JPH0812565A - Skin external preparation - Google Patents

Abstract

PURPOSE:To obtain a skin external preparation having excellent effects on lightening of the color and beautifying and whitening of pigmentation, dermal stains, ephelides, chloasmata, etc., after sunburn and excellent in safety. CONSTITUTION:This skin external preparation is obtained by blending extracts of Aliso (Alnus jorulensis H.B.K.), Allco Quisca (Xanthium Spinosum), Capirona (Capirona decorticans Spruce), Cocona (Solanum quitoense Lam.), Cuti-cuti [Notholuaena nivea (Pair) Desv.], Chinchilcuma (Mutisia acuminata R. & P.), Chilca (Baccharis polyantha), Grama dulce [Cynodon dactulon (L.) Pevs.], Manayupa (Desmodium molliculum or Desmodium limense Hook.), Hierba santa (Cestrum L.), Hinojo (Eremocharis Phil), Toronjil (Melissa officinalis L.), Quinua (Cheno podium quinua willdenow), Maca (Lepidium meyenii Walp), Alacran (Heliotropium sp.), Chupa Sangre (Oenothera rosea), Vira-Vira (Culcitium canscens H.B.K.), Molle (Schinus moiled, Guarango (Prosopis padlida H.B.K.), Que shuar (Buddleja L.), Pasuchaca (Geranium stratorn), Chuchuhuasi (Maythenus krukovii), Ratana (Krameria trianda) or Tumbo therein.

Description

Detailed Description of the Invention

[0001]

The present invention relates to a skin external preparation having a tyrosinase inhibitory activity which is effective in preventing and improving pigmentation, spots, freckles, chloasma, etc. after sunburn by incorporating an extract of a specific plant. Regarding

[0002]

BACKGROUND OF THE INVENTION Although there are some unclear points about the mechanism of skin spots and the like, in general, melanin pigments are formed due to hormonal abnormalities and irritation of ultraviolet rays from the sun, and this is the skin. It is thought to be abnormally deposited inside. This melanin pigment, which causes skin coloring, is produced in melanin-producing granules (melanosomes) in melanocytes (melanocytes) between the epidermis and dermis,
The generated melanin diffuses into adjacent cells by the osmotic effect. The biochemical reaction in this melanocyte is presumed to be as follows.

That is, the process in which tyrosine, which is an essential amino acid, becomes dopaquinone by the action of the enzyme tyrosinase and is converted to black melanin through the red pigment and the colorless pigment by the enzymatic or non-enzymatic oxidation action is the process of producing melanin pigment. is there. Therefore, suppressing the action of tyrosinase, which is the first step of the reaction, is important for suppressing melanin production.

[0004]

However, compounds that suppress the tyrosinase action, except for hydroquinone, have very slow onset of their effects, so that the effect of improving skin pigmentation is not sufficient. On the other hand, although hydroquinone is recognized as having an effect, its use is generally restricted because of its sensitizing properties. Therefore, in order to improve its safety, attempts have been made to use higher fatty acid monoesters or alkyl monoethers (JP-A-58-154507), but the esters are decomposed by a hydrolase in the body. Therefore, it is not always safe, and ethers have not been sufficiently satisfactory in terms of safety.

[0005]

As a result of investigating the tyrosinase activity inhibitory effect of various substances as a solution to these problems, the inventors of the present invention have found that a specific plant extract has a tyrosinase activity inhibitory effect. The present invention has been completed and the present invention has been completed. There has been no report on the tyrosinase activity inhibitory action of the extracts of these plants described later, and its application to a whitening agent has never been known. The present inventors have completed the present invention based on the above findings.

That is, the present invention is an external preparation for skin, which comprises one or more selected from the following plant extracts.

(1) Aliso (scientific name: Alnus jo
rulensis HBK) (2) Allco Quisca (scientific name: Xanthium Spinosum) (3) Capirona (scientific name: Capirona d)
ecorticans Spruce) (4) Cocona, Scientific name: Solanum quitoense
Lam.) (5) Cutie-Cuti (scientific name:
Notholuaena nivea (Poir) Desv. (Fern plant)) (6) Chinchilcuma (scientific name: Mutisia acuminata R. & P.) (7) Chilka (scientific name: Baccharis polyanth)
a) (8) Grama dulce, scientific name:
Cynodon dactulon (L.) Pevs. (Poaceae)) (9) Manayupa (scientific name: Desmodium mo)
lliculum (or D.limense Hook.) (10) Hierba Santa,
(Scientific name: Cestrum L. (Solanaceae)) (11) Hinojo (scientific name: Eremocharis Phi
l) (12) Toronjil, scientific name: Melissa o
fficinalis L.) (13) Quinoa (scientific name: Cheno podium qu)
inua willdenow) (14) Maca (scientific name: Lepidium meyenii Walp) (15) Alacran (scientific name: Heliotropiu
m sp.) (16) Chupa Sangre,
(Scientific name: Oenothera rosea) (17) Vila-Vira, Scientific name: Culciti
um canscens HBK) (18) Mole (scientific name: Schinus molle) (19) Guarango (scientific name: Prosopis
padlida HBK) (20) Que shar (scientific name: Buddl
eja L.) (21) Paschaca (scientific name: Geraniu)
m stratorn) (22) Chuchuhuasi (scientific name: Maythenus Krukovii) (23) Ratana (scientific name: Krameria triand)
a) (24) Tambo

The structure of the present invention will be described in detail below. The plants used in the present invention are plants that grow in South America, especially dry grasslands such as the Andes, grasses and the like. The extract used in the present invention, such as leaves and stems or fruits of the above-mentioned plants, after soaking or heating under reflux with the whole plant with an extraction solvent,
Obtained by filtration and concentration. The extraction solvent used in the present invention may be any solvent used in ordinary extraction,
In particular, alcohols such as methanol and ethanol, hydroalcohols, organic solvents such as acetone and ethyl acetate can be used alone or in combination.

The blending amount of the plant extract in the present invention is 0.005 to 20.0% by weight, preferably 0.01 to 10.0% by weight, as a dried product, in the total amount of the external preparation. 0.
If it is less than 005% by weight, the effect of the present invention is not sufficiently exhibited, and if it exceeds 20.0% by weight, formulation is difficult, which is not preferable. Further, even if it is blended in an amount of 10.0% by weight or more, the effect is not so much improved.

In addition to the above-mentioned essential components, the external preparation for skin of the present invention also contains components that are usually used in external preparations for skin such as cosmetics and pharmaceuticals, such as other whitening agents, moisturizers, antioxidants and oily ingredients. , UV absorber, surfactant, thickener,
Alcohols, powder components, coloring agents, aqueous components, water, various skin nutrients and the like can be appropriately added as necessary.

Other metal sequestering agents such as disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, caffeine, tannin, verapamil, tranexamic acid and its derivatives, licorice extraction Substance, glabridin, hot water extract of fruits of fire thorns, various crude drugs, tocopherol acetate,
Drugs such as glycyrrhizic acid and its derivatives or salts thereof, vitamin C, magnesium ascorbate phosphate,
Other whitening agents such as ascorbic acid glucoside, arbutin, kojic acid, glucose, fructose, mannose,
Sugars such as sucrose and trehalose can also be appropriately added.

The external preparation for skin of the present invention may be any ointment, cream, milky lotion, lotion, pack, bath agent or the like as long as it is a conventional external preparation for skin, and its form is not particularly limited.

[0013]

Next, the present invention will be described in more detail by way of examples. The present invention is not limited to this. The blending amount is% by weight. Prior to the examples, the test method and the result of the tyrosinase activity inhibitory effect of the plant extract of the present invention will be described.

Test Method and Results 1. Sample Preparation (1) Aliso Extract Solution 50 g of the stem and branch portion of Aliso was immersed in ethanol at room temperature for 1 week, and the extract solution was concentrated to obtain 13.1 g of ethanol extract. This extract was dissolved in DMSO at a concentration of 1%, the solution was diluted to adjust the concentration, and the following experiment was conducted using this.

