JPH0767952A - Filter for leukocyte removal - Google Patents

Abstract

(57) [Abstract] [Purpose] The present invention relates to improvement of a leukocyte-removing filter used in medical devices such as blood bags, blood transfusion sets, blood circuits, and pheresis circuits. [1] A leukocyte-removing filter in which a blood filter material is loaded in a flexible housing, and a peripheral portion of the housing is welded. [2] A blood filter material is loaded into a flexible housing, the peripheral portion of the filter is welded to the housing, and the housing is divided into an inflow chamber and an outflow chamber for blood and an inflow chamber for blood. A leukocyte-removing filter which is formed so as to connect a blood inlet and a blood outlet to a blood outlet. [Effect] By sealing the blood filter material with the flexible housing, it is possible to prevent damage to the housing due to impact or drop during transportation. Also, if you centrifuge at the same time as the blood bag,
Prevents damage to the housing and blood bag. Further, since the peripheral portion of the blood filter material is welded, the airtightness is not deteriorated and the blood leak does not occur even if the blood filter material is thickened or the number of stacked sheets is increased.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an improved leukocyte-removing filter used in medical devices such as blood bags, blood transfusion sets, blood circuits, and pheresis circuits.

[0002]

2. Description of the Related Art FIG. 7 is a sectional view of a conventional leukocyte-removing filter 31, which is a blood filter material 33 made of a non-woven fabric or a porous filter and a two-piece made of a hard synthetic resin. Housing 32, groove 37 of 32
Then, the filter 33 is sandwiched and the end portions 38 of the housings 32, 32 are welded to each other to press the filter 33 and press it.
Leakage from the three end faces is prevented (39 in FIG. 7 is a welded portion). However, since the filter 33 is only physically crimped by the housing, the crimping force of the filter 33 is reduced when the thickness of the filter 33 is increased or the number of the filters 33 is increased. The airtightness of the filter was reduced, causing blood leakage from the end surface of the filter 33. Further, when the pressure force of the filter 33 is increased, it becomes difficult to weld the housings 32, 32 to each other, and the housing 32 after welding is easily damaged by residual stress. Moreover, since the housing 32 is formed of a hard synthetic resin for crimping the filter 33, the impact resistance and the chemical resistance are poor, leading to cracks caused by chemicals and damage caused by impact or drop during transportation. . Therefore, the present inventor has earnestly studied to solve the above problems, and as a result, arrived at the following invention.

[0003]

[Means for Solving the Problems]

[1] The present invention provides a leukocyte-removing filter in which a blood filter material is loaded in a flexible housing, and a peripheral portion of the housing is welded. [2] According to the present invention, a blood filter material is loaded into a flexible housing, and a peripheral portion of the filter is welded to the housing to divide the housing into a blood inflow chamber and a blood outflow chamber and to Provided is a leukocyte-removing filter formed so that an inflow chamber communicates with a blood inlet and a blood outflow chamber communicates with a blood outlet. [3] In the present invention, a blood filter material having a peripheral portion sealed from the lower portion to the side portion is mounted on the upper portion of a flexible housing having a blood inlet port on the upper portion and a blood outlet port on the lower portion. Providing a leukocyte removal filter formed so that the housing is divided into a blood inflow chamber and a blood outflow chamber, and a blood inflow chamber is connected to the blood inflow chamber and a blood outflow chamber is connected to the blood outflow chamber. .

[0004]

1 is a schematic view of a leukocyte-removing filter 1 according to the present invention (FIG. 2 is a sectional view taken along the line AA in FIG. 1). The leukocyte-removing filter 1 can include a blood filter material 3. It is configured by loading in the flexible housing 2. As the blood filter material 3, for example, fibers described in Japanese Patent Publication No. 58-54126, and non-woven fabrics and porous bodies described in Japanese Patent Publication No. 60-193468 are used, but it is preferable. A synthetic fiber or a non-woven fabric made of synthetic fiber, which has similar thermal properties and electrical properties to the housing for welding them is preferable. For example, polyester, polyamide,
Polypropylene, polyethylene, polyurethane, polyvinyl chloride, acrylonitrile, styrene elastomer, etc. are used. These can be loaded into the flexible housing 2 by, for example, sandwiching them between two flexible sheets and welding their peripheral portions (4 in FIG. 1 is a sealing portion).

