JPH0788202A - Laser therapy equipment - Google Patents

Abstract

(57) [Summary] [Configuration] A YAG laser oscillator 28 that oscillates a YAG laser fundamental wave, a YAG laser second harmonic generator 31 that generates a YAG laser second harmonic from the YAG laser fundamental wave, and a YAG laser first wave. 2 YAG laser 3rd harmonic generator 34 for generating YAG laser 3rd harmonic from the 2nd harmonic and YAG laser fundamental wave, and YAG laser 3rd harmonic generating laser light having a wavelength corresponding to the characteristics of the photosensitizer Optical parametric oscillator 38
And laser light generated by the optical parametric oscillator 38 and YA oscillated by the YAG laser oscillator 28.
The endoscope 5 for irradiating the lesion with the G laser fundamental wave. [Effect] Both the laser light having the wavelength corresponding to the characteristics of the photosensitizer and the YAG laser fundamental wave can be irradiated to the lesion by the endoscope 5, and the lesion can be effectively treated. .

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a laser treatment apparatus.

[0002]

2. Description of the Related Art In recent years, various treatments using laser light have been carried out in the medical field.

As a therapeutic device using laser light, a cancer therapeutic device using a laser light pulse disclosed in Japanese Patent Publication No. 63-2633 and an endoscope disclosed in Japanese Patent Publication No. 63-21031. There is a device.

A cancer treatment apparatus using a laser pulse light disclosed in Japanese Patent Publication No. 63-2633 has a laser beam having a predetermined wavelength applied to a lesion site in which a photosensitizer having an affinity for cancer tissue is absorbed. Irradiation destroys the cancer tissue.

On the other hand, the endoscope apparatus disclosed in Japanese Examined Patent Publication No. 63-21031 discloses coagulation of biological tissue by irradiating a lesion with a laser beam of a predetermined wavelength.
Hemostasis and transpiration (excision, incision) are performed.

[0006]

However, in the case of carrying out the treatment using the above-mentioned photosensitizer and the treatment by coagulation, hemostasis, transpiration, etc. of the living tissue on the same lesion, the Japanese Patent Publication No. 63- It is necessary to prepare both the cancer treatment apparatus using the laser pulse light disclosed in Japanese Patent No. 2633 and the endoscope apparatus disclosed in Japanese Patent Publication No. 63-21031.

In the cancer treatment apparatus using the laser pulse light, since the excimer laser excitation dye laser is used as the laser light generator, the wavelength of the excitation laser is as short as 308 nm. The dye has a short life, and the excimer laser itself requires frequent replacement of the gas that is the gas medium, which requires cleaning of the mirror that constitutes the resonator.

The present invention solves the above-mentioned problems.
It is an object of the present invention to provide a laser treatment apparatus that is easy to maintain and can perform both laser treatment using a photosensitizer and laser treatment by coagulation, hemostasis, and evaporation of living tissue.

[0009]

In order to achieve the above object, in a laser treatment apparatus according to a first aspect of the present invention, a YAG laser oscillator that oscillates a YAG laser fundamental wave, and a laser that oscillates from the YAG laser oscillator. Y
A YAG laser second harmonic generator for generating a YAG laser second harmonic from an AG laser fundamental wave, and the YAG
A YAG laser third harmonic generator that generates a YAG laser third harmonic from a YAG laser second harmonic generated by the laser second harmonic generator and the YAG laser fundamental wave oscillated from the YAG laser oscillator;
YA generated by the YAG laser third harmonic generator
And an optical parametric oscillator for generating laser light having a wavelength different from that of the YAG laser third harmonic from the G laser third harmonic.

Similarly, in the laser treatment apparatus according to the second aspect of the present invention, a YAG laser oscillator that oscillates a YAG laser fundamental wave, and a YAG laser fundamental wave that oscillates from the YAG laser oscillator are used.
YAG laser second harmonic generator for generating laser second harmonic, YAG laser second harmonic generated by the YAG laser second harmonic generator, and the YAG
And a titanium sapphire laser generator that generates a titanium sapphire laser fundamental wave from a YAG laser fundamental wave oscillated from a laser oscillator.

