JPH08217655A - Wrinkle formation inhibitor - Google Patents

Abstract

(57) [Summary] [Structure] A wrinkle formation inhibitor comprising a hamamelis extract as an active ingredient. [Effect] It has an excellent effect of suppressing wrinkle formation caused by irradiation with ultraviolet rays and is useful as a skin external preparation for wrinkle prevention.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a wrinkle formation inhibitor, and more particularly to a wrinkle formation inhibitor suitably applied to cosmetics and pharmaceuticals such as lotions, creams, emulsions, packs and scalp cosmetics.

[0002]

2. Description of the Related Art Conventionally, retinoic acid and its derivatives (JP-A-6-249585, etc.) have been used as preventive and / or ameliorating agents for wrinkle formation.
Ascorbic acid derivative (JP-A-61-30510, 6
1-152613, etc.), Vitamin E (JP-A-62-62)
No. 1951, 62-87506, etc.), .gamma.-aminobutyric acid derivatives (JP-A-62-255405, JP-A-2).
No. -62810, etc.) has been proposed, but these have not been sufficient in terms of stability, safety, efficacy and the like.

On the other hand, recently, from the viewpoint of the preventive effect against wrinkle formation and the safety, active ingredients obtained from natural products have been regained attention. In particular, there are various extracts of plants that have various effects. These are mild in action, and their effects are sufficiently exerted by application, and since they are highly safe, they are used as a compounding agent for cosmetics and pharmaceuticals. Considered preferable.

Therefore, an object of the present invention is to provide a wrinkle formation inhibitor which is excellent in the effect of suppressing wrinkle formation by incorporating a plant component.

[0005]

Under these circumstances, the present inventor has conducted extensive studies on the inhibitory effect on wrinkle formation after irradiation of ultraviolet rays with respect to a wide range of naturally occurring plant extract components. The inventors have found that it has a wrinkle formation inhibiting effect and completed the present invention.

[0006] That is, the present invention provides a wrinkle formation inhibitor containing Hamamelis extract as an active ingredient.

The Hammamelis extract used in the present invention is
Hamamelis virginiana
L. ) Whole plant or its leaves, bark, roots and branches 1
Alternatively, after drying or crushing two or more places (hereinafter referred to as "the raw material") without drying, extraction is performed with a solvent at room temperature or under heating, or extraction is performed using an extraction device such as a Soxhlet extractor. Can be obtained.

The solvent used here is not particularly limited, and examples thereof include water, primary alcohols such as methyl alcohol and ethyl alcohol, propylene glycol, and 1,3-.
Liquid polyhydric alcohol such as butylene glycol, acetic acid lower alkyl ester such as acetic acid ethyl ester, benzene,
Known solvents such as hydrocarbons such as hexane, ethyl ether, acetone and the like can be mentioned, and these solvents can be used alone or in combination of two or more kinds.

A specific example of a preferable extraction method from the drug substance is 50 v / v% per 100 g of dried and dried hamamelis.
Add 1000 ml of ethanol aqueous solution and perform extraction for 3 days at room temperature with occasional stirring. The extract thus obtained is filtered, the filtrate is allowed to stand at 5 ° C. for 3 days and then filtered again to obtain a supernatant. The obtained Hamamelis extract can be used as an active ingredient of the present invention as it is as an extraction solution, and if necessary, it can be used after being subjected to treatments such as concentration and filtration.

The compounding amount of the Hamamelis extract in the wrinkle formation inhibitor of the present invention is not particularly limited,
From the viewpoint of color, odor, feel, etc., it is usually preferable that the dry solid content is 0.0001 to 10% by weight, and
It is particularly preferable that the amount be 001 to 5% by weight.

The wrinkle formation inhibitor of the present invention may be further mixed with one or more selected from anti-inflammatory agents, various plant extracts other than Hamamelis, singlet oxygen scavengers, and antioxidants to reduce wrinkles. The formation suppressing effect can be improved. Examples of the anti-inflammatory agent include allantoin, lysozyme chloride, guaizulene, γ-oryzanol, glycyrrhizic acid and its salt, glycyrrhetinic acid and its salt, and the like. The compounding amount of the anti-inflammatory agent is preferably 0.01 to 20% by weight in the wrinkle formation inhibitor of the present invention.