(2) Allco Quisca
50 g of the stem and branch portion of Allco Quisca was immersed in ethanol at room temperature for 1 week, and the extract was concentrated to obtain 3.4 g of an ethanol extract. This extract was dissolved in DMSO at a concentration of 1%, the solution was diluted to adjust the concentration, and the following experiment was conducted using this.

(3) Capirona Extract Liquid Capirona stem and branch portion 50
g was immersed in ethanol for 1 week at room temperature, and the extract was concentrated to obtain 12.7 g of ethanol extract. This extract was dissolved in DMSO at a concentration of 1%, the solution was diluted to adjust the concentration, and the following experiment was conducted using this.

(4) Cocoa Extract 50 g of the stem and branch of Cocona was immersed in ethanol at room temperature for 1 week, and the extract was concentrated to obtain 7.2 g of an ethanol extract. This extract was dissolved in DMSO at a concentration of 1%, the solution was diluted to adjust the concentration, and the following experiment was conducted using this.

(5) Cutie-cu
ti) Extract Solution 50 g of the stem and branch part of Cuti-cuti was immersed in ethanol at room temperature for 1 week, and the extract solution was concentrated to obtain 3.0 g of an ethanol extract. This extract was dissolved in DMSO at a concentration of 1%, the solution was diluted to adjust the concentration, and the following experiment was conducted using this.

(6) Chinchilcuma
uma) extract 50 g of the stems and branches of Chinchilcuma are immersed in ethanol at room temperature for 1 week,
The extract was concentrated to obtain 10.3 g of ethanol extract.
This extract was dissolved in DMSO at a concentration of 1%, the solution was diluted to adjust the concentration, and the following experiment was conducted using this.

(7) Chilca Extract Solution Chilca stem and branch parts (50 g) were immersed in ethanol at room temperature for 1 week, and the extract solution was concentrated to obtain 7.0 g of an ethanol extract. This extract was dissolved in DMSO at a concentration of 1%, the solution was diluted to adjust the concentration, and the following experiment was conducted using this.

(8) Grama dul
ce) Extract 50 g of the stem and branch of Grama dulce was immersed in ethanol at room temperature for 1 week, and the extract was concentrated to obtain 1.0 g of ethanol extract. This extract was dissolved in DMSO at a concentration of 1%, the solution was diluted to adjust the concentration, and the following experiment was conducted using this.

(9) Manayupa extract Manayupa stem and branch portion 50 g
Was immersed in ethanol for 1 week at room temperature and the extract was concentrated to obtain 3.3 g of an ethanol extract. This extract is D
The solution was dissolved in MSO at 1%, the solution was diluted to adjust the concentration, and the following experiment was carried out using this.

(10) Hierba Santa
50 g of the stem and branch of Hierba santa was immersed in ethanol at room temperature for 1 week, and the extract was concentrated to obtain 5.0 g of an ethanol extract. This extract was dissolved in DMSO at a concentration of 1%, the solution was diluted to adjust the concentration, and the following experiment was conducted using this.

(11) Hinojo Extract Liquid 50 g of stem and branch parts of Hinojo were
It was immersed in ethanol at room temperature for 1 week, and the extract was concentrated to obtain 6.3 g of ethanol extract. DMSO
1%, and the solution was diluted to adjust the concentration, and the following experiment was conducted using the solution.

(12) Toronjil Extract Solution Toronjil stem and branch parts 50
g was immersed in ethanol at room temperature for 1 week and the extract was concentrated to obtain 4.9 g of an ethanol extract. This extract is D
The solution was dissolved in MSO at 1%, the solution was diluted to adjust the concentration, and the following experiment was carried out using this.

(13) Quinoua extract A 50 g portion of the stem and branch of Quinoa was
It was immersed in ethanol at room temperature for 1 week and the extract was concentrated to obtain 1.0 g of ethanol extract. DMSO
1%, and the solution was diluted to adjust the concentration, and the following experiment was conducted using the solution.

(14) Maca Extract Liquid 50 g of maca stem and branch portions were stirred at room temperature for 1 hour.
It was soaked in ethanol for a week and the extract was concentrated to obtain 14.1 g of ethanol extract. 1% of this extract in DMSO
After dissolution, this solution was diluted to adjust the concentration, and the following experiment was conducted using this.

(15) Alacran Extract Liquid Alacran stem and branch portion 50 g
Was immersed in ethanol for 1 week at room temperature and the extract was concentrated to obtain 2.0 g of an ethanol extract. This extract is D
The solution was dissolved in MSO at 1%, the solution was diluted to adjust the concentration, and the following experiment was carried out using this.

(16) Chupa Sangre (Chupa S
50 g of stem and branch parts of Chupa Sangre were immersed in ethanol at room temperature for 1 week, and the extract was concentrated to obtain 2.5 g of ethanol extract. This extract was dissolved in DMSO at a concentration of 1%, the solution was diluted to adjust the concentration, and the following experiment was conducted using this.

(17) Vila-Vira
Extract Vira-Vira stem and branch part 5
0 g was immersed in ethanol at room temperature for 1 week, and the extract was concentrated to obtain 6.4 g of an ethanol extract. This extract was dissolved in DMSO at a concentration of 1%, the solution was diluted to adjust the concentration, and the following experiment was conducted using this.

(18) Molle Extract Solution 50 g of stem and branch parts of Molle were immersed in ethanol at room temperature for 1 week, and the extract solution was concentrated to obtain 7.9 g of an ethanol extract. 1% of this extract in DMSO
After dissolution, this solution was diluted to adjust the concentration, and the following experiment was conducted using this.

(19) Guarango Extract Guarango Stem and Branch Part 50
g was immersed in ethanol at room temperature for 1 week, and the extract was concentrated to obtain 3.1 g of an ethanol extract. This extract is D
The solution was dissolved in MSO at 1%, the solution was diluted to adjust the concentration, and the following experiment was carried out using this.

(20) Que shea
r) Extract solution 50 g of the stem and branch parts of Que shar were immersed in ethanol at room temperature for 1 week, and the extract solution was concentrated to obtain 4.0 g of an ethanol extract. This extract was dissolved in DMSO at a concentration of 1%, the solution was diluted to adjust the concentration, and the following experiment was conducted using this.

(21) Paschaca
Extract stem and branch part of Paschaca 5
0 g was immersed in ethanol at room temperature for 1 week, and the extract was concentrated to obtain 7.1 g of an ethanol extract. This extract was dissolved in DMSO at a concentration of 1%, the solution was diluted to adjust the concentration, and the following experiment was conducted using this.

(22) Chuchuhu reed
asi) Extract 50 g of Chuchuhuasi stem and branch were soaked in ethanol at room temperature for 1 week, and the extract was concentrated to obtain 1.1 g of ethanol extract. This extract was dissolved in DMSO at a concentration of 1%, the solution was diluted to adjust the concentration, and the following experiment was conducted using this.

(23) Ratana (Ratana) Extract 50 g of the rattan stem and branch was immersed in ethanol at room temperature for 1 week, and the extract was concentrated to obtain 3.1 g of an ethanol extract. This extract was dissolved in DMSO at a concentration of 1%, the solution was diluted to adjust the concentration, and the following experiment was conducted using this.

(24) Tambo Extract Solution 50 g of stem and branch parts of Tambo were immersed in ethanol at room temperature for 1 week, and the extract was concentrated to obtain 8.3 g of ethanol extract. This extract was added to DMSO 1
%, The solution was diluted to adjust the concentration, and the following experiment was performed using this.

2. Cell Culture Method B16 melanoma cultured cells derived from mouse were used. 1
0% FBS and theophylline (0.09 mg / ml)
The cells were cultured in an Eagle MEM medium containing C. in a CO ₂ incubator (95% air, 5% carbon dioxide) at 37 ° C. After 24 hours of culturing, the sample solution was added so as to have a final concentration (concentration of extracted dry matter) of 10 ^-2 to 10 ^-5 % by weight, culturing was continued for 3 days, and the tyrosinase activity inhibitory effect was measured by the following method. did.