[0011]

In the laser treatment apparatus according to the first aspect of the present invention, the YAG laser second harmonic generator is used for Y
The YAG laser second harmonic is generated from the AG laser fundamental wave, and the YAG laser third harmonic generator is used to generate YAG laser second harmonic.
Laser fundamental wave and YAG laser second harmonic to YAG
Generates laser third harmonic.

Further, the optical parametric oscillator is used for Y
A laser beam having a wavelength corresponding to the characteristics of the photosensitizer is generated from the AG laser third harmonic, and the laser light generated by the optical parametric oscillator is applied to the lesion part where the photosensitizer is absorbed to irradiate the lesion part. Give treatment.

Also, the YAG laser fundamental wave oscillated from the YAG laser oscillator is applied to the lesion to treat the lesion.

In the laser treatment apparatus according to the second aspect of the present invention, the YAG laser second harmonic is generated from the YAG laser fundamental wave by the YAG laser second harmonic generator.

Furthermore, a titanium sapphire laser fundamental wave is generated from the YAG laser fundamental wave and the second harmonic of the YAG laser by a titanium sapphire laser generator, and the titanium sapphire laser fundamental wave is emitted as a light. Irradiation is performed on the lesion where the sensitive substance is absorbed to treat the lesion.

Further, a YAG laser fundamental wave oscillated from a YAG laser oscillator is applied to the lesion to treat the lesion.

[0017]

Embodiments of the present invention will be described below with reference to the drawings.

1 and 2 show a first embodiment of the laser treatment apparatus according to the present invention, and this embodiment corresponds to claim 1 of the present invention.

Reference numeral 1 denotes a solid-state laser generator. The solid-state laser generator 1 has a YAG laser generator 2 for generating a laser beam having a predetermined wavelength and a laser beam generated by the YAG laser generator 2 having a different wavelength. The optical parametric oscillator 3 generates a laser beam.

The solid-state laser generator 1 has a YA
Cooling water supply pipe 4 for supplying cooling water to the G laser generating section 2 and suppressing a temperature rise of the YAG laser generating section 2.
Are connected.

Reference numeral 5 denotes an endoscope, and the endoscope 5 has a lesion portion 6
It is used for the observation and treatment of.

The endoscope 5 guides the light emitted from the illumination xenon lamp 7 to the lesion area 6 and illuminates the lesion area 6, and the observation optical fiber 9 for observing the lesion area 6. And irradiation optical fibers 10 and 11 for irradiating the lesion 6 with laser light generated in the solid-state laser generator 1.

Further, in the endoscope 5, cleaning water and cleaning air are fed to the respective tip portions of the illumination optical fiber 8, the observation optical fiber 9, and the irradiation optical fibers 10 and 11, and the illumination optical fiber 8 is supplied. A cleaning water supply pipe 12 and a cleaning air supply pipe 13 for cleaning the respective line ends of the observation optical fiber 9 and the irradiation optical fibers 10 and 11 are connected, and by the cleaning water supply pipe 12 and the cleaning air supply pipe 13. A drainage exhaust pipe 14 for discharging the supplied water and air can be connected.

Reference numeral 15 is an image display device, and the image display device 15 is used for observing the lesion 6.

The image display device 15 converts a color television camera 16 for taking an image of the lesion 6 through the observation optical fiber 9 and an image signal 17 output from the color television camera 16 into an image processing signal 18. An image processing unit 19, a television monitor 20 for displaying an actual image of the lesion 6 based on the image processing signal 18, and an image processing signal 18 for recording and recording the image processing signal 18.
To the TV monitor 20 via the image processing unit 19,
A recording / reproducing device 21 such as a video tape recorder capable of displaying a reproduced image of a photographed image of the lesion 6 on a television monitor 20 is provided.

Reference numeral 22 denotes an operation panel, and the operation panel 2
2 is designed to output a command signal 23 for operating the solid-state laser generator 1, the image display device 15, and the illumination xenon lamp 7 when the operator performs an input operation.

