JPH0782159A - Iodine-based disinfectant to be applied in the form of mousse - Google Patents
Iodine-based disinfectant to be applied in the form of mousseInfo
- Publication number
- JPH0782159A JPH0782159A JP26147493A JP26147493A JPH0782159A JP H0782159 A JPH0782159 A JP H0782159A JP 26147493 A JP26147493 A JP 26147493A JP 26147493 A JP26147493 A JP 26147493A JP H0782159 A JPH0782159 A JP H0782159A
- Authority
- JP
- Japan
- Prior art keywords
- iodine
- disinfectant
- mousse
- polyvinyl alcohol
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000645 desinfectant Substances 0.000 title claims abstract description 46
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 title claims abstract description 38
- 229910052740 iodine Inorganic materials 0.000 title claims abstract description 38
- 239000011630 iodine Substances 0.000 title claims abstract description 38
- 241000195940 Bryophyta Species 0.000 title claims abstract description 14
- 235000011929 mousse Nutrition 0.000 title claims abstract description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 13
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 13
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 6
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000008213 purified water Substances 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000012153 distilled water Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- 238000005187 foaming Methods 0.000 claims description 3
- 239000003949 liquefied natural gas Substances 0.000 claims 3
- 238000004040 coloring Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 8
- 230000000840 anti-viral effect Effects 0.000 abstract description 7
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 abstract description 6
- 239000002085 irritant Substances 0.000 abstract description 5
- 231100000021 irritant Toxicity 0.000 abstract description 5
- 238000001228 spectrum Methods 0.000 abstract description 4
- 239000003345 natural gas Substances 0.000 abstract description 3
- 230000000638 stimulation Effects 0.000 abstract 2
- DKNPRRRKHAEUMW-UHFFFAOYSA-N Iodine aqueous Chemical compound [K+].I[I-]I DKNPRRRKHAEUMW-UHFFFAOYSA-N 0.000 abstract 1
- 230000002542 deteriorative effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 10
- 238000010790 dilution Methods 0.000 description 6
- 239000012895 dilution Substances 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 230000007794 irritation Effects 0.000 description 5
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 4
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 210000004400 mucous membrane Anatomy 0.000 description 3
- GSGDTSDELPUTKU-UHFFFAOYSA-N nonoxybenzene Chemical compound CCCCCCCCCOC1=CC=CC=C1 GSGDTSDELPUTKU-UHFFFAOYSA-N 0.000 description 3
- FFJCNSLCJOQHKM-CLFAGFIQSA-N (z)-1-[(z)-octadec-9-enoxy]octadec-9-ene Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCCCCCCC\C=C/CCCCCCCC FFJCNSLCJOQHKM-CLFAGFIQSA-N 0.000 description 2
- FDCJDKXCCYFOCV-UHFFFAOYSA-N 1-hexadecoxyhexadecane Chemical compound CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC FDCJDKXCCYFOCV-UHFFFAOYSA-N 0.000 description 2
- 244000063299 Bacillus subtilis Species 0.000 description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000606790 Haemophilus Species 0.000 description 2
- 241001428586 Human adenovirus D8 Species 0.000 description 2
- 241000725303 Human immunodeficiency virus Species 0.000 description 2
- 241000588747 Klebsiella pneumoniae Species 0.000 description 2
- 241000588629 Moraxella lacunata Species 0.000 description 2
- 241000588650 Neisseria meningitidis Species 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 2
- 241000607768 Shigella Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 241000191963 Staphylococcus epidermidis Species 0.000 description 2
- 241000193998 Streptococcus pneumoniae Species 0.000 description 2
- 241000193996 Streptococcus pyogenes Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 231100000344 non-irritating Toxicity 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 239000011505 plaster Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 2
- 229940098465 tincture Drugs 0.000 description 2
- 241001529453 unidentified herpesvirus Species 0.000 description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- -1 Sulfite tetraoleate Chemical compound 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 230000000531 effect on virus Effects 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 210000003371 toe Anatomy 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、白色のヨウ素系消毒剤
に関するTECHNICAL FIELD The present invention relates to a white iodine-based disinfectant.