3. Measurement of tyrosinase activity Before the measurement, the medium in the wells is removed, and the wells are washed twice with 100 μl of PBS. 45 μl of 1% Triton-X in each well
(Rohm and Haas product name, surfactant) containing PBS is added. Shake the plate for 1 minute, break the cell membrane well, and use a microplate reader for 475n.
The absorbance at m was measured, and this was taken as the absorbance at 0 minutes. Then, 5 μl of 10 mM L-DOPA solution was quickly added, and the mixture was transferred to an incubator at 37 ° C. and reacted for 60 minutes. The plate was shaken for 1 minute, and the absorbance (475 nm) at 60 minutes was measured. The tyrosinase activity inhibition rate (%) was defined as the decrease in the absorbance difference of the plant extract-added sample with respect to the absorbance difference at 0 minutes and 60 minutes in the case of the sample to which the plant extract was not added (control). The results are shown in Tables 1 and 2. In addition, as a reference example, the same test as described above was performed on an ethanol extract of mussel, which has already been known to have a tyrosinase activity-inhibiting action. The results are also shown in Table 2. In the table, "toxic" means that cytotoxicity was observed, and "-" means that no significant difference was observed within a risk rate of 5% as compared with the control.

[0040]

[Table 1] ──────────────────────────── Test tyrosinase activity inhibition rate (%) ───────── ─── ────────────── Concentration (wt%) 10 ^-5 10 ^-4 10 ^-3 10 ^-2 ──────────────── ──────────── Aliso extract 30 58 Toxic Toxic Alco Kisca extract − 19 54 Toxic Capilona extract 17 23 25 Toxic Cocoa extract 24 29 43 Toxic Cutie-Cuty extract 17 14 33 Toxic Chinchirucuma Extract 19 17 26 Toxic Chiruka Extract 41 − Toxic Toxicity Gramma Dhalus Extract − − 17 Toxic Manayupa Extract 39 30 39 55 Hierva / Santa Extract − − 36 Toxic Hinokijo Extract − − 21 33 Trondil Extract − − 29 Toxic Kiukia extract 15 − − 33 ────────────────────────────

[0041]

[Table 2] ──────────────────────────── Test tyrosinase activity inhibition rate (%) ─────────── ───────────────── Concentration (wt%) 10 ^-5 10 ^-4 10 ^-3 10 ^-2 ────────────────── ─────────── Maca extract − 13 11 17 Alacran extract 23 14 − 46 Chupa-Sangre extract − − − 74 Villa − Villa extract − − 19 Toxic extract 23 − 38 Toxic Guarango extract − 19 − Toxic queer and sherh extract − − 31 Toxic pastechaca extract − − − 27 Chuchufushi extract − 25 32 Toxic ratana extract 27 − 46 Toxic tambo extract − − − 46 ───── ─────────────────────── Kaigai Extract − − − 55 ───────────────────── ────────

Example 1 Cream (Formulation) Stearic acid 5.0% by weight Stearyl alcohol 4.0 Isopropyl myristate 18.0 Glycerin monostearate 3.0 Propylene glycol 10.0 Arisomethanol extract 0.01 Caustic potash 0 .2 Sodium bisulfite 0.01 Preservative Suitable amount Perfume Suitable amount Ion-exchanged water Residual (production method) Dissolve propylene glycol, alysomethanol extract and caustic potash in ion-exchanged water and heat to 7
Keep at 0 ° C (aqueous phase). Mix other ingredients and heat to melt
Keep at 0 ° C (oil phase). The oil phase is gradually added to the water phase, and after the addition is completed, the temperature is maintained for a while to cause the reaction. Then, it is uniformly emulsified with a homomixer and cooled to 30 ° C. with thorough stirring.

Example 2 Cream (Formulation) Stearic acid 2.0% by weight Stearyl alcohol 7.0 Hydrogenated lanolin 2.0 Squalane 5.0 2-Octyldodecyl alcohol 6.0 Polyoxyethylene (25 mol) cetyl alcohol ether 3.0 Glycerin monostearate 2.0 Propylene glycol 5.0 Alisoethanol extract 0.05 Sodium hydrogen sulfite 0.03 Ethylparaben 0.3 Perfume proper amount Ion-exchanged water Residue (production method) Propylene glycol is added to ion-exchanged water In addition,
Heat to maintain 70 ° C (aqueous phase). The other ingredients are mixed, heated and melted and maintained at 70 ° C. (oil phase). The oil phase is added to the aqueous phase to carry out preliminary emulsification, and the mixture is uniformly emulsified with a homomixer and then cooled to 30 ° C. with thorough stirring.

Example 3 Cream (Formulation) Solid paraffin 5.0% by weight Beeswax 10.0 Vaseline 15.0 Liquid paraffin 41.0 Glycerin monostearate 2.0 Polyoxyethylene (20 mol) sorbitan monolaurate 2 0.0 Soap powder 0.1 Borax 0.2 Alco-Khiska acetone extract 0.05 Alco-Khiska ethanol extract 0.05 Sodium hydrogen sulfite 0.03 Ethylparaben 0.3 Perfume proper amount Ion-exchanged water Residual (production method ) Soap powder and borax are added to ion-exchanged water, and the mixture is heated and melted and maintained at 70 ° C (aqueous phase). The other ingredients are mixed, heated and melted and maintained at 70 ° C. (oil phase). The oil phase is stirred into the water phase and gradually added to carry out the reaction. After the reaction is completed, the mixture is uniformly emulsified with a homomixer, and after emulsification, the mixture is cooled to 30 ° C. with thorough stirring.

Example 4 Emulsion (formulation) Stearic acid 2.5% by weight Cetyl alcohol 1.5 Vaseline 5.0 Liquid paraffin 10.0 Polyoxyethylene (10 mol) monooleate 2.0 Polyethylene glycol 1500 3. 0 Triethanolamine 1.0 Carboxyvinyl polymer 0.05 (trade name: Carbopol 941, BFGoodrich Chemical company) Alco-Khiska acetic acid ethyl ester extract solution 0.01 Sodium hydrogen sulfite 0.01 Ethylparaben 0.3 Perfume proper amount Ion Exchanged water Residue (production method) A carboxyvinyl polymer is dissolved in a small amount of ion exchanged water (phase A). Polyethylene glycol 1500 and triethanolamine were added to the remaining ion-exchanged water, and the mixture was heated and dissolved and maintained at 70 ° C (aqueous phase). The other ingredients are mixed, heated and melted and maintained at 70 ° C. (oil phase). The oil phase is added to the aqueous phase for preliminary emulsification, the phase A is added and the mixture is homogenized with a homomixer, and after emulsification, the mixture is cooled to 30 ° C. while being well stirred.

Example 5 Emulsion (Formulation) Microcrystalline wax 1.0 wt% Beeswax 2.0 Lanolin 20.0 Liquid paraffin 10.0 Squalane 5.0 Sorbitan sesquioleate 4.0 Polyoxyethylene (20 mol) ) Sorbitan monooleate 1.0 Propylene glycol 7.0 Capirona acetone extract 10.0 Sodium hydrogen sulfite 0.01 Ethylparaben 0.3 Perfume suitable amount Ion-exchanged water Residue (production method) Add propylene glycol to ion-exchanged water ,
Heat to maintain 70 ° C (aqueous phase). The other ingredients are mixed, heated and melted and kept at 70 ° C. (oil phase). While stirring the oil phase, the aqueous phase is gradually added to this and the mixture is uniformly emulsified with a homomixer. After emulsification, cool to 30 ° C while stirring well.

