JPH0751385A - Automatic preparation method for prepared or dissolved infusion, etc., and tray used therefor - Google Patents

Abstract

PURPOSE:To produce infusion and to take a designated injection drug out of many injection drugs without manual means by utilizing computer control and robot arm control to select each injection drug, to take out, to prepare automatically and to take out the produced drug automatically and inspecting it manually. CONSTITUTION:Using an injection auxiliary drug container 2, vial 14 and an infusion container 21 set on the preparation desk, preparation and mixing of infusion and injection drug are performed by putting an injection fluid, which is sucked in a pump main body 109 from a injection fluid 17 in a vial 14 by the suction action of a syringe 119 of a pump 9 in a state valve mechanisms 10 and 1111 are controlled by a computer control system and a piping for connection between the vial 14 and the pump 9 is connected, into infusion 23 in the infusion container 21. When dissolved infusion in produced, the used vial 14 is removed from an injection needle 16 for suction and returned to a designated position of tray.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for automatically preparing and mixing an infusion solution such as an infusion solution for injection or a solution solution for injection via computer control, and a tray used in the automatic compounding method. .

[0002]

2. Description of the Related Art Conventionally, a method for producing a prepared infusion solution or a dissolved infusion solution for injection is usually based on a human means (mainly a nurse). Insert an injection needle into each drug or injectable drug, mix and mix the drug solution such as the injectable solution filled in the container with the infusion solution filled in the infusion container, or dissolve the powdered drug. A method is used in which the prepared infusion solution or the dissolved infusion solution is produced after mixing and mixing with the infusion solution filled in the infusion solution container.

However, the conventional method is human means,
In other words, there are problems such as the manual work of the nurse, which is difficult and troublesome, and a lot of manpower is required, and there is a recent problem that labor saving is being called for. In particular, the treatment of anti-cancer agents, whose handling is a problem, is an issue to be solved immediately.

The following documents can be found when the prior arts which are considered to be useful for solving the above problems and are similar in content to the present invention are listed. (1) There is a method and device for automatic inspection of drug administration disclosed in JP-A-63-9442, the gist of which is to take out medicines under computer control, and to prepare and dispense via an automatic preparation system and an inspection system. Then, the packaged medicine is generated. (2) There is an automatic dispensing system disclosed in Japanese Patent Laid-Open No. 63-230166, the gist of which is an integrated management system for medicines in hospitals, etc., which automatically takes out medicines, prepares them, stores them in a medicine bag, inspects and conveys them. It is configured to control. (3) There is an automatic dispensing device disclosed in JP-A-63-229054, and the gist thereof is to automatically select a drug stored in a storage shelf via computer control, inspect the dispensed drug, and automatically supply it to a patient. It is configured to do. (4) There is a medicine dispensing device of JP-A-62-34564, and the gist thereof is a tablet that is distributively accommodated in a shelf,
The tablet has a structure for distributing the tablet with prescription data input to a computer and a means for taking out and inspecting a predetermined amount of the distributed tablet, and has a structure mainly adopted in large hospitals and nursing homes. Has become. (5) There is a medication tray of Japanese Patent Laid-Open No. 4-92667, and its gist is a medication tray in which a plurality of boxes are stored in the tray, and the box is divided into a main box and a side box. The main wall of the main box is provided with a recess and an opening for accommodating a syringe.

[0005]

Each of the inventions described in detail above employs a computer system to take out (select, take out) medicines based on a prescription, mix and pack, pay out, etc. It is structured to bring about improvements to the main method.

However, automatic selection of tablets, drugs, etc.,
The scope is limited to simple operations such as taking out, mixing and dispensing, or simple mixing and mixing operations of several kinds of drugs. Therefore, the infusion preparations for various types of injectable drug intended by the present invention are properly and correctly operated without any operation such as disinfection and preparation, mixing, etc., and moreover, accurate and clean preparation infusion without human labor. Alternatively, it is impossible to generate an infusion such as a dissolved infusion.

[0007]

In view of the above, the present invention takes out a predetermined injection drug from a large number of injection drugs (referred to as various drugs such as injection drugs) without the need for manpower, and stores it in a container. Disinfection
The following configuration is adopted for the purpose of accurately and automatically generating an infusion such as a preparation infusion or a dissolution infusion through opening or insertion / removal of an injection needle, and preparation and mixing operations.