Reference numeral 24 is a control device, which controls the solid-state laser generator 1 based on the command signal 23.
To the YAG laser generation unit 2, an operation signal 26 to operate the image display device 15 to the image processing unit 19, and a lighting command signal 27 to the xenon lamp 7 for illumination. It is designed to output.

Hereinafter, Y of the solid-state laser generator 1 will be described.
The configuration of the AG laser generator 2 will be described with reference to FIG.

28 is a laser beam (Y
This is a YAG laser oscillator that oscillates a fundamental wave of an AG laser. The YAG laser oscillator 28 turns on a voltage by a Q switch applied voltage adjusting device 29 as shown in FIG.
Performing Q-switch pulse oscillation to generate an extremely short pulse laser beam with a high peak value when turned OFF, and performing normal pulse oscillation to generate a pulse laser beam with a long pulse width by constantly applying a voltage as shown in FIG. Is able to.

Reference numeral 30 denotes a total reflection mirror, and the total reflection mirror 30 is provided so that it can be located on the optical path of the YAG laser fundamental wave oscillated by the YAG laser oscillator 28.

The total reflection mirror 30 is positioned in the optical path of the YAG laser fundamental wave, and the YAG laser oscillator 2
When a normal pulse YAG laser fundamental wave (see FIG. 6) is oscillated from 8, the YAG laser fundamental wave reflected by the total reflection mirror 30 is guided to the irradiation optical fiber 11 (see FIG. 1) of the endoscope 5. It is like this.

Reference numeral 31 is a YAG laser second harmonic generator, and the YAG laser second harmonic generator 31 is 1 / λ ₂ = 1 / from the YAG laser fundamental wave oscillated by the YAG laser oscillator 28. λ ₁ + 1 / λ ₁ (1) (λ ₁ : YAG laser fundamental wave, λ ₂ : YAG laser second harmonic) relationship (second harmonic generation) causes a wavelength 53
A laser beam of 2 nm (second harmonic of YAG laser) is generated.

Reference numeral 32 is a total reflection mirror, and the total reflection mirror 32 is the YAG laser second harmonic generator 31.
The second harmonic of YAG laser generated in the second harmonic and the second harmonic of YAG laser generated by the second harmonic generator 31 of YAG laser are both reflected.

Reference numeral 33 is a total reflection mirror, and the total reflection mirror 33 is adapted to reflect both the YAG laser fundamental wave and the YAG laser second harmonic wave from the total reflection mirror 32.

Reference numeral 34 denotes a YAG laser third harmonic generator. The YAG laser third harmonic generator 34 includes a YAG laser fundamental wave and a YAG laser second harmonic reflected by the total reflection mirror 33. , 1 / λ ₃ = 1 / λ ₁ + 1 / λ ₂ (2) (λ ₁ : YAG laser fundamental wave, λ ₂ : YAG laser second harmonic, λ ₃ : YAG laser third harmonic) ( Laser light having a wavelength of 355 nm (YAG laser third harmonic) is generated by the third harmonic generation).

Reference numeral 35 is a dichroic mirror, and the dichroic mirror 35 is the third YAG laser
Only the YAG laser third harmonic generated by the harmonic generator 34 is reflected and the YAG laser third harmonic generator 3
The remaining YAG laser fundamental wave that has not been converted by 4 and the YAG laser second harmonic wave are transmitted.

Reference numeral 36 is a beam damper, and the beam damper 36 blocks the YAG laser fundamental wave and the YAG laser second harmonic wave which pass through the dichroic mirror 35.

Reference numeral 37 is a total reflection mirror, and the total reflection mirror 37 reflects the third harmonic of the YAG laser reflected by the dichroic mirror 35.

Next, the structure of the optical parametric oscillator 3 will be described.

Reference numeral 38 denotes an optical parametric oscillator. The optical parametric oscillator 38 includes a nonlinear optical crystal 39 such as a BBO crystal, an end mirror (resonator mirror) 40 and a front mirror (which face each other through the nonlinear optical crystal 39). Resonator mirror) 41.

The optical parametric oscillator 38 is the third YAG laser reflected by the total reflection mirror 37.
From the harmonics, 1 / λp = 1 / λs + 1 / λi (3) (λp: excitation light wave = YAG laser third harmonic, λs: signal light wave, λi: idler light wave) And idler light.