Example 6 Jelly (formulation) 95% ethyl alcohol 10.0 wt% dipropylene glycol 15.0 polyoxyethylene (50 mol) oleyl alcohol ether 2.0 carboxyvinyl polymer 1.0 (trade name: Carbopol 940, BFGoodrich Chemical company) Caustic soda 0.15 L-arginine 0.1 Capilona 50% ethanol aqueous solution extract 7.0 2-Hydroxy-4-methoxybenzophenone sulfonate sodium 0.05 Ethylenediaminetetraacetate / 3 sodium / dihydrate 0 .05 Methylparaben 0.2 Fragrance Suitable amount Ion-exchanged water Residual (production method) Carbopol 940 is uniformly dissolved in ion-exchanged water, while Capilona 50% ethanol aqueous solution extract and polyoxyethylene (50 mol) in 95% ethanol.
Dissolve the oleyl alcohol ether and add to the aqueous phase. Next, after adding other ingredients, caustic soda, L
-Neutralize with arginine to thicken.

Example 7 Beauty Serum (Formulation) (Phase A) Ethyl Alcohol (95%) 10.0% by Weight Polyoxyethylene (20 mol) Octyldodecanol 1.0 Pantotenyl Ethyl Ether 0.1 Cocoa Methanol Extract 1.5 Methylparaben 0.15 (Phase B) Potassium hydroxide 0.1 (Phase C) Glycerin 5.0 Dipropylene glycol 10.0 Sodium bisulfite 0.03 Carboxyvinyl polymer 0.2 (trade name: Carbopol 940 , BFGoodrich Chemical company) Purified water Residual (manufacturing method) A phase and C phase are uniformly dissolved, and A is added to C phase.
Add phase and solubilize. Next, phase B is added and then filling is performed.

Example 8 Pack (formulation) (Phase A) Dipropylene glycol 5.0% by weight Polyoxyethylene (60 mol) hydrogenated castor oil 5.0 (Phase B) Coconamethanol extract 0.01 Olive oil 5.0 Tocopherol acetate 0.2 Ethylparaben 0.2 Perfume 0.2 (Phase C) Sodium hydrogen sulfite 0.03 Polyvinyl alcohol 13.0 (Saponification degree 90, degree of polymerization 2,000) Ethanol 7.0 Purified water Residual (manufacturing method ) A phase, B phase, and C phase are uniformly dissolved,
Phase B is added to the phase to solubilize it. Next, this is added to phase C and then filled.

Example 9 Solid foundation (formulation) Talc 43.1% by weight Kaolin 15.0 Sericite 10.0 Zinc white 7.0 Titanium dioxide 3.8 Yellow iron oxide 2.9 Black iron oxide 0.2 Squalane 8 0.0 isostearic acid 4.0 POE sorbitan monooleate 3.0 isocetyl octanoate 2.0 cutie-cutie ethanol extract 1.0 preservative appropriate amount perfume appropriate amount (manufacturing process) Talc to black iron oxide powder component with a blender After thoroughly mixing and adding thereto an oily component of squalane to isocetyl octoate, a cutie-cutie ethanol extract, an antiseptic and a fragrance, the mixture is well kneaded, and then filled into a container and molded.

Example 10 Emulsion type foundation (cream type) (Formulation) (Powder part) Titanium dioxide 10.3 wt% Sericite 5.4 Kaolin 3.0 Yellow iron oxide 0.8 Bengala 0.3 Black iron oxide 0.2 (oil phase) decamethylcyclopentasiloxane 11.5 liquid paraffin 4.5 polyoxyethylene-modified dimethylpolysiloxane 4.0 (aqueous phase) purified water 50.0 1,3-butylene glycol 4.5 cutie -Cuti ethanol extract 1.5 Sorbitan sesquioleate 3.0 Preservative proper amount Perfume proper amount (Production method) After heating and stirring the water phase, a powder portion thoroughly mixed and pulverized is added and treated with a homomixer. Further, the heated and mixed oil phase is added and subjected to a homomixer treatment, and then a fragrance is added with stirring and cooled to room temperature.

Example 11 Cream (Formulation) Stearic acid 5.0% by weight Stearyl alcohol 4.0 Isopropyl myristate 18.0 Glycerin monostearate 3.0 Propylene glycol 10.0 Chintyl cuma methanol extract 0.01 Caustic potash 0.2 Sodium bisulfite 0.01 Preservative proper amount Perfume proper amount Ion-exchanged water Residual (production method) Dissolve propylene glycol, tintilcuma methanol extract and caustic potash in ion-exchanged water, heat and keep at 70 ° C ( Water phase). The other ingredients are mixed, heated and melted and maintained at 70 ° C. (oil phase). The oil phase is gradually added to the water phase, and after the addition is completed, the temperature is maintained for a while to cause the reaction. After that, homogenize with a homomixer,
Cool to 30 ° C while stirring well.

Example 12 Cream (Formulation) Stearic acid 2.0% by weight Stearyl alcohol 7.0 Hydrogenated lanolin 2.0 Squalane 5.0 2-Octyldodecyl alcohol 6.0 Polyoxyethylene (25 mol) cetyl alcohol ether 3.0 Glycerin monostearate 2.0 Propylene glycol 5.0 Chintyl cuma ethanol extract 0.05 Sodium bisulfite 0.03 Ethylparaben 0.3 Perfume suitable amount Ion-exchanged water Residue (production method) Propylene in ion-exchanged water Add glycol,
Heat to maintain 70 ° C (aqueous phase). The other ingredients are mixed, heated and melted and maintained at 70 ° C. (oil phase). The oil phase is added to the aqueous phase to carry out preliminary emulsification, and the mixture is uniformly emulsified with a homomixer and then cooled to 30 ° C. with thorough stirring.

Example 13 Cream (Formulation) Solid paraffin 5.0% by weight Beeswax 10.0 Vaseline 15.0 Liquid paraffin 41.0 Glycerin monostearate 2.0 Polyoxyethylene (20 mol) sorbitan monolaurate 2 0.0 Soap powder 0.1 Borax 0.2 Chilcaacetone extract 0.05 Chilka ethanol extract 0.05 Sodium hydrogen sulfite 0.03 Ethylparaben 0.3 Fragrance suitable amount Ion-exchanged water Residual (production method) Soap to ion-exchanged water The powder and borax are added, melted by heating and kept at 70 ° C. (aqueous phase). The other ingredients are mixed, heated and melted and maintained at 70 ° C. (oil phase). The oil phase is stirred into the water phase and gradually added to carry out the reaction. After the reaction is completed, the mixture is uniformly emulsified with a homomixer, and after emulsification, the mixture is cooled to 30 ° C. with thorough stirring.

Example 14 Emulsion (formulation) Stearic acid 2.5% by weight Cetyl alcohol 1.5 Vaseline 5.0 Liquid paraffin 10.0 Polyoxyethylene (10 mol) monooleate 2.0 Polyethylene glycol 1500 3. 0 Triethanolamine 1.0 Carboxyvinyl polymer 0.05 (Brand name: Carbopol 941, BFGoodrich Chemical company) Ethyl ester extract of tilca acetate 0.01 Sodium hydrogen sulfite 0.01 Ethylparaben 0.3 Perfume proper amount Ion exchange water Residual (manufacturing method) The carboxyvinyl polymer is dissolved in a small amount of ion-exchanged water (phase A). Polyethylene glycol 1500 and triethanolamine were added to the remaining ion-exchanged water, and the mixture was heated and dissolved and maintained at 70 ° C (aqueous phase). The other ingredients are mixed, heated and melted and maintained at 70 ° C. (oil phase). The oil phase is added to the aqueous phase for preliminary emulsification, the phase A is added and the mixture is homogenized with a homomixer, and after emulsification, the mixture is cooled to 30 ° C. while being well stirred.