[0008] That is, the automatic infusion preparation method of the infusion solution or the infusion solution of the present invention is a prescription for selecting an auxiliary drug for injection or an injectable drug and other drugs required for the production of an infusion by a computer and a prescription-based preparation. Alternatively, an input means for inputting a program for process control such as mixing process and procedure, and an auxiliary drug for injection or injection drug or other drug required for infusion production based on the prescription of this input means are selected and designated. Set means to be placed on the tray, injection auxiliary drug or injection drug deployed by the setting means, human inspection means for visually observing other drugs, injection auxiliary drug or injection drug selected by this setting means, etc. Based on the prescription and the program, the drug is supplied through the program input by the input means, the injection auxiliary drug or the injectable drug, and the total connection pipe for the drug. And automatic formulating and mixing means to formulate or mix Te, and the retrieval means for retrieving the infusion, such as Formulation infusion or dissolution infusion produced by the automatic formulating and mixing means, in constructed.

Further, according to the present invention, the tray used in the method for automatically preparing an infusion such as the above-mentioned infusion solution or dissolution infusion contains injection auxiliary agents such as distilled water for injection and physiological saline solution for injection.
A chamber, a rising bottom surface provided on the bottom surface of the first chamber to stand up an injection auxiliary drug, and a large number of storage cylinders adjacent to the first chamber into which a large number of injection drugs such as ampoules and vials can be inserted It is composed of a second chamber and a clamp for standing the injection drug, which is provided on the inner bottom surface of each container of the second chamber.

[0010]

Next, the operation of the present invention (from selection of various medicines to generation of infusion such as compounded infusion or dissolved infusion) will be described below. First, a prescription program for selecting an auxiliary drug for injection or an injectable drug necessary for administration (injection, infusion, etc.) to a computer, and other drugs (hereinafter, simply referred to as drugs). Based on the prescription, a so-called process control program for selecting the medicines in order, disinfecting, opening the container, and automatically mixing and mixing the chemicals is input. Then, according to a command from the computer, the robot arm selects a predetermined drug from the drug rack based on the prescription, and stores the drug in a predetermined place in a tray prepared for each patient or in an arbitrary place. And, preferably, a relatively large container for injectable distilled water, injectable physiological saline solution, or other injection auxiliary agent (hereinafter referred to as injectable distilled water and its container) is placed in the first chamber of the tray. Set (accommodate) horizontally. Further, a comparatively small container such as an ampoule or a vial, in which the standing state is unstable (so-called uncomfortable container) is set in the holding tool of the second chamber.

As described above, when the injection drug required for administration to each patient is set in each tray, the correct drug based on the above prescription is set at that place or the carried inspection place. However, it is inspected (confirmed) by human means (usually a pharmacist). Each tray that has been inspected by this inspection is then housed in a shelf (not shown), and is stored in the shelf in an orderly manner until the instruction of the below-mentioned mixing and mixing is instructed by the computer.

Thereafter, based on a command from the computer, the specified tray is taken out from the shelf and the tray is carried out to a mixing table (not shown). Hereinafter, one example of the mixing and mixing will be specifically described. explain.

For example, based on a command from a computer, a robot arm takes out an injectable auxiliary drug container filled with distilled water for injection stored in the first chamber of the tray, and disinfects (cleans and dust-proof) it. The lid is placed on the blending table or the disinfecting (cleaning / dustproofing) blending base (hereinafter simply referred to as the blending table) with its bottle mouth facing downward and the bottle mouth of the auxiliary drug container for injection. An external air introduction tube equipped with a filter is communicated with the body through an external air introduction injection needle (hereinafter, simply referred to as an external air injection needle), and a lid provided on the bottle mouth of the injection auxiliary drug container. A transport pipe is connected to the body via a first switching valve (electromagnetic valve), and as shown in the drawing, distilled water for injection or physiological saline for injection (hereinafter, as a general rule, distilled water for injection is used). Injection) (Hereinafter, simply referred to as the injection needle and delivery.) Is inserted.

On the other hand, based on the command from the computer,
When the ampoule contained in the second chamber of the tray is taken out by the robot arm, for example,
The ampoule cut site is disinfected with alcohol cotton, and in some cases the ampoule is vibrated so that the drug remaining on the head is dropped on the main body (see FIGS. 2 and 3). Disinfection as described above,
When the ampoule is filled with the injection drug, the ampoule cut site is subsequently detected through a visual confirmation means such as a camera (see FIG. 4). As a method of this detection, for example,
A method of fixing the visual recognition means, appropriately rotating the ampoule, and detecting the cut portion thereof is adopted.