In the above optical parametric oscillator 38, if the excitation light wave λp is determined, the signal light wave λs and the idler light wave λi are determined according to the angle of the nonlinear optical crystal 39.

Reference numeral 42 is a prism, and the prism 42
Is configured to separate the signal light and the idler light generated by the optical parametric oscillator 38 from the excitation light (YAG laser third harmonic) that has not been converted by the optical parametric oscillator 38 for each wavelength.

Of these separated laser lights, the signal light is guided to the irradiation optical fiber 10 of the endoscope 5 (see FIG. 1).

The operation of this embodiment will be described below.

When the lesion 6 is treated, a hematoporphyrin derivative (HPD), which is a photosensitizer having an affinity for cancer tissue, is injected into the patient's blood vessel to advance the lesion 6 in advance. Absorb.

The hematoporphyrin derivative is specifically absorbed by cancer tissues, but hardly absorbed by normal living tissues.

When the lesion 6 having absorbed the hematoporphyrin derivative was irradiated with laser light having a wavelength of 630 nm, the laser light destroyed the cancer tissue having absorbed the hematoporphyrin derivative, while almost absorbing the hematoporphyrin derivative. No effect on normal living tissue.

After the hematoporphyrin derivative is absorbed in the lesion area 6, the endoscope 5 is positioned so that the distal end portion thereof substantially faces the lesion area 6.

On the other hand, if the angle of the nonlinear optical crystal 39 shown in FIG.
It is set to be nm.

By operating the operation panel 22 in this state, a command signal 23 for operating the image display device 15 and the illumination xenon lamp 7 from the operation panel 22.
Is output to the control device 24, and the control device 24 outputs an operation signal 26 to the image processing unit 19 and also outputs a lighting command signal 27 to the illumination xenon lamp 7 so that the lesion is generated by the light emitted from the illumination xenon lamp 7. The portion 6 is illuminated, and a real image of the lesion 6 captured by the color television camera 16 is displayed on the television monitor 20 to observe the lesion 6.

Then, by operating the operation panel 22, a command signal 23 for operating the solid-state laser generator 1 is output from the operation panel 22 to the controller 24, and the controller 24 causes the YAG laser generator 2 to operate. To output the operation signal 25.

When the operation signal 25 instructing the Q switch pulse oscillation (see FIG. 5) is input to the YAG laser generator 2, the YAG laser oscillator 28 shown in FIG.
From the YAG laser oscillator 28, Q of wavelength 1064 nm
The switch pulse laser light (YAG laser fundamental wave) is oscillated, and the YAG laser second harmonic generator 31 generates a YAG laser second harmonic wave having a wavelength of 532 nm from the YAG laser fundamental wave according to the relationship of the above-mentioned formula (1). To do.

This YAG laser second harmonic and YAG
The YAG laser fundamental wave remaining without being converted by the laser second harmonic generator 31 enters the YAG laser third harmonic generator 34 via the total reflection mirrors 32 and 33, and the YAG laser third harmonic generator is generated. The YAG laser third harmonic having a wavelength of 355 nm is generated from the YAG laser fundamental wave and the YAG laser second harmonic by the device 34 according to the relationship of the above equation (2).

The YAG laser fundamental wave and the YAG laser second harmonic that have not been converted by the YAG laser third harmonic and the YAG laser third harmonic generator 34 are incident on the dichroic mirror 35 and the dichroic mirror 35. The third harmonic of the YAG laser is reflected by 35 and enters the optical parametric oscillator 38, and the fundamental wave of the YAG laser and the second harmonic of the YAG laser pass through the dichroic mirror 35 and are blocked by the beam damper 36.

When the third harmonic of the YAG laser is incident on the optical parametric oscillator 38, the wavelength of 630n is obtained from the third harmonic of the YAG laser according to the relation of the above equation (3).
m laser light (signal light) and a laser light having a wavelength of 813 nm (idler light) are generated.

The laser light of wavelength 630 nm, the laser light of wavelength 813 nm and the optical parametric oscillator 3
The third harmonic wave (excitation light) of the YAG laser that remains without being converted by 8 is incident on the prism 42 and separated for each wavelength.