【０００２】[0002]
【従来の技術】家庭用消毒薬としては従来より多くの発
明が知られている。例えばヨウ素系の消毒剤いわゆるヨ
ウチンは広い抗菌スペクトラム、抗ウィルス作用さらに
安価性より古くから使われてきた。抗生剤の使いすぎに
起因して生じた多剤耐性菌（ＭＲＳＡ）に対してもヨウ
素系消毒剤は有効であることから最近病院において高頻
度に使われている。しかしながら、ヨウ素系消毒剤を傷
口に塗布した場合刺激性が強く非常に痛いこと（擦傷を
負ったワンパクに［男の子なら我慢しなさい］といって
痛がる子供にヨウチンを付けてあげる場面は今でも結構
見かける）さらに顔等に塗布した場合には塗布した部分
が真っ赤になるためなんとも目立つ、加えて塗布時の色
は数日間はとれないため女性に塗布するのはまず不可能
である。そのような理由からマキロン等の透明で刺激性
のない消毒薬が市販されているがこれらの消毒薬は使用
感がなくさらに余分の消毒薬が垂れてこぼれ落ちてしま
う。抗菌スペクトルにも問題がある。2. Description of the Related Art Many inventions have been known as household disinfectants. For example, iodine-based disinfectant, so-called iodine, has been used for a long time because of its broad antibacterial spectrum, antiviral effect, and low cost. Recently, iodine-based disinfectants are frequently used in hospitals because they are effective against multidrug-resistant bacteria (MRSA) caused by overuse of antibiotics. However, when an iodine-based disinfectant is applied to the wound, it is very irritating and very painful. However, when it is applied to the face, etc., it is very noticeable because the applied part becomes bright red. In addition, it is impossible to apply to women because the color at the time of application cannot be taken for several days. For that reason, transparent and non-irritating disinfectants such as maquilon are commercially available, but these disinfectants do not have a feeling of use, and an extra disinfectant drips and falls off. There are also problems with the antibacterial spectrum.
【０００３】刺激性がなく色もつかず局所にのみ塗付可
能なものとしてクロルヘキシジンを含んだ軟膏が市販さ
れているが、この軟膏の場合独特の強いにおいとべとつ
きがある。さらにウィルスに対する作用は不明である。
最近は小型の救急用のバンソウ膏型のものも良く使われ
ている。これだと使用感もあり、患部にだけ付けること
ができ、色は目立たない肌色であるので女性でも使用で
きる。しかし、バンソウ膏型のものは一旦風呂やプール
に入ると濡れてしまい、患部がムレてそのままにしてお
くと返って悪化したりする弱点がある。一般的に夏場の
湿気の多いときに貼りっぱなしにしておくと切傷が悪化
する例も多い。また、病院において手足指の一般的消毒
には使用できない。以上の解決を目的のひとつとして本
発明者等はヨウ素系消毒剤の改良を試み、眼科用に使わ
れてきたポリビニルアルコール系溶媒に含有させたヨウ
素系消毒剤を一般家庭用に利用することで刺激性のない
ヨウ素系消毒剤を提供できることを見出した。しかしヨ
ウ素の色を無くすことには成功しなかった。An ointment containing chlorhexidine which is non-irritating and has no color and which can be applied only locally is commercially available. However, this ointment has a unique strong odor and stickiness. Furthermore, its effect on viruses is unknown.
Recently, the small-sized first-aid Bansou plaster type is often used. This has a feeling of use, and can be applied only to the affected area, and since the color is inconspicuous, it can be used by women. However, there is a weak point that the bansou plaster type gets wet once it enters the bath or pool, and if the affected area gets stuffy and it is left as it is, it will worsen. In general, there are many cases where the cuts worsen if left untouched when the humidity is high in the summer. Also, it cannot be used for general disinfection of toes and fingers in hospitals. As one of the objects of the above solution, the present inventors have tried to improve the iodine-based disinfectant, and by utilizing the iodine-based disinfectant contained in the polyvinyl alcohol solvent used for ophthalmology for general household use. It was found that an iodine-based disinfectant that is not irritating can be provided. However, it did not succeed in eliminating the color of iodine.