Example 15 Emulsion (formulation) Microcrystalline wax 1.0% by weight Beeswax 2.0 Lanolin 20.0 Liquid paraffin 10.0 Squalane 5.0 Sorbitan sesquioleate 4.0 Polyoxyethylene (20 mol) ) Sorbitan monooleate 1.0 Propylene glycol 7.0 Gramma Dalscetone extract 10.0 Sodium bisulfite 0.01 Ethylparaben 0.3 Fragrance Ion-exchanged water Residual (production method) Propylene glycol is added to ion-exchanged water In addition,
Heat to maintain 70 ° C (aqueous phase). The other ingredients are mixed, heated and melted and kept at 70 ° C. (oil phase). While stirring the oil phase, the aqueous phase is gradually added to this and the mixture is uniformly emulsified with a homomixer. After emulsification, cool to 30 ° C while stirring well.

Example 6 Jelly (formulation) 95% ethyl alcohol 10.0% by weight dipropylene glycol 15.0 polyoxyethylene (50 mol) oleyl alcohol ether 2.0 carboxyvinyl polymer 1.0 (trade name: Carbopol 940, BFGoodrich Chemical company) Caustic soda 0.15 L-arginine 0.1 Gramma Dals 50% ethanol aqueous solution extract 7.0 2-Hydroxy-4-methoxybenzophenone sodium sulfonate 0.05 Ethylenediaminetetraacetate-3 sodium-2 Water 0.05 Methylparaben 0.2 Perfume Appropriate amount Ion-exchanged water Residual (production method) Carbopol 940 is uniformly dissolved in ion-exchanged water, while 95% ethanol is used in 50% Gramma Dals.
An aqueous ethanol solution extract and polyoxyethylene (50 mol) oleyl alcohol ether are dissolved and added to the aqueous phase. Next, after adding other ingredients, caustic soda,
Thicken by neutralizing with L-arginine.

Example 17 Beauty Serum (Formulation) (Phase A) Ethyl Alcohol (95%) 10.0% by Weight Polyoxyethylene (20 mol) Octyldodecanol 1.0 Pantotenyl Ethyl Ether 0.1 Manayupa Methanol Extraction Substance 1.5 Methylparaben 0.15 (Phase B) Potassium hydroxide 0.1 (Phase C) Glycerin 5.0 Dipropylene glycol 10.0 Sodium hydrogen sulfite 0.03 Carboxyvinyl polymer 0.2 (trade name: Carbopol 940, BFGoodrich Chemical company) Purified water Residue (production method) Phases A and C are uniformly dissolved, and A is added to phase C.
Add phase and solubilize. Next, phase B is added and then filling is performed.

Example 18 Pack (formulation) (Phase A) Dipropylene glycol 5.0% by weight Polyoxyethylene (60 mol) hydrogenated castor oil 5.0 (Phase B) Manayupa methanol extract 0.01 Olive oil 5. 0 Tocopherol acetate 0.2 Ethylparaben 0.2 Perfume 0.2 (Phase C) Sodium hydrogen sulfite 0.03 Polyvinyl alcohol 13.0 (Saponification degree 90, degree of polymerization 2,000) Ethanol 7.0 Purified water Residual ( Manufacturing method) A phase, B phase, and C phase are uniformly dissolved, respectively.
Phase B is added to the phase to solubilize it. Next, this is added to phase C and then filled.

Example 19 Solid Foundation (Formulation) Talc 43.1 wt% Kaolin 15.0 Sericite 10.0 Zinc white 7.0 Titanium dioxide 3.8 Yellow iron oxide 2.9 Black iron oxide 0.2 Squalane 8 0.0 isostearic acid 4.0 POE sorbitan monooleate 3.0 isocetyl octanoate 2.0 hierva-santa ethanol extract 1.0 preservative appropriate amount perfume appropriate amount (manufacturing process) Talc to black iron oxide powder component is sufficient with a blender After mixing, an oily component of squalane to isocetyl octoate, an extract of Hierva-Santa ethanol, an antiseptic and a fragrance are added and kneaded well, then filled into a container and molded.

Example 20 Emulsion type foundation (cream type) (Formulation) (Powder part) Titanium dioxide 10.3% by weight Sericite 5.4 Kaolin 3.0 Yellow iron oxide 0.8 Bengala 0.3 Black iron oxide 0.2 (Oil phase) Decamethylcyclopentasiloxane 11.5 Liquid paraffin 4.5 Polyoxyethylene-modified dimethylpolysiloxane 4.0 (Aqueous phase) Purified water 50.0 1,3-Butylene glycol 4.5 Hierva -Santa ethanol extract 1.5 Sorbitan sesquioleate 3.0 Preservative proper amount Perfume proper amount (Production method) After heating and stirring the aqueous phase, a powder portion thoroughly mixed and pulverized is added and treated with a homomixer. Further, the heated and mixed oil phase is added and subjected to a homomixer treatment, and then a fragrance is added with stirring and cooled to room temperature.

Example 21 Cream (formulation) Stearic acid 5.0% by weight Stearyl alcohol 4.0 Isopropyl myristate 18.0 Glycerin monostearate 3.0 Propylene glycol 10.0 Hinokymethanol extract 0.01 Caustic potash 0.2 Sodium bisulfite 0.01 Preservative Suitable amount Perfume Suitable amount Ion-exchanged water Residual (production method) Dissolve propylene glycol, hinjojomethanol extract and caustic potash in ion-exchanged water, heat and keep at 70 ° C (water phase) ). The other ingredients are mixed, heated and melted and maintained at 70 ° C. (oil phase). The oil phase is gradually added to the water phase, and after the addition is completed, the temperature is maintained for a while to cause the reaction. Then, it is uniformly emulsified with a homomixer and cooled to 30 ° C. with thorough stirring.

Example 22 Cream (Formulation) Stearic acid 2.0% by weight Stearyl alcohol 7.0 Hydrogenated lanolin 2.0 Squalane 5.0 2-Octyldodecyl alcohol 6.0 Polyoxyethylene (25 mol) cetyl alcohol ether 3.0 Glycerin monostearate ester 2.0 Propylene glycol 5.0 Hinokyoethanol extract 0.05 Sodium hydrogen sulfite 0.03 Ethylparaben 0.3 Perfume suitable amount Ion-exchanged water Residue (production method) Propylene glycol in ion-exchanged water And add
Heat to maintain 70 ° C (aqueous phase). The other ingredients are mixed, heated and melted and maintained at 70 ° C. (oil phase). The oil phase is added to the aqueous phase to carry out preliminary emulsification, and the mixture is uniformly emulsified with a homomixer and then cooled to 30 ° C. with thorough stirring.

Example 23 Cream (Formulation) Solid paraffin 5.0% by weight Beeswax 10.0 Vaseline 15.0 Liquid paraffin 41.0 Glycerin monostearate 2.0 Polyoxyethylene (20 mol) sorbitan monolaurate 2 .0 soap powder 0.1 borax 0.2 trondyl acetone extract 0.05 trondil ethanol extract 0.05 sodium bisulfite 0.03 ethylparaben 0.3 perfume proper amount ion-exchanged water residual (production method) ion-exchanged water Soap powder and borax are added to the mixture, heated and melted and kept at 70 ° C (aqueous phase). The other ingredients are mixed, heated and melted and maintained at 70 ° C. (oil phase). The oil phase is stirred into the water phase and gradually added to carry out the reaction. After the reaction is completed, the mixture is uniformly emulsified with a homomixer, and after emulsification, the mixture is cooled to 30 ° C. with thorough stirring.

Example 24 Emulsion (formulation) Stearic acid 2.5 wt% Cetyl alcohol 1.5 Vaseline 5.0 Liquid paraffin 10.0 Polyoxyethylene (10 mol) monooleate 2.0 Polyethylene glycol 1500 3. 0 Triethanolamine 1.0 Carboxyvinyl polymer 0.05 (trade name: Carbopol 941, BFGoodrich Chemical company) Extraction solution of ethyl ester of trondyl acetate 0.01 Sodium hydrogen sulfite 0.01 Ethyl paraben 0.3 Perfume proper amount Ion exchange water Residual (manufacturing method) The carboxyvinyl polymer is dissolved in a small amount of ion-exchanged water (phase A). Polyethylene glycol 1500 and triethanolamine were added to the remaining ion-exchanged water, and the mixture was heated and dissolved and maintained at 70 ° C (aqueous phase). The other ingredients are mixed, heated and melted and maintained at 70 ° C. (oil phase). The oil phase is added to the aqueous phase for preliminary emulsification, the phase A is added and the mixture is homogenized with a homomixer, and after emulsification, the mixture is cooled to 30 ° C. while being well stirred.