Of these separated laser beams, the laser beam having a wavelength of 630 nm is guided to the irradiation optical fiber 10 (see FIG. 1) of the endoscope 5 and to the lesion 6 via the irradiation optical fiber 10. Irradiated, wavelength 630nm
The laser light destroys the cancer tissue that has absorbed the hematoporphyrin derivative.

In the above-mentioned cancer treatment, the hematoporphyrin derivative was used as the photosensitizer, but when a photosensitizer other than the hematoporphyrin derivative is used, the nonlinear optical crystal 39 of the optical parametric oscillator 38 is used.
The wavelength of the laser light oscillated by the optical parametric oscillator may be made to correspond to the characteristics of the photosensitive substance by appropriately adjusting the angle of.

On the other hand, coagulation of living tissue with respect to the lesion site 6,
When performing treatment such as hemostasis, transpiration (ablation, incision), the total reflection mirror 30 is positioned in the optical path of the YAG laser fundamental wave oscillated by the YAG laser oscillator 28.

Thus, the total reflection mirror 30 is positioned in the optical path of the YAG laser fundamental wave, and the YAG laser generator 2
When the operation signal 25 instructing normal pulse oscillation (see FIG. 6) is input to the endoscope 5, normal pulse laser light (YAG laser fundamental wave) having a wavelength of 1064 nm emitted from the YAG laser oscillator 28 is used for irradiating the endoscope 5. It is guided to the optical fiber 11 (see FIG. 1) and irradiated with the normal pulse laser light having a wavelength of 1064 nm to the lesion site 6, and coagulation, hemostasis, evaporation (ablation, incision) and the like of living tissue can be performed.

3 and 4 show a second embodiment of the laser treatment apparatus according to the present invention, and this embodiment corresponds to claim 2 of the present invention.

This embodiment has a structure in which the solid-state laser generator 1 using the optical parametric oscillation in the first embodiment described above is replaced with a solid-state laser generator 43 using a titanium sapphire laser. 1 and 2, the parts denoted by the same reference numerals represent the same parts.

The solid-state laser generator 43 includes a YAG laser generator 44 for generating laser light having a predetermined wavelength,
It is composed of a titanium sapphire laser generating unit 45 which generates laser light of different wavelengths by the laser light generated in the YAG laser generating unit 44.

The solid-state laser generator 43 supplies cooling water to the YAG laser generator 44 to suppress the temperature rise of the YAG laser generator 44.
Are connected.

The structure of the YAG laser generator 44 of the solid-state laser generator 43 will be described below with reference to FIG.

As with the YAG laser generating section 2 shown in FIG. 2, the YAG laser generating section 44 turns on and off the voltage as shown in FIG. 5 by the Q switch applied voltage adjusting device 29.
Q to generate ultra-short pulsed laser light with high peak value
A YAG laser oscillator 28 for excitation that performs switch pulse oscillation and normal pulse oscillation that generates a pulse laser beam having a long pulse width by constantly applying a voltage as shown in FIG. 6, and a YAG oscillator oscillated by the YAG laser oscillator 28. A total reflection mirror 30 provided so as to be positioned in the optical path of the laser fundamental wave, and a YAG laser oscillator 28.
From the YAG laser fundamental wave oscillated by
And a YAG laser second harmonic generator 31 for generating laser light (YAG laser second harmonic) having a wavelength of 532 nm according to
The second harmonic of the YAG laser at
A dichroic mirror 59 that transmits the remaining YAG laser fundamental wave that has not been converted into the YAG laser second harmonic in the laser second harmonic generator 31, and a beam damper that blocks the YAG laser fundamental wave that passes through the dichroic mirror 59. And 60.

The total reflection mirror 30 is located in the optical path of the YAG laser fundamental wave, and the YAG laser oscillator 28 produces a normal pulse YAG laser fundamental wave (see FIG. 6).
Is reflected by the total reflection mirror 30,
An optical fiber 1 for irradiating the endoscope 5 with the AG laser fundamental wave
1 (see FIG. 1).

