｖプロテアーゼ阻害剤 Pending JPH07501056A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78643591A 1991-11-01 1991-11-01
US786,435 1991-11-01
PCT/US1992/009402 WO1993009132A1 (en) 1991-11-01 1992-10-30 Hiv protease inhibitors containing guanidine

Publications (1)

Publication Number Publication Date
JPH07501056A true JPH07501056A (ja) 1995-02-02

Family

ID=25138568

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5508659A Pending JPH07501056A (ja) 1991-11-01 1992-10-30 グアニジン含有ｈｉｖプロテアーゼ阻害剤

Country Status (7)

Country Link
EP (1) EP0610431A1 (pt)
JP (1) JPH07501056A (pt)
AU (1) AU3069192A (pt)
MX (1) MX9206294A (pt)
PT (1) PT101026A (pt)
WO (1) WO1993009132A1 (pt)
ZA (1) ZA928396B (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006070036A (ja) * 1994-06-15 2006-03-16 Biomolecular Research Inst Ltd 抗ウイルス性デンドリマー

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430150A (en) * 1992-12-16 1995-07-04 American Cyanamid Company Retroviral protease inhibitors
US5455351A (en) * 1993-12-13 1995-10-03 Abbott Laboratories Retroviral protease inhibiting piperazine compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3809145A1 (de) * 1988-03-18 1989-09-28 Merck Patent Gmbh Aminosaeurederivate
DE3812328A1 (de) * 1988-04-14 1989-10-26 Merck Patent Gmbh Aminosaeurederivate
IL91307A0 (en) * 1988-08-24 1990-03-19 Merck & Co Inc Hiv protease inhibitors and pharmaceutical compositions for the treatment of aids containing them

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006070036A (ja) * 1994-06-15 2006-03-16 Biomolecular Research Inst Ltd 抗ウイルス性デンドリマー

Also Published As

Publication number Publication date
AU3069192A (en) 1993-06-07
MX9206294A (es) 1993-08-01
ZA928396B (en) 1993-05-12
EP0610431A1 (en) 1994-08-17
PT101026A (pt) 1994-05-31
WO1993009132A1 (en) 1993-05-13

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