JPH08198768A - Antidiabetic agent - Google Patents

Abstract

(57) [Summary] [Object] The present invention relates to a therapeutic agent for diabetes which can lower the blood glucose level and reduce the symptoms of diabetes. [Structure] 1) A therapeutic agent for diabetes, which is characterized by mixing 35% by weight of Tenkafun (tenkafun), 35% by weight of dough (Kizio), 30% by weight of Astragalus (Astragalus) and a slight amount of glibenclamide. 2) The anti-diabetic agent according to claim 1, which is obtained by mixing about 1/1000 of glibenclamide with respect to the total amount of sky pollen (tenkafun), dough yellow (kizio), and astragalus (astragalus). [Effect] A therapeutic agent for diabetes that not only has the effect of lowering blood glucose level, but can also reduce side effects such as weakness, high hunger, sweating, tremor, sensory disturbance, and severe hypoglycemia. Can be provided.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a therapeutic agent for diabetes which can lower the blood glucose level and reduce the symptoms of diabetes.

[0002]

2. Description of the Related Art As conventional therapeutic agents for diabetes, drugs such as insulin and oral hypoglycemic agents have been used. However, insulin was only effective as an injection.

As the above-mentioned oral hypoglycemic agents, that is, therapeutic agents capable of lowering blood glucose levels and alleviating the symptoms of diabetes, sulfonylurea drugs such as glibenclamide, biguanides, epalrestat and the like are known. Among them, sulfonylurea drugs such as glibenclamide stimulate Langerhans islet β cells in the pancreas to increase insulin secretion and lower blood glucose level. It also has the function of enhancing the action of insulin in the body.

[0004]

However, in the above-mentioned conventional therapeutic agents for diabetes consisting of glibenclamide,
Side effects such as weakness, high hunger, sweating, tremor, and sensory disturbance are known. Especially severe hypoglycemia may occur, so that it was necessary to take extreme caution in taking the drug.

There is also a limitation that oral hypoglycemic agents are ineffective against diabetic coma and juvenile diabetes.

The anti-diabetic agent of the present invention is intended to solve the above-mentioned drawbacks of the conventional examples.
It is an object of the present invention to provide a therapeutic agent for diabetes that can reduce side effects such as sweating, tremor, sensory disturbance, and severe hypoglycemia.

[0007]

[Means for Solving the Problems] That is, the anti-diabetic agent of the present invention comprises 35% by weight of sky pollen (Tenkafun), 35% by weight of crude herb (Diou), 30% by weight of Astragalus sinensis (Augi) and a small amount of glibenclamide. It is characterized by that.

The antidiabetic agent of the present invention is also known as Heavenly Pollen (Tenkafun), Crude Medicinal Yellow (Ziou), Radix Astragalus (Ougi).
It is also characterized in that about 1/1000 of glibenclamide was mixed with respect to the total amount.

The heavenly pollen (tenkafun) used in the present invention is a white starch taken from the roots of Cichlid cucumber,
It is usually applied to eczema, used as a cosmetic or as a decoction for antitussive, antipyretic, and diuretic.

[0010] Crude medicinal ground yellow (Ziou) is known to have an effect on blood supplementation in the rhizome of the ground yellow, which is a perennial plant of the family Scutellariae.

[0011] Astragalus (Ougi) is a person whose physical strength has decreased,
It is known to be taken when tired easily, and it is said to be effective for weak constitution, weakness after illness, night sweats and the like.

Glibenclamide is a sulfonylurea drug, which stimulates Langerhans islet β cells in the pancreas to increase insulin secretion and lowers blood glucose level. It also has the function of enhancing the action of insulin in the body.

[0013]

Since the therapeutic agent for diabetes of the present invention is constituted as described above, it not only has the effect of lowering the blood glucose level, but also has a feeling of weakness, a high degree of hunger, sweating, tremor, sensory disturbance, and a serious low level. It is possible to provide a therapeutic agent for diabetes that can reduce side effects such as blood sugar.