When the cut portion is detected, the head of the ampoule is pressed in the direction opposite to the cut portion, the head is cut, and the ampoule is opened (see FIG. 5). The opened ampoule (hereinafter, referred to as an open ampoule) is erected on the mixing table via a computer-controlled robot arm (hereinafter, simply referred to as a robot arm), and at the same time as the opened ampoule. Alternatively, it is communicated with the infusion solution container filled with the infusion solution, which is already provided on the blending table, through the robot arm through the connecting pipe. Through the connecting pipe and the transportation pipe, distilled water for injection in the above-mentioned auxiliary drug container for injection, injectable drug in an open ampoule (hereinafter, in principle, injectable drug), and infusion in an infusion container (hereinafter, in principle). Infusion)
The distilled water for injection, the injection drug, and the infusion solution can be freely mixed and mixed through the first switching valve and the second switching valve provided in the connecting pipe, which are communicated with each other and controlled by a computer. (See FIG. 1).

An injection needle for inhaling an injection (hereinafter, simply referred to as an injection needle) provided at one free end of the connecting pipe is provided at the opening of the ampoule, and a lid of the infusion container is provided. Is provided with an injection needle with a mixing liquid introducing filter (hereinafter, simply referred to as a filter injection needle) provided at the other free end of the connecting pipe. The lid of the infusion container is provided with an air bleeding injection needle (hereinafter, simply referred to as an air bleeding injection needle). A pump with a syringe is connected to the second switching valve.

As described above, the auxiliary drug container for injection, the open ampoule, and the infusion container provided on the mixing table are appropriately mixed by computer control. For example, as shown in FIG. 6, the first and second switching is performed. Control each valve of the valve (hereinafter,
When controlling the first and second switching valves, the valve mechanism is simply controlled. ), And in a state where the open ampoule and the connecting pipe for the pump are in communication with each other, the injection drug (injection solution) in the open ampoule is sucked into the pump body through the operation of pulling out the syringe of the pump, The inhaled injection drug is injected into the infusion solution in the infusion container through the pushing operation of the syringe, so that the infusion solution and the injection drug are mixed and mixed. In this way, the injectable drug in the open ampoule is mixed and mixed with the infusion solution to produce a prepared infusion solution. In this way, when the prepared infusion solution is generated (see FIG. 7), the used open ampoule is removed from the injection needle for inhalation via the robot arm and returned to a predetermined position on the tray.

When it is necessary to mix and mix the powder and solid-state drug ampoule (referred to as powder-containing ampoule) shown in FIGS. 8 to 16 with an infusion solution, a robot arm is used. The powder-containing ampoule contained in the second chamber of the tray is taken out, and the powder-containing ampoule cut portion is disinfected (see FIG. 8). When this disinfection is completed, the cut portion of the powder-containing ampoule is subsequently detected through a visual confirmation means such as a camera (see FIG. 9). The detection method can be considered similar to the above-mentioned example. After that, the powder-containing ampoule is cut in the same manner as in the above-mentioned example, and the powder-containing ampoule is erected on the mixing table via the robot arm, and as a general rule, it is connected to the infusion container and the connecting pipe already installed. Communicate with each other.

Through this connecting pipe and transport pipe, the distilled water for injection of the auxiliary drug container for injection, the injection drug of the ampoule containing the open powder and the infusion liquid of the infusion container are communicated with each other and controlled by a computer. The distilled water for injection, the injection drug, and the infusion solution are freely mixed and mixed through the first switching valve controlled by the above and the second switching valve provided in the connecting pipe (see FIG. 1). An injection needle for inhaling an injection drug (hereinafter, simply referred to as an injection needle for inhalation) provided at one free end of the connecting pipe at the opening of the powder-containing ampoule.
However, an injection needle with a filter provided at the other free end of the connecting pipe is provided on the lid of the infusion container. The lid of the infusion container is provided with an air bleeding injection needle. Furthermore, a pump with a syringe is connected to the second switching valve.

As described above, the injection auxiliary drug container, the powdered ampoule, and the infusion solution container provided on the preparation table are prepared by computer control. First, FIG.
As described above, the distilled water for injection is sucked into the pump body through the pulling-out operation of the syringe of the pump (in principle, computer control. The same applies below) and the control of the valve mechanism, and then the injection body is sucked into the pump body. Distilled water is introduced into the powder-containing ampoule through the pushing operation of the pump syringe (in principle, computer control. The same applies below) and the valve mechanism control to dissolve the powder drug in the powder-containing ampoule (Fig. 12). Usually, it is not possible to dissolve it in one time, so first of all, dissolved drug partially dissolved and distilled water for injection introduced into the ampoule containing powder,
It is again introduced into the ampoule body through the operation of pulling out the syringe and controlling the valve mechanism (see FIGS. 13 and 14). The above-mentioned dissolving work is repeated between the powder-containing ampoule and the pump body until the powder medicine in the powder-containing ampoule is completely dissolved.