【０００４】[0004]
【発明が解決しようとする課題】以上より、消毒薬とし
てヨウ素系消毒薬と同等の広い抗菌スペクトラムを有し
抗ウィルス作用も広くしかも刺激性がすくなくて色が肌
につかず、かといってべとついたりにおいのひどくない
外用消毒薬の提供を課題とするAs described above, as a disinfectant, it has a broad antibacterial spectrum equivalent to that of iodine-based disinfectants, has a broad antiviral action, and has a low irritation and does not stick to the skin. The challenge is to provide an external disinfectant that does not have a bad smell
【０００５】[0005]
【課題を解決するための手段】本発明者等は、上記状況
に鑑みて鋭意研究努力した結果、ヨウ素系消毒剤をムー
ス化（泡沫化）することによって薬液の色を白色とし、
特にポリビニルアルコール系溶媒を用いたヨウ素系消毒
剤をムース化することによって殺菌および抗ウィルス特
性を変えずに刺激がすくないがそれでいて使用感もあ
り、且つ余分の消毒剤が付着しないため肌に着色がほと
んど無く、においやべとつき感もない女性を含む全年齢
の人が使用しても全く問題のない消毒薬となることを見
出し本研究を完成させた。さらに本発明の消毒薬は一般
家庭用のみならず病院等において皮膚および柔らかい皮
膚粘膜の一般的消毒に用いることもできる。本発明はポ
リビニルアルコール系溶媒に溶解したヨウ素溶液１〜５
０％、好ましくは５〜３０％を１〜数種の非イオン性界
面活性剤の０．１〜５％、好ましくは０．５〜２％とな
るように精製水または蒸留水で希釈したものであるが、
場合により消泡時間の短縮を目的として適当量のエタノ
ール、好ましくは５〜４０％のエタノールを加えて総量
１００％としたものを耐圧性容器に充填し適当量のＬＰ
ガスまたはプロパンガス等のガス体を充填しノズルより
ガスとともにムース状に噴霧して使用することを特徴と
する。Means for Solving the Problems As a result of earnest research efforts in view of the above situation, the present inventors have made the iodine-based disinfectant mousse (foaming) to change the color of the liquid medicine to white,
In particular, by moussing an iodine-based disinfectant that uses a polyvinyl alcohol-based solvent, it does not change the bactericidal and antiviral properties and does not cause irritation, but it also has a feeling of use, and since the disinfectant does not adhere to it, the skin is colored. We have completed this study by discovering that it is a disinfectant that can be used by people of all ages, including women with little or no odor and stickiness, and has no problems at all. Furthermore, the disinfectant of the present invention can be used not only for general household use but also for general disinfection of skin and soft skin mucous membranes in hospitals and the like. The present invention is an iodine solution 1 to 5 dissolved in a polyvinyl alcohol solvent.
0%, preferably 5 to 30% diluted with purified water or distilled water to 0.1 to 5%, preferably 0.5 to 2% of 1 to several kinds of nonionic surfactants. In Although,
In some cases, for the purpose of shortening the defoaming time, a suitable amount of ethanol, preferably 5 to 40% of ethanol is added to make 100% in total, is filled in a pressure resistant container, and an appropriate amount of LP is added.
It is characterized in that it is filled with a gas body such as gas or propane gas and sprayed in a mousse form together with the gas from a nozzle for use.
【０００６】ポリビニル系アルコール系溶媒に溶解した
ヨウ素溶液の組成としてはヨウ素を０．０１〜５％好ま
しくは０．１〜２％含有しヨウ化カリウムを０．１〜３
％好ましくは０．１〜２％含有しポリビニルアルコール
１〜２０％好ましくは４〜１０％含有するのが好まし
い。非イオン性界面活性剤としては如何なるものでも用
いることができるが例としてノニルフェニルエーテル、
スルビットテトラオレエート、オレイルエーテル、セチ
ルエーテル等を上げることができこれらを単独または混
合して用いることができる。以下に実施例を上げて本発
明を詳細に説明するが、本実施例によって本発明を限定
するものではない。The composition of an iodine solution dissolved in a polyvinyl alcohol solvent is 0.01-5% iodine, preferably 0.1-2%, and potassium iodide 0.1-3.