Example 25 Emulsion (Formulation) Microcrystalline wax 1.0% by weight Beeswax 2.0 Lanolin 20.0 Liquid paraffin 10.0 Squalane 5.0 Sorbitan sesquioleate 4.0 Polyoxyethylene (20 moles) ) Sorbitan monooleate 1.0 Propylene glycol 7.0 Kiinua acetone extract 10.0 Sodium hydrogen sulfite 0.01 Ethylparaben 0.3 Perfume suitable amount Ion-exchanged water Residue (production method) Propylene glycol is added to ion-exchanged water,
Heat to maintain 70 ° C (aqueous phase). The other ingredients are mixed, heated and melted and kept at 70 ° C. (oil phase). While stirring the oil phase, the aqueous phase is gradually added to this and the mixture is uniformly emulsified with a homomixer. After emulsification, cool to 30 ° C while stirring well.

Example 26 Jelly (formulation) 95% ethyl alcohol 10.0% by weight dipropylene glycol 15.0 polyoxyethylene (50 mol) oleyl alcohol ether 2.0 carboxyvinyl polymer 1.0 (trade name: Carbopol 940, BFGoodrich Chemical company) Caustic soda 0.15 L-Arginine 0.1 Quinoa 50% ethanol aqueous solution extract 7.0 2-Hydroxy-4-methoxybenzophenone sodium sulfonate 0.05 Ethylenediaminetetraacetate ・ 3 sodium ・ 2 water 0 .05 Methylparaben 0.2 Fragrance Appropriate amount Ion-exchanged water Residual (production method) Carbopol 940 was uniformly dissolved in ion-exchanged water, while 95% ethanol was extracted with 50% ethanol solution of Kinuia, polyoxyethylene (50 mol) oleyl Arco Was dissolved ether, is added to the aqueous phase.
Next, after adding other components, the mixture is neutralized with caustic soda and L-arginine to increase the viscosity.

Example 27 Beauty Serum (Formulation) (Phase A) Ethyl Alcohol (95%) 10.0% by Weight Polyoxyethylene (20 mol) Octyldodecanol 1.0 Pantotenyl Ethyl Ether 0.1 Macamethanol Extract 1.5 Methylparaben 0.15 (Phase B) Potassium hydroxide 0.1 (Phase C) Glycerin 5.0 Dipropylene glycol 10.0 Sodium bisulfite 0.03 Carboxyvinyl polymer 0.2 (trade name: Carbopol 940 , BFGoodrich Chemical company) Purified water Residual (manufacturing method) A phase and C phase are uniformly dissolved, and A is added to C phase.
Add phase and solubilize. Next, phase B is added and then filling is performed.

Example 28 Pack (formulation) (Phase A) Dipropylene glycol 5.0% by weight Polyoxyethylene (60 mol) hydrogenated castor oil 5.0 (Phase B) Maca methanol extract 0.01 Olive oil 5.0 Tocopherol acetate 0.2 Ethylparaben 0.2 Perfume 0.2 (Phase C) Sodium hydrogen sulfite 0.03 Polyvinyl alcohol 13.0 (Saponification degree 90, degree of polymerization 2,000) Ethanol 7.0 Purified water Residual (manufacturing method ) A phase, B phase, and C phase are uniformly dissolved,
Phase B is added to the phase to solubilize it. Next, this is added to phase C and then filled.

Example 29 Solid Foundation (Formulation) Talc 43.1% by weight Kaolin 15.0 Sericite 10.0 Zinc white 7.0 Titanium dioxide 3.8 Yellow iron oxide 2.9 Black iron oxide 0.2 Squalane 8 0.0 isostearic acid 4.0 POE sorbitan monooleate 3.0 isocetyl octanoate 2.0 alacran ethanol extract 1.0 preservative appropriate amount perfume appropriate amount (manufacturing method) Talc-black iron oxide powder components are thoroughly mixed with a blender. Then, an oily component of squalane to isocetyl octoate, an alacran ethanol extract, a preservative and a fragrance are added thereto, and the mixture is well kneaded, and then filled into a container and molded.

Example 30 Emulsion Foundation (Cream Type) (Prescription) (Powder Part) Titanium Dioxide 10.3% by Weight Sericite 5.4 Kaolin 3.0 Yellow Iron Oxide 0.8 Bengala 0.3 Black Iron Oxide 0.2 (oil phase) decamethylcyclopentasiloxane 11.5 liquid paraffin 4.5 polyoxyethylene-modified dimethylpolysiloxane 4.0 (water phase) purified water 50.0 1,3-butylene glycol 4.5 ara Clan ethanol extract 1.5 Sorbitan sesquioleate 3.0 Preservative proper amount Perfume proper amount (Production method) The aqueous phase is heated and stirred, and then the powder portion thoroughly mixed and pulverized is added to perform homomixer treatment. Further, the heated and mixed oil phase is added and subjected to a homomixer treatment, and then a fragrance is added with stirring and cooled to room temperature.

Example 31 Cream (Formulation) Stearic acid 5.0% by weight Stearyl alcohol 4.0 Isopropyl myristate 18.0 Glycerin monostearate 3.0 Propylene glycol 10.0 Chupa Sangre methanol extract 0.01 Caustic potassium 0.2 Sodium bisulfite 0.01 Preservative Suitable amount Perfume Suitable amount Ion-exchanged water Residue (production method) Dissolve propylene glycol, Chupa-Sangre methanol extract and caustic potash in ion-exchanged water,
Heat to maintain 70 ° C (aqueous phase). The other ingredients are mixed, heated and melted and maintained at 70 ° C. (oil phase). The oil phase is gradually added to the water phase, and after the addition is completed, the temperature is maintained for a while to cause the reaction. After that, homogenize with a homomixer,
Cool to 30 ° C while stirring well.

Example 32 Cream (Formulation) Stearic acid 2.0% by weight Stearyl alcohol 7.0 Hydrogenated lanolin 2.0 Squalane 5.0 2-Octyldodecyl alcohol 6.0 Polyoxyethylene (25 mol) cetyl alcohol ether 3.0 Glycerin monostearate 2.0 Propylene glycol 5.0 Chupa Sangre ethanol extract 0.05 Sodium hydrogen sulfite 0.03 Ethylparaben 0.3 Perfume suitable amount Ion-exchanged water Residual (production method) Propylene in ion-exchanged water Add glycol,
Heat to maintain 70 ° C (aqueous phase). The other ingredients are mixed, heated and melted and maintained at 70 ° C. (oil phase). The oil phase is added to the aqueous phase to carry out preliminary emulsification, and the mixture is uniformly emulsified with a homomixer and then cooled to 30 ° C. with thorough stirring.

Example 33 Cream (Formulation) Solid paraffin 5.0% by weight Beeswax 10.0 Vaseline 15.0 Liquid paraffin 41.0 Glycerin monostearate 2.0 Polyoxyethylene (20 mol) sorbitan monolaurate 2 0.0 Soap powder 0.1 Borax 0.2 Vila-Villa Acetone extract 0.05 Vila-Villa ethanol extract 0.05 Sodium hydrogen sulfite 0.03 Ethylparaben 0.3 Perfume proper amount Ion-exchanged water Residual (production method) Ion-exchange Soap powder and borax are added to water, dissolved by heating and kept at 70 ° C (aqueous phase). The other ingredients are mixed, heated and melted and maintained at 70 ° C. (oil phase). The oil phase is stirred into the water phase and gradually added to carry out the reaction. After the reaction is completed, the mixture is uniformly emulsified with a homomixer, and after emulsification, the mixture is cooled to 30 ° C. with thorough stirring.