After that, when the powdered drug in the powdered ampoule is completely dissolved, the dissolved drug solution is introduced into the pump body through the drawing operation of the syringe of the pump and the control of the valve mechanism (see FIG. 15). Then, the dissolved drug solution sucked into the pump main body is injected into the infusion solution in the infusion container via the pushing operation of the syringe and the control of the valve mechanism to prepare and mix the infusion solution and the dissolved drug solution. In this way, when the dissolved drug solution in the powder-containing ampoule is prepared and mixed with the infusion solution to generate a dissolved infusion solution (see FIG. 16), the used ampoule is removed from the inhalation needle via the robot arm. Remove and return to the desired location on the tray.

Further, when it is necessary to prepare and mix the vial containing the liquid medicine shown in FIGS. 17 to 19 with the infusion solution,
The vial accommodated in the second chamber of the tray is taken out via the robot arm, is erected on the preparation table, and the insertion site of the inhalation injection needle of the vial is sterilized (see FIG. 17). In order to prevent coring (meaning that the rubber of the insertion site is cut off by the injection needle for inhalation and enters the injection solution in the vial) when inserting the injection needle for inhalation into the insertion site, The inhalation needle is inserted at an angle. After that, the infusion container that has already been deployed is communicated with the connecting pipe. Through the connecting pipe and the transport pipe, the distilled water for injection in the injection auxiliary drug container, the injection drug in the vial, and the infusion solution in the infusion container are
The distilled water for injection, the injection drug, and the infusion solution can be freely mixed and mixed through the first switching valve and the second switching valve provided in the connecting pipe, which are communicated with each other and controlled by a computer. In addition, the lid of the auxiliary drug container for injection is provided with an injection needle with a filter, the lid of the infusion container is provided with an air bleeding needle, and the second switching valve is connected with a pump with a syringe. It is set up.

As described above, the auxiliary drug container for injection, the vial and the infusion container provided on the mixing table are appropriately mixed and mixed by computer control. For example, as shown in FIG. 18, a valve mechanism is controlled by computer. The injection liquid in the vial is inhaled into the pump body through the pulling operation of the syringe of the pump in a state in which the pipe for connecting the vial and the pump is in communication with each other. The liquid is injected into the infusion solution in the infusion container through the pushing operation of the syringe to prepare and mix the infusion solution and the injection solution. In this way, when the injection solution in the vial is mixed and mixed with the infusion solution to generate the dissolved infusion solution (see FIG. 19), the used vial is removed from the inhalation injection needle via the robot arm, and the tray is removed. Return to the designated place.

When it is necessary to prepare and mix the vials containing powder and solid medicine shown in FIGS. 20 to 25 (hereinafter, referred to as powder-containing vials), it is necessary to prepare a tray via a robot arm. The powder-containing vial housed in the second chamber is taken out, and the powder-containing vial is stood upright and the inhalation needle insertion site of the powder-containing vial is sterilized (see FIG. 20). The inhalation needle is inserted at an angle to prevent coring. The insertion of the injection needle for inhalation allows the vial containing the powder to communicate with the infusion container already provided through the connecting pipe.

Through the connecting pipe and the transport pipe, the distilled water for injection in the auxiliary drug container for injection, the injectable drug in the vial containing the open powder and the infusion liquid in the infusion container are communicated with each other and are controlled by a computer. The distilled water for injection, the injection drug, and the infusion solution are freely mixed and mixed through the first switching valve controlled by the above and the second switching valve provided in the connecting pipe (see FIG. 1). An inhalation needle is inserted into the opening of the powder-containing vial at the insertion site, but the inhalation needle is inserted at an angle to prevent coring. An injection needle for inhaling the injection drug (hereinafter, simply referred to as an injection needle) provided at one free end of the connecting pipe, and the other end of the connecting pipe for the lid of the infusion container. An injection needle with a filter installed at the end
In addition to being deployed, the lid of this infusion container is provided with an air bleeding injection needle. Furthermore, a pump with a syringe is connected to the second switching valve.

As described above, the auxiliary drug container for injection, the vial containing powder, and the infusion container provided on the preparation table are prepared by computer control. First, as shown in FIG. 21, the syringe of the pump is pulled out. Through the operation and control of the valve mechanism, the distilled water for injection is sucked into the pump body, and then the distilled water for injection sucked into the pump body is pushed through the operation of the syringe of the pump and the control of the valve mechanism, Introduced into a powdered vial and optionally the powdered drug in the powdered vial, for example,
Vibration or the like is applied to melt the resin (see FIG. 22). Usually 1
This dissolution operation is repeated several times because it cannot be dissolved in several times. That is, the same operation as in the case of the above-mentioned vial can be considered (see FIGS. 23 and 24).