The anti-diabetic agent of the present invention is capable of producing saliva, polydipsia, polyuria, polyphagia, leanness,
It is effective for tiredness, lethargy, lack of sleep, low back pain, and high urinary glucose and blood sugar levels.

[0015]

EXAMPLE An example of the therapeutic agent for diabetes of the present invention will be described in detail below. (Example 1) 35% by weight of powdered heaven pollen (Tenkafun), 35% by weight of herbal medicine (Zhou), Astragalus (Astragalus) 3
0% by weight and 1/1000 of glibenclamide with respect to the total amount thereof were mixed, kneaded with a small amount of water to prepare a formulation, and dried to prepare a pill. The obtained pills were black and had a particle size of about 0.25 g.

The amount of glibenclamide in the above pills is
The compounding amount was 0.25 mg based on about 0.25 g of pills.

This pill is used by diabetic patients with high blood sugar level three times a day with a small amount of hot water, and then increased from about 5 to 10 (about 1.25 g to 2.5 g) for therapeutic effect. Oral administration was continued until the onset of the symptoms appeared, and after the effect on the blood glucose level was observed, the amount of the maintenance agent was reduced to about twice daily. (Example 2) Heaven pollen (Tenkafun) 35% by weight, crude drug ground yellow (Diou) 35% by weight, Astragalus (Astragalus) 30% by weight
Then, 1/1000 of glibenclamide was mixed with the total amount of these to prepare with alcohol to prepare a solution.
The obtained solution was diluted about 10 to 30 times to obtain an injection solution.

The amount of glibenclamide in the above injection solution was 1/1000 of the total amount of the injection solution.

This injection solution is used for diabetic patients with high blood sugar level.
After subcutaneous or intramuscular injection several times a day, continue administration by injection until the therapeutic effect appears, and after the effect on blood glucose level is seen,
The amount of maintenance agent was reduced to about twice daily.

The same effect was obtained by intravenously injecting or instilling the above injection solution to a diabetic patient having a high blood glucose level several times a day by adjusting the use amount. [Pharmacological properties] As a result of the above administration, a significant improvement in blood glucose was observed, and side effects such as weakness and a high degree of hunger, sweating, tremor, sensory disturbance, and severe hypoglycemia were observed during administration. It was hardly seen.

Moreover, saliva is produced when the drug is taken, and there are no symptoms such as polydipsia, polyuria, polyphagia, leanness, tiredness, lethargy, sleep deprivation, and backache, and there is no problem in daily life. The symptoms were improved. Of course, it is important to combine it with diet therapy and exercise therapy. [Therapeutic Application] The product is administered, for example, in the form of pills, and is administered on a trial basis to diabetic patients with high blood glucose levels, and then 3 days a day.
About 5 to 10 doses (about 1.25 g to 2.5 g) are orally administered until the therapeutic effect appears. [Toxicological Properties] In the present invention, the use amount of glibenclamide needs to be strictly limited, and when the use amount of the antidiabetic agent exceeds an appropriate amount, serious hypoglycemia may occur. is there.

[0022]

EFFECTS OF THE INVENTION Since the therapeutic agent for diabetes of the present invention is constituted as described above, it not only has the effect of lowering the blood glucose level, but also has a feeling of weakness, a high degree of hunger, sweating, tremor, sensory disturbance, and seriousness. It is possible to provide a therapeutic agent for diabetes that can reduce side effects such as various hypoglycemia.

The antidiabetic agent of the present invention is capable of producing saliva, polydipsia, polyuria, polyphagia, leanness,
It is effective for tiredness, lethargy, lack of sleep, low back pain, and high urinary glucose and blood sugar.

Claims (2)

[Claims] 1. Ten percent pollen (Tenkafun) 35% by weight, Crude medicinal yellow (Diou) 35% by weight, Astragalus (Ougi) 30% by weight
And a therapeutic agent for diabetes characterized by mixing a small amount of glibenclamide. 2. The anti-diabetic agent according to claim 1, which is obtained by mixing about 1/1000 of glibenclamide with respect to the total amount of sky pollen (tenkafun), crude drug ground yellow (dio), and yellow radish (Ougi).