Example 34 Emulsion (formulation) Stearic acid 2.5% by weight cetyl alcohol 1.5 Vaseline 5.0 Liquid paraffin 10.0 Polyoxyethylene (10 mol) monooleate 2.0 Polyethylene glycol 1500 3. 0 Triethanolamine 1.0 Carboxyvinyl polymer 0.05 (Brand name: Carbopol 941, BFGoodrich Chemical company) Vila-Vila acetic acid ethyl ester extract solution 0.01 Sodium hydrogen sulfite 0.01 Ethylparaben 0.3 Perfume proper amount Ion Exchanged water Residue (production method) A carboxyvinyl polymer is dissolved in a small amount of ion exchanged water (phase A). Polyethylene glycol 1500 and triethanolamine were added to the remaining ion-exchanged water, and the mixture was heated and dissolved and maintained at 70 ° C (aqueous phase). The other ingredients are mixed, heated and melted and maintained at 70 ° C. (oil phase). The oil phase is added to the aqueous phase for preliminary emulsification, the phase A is added and the mixture is homogenized with a homomixer, and after emulsification, the mixture is cooled to 30 ° C. while being well stirred.

Example 35 Emulsion (Formulation) Microcrystalline wax 1.0% by weight Beeswax 2.0 Lanolin 20.0 Liquid paraffin 10.0 Squalane 5.0 Sorbitan sesquioleate 4.0 Polyoxyethylene (20 mol) ) Sorbitan monooleate 1.0 Propylene glycol 7.0 More acetone extract 10.0 Sodium bisulfite 0.01 Ethylparaben 0.3 Perfume suitable amount Ion-exchanged water Residual (production method) Add propylene glycol to ion-exchanged water,
Heat to maintain 70 ° C (aqueous phase). The other ingredients are mixed, heated and melted and kept at 70 ° C. (oil phase). While stirring the oil phase, the aqueous phase is gradually added to this and the mixture is uniformly emulsified with a homomixer. After emulsification, cool to 30 ° C while stirring well.

Example 36 Jelly (formulation) 95% ethyl alcohol 10.0% by weight dipropylene glycol 15.0 polyoxyethylene (50 mol) oleyl alcohol ether 2.0 carboxyvinyl polymer 1.0 (trade name: Carbopol) 940, BFGoodrich Chemical company) Caustic soda 0.15 L-arginine 0.1 More 50% ethanol aqueous solution extract 7.0 2-Hydroxy-4-methoxybenzophenone sodium sulfonate 0.05 Ethylenediaminetetraacetate ・ 3 sodium ・ 2 water 0 .05 Methylparaben 0.2 Fragrance Suitable amount Ion-exchanged water Residual (production method) Carbopol 940 was uniformly dissolved in ion-exchanged water, while 95% ethanol was extracted with 50% ethanol aqueous solution and polyoxyethylene (50 mol) oleyl. Alcohol a It was dissolved Le, added to the aqueous phase. Next, after adding other components, the mixture is neutralized with caustic soda and L-arginine to increase the viscosity.

Example 37 Beauty Serum (Formulation) (Phase A) Ethyl Alcohol (95%) 10.0% by Weight Polyoxyethylene (20 mol) Octyldodecanol 1.0 Pantotenyl Ethyl Ether 0.1 Guarango Methanol Extraction Substance 1.5 Methylparaben 0.15 (Phase B) Potassium hydroxide 0.1 (Phase C) Glycerin 5.0 Dipropylene glycol 10.0 Sodium hydrogen sulfite 0.03 Carboxyvinyl polymer 0.2 (trade name: Carbopol 940, BFGoodrich Chemical company) Purified water Residue (production method) Phases A and C are uniformly dissolved, and A is added to phase C.
Add phase and solubilize. Next, phase B is added and then filling is performed.

Example 38 Pack (formulation) (Phase A) Dipropylene glycol 5.0% by weight Polyoxyethylene (60 mol) hydrogenated castor oil 5.0 (Phase B) Guarangomethanol extract 0.01 Olive oil 5. 0 Tocopherol acetate 0.2 Ethylparaben 0.2 Perfume 0.2 (Phase C) Sodium hydrogen sulfite 0.03 Polyvinyl alcohol 13.0 (Saponification degree 90, degree of polymerization 2,000) Ethanol 7.0 Purified water Residual ( Manufacturing method) A phase, B phase, and C phase are uniformly dissolved, respectively.
Phase B is added to the phase to solubilize it. Next, this is added to phase C and then filled.

Example 39 Solid Foundation (Formulation) Talc 43.1% by weight Kaolin 15.0 Sericite 10.0 Zinc white 7.0 Titanium dioxide 3.8 Yellow iron oxide 2.9 Black iron oxide 0.2 Squalane 8 0.0 isostearic acid 4.0 POE sorbitan monooleate 3.0 isocetyl octanoate 2.0 quesher ethanol extract 1.0 preservative appropriate amount perfume appropriate amount (manufacturing process) Talc to black iron oxide powder components are sufficient with a blender Mix, and then add squalane to isocetyl octoate oil component, quescher ethanol extract, preservative,
Add fragrance and knead well, then fill and mold in a container.

Example 40 Emulsion type foundation (cream type) (Formulation) (Powder part) Titanium dioxide 10.3% by weight Sericite 5.4 Kaolin 3.0 Yellow iron oxide 0.8 Bengala 0.3 Black iron oxide 0.2 (Oil phase) Decamethylcyclopentasiloxane 11.5 Liquid paraffin 4.5 Polyoxyethylene-modified dimethylpolysiloxane 4.0 (Aqueous phase) Purified water 50.0 1,3-Butylene glycol 4.5 Que Shah ethanol extract 1.5 Sorbitan sesquioleate 3.0 Preservative proper amount Perfume proper amount (Production method) After heating and stirring the aqueous phase, a powder portion thoroughly mixed and pulverized is added to perform homomixer treatment. Further, the heated and mixed oil phase is added and subjected to a homomixer treatment, and then a fragrance is added with stirring and cooled to room temperature.

Example 41 Cream (Formulation) Stearic acid 5.0% by weight Stearyl alcohol 4.0 Isopropyl myristate 18.0 Glycerin monostearate 3.0 Propylene glycol 10.0 Pastechaca methanol extract 0.01 Caustic potash 0.2 Sodium bisulfite 0.01 Preservative Suitable amount Perfume Suitable amount Ion-exchanged water Residual (Production method) Propylene glycol, pastechaca methanol extract and caustic potash are added to ion-exchanged water and dissolved, and heated to 70 ° C (water phase) ). The other ingredients are mixed, heated and melted and maintained at 70 ° C. (oil phase). The oil phase is gradually added to the water phase, and after the addition is completed, the temperature is maintained for a while to cause the reaction. Then, it is uniformly emulsified with a homomixer and cooled to 30 ° C. with thorough stirring.

Example 42 Cream (Formulation) Stearic acid 2.0% by weight Stearyl alcohol 7.0 Hydrogenated lanolin 2.0 Squalane 5.0 2-Octyldodecyl alcohol 6.0 Polyoxyethylene (25 mol) cetyl alcohol ether 3.0 Glycerin monostearate 2.0 Propylene glycol 5.0 Pastechaca ethanol extract 0.05 Sodium bisulfite 0.03 Ethylparaben 0.3 Perfume proper amount Ion-exchanged water Residual (production method) Ion-exchanged water with propylene glycol And add
Heat to maintain 70 ° C (aqueous phase). The other ingredients are mixed, heated and melted and maintained at 70 ° C. (oil phase). The oil phase is added to the aqueous phase to carry out preliminary emulsification, and the mixture is uniformly emulsified with a homomixer and then cooled to 30 ° C. with thorough stirring.