After that, when the powder drug in the powder-containing vial is completely dissolved, the dissolved drug solution is introduced into the pump main body through the operation of pulling out the syringe of the pump and the control of the valve mechanism. Then, the dissolved drug solution sucked into the pump body is injected into the infusion solution in the infusion container via the pushing operation of the syringe and the control of the valve mechanism,
Prepare and mix infusion and dissolved drug solution. In this way, the dissolved drug solution in the vial containing powder is mixed with the infusion solution,
When mixing is performed and a dissolved infusion is produced (see FIG. 25),
The used vial is removed from the needle for inhalation via the robot arm, and the vial is returned to a predetermined position on the tray.

Each of the blending and mixing described above is
They are combined according to the above prescription (symptoms of each patient). In the above-mentioned example, an ampoule containing an ampoule and a vial and an injection solution in a vial containing a powder are combined with an infusion solution (preparation and mixing). However, the present invention is not limited to this example. Furthermore, it is naturally possible to combine other injection drugs.

After the mixing and mixing operations are completed through the above-mentioned respective examples, after the used infusion container, the injection auxiliary drug container, and the injection drug are accommodated in the tray, the tray is prepared by mixing It is stored in a used shelf (may also be used as the above-mentioned shelf), and the presence or absence of each container and the residual liquid of each drug are inspected by human means. After that, it will be delivered to the ward, and unnecessary containers and ampoules will be discarded. As a result, a series of preparation, mixing, dispensing, and disposal operations complete the operation of generating an infusion solution corresponding to the above prescription.

A circuit through which the injectable drug passes, that is, a pipe for transportation,
Connection piping (eg, connection piping, suction needle,
In principle, this is not necessary if the injection needle with a filter, pump, etc. is a disposable type. The same shall apply hereinafter), but it is usually carried out after the above-mentioned preparation and mixing are completed, for example, before the next preparation and mixing operation is started. An example thereof will be described with reference to FIGS. 26 to 29. The syringe of the pump is pulled out and the distilled water for injection is sucked into the pump body via the computer control and the control of the valve mechanism.
At this time, it is important to note that it is important to suck in a larger amount of distilled water for injection than the amount of drug solution sucked into the pump body (see FIG. 26). In this way, the distilled water for injection sucked into the pump body is discharged to the outside through the connecting pipe under the control of the computer and the valve mechanism (see FIG. 27). Then, it is desirable to repeat suction or discharge to the pump body (see FIG. 28).

As shown in FIGS. 30 and 31, circuits for injection drugs and other chemicals, that is, transportation pipes, connecting pipes (for example, connecting pipes, suction needles, filter injection needles, pumps, etc.) In the case of the throw-away method, it is not necessary in principle. The same shall apply to the following). Such an operation is usually performed after the completion of the mixing and mixing operations directly from ampoules, vials and the like. An example of this is shown in FIG. 30. As shown in FIG. 30, the syringe of the pump is pulled out through the computer control and the control of the valve mechanism, and the pump body is used for injection of residual drug in the pipe for transportation and the pipe for connection. Inhale into the pump body with distilled water. At this time, if the set amount is sucked into the pump body, the pump syringe is pushed in by the computer control and the valve mechanism control, and the pump body is sucked through the connecting pipe. Inject the remaining residual injection and distilled water for injection into the infusion solution in the infusion container.

In addition, the following means may be adopted. That is, first of all, in order to prevent the anticancer drug from being mixed with injectables and infusions of other prescriptions, for example,
A circuit through which an injectable drug passes (for example, a pipe for transportation, a delivery needle, etc.) for a prescription containing an anti-cancer agent and a circuit for prescription containing no anti-cancer agent (for example, a connecting pipe, an injection needle for suction) , Injection needle with filter, etc.), and a mechanism that cannot be mixed by any means. Secondly, in order to prevent changes in the composition and decomposition after mixing, build a database of injectables and infusions that cause changes in the composition and check if they are entered into the computer, or enter the mixing time. By doing so, the following main tasks such as automatically mixing at the set time and printing out the mixed time to minimize decomposition until administration are performed by a computer. It is naturally possible to control.