[0012] Various plant extracts other than Hamamelis include button pipi, chickweed grass, senzuru grass, shuyaku, cowpea, parsley, sweet tea, sweetened, rensai grass, persimmon leaf, chamomile,
Chiyenko, floating grass, ginger, life-prolonging grass, thyme, sagebrush, aloe, ginkgo, sardine, sardine, sardine, licorice, kyokyou, chrysanthemum, kyonin, kumazasa, gentian, konfrey, hawthorn, gardenia, peony, duckweed, walnut Extracts such as yarrow, senkyu, mulberry, chimpanzee, daffodil, tonin, spruce, nova, loquat, safflower, mint, marronnier, sucrose, peach leaf, cornflower, lily, yokuinin, litchi, forsythia and the like can be mentioned. These plant extracts can be obtained by the same operations as those for the Hamamelis extract described above. These plant extracts can be used alone or in combination of two or more. The blending amount of these plant extracts is usually 0.0 as a dry solid content from the viewpoint of color, odor, feel and the like.
It is preferably 001 to 10% by weight, and particularly 0.0
It is preferably set to 01 to 5% by weight.

As the singlet oxygen scavenger or antioxidant,
α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthin, lutein, zeaxanthin,
Carotenoids such as isozeaxanthin, rhodoxanthin and crocetin; 1,4-diazadichlorooctane, 2,
5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran,
α-tocopherol, β-tocopherol, γ-tocopherol, d-tocopherol, histidine, tryptophan, methionine, alanine or an alkyl ester thereof, dibutylhydroxytoluene, butylhydroxyanisole, tannic acid, epicatechin, epigallocatechin, epicatechin gallate, Tannins such as epigallocatechin gallate; flavonoids such as rutin. The blending amount of these singlet scavengers or antioxidants is 0.
It is preferably set to 01 to 5% by weight.

Further, in the wrinkle formation inhibitor of the present invention, in addition to the above components within the range that does not impair the effects of the present invention, an aqueous component, a powder, an oil agent, a moisturizing agent, which is commonly used in cosmetics and pharmaceuticals, Alcohols, pH adjusters, antiseptics, dyes, ultraviolet absorbers, thickeners, fragrances, beauty ingredients and the like can be appropriately added.

The wrinkle formation inhibitor of the present invention can be produced according to a conventional method and includes emulsions, creams, lotions, beauty essences,
It can be applied as a wrinkle formation inhibitor in the form of cleansing agents, packs, detergents, cosmetics such as foundations, pharmaceuticals such as dispersions, granules, tablets, syrups and ointments, and quasi drugs.

[0016]

INDUSTRIAL APPLICABILITY The wrinkle formation inhibitor of the present invention has an excellent effect of suppressing wrinkle formation caused by irradiation with ultraviolet rays and is useful as a skin external preparation for wrinkle prevention.

[0017]

The present invention will be described below with reference to examples, but the present invention is not limited to these examples.

Production Example 1 Production method of hamamelis extract: To 100 g of dried and dried hamamelis, 1000 ml of 50 v / v% ethanol was added, and extraction was carried out at room temperature for 3 days with occasional stirring. The extract obtained is filtered and the filtrate is washed at 5 ° C for 3 times.
After standing for a day, it was filtered again to obtain a supernatant.

Production Example 2 Production method of various plant extracts: Various plant extracts were produced in the same manner as in Production Example 1 except that the dry pulverized product of various plants was used in place of the dry pulverized product of Hamamelis in Production Example 1. .