Reference numeral 46 is a half mirror, and the half mirror 46 is adapted to reflect a part of the second harmonic of the YAG laser reflected by the dichroic mirror 59.

Reference numeral 47 is a lens, and the lens 47 is adapted to converge the second harmonic of the YAG laser transmitted through the half mirror 46.

Reference numeral 48 is a total reflection mirror, and the total reflection mirror 48 reflects the YA reflected by the half mirror 46.
It is designed to reflect the G laser second harmonic.

Reference numeral 49 is a lens, and the lens 49 is a second YAG laser which is reflected by the total reflection mirror 48.
It is designed to converge harmonics.

Next, the titanium sapphire laser generator 4
The structure of No. 5 will be described.

50 is a titanium sapphire laser generator, and the titanium sapphire laser generator 50 is
A titanium sapphire laser rod 51 for oscillation, a wavelength tuning element (wavelength selecting element) 52 such as a birefringent filter,
It includes a front mirror 53 and an end mirror 54 that form a resonator, and a titanium sapphire laser rod 55 for amplification.

Titanium sapphire laser rod 5 for oscillation
1 is the wavelength of 670 to 110 from the second harmonic of the YAG laser
It emits light having a wavelength component of 0 nm.

A dichroic mirror 56 allows the second harmonic of the YAG laser converged by the lens 47 to enter the titanium sapphire laser rod 51 for oscillation.

The above dichroic mirror 56 is YA
Light having a wavelength other than the second harmonic of the G laser is transmitted.

The wavelength tuning element 52 has a wavelength of 670 to 670 generated by the titanium sapphire laser rod 51 for oscillation.
A wavelength of 670 to 670 generated by the titanium sapphire laser rod 51 for oscillation, which has a characteristic of allowing only a specific wavelength of light having a wavelength component of 1100 nm to pass through well.
It is arranged between the front mirror 53 and the end mirror 54 that resonate the light having the wavelength component of 1100 nm.

Titanium Sapphire Laser Rod 5 for Amplification
Reference numeral 5 is for amplifying a titanium sapphire laser fundamental wave having an arbitrary wavelength between 670 and 1100 nm which is transmitted from the wavelength tuning element 52 and resonates with the front mirror 53 and the end mirror 54 and is emitted from the front mirror 53. .

The titanium sapphire laser rod 55 for amplification receives the second harmonic of the YAG laser converged by the lens 49 by the dichroic mirror 57 as excitation light and is a front mirror 53 to be amplified.
A titanium sapphire laser fundamental wave having an arbitrary wavelength between 670 and 1100 nm is emitted.

The above dichroic mirror 57 is YA
Light having a wavelength other than the second harmonic of the G laser is transmitted.

Reference numeral 58 is a prism, and the prism 58
Is a titanium sapphire laser fundamental wave having an arbitrary wavelength between 670 and 1100 nm emitted from the titanium sapphire laser rod 55 for amplification of the titanium sapphire laser generator 50 having the above-mentioned configuration and the YAG laser second.
The harmonics are separated for each wavelength.

Of these separated laser lights, the titanium sapphire laser fundamental wave is guided to the irradiation optical fiber 10 of the endoscope 5 (see FIG. 3).

In this embodiment, the control device 24
The operation signal 25 for operating the solid-state laser generator 43 is output to the YAG laser generator 44.

The operation of this embodiment will be described below.

When the lesion 6 is treated, a photosensitizer having an affinity for the cancer tissue is injected into the blood vessel of the patient so as to be absorbed in the lesion 6 in advance.

On the other hand, the optical characteristics of the wavelength tuning element 52 shown in FIG. 4 are set so that light having a wavelength suitable for the photosensitizing substance absorbed by the lesion 6 is transmitted.

By operating the operation panel 22 in this state, the lesion 6 is illuminated by the light emitted from the xenon lamp 7 for illumination as in the laser treatment apparatus shown in FIGS. 1 and 2. , Color TV camera 1
The live-view image of the lesion 6 captured by 6 is displayed on the TV monitor 20.
An image is displayed on the screen and the lesion 6 is observed.