[0033]

EXAMPLE A circuit for preparing and mixing an injectable drug and a tray used in an example of the present invention will be described below. First, a circuit for compounding and mixing an injectable drug will be described. A compounding table (not shown) (the compounding table automatically removes angle heads or the like by cutting ampoules described later or automatically removes scraps for preventing vial coring). For the purpose of elimination or the like, for example, an inclined surface may be provided.) A bottle port 201 of an auxiliary drug container for injection 2 for storing distilled water for injection 1 provided therein.
An injection needle for introducing outside air (injection needle for outside air) 4 and an injection needle for delivering distilled water for injection (injection needle for delivery) 5 are inserted into the lid 3 provided in the. An outside air introducing pipe 7 having a filter 6 is connected to the outside air injection needle 4. By adopting such a configuration, for example,
The filtered air 111 is introduced into the auxiliary drug container for injection 2 through the external air introducing tube 7 and the injection needle for external air 4, and the distilled water for injection 1 filled in the auxiliary drug container for injection 2 is smoothly discharged. Plan. Further, the delivery needle 5 is connected to a transportation pipe 8 for delivering the distilled water 1 for injection to a pump 9.

The transport pipe 8 is connected to the connecting pipe 11 via the first switching valve 10. Therefore, the distilled water for injection 1 introduced into the pump body 109 of the pump 9 is introduced into the powder-containing ampoule 13 or the powder-containing vial 15 through the connecting pipe 11, and the powder-containing ampoule 13 or the powder-containing ampoule 13 is contained. The dissolution of the drug (medicine) such as powder in the vial 15 is promoted. Further, the ampoule 13 containing the powder may be vibrated for a predetermined time to further dissolve the powder. Further, one of the connecting pipes 11 has
Via an injection needle (inhalation needle) 16 for inhaling injection drug,
The ampoule 12 or the vial 14 is connected, and the injection drug 17 filled in the ampoule 12 or the like is supplied to the pump body 1
Aspirate to 0. In the figure, 119 is a syringe provided in the pump 9, 1111 is provided in the connecting pipe 11, and distilled water 1 for injection into the pump body 10, injection drug 17, or dissolved drug 1
8 is a second switching valve that controls the control valve 8. Further, 19 refers to a drug in powder, solid form, granular form or the like.

Incidentally, the first switching valve 10 and the second switching valve 11
Reference numeral 11 uses an electromagnetic valve and is of a three-way switching type through computer control, and various mixing and mixing operations described in detail above are performed.

An injection needle with a filter (injection needle with a filter) 20 for introducing a mixed drug provided on the other side of the connecting pipe 11 is inserted into a lid 2112 provided at a bottle port 2111 of an infusion container 21. An infusion container 21 is connected to the connecting pipe 11 through the filter-attached injection needle 20. Therefore, the mixing liquid 22 generated by the pump body 10 is mixed with the infusion liquid 23 in the infusion container 21 to generate the mixing injection liquid. Further, the infusion container 21 is provided with an injection needle (air bleeding injection needle) 24 for bleeding air.

In the figure, 121 is the head of the ampoule 12, 1
22 is a mark of the cutting site, 131 is a head of the ampoule 13 with powder, 132 is a mark of the cutting site, 141 is an insertion site for inserting the injection needle 16 for inhalation of the vial 14, and 151 is powder. The insertion sites for inserting the inhalation needle 16 of the vial 15 are shown respectively, and further 30
Indicates a television camera, 31 indicates a robot arm, and 32 indicates alcohol cotton. At least the inhalation needle 16 or the filter injection needle 20 is replaced when the number of times of use is reached.

Next, the tray shown in FIGS. 32 to 34 will be described. The tray 40 includes a second chamber 41 in which an ampoule 12, an ampoule containing powder, 13 or a vial 14, and a vial 15 containing powder are erected, and an injection. And a first chamber 42 in which the distilled water 1 for storage is stored. First, a large number of storage areas 411 are formed in the second chamber 41, and a holding tool 412 for securely holding the ampoule 12 and the like is installed in each of the storage areas 411. Also the first
The chamber 42 is provided with a rising bottom surface 421 for standing up the injection auxiliary medicine container 2 housed therein. For example, by operating the robot arm 31, the rising bottom surface 421 is erected and the injection is performed. The auxiliary drug container 2 is structured to be held upright. The gripping tool 412 is composed of a base 412a, and a plurality of substantially L-shaped strip-shaped gripping arm pieces 412b which are provided upright from the base 412a, and are composed of a large number of the gripping arm pieces 412b. ,
The angle 12 and the like are held (supported) through the large number of gripping arm pieces 412b. The tray 40
The configuration is only an example, and any structure is possible as long as it can reliably hold a large number of ampules 12 and the like in a standing state (during extraction) (refer to a standing state such as support and hug). Is.