%, Preferably 0.1 to 2%, polyvinyl alcohol 1 to 20%, preferably 4 to 10%. As the nonionic surfactant, any one can be used, but as an example, nonylphenyl ether,
Sulfite tetraoleate, oleyl ether, cetyl ether and the like can be used, and these can be used alone or in combination. Hereinafter, the present invention will be described in detail with reference to examples, but the present invention is not limited to the examples.
【０００７】実施例１：ポリビニールアルコール系溶媒
に溶解したヨウ素消毒剤の製法（１） ヨウ素 ０．２％ ヨウ化カリウム ０．２％ ポリビニールアルコール ８．０％ 精製水 ９１．６％ 本消毒剤は１６倍希釈の状態で０．５分間でほぼ完全に
ＨＩＶビールスを失活させ、また同希釈液でＡＨＣウィ
ルス、アデノウィルス８型、ヘルペスウィルスに対して
１分以内に検出限界以下に失活させた。さらに緑膿菌、
赤痢菌、大腸菌、肺炎桿菌、モルガン変形菌、鼠チフス
菌、枯草菌の芽胞、黄色ブドウ球菌、表皮ブドウ球菌、
化膿連鎖球菌、乾燥症菌、肺炎双球菌、モラクセラ ラ
クナータ、ヘモフィルス エジプテウス、髄膜炎菌に対
して８０倍希釈で１分以内に検出限界以下にまで殺菌し
た。本消毒薬はイソジン等に比較して臭いが温和で、皮
膚粘膜等に対する刺激性も少なく、皮膚からの洗い流し
も容易であった。しかし色は紫色をしていてイソジンや
ヨウドチンキ等とは異なっていたが依然として残ってい
た。Example 1: Method for producing iodine disinfectant dissolved in polyvinyl alcohol solvent (1) Iodine 0.2% Potassium iodide 0.2% Polyvinyl alcohol 8.0% Purified water 91.6% Main disinfection The agent almost completely inactivates HIV virus in 0.5 minutes in a 16-fold dilution, and with the same dilution, it inactivates below the detection limit against AHC virus, adenovirus type 8 and herpes virus within 1 minute. Let Pseudomonas aeruginosa,
Shigella, Escherichia coli, Klebsiella pneumoniae, Morgan bacterium, Salmonella typhi, Bacillus subtilis spores, Staphylococcus aureus, Staphylococcus epidermidis,
It was sterilized to less than the detection limit within 1 minute with 80-fold dilution against Streptococcus pyogenes, Pseudomonas aeruginosa, Streptococcus pneumoniae, Moraxella lacunata, Haemophilus ediptheus, and Neisseria meningitidis within 1 minute. This disinfectant had a milder odor than isodine and the like, had less irritation to skin and mucous membranes, and was easily washed off the skin. However, the color was purple, and although it was different from isodine and tincture of iodine, it still remained.