Test Example 1 Wrinkle formation inhibition test by hairless mouse: 80 μl of a 1% ethanol solution of the test substance shown in Table 1 was applied to the back of a hairless mouse (HR / ICR, 6 weeks old at the start of the experiment). After 2 hours, wipe down the plant extract on the skin surface with 70% ethanol, prepare 6 health ray lamps (Toshiba, SE20), and irradiate once
The UV-B light was radiated by adjusting the MED to be not more than MED, and the irradiation was performed 5 times a week for 16 weeks. The amount of irradiation energy is UV-Radiometer (TOKY
O OPTICAL, UVR-305 / 365D)
The total irradiation dose is 100 at an energy amount of 0.28 mW / cm ² so that the irradiation amount per time is 1 MED.
It was set to mJ / cm ² . As a control, a sample coated with only ethanol was tested in the same manner as the sample. After the test was completed, the frequency of the wrinkles formed was visually evaluated by the following criteria (wrinkle index). The results are shown in Table 1.

Wrinkle index 0: No wrinkle formation. 1: Wrinkles are slightly formed. 2: Trace formation of wrinkles. 3: Some wrinkles formed. 4: Wrinkles are strongly formed.

Test Example 2 Analysis of wrinkles: In order to analyze the wrinkles formed in Test Example 1 in detail, a hydrophilic Exaflex hydrophilic vinyl silicone impression agent was used for each mouse to form 3 circles with a diameter of 1 cm. A skin replica was collected from. This replica was irradiated with light from the direction of 30 degrees in a horizontal state, and the proportion of shadows formed by wrinkles was obtained as an area ratio using an image analyzer.
The results are shown in Table 1.

[0023]

[Table 1]

From Table 1, when Hamamelis extract is used alone, Hamamelis extract is mixed with one or more selected from anti-inflammatory agents, various plant extracts, singlet oxygen scavengers and antioxidants. It was found that each of the above cases had excellent efficacy in suppressing wrinkle formation.

The cosmetics shown in Examples 1 to 4 were prepared by a conventional method.

Example 1 Cream:

[Table 2] (Components) (% by weight) Hamamelis extract 3 Guaiazulene 0.05 Squalane 5 Stearic acid 2 Glycerine monostearate 10 Ethanol 2 Methyl paraoxybenzoate 0.2 Cetanol 2 Olive oil 4 Vaseline 5 Glycyrrhizic acid 1 Vitamin E 0 .5 Fragrances, dyes, micro- purified water, fuel gauge 100.00

Example 2 Skin lotion:

[Table 3] (Components) (% by weight) Hamamelis extract 2 Glycerin monostearate 1 Ethanol 15 Propylene glycol 4 Isopropyl palmitate 3 Lanolin 1 Methyl paraoxybenzoate 0.1 Ceramide 1 Perfume, pigment Micro purified water Residual amount 100 .0

Example 3 Packing agent:

[Table 4] (Ingredients) (wt%) Hamamelis extract 3 Polyvinyl alcohol 20 Glycerin 5 Ethanol 16 Perfume, pigment Micro purified water Residual amount meter 100

Example 4 Foundation:

[Table 5] (Components) (% by weight) Lycopene 0.01 Tannic acid 0.01 Hammamelis extract 3.00 Liquid paraffin 27.00 Lanolin 10.00 Solid paraffin 5.00 Sorbitan sesquioleate 5.00 Powder colorant 35 0.000 Perfume Proper amount Preservative Proper amount Purified water Fuel gauge 100.00

 ─────────────────────────────────────────────────── ─── Continuation of front page (72) Inventor Yoshinori Takeuma 5-26-6 Gion, Minamikochi-cho, Kawachi-gun, Tochigi Prefecture (72) Inventor Hiroyuki Osu 2606-6 (72) Akabane, Kai-cho, Haga-gun, Tochigi Prefecture Ogawa Ayumi 3322 Yamauchi, Mogi-cho, Haga-gun, Tochigi Prefecture Inventor Yusuke Shibuya 2-11 Asuka, Iwase-cho, Nishi-Ibaraki-gun, Ibaraki Prefecture (72) Yoshinori Nishizawa 1-17-10 Kiyoharadai, Utsunomiya-shi, Tochigi Prefecture

Claims (2)

[Claims] 1. A wrinkle formation inhibitor comprising a hamamelis extract as an active ingredient. 2. An anti-inflammatory agent, a plant extract other than Hamamelis, a singlet oxygen scavenger and an antioxidant 1
The wrinkle formation inhibitor according to claim 1, characterized in that it is blended in one kind or two or more kinds.