Then, by operating the operation panel 22, the solid-state laser generator 43 is operated from the operation panel 22.
A command signal 23 for operating the control signal is output to the control device 24, and the control device 24 outputs the operation signal 25 to the YAG laser generator 44.

The operation signal 25 is sent to the YAG laser generator 44.
Is input, the YAG laser oscillator 28 shown in FIG.
Is activated, and the wavelength 106 from the YAG laser oscillator 28 is activated.
A 4 nm Q-switched pulsed laser light (YAG laser fundamental wave) is oscillated, and the YAG laser second harmonic generator 31 causes the YAG laser second harmonic to have a wavelength of 532 nm from the YAG laser fundamental wave according to the above-described formula (1). Waves are generated.

The second harmonic of the YAG laser enters the half mirror 46 via the dichroic mirror 59.

Of the laser light incident on the half mirror 46, part of the second harmonic of the YAG laser passes through the half mirror 46 and is converged by the lens 47, and further passes through the dichroic mirror 56 to oscillate a titanium sapphire laser rod 51. And the titanium sapphire laser rod 51 for oscillation generates light having a wavelength component of 670 to 1100 nm.

Of the light having the wavelength component of 670 to 1100 nm, only the light of a specific wavelength passes through the wavelength tuning element 52 and resonates by the resonator constituted by the front mirror 53 and the end mirror 54, and the front mirror 5
A fundamental wave of titanium sapphire laser having a wavelength suitable for the photosensitizer is emitted from 3.

The titanium sapphire laser fundamental wave described above enters the titanium sapphire laser rod 55 for amplification.

On the other hand, YAG incident on the half mirror 46
The second harmonic of the laser passes through the half mirror 46 and the total reflection mirror 48, is converged by the lens 49, and further enters the amplification titanium sapphire laser rod 55 through the dichroic mirror 57.

The titanium sapphire laser rod 55 for amplification is excited by the second harmonic of the YAG laser, and the titanium sapphire laser fundamental wave incident on the titanium sapphire laser rod 55 for amplification is amplified.

The titanium sapphire laser fundamental wave and the YAG laser second harmonic emitted from the amplifying titanium sapphire laser rod 55 enter the prism 58 and are separated for each wavelength.

Of these separated laser beams, the titanium sapphire laser fundamental wave is guided to the irradiation optical fiber 10 (see FIG. 3) of the endoscope 5 and is irradiated to the lesion 6 via the irradiation optical fiber 10. , Titanium sapphire laser fundamental wave destroys the cancer tissue which has absorbed the photosensitizer.

On the other hand, the coagulation of the living tissue with respect to the lesion area 6,
When performing treatment such as hemostasis, transpiration (ablation, incision), the total reflection mirror 30 is positioned in the optical path of the YAG laser fundamental wave oscillated by the YAG laser oscillator 28.

In this way, the total reflection mirror 30 is positioned in the optical path of the YAG laser fundamental wave, and the YAG laser generator 2
When the operation signal 25 instructing normal pulse oscillation (see FIG. 6) is input to the endoscope 5, normal pulse laser light (YAG laser fundamental wave) having a wavelength of 1064 nm emitted from the YAG laser oscillator 28 is used for irradiating the endoscope 5. It is guided to the optical fiber 11 (see FIG. 1) and irradiated with the normal pulse laser light having a wavelength of 1064 nm to the lesion site 6, and coagulation, hemostasis, evaporation (ablation, incision) and the like of living tissue can be performed.

The laser treatment apparatus of the present invention is not limited to the above-described embodiment, but laser light output from an optical parametric oscillator or titanium sapphire laser generator and YAG laser output from a YAG laser oscillator. The laser fundamental wave is configured to irradiate the lesion with separate endoscopes,
It is needless to say that the optical fiber is directly inserted into the body to irradiate the lesion without using an endoscope, and other various changes can be made without departing from the scope of the present invention.

[0102]

As described above, according to the laser treatment apparatus of the present invention, various excellent effects as described below can be obtained.