【０００８】実施例２：ポリビニールアルコール系溶媒
に溶解したヨウ素消毒剤の製法（２） ヨウ素 ０．５％ ヨウ化カリウム １．０％ ポリビニールアルコール ８．０％ 精製水 ９０．５％ 本消毒剤は３２倍希釈の状態で０．５分間でほぼ完全に
ＨＩＶビールスを失活させ、また同希釈液でＡＨＣウィ
ルス、アデノウィルス８型、ヘルペスウィルスに対して
１分以内に検出限界以下に失活させた。さらに緑膿菌、
赤痢菌、大腸菌、肺炎桿菌、モルガン変形菌、鼠チフス
菌、枯草菌の芽胞、黄色ブドウ球菌、表皮ブドウ球菌、
化膿連鎖球菌、乾燥症菌、肺炎双球菌、モラクセラ ラ
クナータ、ヘモフィルス エジプテウス、髄膜炎菌に対
して１６０倍希釈で１分以内に検出限界以下にまで殺菌
した。本消毒薬はイソジン等に比較して臭いが温和で、
皮膚粘膜等に対する刺激性も少なく、皮膚からの洗い流
しも容易であった。しかし色は紫色をしていてイソジン
やヨウドチンキ等とは異なっていたが依然として残って
いた。Example 2: Method for producing iodine disinfectant dissolved in polyvinyl alcohol solvent (2) Iodine 0.5% Potassium iodide 1.0% Polyvinyl alcohol 8.0% Purified water 90.5% Main disinfection The agent almost completely inactivates HIV virus in 0.5 minutes in a 32-fold dilution, and also inactivates below the detection limit within 1 minute against AHC virus, adenovirus type 8 and herpes virus with the same dilution solution. Let Pseudomonas aeruginosa,
Shigella, Escherichia coli, Klebsiella pneumoniae, Morgan bacterium, Salmonella typhi, Bacillus subtilis spores, Staphylococcus aureus, Staphylococcus epidermidis,
It was sterilized to below the detection limit within 1 minute with a 160-fold dilution against Streptococcus pyogenes, Pseudomonas aeruginosa, Streptococcus pneumoniae, Moraxella lacunata, Haemophilus ediptheus, and N. meningitidis within 1 minute. This disinfectant has a milder odor than isodine,
There was little irritation to the skin and mucous membranes, and it was easy to wash off from the skin. However, the color was purple, and although it was different from isodine and tincture of iodine, it still remained.
【０００９】 実施例３：ムース化ヨウ素消毒液（１） 製法 重量％ 実施例１のヨウ素消毒液 １０．００ ＰＯＥ（５）ノニルフェニルエーテル ０．４０ ＰＯＥ（１０）ノニルフェニルエーテル ０．６０ ９９％エタノール ３０．００精製水 ５９．００ １００．００ ｐＨ５．５２（２５℃） 上記組成の消毒液の６４．５ｇを小型のプラスチック性
圧力容器に充填し天然ガス（ＬＰ３．２）５．５ｇを充
填しムース（泡状）として患部に噴霧して処置する。本
例においては噴霧されたものはムース状で白色であり、
肌に塗布した場合も肌をほとんど着色せず、それでいて
抗ウィルス活性と抗菌活性は実施例１のヨウ素消毒剤を
１０倍に希釈したものと同等に維持され低刺激性と低刺
激臭を有していた。Example 3: Moussing iodine disinfectant solution (1) Manufacturing method% by weight Iodine disinfectant solution of Example 1 10.00 POE (5) nonylphenyl ether 0.40 POE (10) nonylphenyl ether 0.60 99% Ethanol 30.00 Purified water 59.00 100.00 pH 5.52 (25 ° C) Fill a small plastic pressure vessel with 64.5 g of the disinfectant solution of the above composition and 5.5 g of natural gas (LP3.2). The mousse (foam) is sprayed onto the affected area for treatment. In this example, the sprayed product is mousse-shaped and white,
Even when applied to the skin, the skin is hardly colored, and yet the antiviral activity and antibacterial activity are maintained at the same level as those obtained by diluting the iodine disinfectant of Example 1 by 10 times, and it has a low irritant and a low odor. Was there.