[0039]

As described in detail above, the present invention utilizes computer control and robot arm control to automatically select and remove each injectable drug solution, and then automatically mix and mix, and the prepared and mixed products. The infusion solution is automatically taken out, and after each selection, taking-out work, mixing, and mixing operation, it is inspected (confirmed) through a human means. Therefore, by adopting the method of the present invention, automation of infusion production, which was conventionally prepared and mixed by human (nurse, etc.) means, is achieved, and the human working environment for nurses, etc. is improved and reduced. Useful for humanization. Moreover, the risk of secondary infection due to the drug solution is avoided. And so on. In particular, it is an invention that is expected to avoid the danger of anticancer agents and the like from the viewpoint of improving the working environment and protecting human resources. In addition, by computer control and inspection by two-stage human means,
It has effects such as achievement of accurate and clean infusion solution generation work, and contribution to accurate and clean infusion solution generation.

[Brief description of drawings]

FIG. 1 is a schematic diagram showing an entire circuit.

FIG. 2 is a schematic diagram showing a state in which an ampoule filled with a liquid medicine is disinfected.

FIG. 3 is a schematic diagram showing a state in which an ampoule filled with a liquid drug is vibrated and dropped onto the ampoule body.

FIG. 4 is a schematic view showing a state in which a cut portion of an ampoule filled with a liquid medicine is searched for.

FIG. 5 is a schematic diagram showing a state in which the head is cut after searching for a cutting point of an ampoule filled with a liquid medicine.

FIG. 6 is a schematic view showing a state in which a syringe is pulled out and a drug in an ampoule is sucked by a pump.

FIG. 7 is a schematic diagram showing a state in which a syringe is pushed in and a drug in an ampoule is introduced into an infusion container.

FIG. 8 is a schematic view showing a state of disinfecting an ampoule containing powder.

FIG. 9 is a schematic diagram showing a state in which a cut portion of an ampoule containing powder filled with a liquid medicine is searched.

FIG. 10 is a schematic diagram showing a state in which the head is cut after searching for the cutting point of the powder-containing ampoule filled with the powdered drug.

FIG. 11 is a schematic view showing a state in which a syringe is pulled out and distilled water for injection is sucked into a pump from an auxiliary drug container for injection.

FIG. 12 is a schematic view showing a state where the injection distilled water introduced into the pump is introduced into the powder-containing ampoule.

FIG. 13 is a schematic diagram showing a state in which a dissolved drug in a melted powder-containing ampoule is drawn out from a syringe and the dissolved drug is sucked by a pump.

FIG. 14 is a schematic diagram showing a state in which the distilled water for injection introduced into the pump is introduced into an ampoule containing powder and further dissolution is promoted.

FIG. 15 is a schematic diagram showing a state where the powdered drug in the powder-containing ampoule is completely dissolved and the dissolved drug is sucked into the pump by pulling out the syringe.

FIG. 16 is a schematic view showing a state in which a dissolved drug in an ampoule is introduced into an infusion container by pushing a syringe.

FIG. 17 is a schematic diagram showing a state in which a vial containing powder is sterilized.

FIG. 18 is a schematic view showing a state in which a syringe is extracted and a drug in a vial is sucked by a pump.

FIG. 19 is a schematic view showing a state in which the syringe is pushed in and the drug in the vial is introduced into the infusion container.

FIG. 20 is a schematic view showing a state in which a vial containing powder is sterilized.

FIG. 21 is a schematic view showing a state where a syringe is pulled out and distilled water for injection in an auxiliary container for injection is sucked by a pump.

FIG. 22 is a schematic diagram showing a state where the distilled water for injection introduced into the pump is introduced into a vial containing powder.

FIG. 23 is a schematic diagram showing a state in which a dissolved drug in a vial containing dissolved powder is pulled out from a syringe and the dissolved drug is sucked by a pump.

FIG. 24 is a schematic diagram showing a state where the distilled water for injection introduced into the pump is introduced into a vial containing powder and further dissolved.

FIG. 25 is a schematic view showing a state in which a powdered drug in a powder-containing vial is completely dissolved and the dissolved drug is sucked into a pump by pulling out a syringe.

FIG. 26 is a schematic view showing a state in which distilled water for injection is introduced into the ampoule through pulling out the syringe.

FIG. 27 is a schematic view showing a state in which distilled water for injection introduced into an ampoule is discharged to the outside from a connecting pipe via pushing of a syringe.