(1) In the laser treatment apparatus according to claim 1 of the present invention, the photosensitivity generated by the YAG laser oscillator, the YAG laser second harmonic generator, the YAG laser third harmonic generator, and the optical parametric oscillator. Laser light having a wavelength corresponding to the characteristics of the substance, and the YAG
Both the YAG laser fundamental wave generated by the laser oscillator can be applied to the lesion to treat the lesion, so that it is possible to effectively treat the lesion. It is possible to effectively utilize the treatment space.

(2) In the laser treatment apparatus according to claim 2 of the present invention, the wavelength corresponding to the characteristics of the photosensitizer generated by the YAG laser oscillator, the YAG laser second harmonic generator, and the titanium sapphire laser generator. Both the titanium sapphire laser light and the YAG laser fundamental wave generated by the YAG laser oscillator can be applied to the lesion area to treat the lesion area, so that the lesion area can be effectively treated. It is possible to perform the treatment, and it is possible to effectively utilize the treatment space.

(3) In any of the laser treatment apparatuses described in claim 1 and claim 2 of the present invention, YAG
Since the laser oscillator is used, maintenance of the device becomes easy.

[Brief description of drawings]

FIG. 1 is a block diagram showing a first embodiment of a laser treatment apparatus of the present invention.

FIG. 2 is a block diagram showing the concept of the optical system in the first embodiment of the laser treatment apparatus of the present invention.

FIG. 3 is a block diagram showing a second embodiment of the laser treatment apparatus of the present invention.

FIG. 4 is a block diagram showing the concept of an optical system in a second embodiment of the laser treatment apparatus of the present invention.

FIG. 5 is a graph showing the applied voltage and the pulse laser output with time during Q-switch pulse oscillation.

FIG. 6 is a graph showing applied voltage and pulse laser output with time during normal pulse oscillation.

[Explanation of symbols]

 6 Lesion 28 YAG Laser Oscillator 31 YAG Laser Second Harmonic Generator 34 YAG Laser Third Harmonic Generator 38 Optical Parametric Oscillator 50 Titanium Sapphire Laser Generator

Front page continuation (72) Inventor Takeshi Udagawa 3-15-1, Toyosu, Koto-ku, Tokyo Ishikawajima Harima Heavy Industries Ltd. Toji Technical Center (72) Inventor Daiji Nishizawa 3-1-1, Toyosu, Koto-ku, Tokyo No. 15 Ishikawajima Harima Heavy Industries Co., Ltd. Toni Technical Center (72) Inventor Tetsuya Shiraishi 3-15-1, Toyosu Koto-ku, Tokyo Tokyo Ishikawajima Harima Heavy Industries Co., Ltd. Toji Technical Center (72) Inventor Katsushi Inoue Tokyo 3-15-15 Toyosu, Koto-ku, Ishikawajima Harima Heavy Industries Co., Ltd. Toji technical center (72) Inventor Seiji Fukutomi 3-15-15 Toyosu, Koto-ku, Tokyo Ishikawajima Harima Heavy Industries Co., Ltd. Toji technical center

Claims (2)

[Claims] 1. A YAG which oscillates a YAG laser fundamental wave.
A laser oscillator, a YAG laser second harmonic generator for generating a YAG laser second harmonic from a YAG laser fundamental wave oscillated from the YAG laser oscillator, and a YAG generated by the YAG laser second harmonic generator.
A YAG laser third harmonic generator for generating a YAG laser third harmonic from the laser second harmonic and the YAG laser fundamental wave oscillated from the YAG laser oscillator, and the YAG laser third harmonic generator YAG laser 3rd harmonic from the YAG laser 3rd
A laser treatment apparatus comprising: an optical parametric oscillator that generates a laser beam having a wavelength different from a harmonic. 2. A YAG which oscillates a YAG laser fundamental wave.
A laser oscillator, a YAG laser second harmonic generator for generating a YAG laser second harmonic from a YAG laser fundamental wave oscillated from the YAG laser oscillator, and a YAG generated by the YAG laser second harmonic generator.
A laser treatment apparatus comprising: a titanium sapphire laser generating device that generates a titanium sapphire laser fundamental wave from a laser second harmonic and a YAG laser fundamental wave oscillated from the YAG laser oscillator.