【００１０】 実施例４：ムース化ヨウ素消毒液（２） 製法 重量％ 実施例１のヨウ素消毒液 ２０．００ ＰＯＥ（６０）ソルビットテトラオレエート ０．５０ ＰＯＥ（５０）オレイルエーテル ０．５０ ＰＯＥ（２３）セチルエーテル ０．２５ ９９％エタノール ３５．００精製水 ４３．７５ １００．００ ｐＨ５．５２（２５℃） 上記組成の消毒液の５２．８ｇを小型のプラスチック性
圧力容器に充填し天然ガス（ＬＰ３．６）７．２ｇを充
填しムース（泡状）として患部に噴霧して処置する。本
例においても噴霧されたものはムース状で白色であり、
肌に塗布した場合も肌をほとんど着色せず、それでいて
抗ウィルス活性と抗菌活性は実施例１のヨウ素消毒剤を
５倍に希釈したものと同等に維持され低刺激性と低刺激
臭を有していた。さらに本例では消泡時間が短縮され
た。Example 4: Moussing iodine disinfectant solution (2) Manufacturing method% by weight Iodine disinfectant solution of Example 1 20.00 POE (60) sorbit tetraoleate 0.50 POE (50) oleyl ether 0.50 POE ( 23) Cetyl ether 0.25 99% ethanol 35.00 Purified water 43.75 100.00 pH 5.52 (25 ° C) A small plastic pressure vessel was filled with 52.8 g of the disinfectant solution of the above composition and natural gas ( LP3.6) (7.2 g) is filled and treated as a mousse (foam) by spraying on the affected area. Also in this example, the sprayed product is mousse and white,
Even when applied to the skin, the skin is hardly colored, yet the antiviral activity and antibacterial activity are maintained at the same level as those obtained by diluting the iodine disinfectant of Example 1 by 5 times, and it has a low irritant and a low irritant odor. Was there. Further, in this example, the defoaming time was shortened.
【００１１】[0011]
【発明の効果】下表にまとめたように本実施例のムース
状消毒薬は他のヨーソ系消毒薬と同等の抗菌、抗ウィル
ス作用をもちながら刺激性と色がなく肌を赤で汚すこと
が無いのが特徴である。 As summarized in the table below, the mousse type disinfectant of this example has the same antibacterial and antiviral effects as those of other yoso type disinfectants, and has no irritation and no color and stains the skin with red. The feature is that there is no
───────────────────────────────────────────────────── フロントページの続き (71)出願人 593020566 石川 邦雄 東京都江東区三好４−９−８ 吉井ビル 403 (72)発明者 松本 振一郎 東京都葛飾区青戸７−１−27 ─────────────────────────────────────────────────── ─── Continuation of front page (71) Applicant 593020566 Kunio Ishikawa 4-9-8 Miyoshi Koto-ku, Tokyo Yoshii Building 403 (72) Inventor Shinichiro Matsumoto 7-1-27 Aoto, Katsushika-ku, Tokyo
Claims (5)
ことによって薬液の色を白色とし、肌への着色もほとん
ど無くしたことを特徴とするムース化したヨウ素系消毒
薬1. A mousse iodine disinfectant characterized in that the iodine disinfectant is made into a mousse (foaming) so that the color of the liquid medicine is white and coloring of the skin is almost eliminated.
ことによって薬液の色を白色とし、肌への着色もほとん
ど無くしたことを特徴とするムース化したヨウ素系消毒
薬の製法2. A process for producing a mousse iodine disinfectant, characterized in that the iodine liquid disinfectant is made into a mousse (foaming) so that the color of the liquid medicine is white and coloring of the skin is almost eliminated.
〜１％含有しヨウ化カリウムを０．１〜３％好ましくは
０．１〜１％含有しポリビニルアルコールを１〜２０％
好ましくは４〜１０％含有するヨウ素系消毒薬を１〜４
０％好ましくは５〜２０％に、さらに１〜数種の非イオ
ン性界面活性剤を０．１〜５％好ましくは０．５〜２％
となるように精製水または蒸留水で希釈したものを小型
の耐圧性容器に充填しさらに液化天然ガスを充填したこ
とを特徴とするムース化したヨウ素系消毒薬3. Iodine in an amount of 0.01 to 5%, preferably 0.1
-1% contained potassium iodide 0.1-3%, preferably 0.1-1% contained polyvinyl alcohol 1-20%
Preferably 1 to 4 iodine disinfectant containing 4 to 10%
0%, preferably 5 to 20%, and 1 to several kinds of nonionic surfactants, 0.1 to 5%, preferably 0.5 to 2%.