FIG. 28 is a schematic diagram showing a state in which distilled water for injection is introduced into the ampoule to the maximum through redrawing of the syringe.

FIG. 29 is a schematic diagram showing a state in which the maximum amount of distilled water for injection introduced into the ampoule is discharged to the outside from the connecting pipe via the pushing of the syringe.

FIG. 30 is a schematic diagram showing a state in which distilled water for injection is introduced into an ampoule through pulling out of a syringe.

FIG. 31 is a schematic diagram showing a state in which distilled water for injection introduced into an ampoule is introduced into an infusion container via pushing of a syringe.

FIG. 32 is an enlarged plan view showing an example of the tray.

FIG. 33 is an enlarged plan view showing an example of a holding tool.

FIG. 34 is an enlarged cross-sectional view of a gripping tool.

FIG. 35 is a flowchart showing the overall flow of the present invention.

[Explanation of symbols]

1 Distilled water for injection 2 Adjuvant container for injection 201 Bottle mouth 3 Lid body 4 Injection needle for introducing outside air (outside air injection needle) 5 Injection needle for delivering distilled water for injection (outjection needle for delivery) 6 Filter 7 Outside air Introducing pipe 8 Transport pipe 9 Pump 109 Pump main body 10 First switching valve 11 Connecting pipe 1111 Second switching valve 12 Ampoule 121 Head part 122 Cutting site mark 13 Powdered ampoule 131 Head part 132 Cutting site mark 14 Vial 141 Insertion site 15 Vial containing powder 151 Insertion site 16 Injection needle for inhaling injection needle (inhalation needle) 17 Injection drug 18 Dissolving drug 19 Drug 20 Injection needle with compounding liquid introduction filter (injection needle with filter) 21 Infusion container 2111 Bottle mouth 2112 Lid 22 Formulation liquid 23 Infusion 24 Air bleeding needle (air bleeding needle 30 television camera 31 the robot arm 32 alcohol swab 40 tray 41 second chamber 411 accommodating Eria 412 Kyojigu 412a based 412b sandwiched arm piece 42 the first chamber 421 rising bottom

Claims (3)

[Claims] 1. A computer for inputting a program for process control such as a prescription for selecting an auxiliary drug for injection or an injectable drug required for generating an infusion solution and other drugs, and a process and a procedure for preparation or mixing based on the prescription. An input means, a setting means for selecting an auxiliary drug for injection or an injection drug required for infusion production based on the prescription of the input means, and other medicines, and disposing them on a predetermined tray, and an injection selected by this setting means. Supplements or injections,
An automatic compounding / mixing means for compounding or mixing other medicines based on the prescription and the program through the program inputted by the input means, the respective injection auxiliary medicines or injectable medicines, and the total connection pipe of other medicines. An automatic blending method for an infusion fluid such as a blended infusion solution or a dissolved infusion fluid, which is configured to take out infusion fluid such as a blended infusion fluid or a dissolved infusion fluid generated by the automatic blending / mixing means. 2. A computer for inputting a program such as a process control such as a prescription for selecting an auxiliary drug for injection or an injection drug required for generating an infusion solution and other drugs, and a process or procedure of compounding or mixing based on the prescription into a computer. Input means, set means for selecting an auxiliary drug for injection or injection drug and other drugs required for infusion solution generation based on the prescription of the input means, and placing them on a predetermined tray, and injection provided by the set means Supplements or injections,
Human inspection means for visually observing other medicines, supplementary drugs for injection or injection medicines selected by this setting means,
An automatic compounding / mixing means for compounding or mixing other medicines based on the prescription and the program through the program inputted by the input means, the respective injection auxiliary medicines or injectable medicines, and the total connection pipe of other medicines. , The removal means for taking out the infusion solution such as the prepared infusion solution or the dissolved infusion solution produced by the automatic compounding / mixing means, and the remaining amount of the infusion solution and the injection auxiliary drug or the injectable drug, and other medicines taken out by this removal means An automatic compounding method for infusions such as compounded infusions or dissolved infusions, which consists of human inspection means. 3. A first chamber for containing an injection aid such as distilled water for injection or physiological saline for injection, a rising bottom surface provided on the bottom surface of the first chamber for raising the injection aid, and the first chamber. A second chamber provided with a large number of accommodating cylinders adjacent to the chamber into which a large number of injectable medicines, such as ampoules and vials, can be inserted, and an injecting medicine stand provided on the inner bottom surface of each accommodating cylinder of the second chamber. A tray used for an automatic compounding method that consists of a holding tool and a holding tool.