The housing 2 is preferably made of a flexible synthetic resin and has similar thermal and electrical properties to the blood filter material, and the material used for the housing 2 is soft vinyl chloride, polyurethane or ethylene. -Vinyl acetate copolymer, hydrogenated product of styrene-butadiene-styrene copolymer, thermoplastic elastomer such as styrene-isoprene-styrene copolymer or hydrogenated product thereof, and thermoplastic elastomer and polyolefin, ethylene-ethyl acrylate And a mixture with a softening agent such as. Preferred are soft vinyl chloride, polyurethane, styrene-butadiene-styrene copolymer, styrene-ethylene-butylene-styrene copolymer and thermoplastic elastomers containing these as the main components.

The welding of the housing 2 may be external heat welding by heat sealing, or internal welding by a high frequency welder or an ultrasonic welder. As a method of welding, the blood filter material 3 and the housing 2 may be simultaneously welded by heat sealing, a high frequency welder, or an ultrasonic welder. Only the peripheral portion of the laminated blood filter material 3 is welded first, and then It may be welded to the housing 2.

The blood inlet 8 and the blood outlet 7 are made of a hard synthetic resin by injection molding or extrusion molding, and are sandwiched between two flexible sheets forming the housing 2 to weld the flexible sheets. At the same time, it can be mounted on the housing 2 (in FIG. 2, reference numerals 5 and 6 are mouth welding portions). Finally, blood transfer tubes 9 and 10 are attached to the blood inlet 8 and the blood outlet 7. Further, instead of the blood inlet 8 and the blood outlet 7, the tips of the blood transfer tubes 9 and 10 can be directly attached. The housing 2 is divided into a blood inflow chamber 8a and a blood outflow chamber 7a by a blood filter material 3, and a blood inflow port 8a is connected to the blood inflow chamber 8a and a blood outflow port 9 is connected to the blood outflow chamber 7a. Has been done.

In the embodiment of the present invention, a polyurethane non-woven fabric is used as the blood filter material 3 and is sealed with a flexible synthetic resin housing. Polyvinyl chloride and polyurethane were used as the flexible synthetic resin, and those having a Shore A hardness of 90 or less were used (see Table 1).

[0009]

[Table 1]

In Examples 1 to 4 and Comparative Examples 1 to 3, 200 g
The iron ball was dropped from a height of 1000 mm and the housing was checked for cracks. From the results in Table 2, no damage was observed in the leukopheresis filter of the present invention.

[0011]

[Table 2]

FIG. 3 is a schematic view of the leukocyte-removing filter 11 of the present invention (FIG. 4 is a view as seen from the arrow A in FIG. 3). The leukocyte-removing filter 1 includes a blood filter material 13 and a housing 12. It is configured by loading inside. As the blood filter material 3, a flat plate-shaped material (including a single layer and a laminated material) is used. For example, the blood filter material 3 is sandwiched between two flexible sheets and the periphery thereof is heat-sealed, a high frequency welder, an ultrasonic welder, etc. It is loaded into the housing 2 composed of two flexible sheets by welding by means of the above means (14 in FIG. 3 is a welding portion).

As a result, the inside of the housing 12 is divided into the blood inflow chamber 18 and the blood outflow chamber 17 by the blood filter material 13,
A blood inlet 16 and a blood outlet 15 are formed so as to communicate with the chambers 17 and 18, respectively. Blood inlet 16 and outlet 1
5 may be formed by injection molding and may be connected to the flexible sheet forming the housing 12 by making a hole, or a flexible tube may be connected to the flexible sheet having a hole. .

The selection and sealing of the materials of the blood filter material 3 and the housing 12 can be performed in the same manner as in the leukocyte removal filter device 1.

In the examples of the present invention, the materials, the number of sheets, the weight per unit area, the material of the housing, the sealing method and the like shown in Tables 3 and 4 were adopted. Examples 6 to 10
An airtightness test, an impact resistance test, and a leak test were performed using the leukocyte removal filter described in 1. The results are shown in Table 5. From the results in Table 5, good results were obtained in all the examples.