A mousse type iodine disinfectant characterized by filling purified water or diluted with distilled water into a small pressure-resistant container and then filling with liquefied natural gas.
〜１％含有しヨウ化カリウムを０．１〜３％好ましくは
０．１〜１％含有しポリビニルアルコールを１〜２０％
好ましくは４〜１０％含有するヨウ素系消毒薬を１〜４
０％好ましくは５〜２０％に、さらに１〜数種の非イオ
ン性界面活性剤を０．１〜５％好ましくは０．５〜２％
に、エタノールを２０〜４０％になるように精製水また
は蒸留水で希釈したものを小型の耐圧性容器に充填しさ
らに液化天然ガスを充填したことを特徴とするムース化
したヨウ素系消毒薬4. Iodine is 0.01 to 5%, preferably 0.1.
-1% contained potassium iodide 0.1-3%, preferably 0.1-1% contained polyvinyl alcohol 1-20%
Preferably 1 to 4 iodine disinfectant containing 4 to 10%
0%, preferably 5 to 20%, and 1 to several kinds of nonionic surfactants, 0.1 to 5%, preferably 0.5 to 2%.
A mousse type iodine disinfectant characterized in that a small pressure resistant container was filled with ethanol diluted with purified water or distilled water so as to be 20 to 40% and further filled with liquefied natural gas.
〜１％含有しヨウ化カリウムを０．１〜３％好ましくは
０．１〜１％含有しポリビニルアルコールを１〜２０％
好ましくは４〜１０％含有するヨウ素系消毒薬を１〜４
０％好ましくは５〜２０％に、さらに１〜数種の非イオ
ン性界面活性剤を０．１〜５％好ましくは０．５〜２％
に、エタノールを２０〜４０％になるように精製水また
は蒸留水で希釈したものを小型の耐圧性容器に充填しさ
らに液化天然ガスを充填したことを特徴とするムース化
したヨウ素系消毒薬の製法5. Iodine in an amount of 0.01 to 5%, preferably 0.1
-1% contained potassium iodide 0.1-3%, preferably 0.1-1% contained polyvinyl alcohol 1-20%
Preferably 1 to 4 iodine disinfectant containing 4 to 10%
0%, preferably 5 to 20%, and 1 to several kinds of nonionic surfactants, 0.1 to 5%, preferably 0.5 to 2%.
In a mousse-type iodine disinfectant characterized in that a small pressure-resistant container was filled with ethanol diluted with purified water or distilled water to 20 to 40% and further filled with liquefied natural gas. Manufacturing method
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26147493A JPH0782159A (en) | 1993-09-13 | 1993-09-13 | Iodine-based disinfectant to be applied in the form of mousse |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26147493A JPH0782159A (en) | 1993-09-13 | 1993-09-13 | Iodine-based disinfectant to be applied in the form of mousse |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0782159A true JPH0782159A (en) | 1995-03-28 |
Family
ID=17362409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP26147493A Pending JPH0782159A (en) | 1993-09-13 | 1993-09-13 | Iodine-based disinfectant to be applied in the form of mousse |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0782159A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103210958A (en) * | 2013-05-15 | 2013-07-24 | 上海宇昂新材料科技有限公司 | Aquaculture compound iodine solution and preparation method thereof |
| AT514751A1 (en) * | 2013-08-16 | 2015-03-15 | Aykler Eszter Mag Dr | Pharmaceutical composition containing iodine-potassium iodide solution |
-
1993
- 1993-09-13 JP JP26147493A patent/JPH0782159A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103210958A (en) * | 2013-05-15 | 2013-07-24 | 上海宇昂新材料科技有限公司 | Aquaculture compound iodine solution and preparation method thereof |
| AT514751A1 (en) * | 2013-08-16 | 2015-03-15 | Aykler Eszter Mag Dr | Pharmaceutical composition containing iodine-potassium iodide solution |
| AT514751B1 (en) * | 2013-08-16 | 2017-12-15 | Eszter Mag Dr Aykler | Pharmaceutical composition containing iodine-potassium iodide solution |
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