Example 43 Cream (Formulation) Solid paraffin 5.0% by weight Beeswax 10.0 Vaseline 15.0 Liquid paraffin 41.0 Glycerin monostearate 2.0 Polyoxyethylene (20 mol) sorbitan monolaurate 2 0.0 Soap powder 0.1 Borax 0.2 Chuchufushi acetone extract 0.05 Tuchufuasi ethanol extract 0.05 Sodium hydrogen sulfite 0.03 Ethylparaben 0.3 Perfume proper amount Ion-exchanged water Residue (production method) Ion-exchanged water Soap powder and borax are added to the mixture, heated and melted and kept at 70 ° C (aqueous phase). The other ingredients are mixed, heated and melted and maintained at 70 ° C. (oil phase). The oil phase is stirred into the water phase and gradually added to carry out the reaction. After the reaction is completed, the mixture is uniformly emulsified with a homomixer, and after emulsification, the mixture is cooled to 30 ° C. with thorough stirring.

Example 44 Emulsion (formulation) Stearic acid 2.5 wt% Cetyl alcohol 1.5 Vaseline 5.0 Liquid paraffin 10.0 Polyoxyethylene (10 mol) monooleate 2.0 Polyethylene glycol 1500 3. 0 Triethanolamine 1.0 Carboxyvinyl polymer 0.05 (Brand name: Carbopol 941, BFGoodrich Chemical company) Tuchufushiacetic acid ethyl ester extract solution 0.01 Sodium hydrogen sulfite 0.01 Ethyl paraben 0.3 Perfume Ion exchange Water Residue (Production Method) A carboxyvinyl polymer is dissolved in a small amount of ion-exchanged water (phase A). Polyethylene glycol 1500 and triethanolamine were added to the remaining ion-exchanged water, and the mixture was heated and dissolved and maintained at 70 ° C (aqueous phase). The other ingredients are mixed, heated and melted and maintained at 70 ° C. (oil phase). The oil phase is added to the aqueous phase for preliminary emulsification, the phase A is added and the mixture is homogenized with a homomixer, and after emulsification, the mixture is cooled to 30 ° C. while being well stirred.

Example 45 Emulsion (formulation) Microcrystalline wax 1.0% by weight Beeswax 2.0 Lanolin 20.0 Liquid paraffin 10.0 Squalane 5.0 Sorbitan sesquioleate 4.0 Polyoxyethylene (20 mol) ) Sorbitan monooleate 1.0 Propylene glycol 7.0 Ratanaacetone extract 10.0 Sodium hydrogen sulfite 0.01 Ethylparaben 0.3 Perfume suitable amount Ion-exchanged water Residue (production method) Propylene glycol is added to ion-exchanged water,
Heat to maintain 70 ° C (aqueous phase). The other ingredients are mixed, heated and melted and kept at 70 ° C. (oil phase). While stirring the oil phase, the aqueous phase is gradually added to this and the mixture is uniformly emulsified with a homomixer. After emulsification, cool to 30 ° C while stirring well.

Example 46 Jelly (formulation) 95% ethyl alcohol 10.0 wt% dipropylene glycol 15.0 polyoxyethylene (50 mol) oleyl alcohol ether 2.0 carboxyvinyl polymer 1.0 (trade name: Carbopol) 940, BFGoodrich Chemical company) Caustic soda 0.15 L-arginine 0.1 Ratana 50% ethanol aqueous solution extract 7.0 2-Hydroxy-4-methoxybenzophenone sulfonate sodium 0.05 Ethylenediaminetetraacetate ・ 3 sodium ・ 2 water 0 .05 Methylparaben 0.2 Fragrance Appropriate amount Ion-exchanged water Residual (production method) Carbopol 940 was uniformly dissolved in ion-exchanged water, while ratana 50% ethanol aqueous solution extract and polyoxyethylene (50 mol) oleyl was added to 95% ethanol alcohol Was dissolved ether, is added to the aqueous phase. Next, after adding other components, the mixture is neutralized with caustic soda and L-arginine to increase the viscosity.

Example 47 Beauty Serum (Formulation) (Phase A) Ethyl Alcohol (95%) 10.0% by Weight Polyoxyethylene (20 mol) Octyldodecanol 1.0 Pantotenyl Ethyl Ether 0.1 Tambomethanol Extract 1.5 Methylparaben 0.15 (Phase B) Potassium hydroxide 0.1 (Phase C) Glycerin 5.0 Dipropylene glycol 10.0 Sodium bisulfite 0.03 Carboxyvinyl polymer 0.2 (trade name: Carbopol 940 , BFGoodrich Chemical company) Purified water Residual (manufacturing method) A phase and C phase are uniformly dissolved, and A is added to C phase.
Add phase and solubilize. Next, phase B is added and then filling is performed.

Example 48 Pack (formulation) (Phase A) Dipropylene glycol 5.0% by weight Polyoxyethylene (60 mol) hydrogenated castor oil 5.0 (Phase B) Tambomethanol extract 0.01 Olive oil 5.0 Tocopherol acetate 0.2 Ethylparaben 0.2 Perfume 0.2 (Phase C) Sodium hydrogen sulfite 0.03 Polyvinyl alcohol 13.0 (Saponification degree 90, degree of polymerization 2,000) Ethanol 7.0 Purified water Residual (manufacturing method ) A phase, B phase, and C phase are uniformly dissolved,
Phase B is added to the phase to solubilize it. Next, this is added to phase C and then filled.

[0090]

Industrial Applicability As described above, the external preparation for skin of the present invention has a tyrosinase activity inhibitory effect, and is excellent in the lightening of pigmentation, spots, freckles, melasma, etc. after sunburn and whitening. It is an external preparation for the skin that is effective and safe.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical display location A61K 35/78 U 8217-4C C 8217-4C W 8217-4C ADA R 8217-4C AED T 8217- 4C (72) Masako Naganuma Masako Naganuma, 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Shiseido Daiichi Research Center Co., Ltd. (72) Inventor Minoru Fukuda, 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Shiseido Daiichi, Co., Ltd. Inside the research center

Claims (2)

[Claims] 1. An external preparation for skin, which comprises one or more selected from the following plant extracts. (1) Aliso (scientific name: Alnus jorulensis HB
K) (2) Allco Quisca (scientific name: Xanthium Spinosum) (3) Capirona (scientific name: Capirona d)
ecorticans Spruce) (4) Cocona, Scientific name: Solanum quitoense
Lam.) (5) Cutie-Cuti (scientific name:
Notholuaena nivea (Poir) Desv. (Fern plant)) (6) Chinchilcuma (scientific name: Mutisia acuminata R. & P.) (7) Chilka (scientific name: Baccharis polyanth)
a) (8) Grama dulce, scientific name:
Cynodon dactulon (L.) Pevs. (Poaceae)) (9) Manayupa (scientific name: Desmodium mo)
lliculum (or D.limense Hook.) (10) Hierba Santa,
(Scientific name: Cestrum L. (Solanaceae)) (11) Hinojo (scientific name: Eremocharis Phi
l) (12) Toronjil, scientific name: Melissa o
fficinalis L.) (13) Quinoa (scientific name: Cheno podium qu)
inua willdenow) (14) Maca (scientific name: Lepidium meyenii Walp) (15) Alacran (scientific name: Heliotropiu
m sp.) (16) Chupa Sangre,
(Scientific name: Oenothera rosea) (17) Vila-Vira, Scientific name: Culciti
um canscens HBK) (18) Morele (scientific name: Schinus molle) (19) Guarango (scientific name: Prosopis
padlida HBK) (20) Que shar (scientific name: Buddl
eja L.) (21) Paschaca (scientific name: Geraniu)
m stratorn) (22) Chuchuhuasi (scientific name: Maythenus Krukovii) (23) Ratana (scientific name: Krameria triand)
a) (24) Tambo 2. The blending amount of the plant extract is 0.005 to 2
The external preparation for skin according to claim 1, which is 0.0% by weight.