[0016]

[Table 3]

[0017]

[Table 4]

[0018]

[Table 5]

FIG. 5 is a schematic view of the leukocyte-removing filter 21 of the present invention (FIG. 6 is a vertical cross-sectional view of FIG. 5). The leukocyte-removing filter 21 has a housing having a blood outlet 26 welded to the bottom thereof. Two
2 and blood inlet 25 mounted on the top of housing 22
It is composed of The blood filter material 23 is formed in the shape of a hook, the peripheral portion is sealed by welding from the lower portion to the side portion, the upper portion is opened, and the upper end portion is welded to the housing 22 (in FIG. 5). 24 is a peripheral sealing part).
The housing 22 is divided into a blood inflow chamber 28 and a blood outflow chamber 27. The blood inflow chamber 28 is formed so that the blood inflow port 25 and the blood outflow chamber 27 are connected to the blood outflow port 26. In the leukocyte-removing filter 21, the outer periphery of the blood filter material 23 is mounted in a suspended state without simultaneously sealing the outer periphery of the housing 22, so that the filtration area becomes large and the filtration speed becomes fast. The materials of the housing 22 and the blood filter material 23 are the same as those of the leukocyte removing filter device 1.

Further, the leukocyte-removing filter 1, 1 of the present invention
Nos. 1 and 21 can be subjected to high-pressure steam sterilization.

[0021]

By sealing the blood filter material with the flexible housing, it is possible to prevent the housing from being damaged by an impact or a drop during transportation. Further, even if the blood bag is centrifuged at the same time, the damage to the housing and the blood bag can be prevented. Further, since the peripheral portion of the blood filter material is welded, the airtightness is not deteriorated and the blood leak does not occur even if the blood filter material is thickened or the number of stacked sheets is increased.

[Brief description of drawings]

FIG. 1 is a schematic view of a filter for removing leukocytes of the present invention.

FIG. 2 is a sectional view taken along line AA of FIG.

FIG. 3 is a sectional view of a filter for removing leukocytes of the present invention.

FIG. 4 is a view on arrow A of FIG.

FIG. 5 is a schematic view of a filter for removing leukocytes of the present invention.

6 is a vertical cross-sectional view of FIG.

FIG. 7 is a sectional view of a conventional leukopheresis filter.

[Explanation of symbols]

 1 White Blood Cell Removal Filter 2 Housing 3 Blood Filter Material 4 Sealing Part 5 Mouth Welding Part 6 Mouth Welding Part 7 Blood Outlet 8 Blood Inlet 7a Blood Outflow Chamber 8a Blood Inflow Chamber 9 Blood Transfer Tube 10 Blood transfer tube 11 Leukocyte removal filter 12 Housing 13 Blood filter material 14 Sealing part 15 Blood outlet 16 Blood inlet 17 Blood outflow chamber 18 Blood inflow chamber 21 Leukocyte removal filter 22 Housing 23 Blood filter Excess material 24 Peripheral sealing portion 25 Blood inflow port 26 Blood outflow port 27 Blood outflow chamber 28 Blood inflow chamber

Claims (3)

[Claims] 1. A leukocyte-removing filter according to claim 1, wherein a blood filter material is loaded in a flexible housing, and the housing and a peripheral portion thereof are welded to each other. 2. A blood filter material is loaded into a flexible housing, and a peripheral portion of the filter is welded to the housing to divide the housing into an inflow chamber and an outflow chamber for blood and inflow of blood. A filter for removing leukocytes, characterized in that a blood inlet is connected to the chamber and a blood outlet is connected to the blood outlet. 3. A blood filter material having a peripheral portion sealed from the lower portion to the side portion is mounted on the upper portion of a flexible housing having a blood inlet port on the upper portion and a blood outlet port on the lower portion, The housing is divided into a blood inflow chamber and a blood outflow chamber, and a blood inflow chamber is connected to a blood inflow port, and a blood outflow chamber is connected to a blood outflow chamber. vessel.