JPH08319213A - Adhesive pack sheet for beauty and medicine - Google Patents

Abstract

(57) [Summary] [Purpose] To provide an adhesive pack sheet having excellent adhesive strength and outstanding water retention. [Structure] A support layer, a release layer and at least one pressure-sensitive adhesive layer are formed, and the pressure-sensitive adhesive layer comprises an active ingredient, a pressure-sensitive adhesive substrate, a polyhydric alcohol, a polyvalent metal salt, an optional stabilizer, a filler, and an optional water-soluble substance. In an adhesive pack sheet containing a water-soluble or water-swellable polymer, the adhesive base is composed of methyl vinyl ether-maleic acid monoalkyl ester copolymer or methyl vinyl ether-maleic anhydride, and polyacrylic acid or a salt thereof. It is a viscous pack sheet. [Effect] The adhesive pack sheet of the present invention has excellent adhesion to the skin, excellent water retention, and no irritation to the skin.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a new pressure-sensitive pack sheet, and more specifically, a methyl vinyl ether maleic acid monoalkyl ester copolymer and / or methyl vinyl ether-maleic anhydride copolymer as an adhesive base. A pressure-sensitive adhesive pack for beauty or medical use, which has at least one water-based pressure-sensitive adhesive layer containing a coalesce and polyacrylic acid and / or a salt thereof, and shows excellent adhesive force to the skin and excellent water retention. Regarding the seat.

[0002]

2. Description of the Related Art A pack for cosmetic purposes usually has a paste, cream or jelly dosage form, is applied to the skin with fingers and is washed with water after a predetermined time has elapsed. Alternatively, since it is designed to be peeled off, there is a problem that not only the pack is troublesome, but also a considerable time is required until the pack agent dries.

In order to avoid the complexity associated with the use of such conventional pack agents, it has been attempted to provide a pack sheet in which an effective cosmetic ingredient is applied on the sheet. For example, a cosmetic pack sheet agent has been proposed in which the adhesive layer comprises a water-soluble polymer such as polyacrylic acid, gelatin, or carboxymethyl cellulose, a polyhydric alcohol, and water (JP-A-54-49334, JP Kaisho 63-1626
No. 10, JP-A-63-78199 and JP-A-1-25.
4612).

However, since these cosmetic pack sheets contain a wide variety of polymeric substances and a large amount of fillers, a homogeneous cross-linking between these components is possible.
, And cross-linking) are not performed, and the shape retention property is deteriorated at a high temperature of about 40 ° C. This causes a problem that when the sheet is removed from the skin, it may remain on the skin and become sticky, or the adhesiveness to the skin is weak and the sheet may be easily peeled off from the skin.

Another cosmetic pack sheet using a methyl vinyl ether-maleic anhydride copolymer as an adhesive base has also been proposed (JP-A-60-34924).
JP-A-61-22012 and JP-A-58-167.
No. 510). However, in these cosmetic pack sheets, latex must be used in parallel to impart adhesive force and adhesive force to the sheet, and a large amount of filler must be contained in order to maintain the shape. There is. Furthermore, since these pack sheets have considerably poor water retention, they cannot be used as water-based adhesive pack sheets, and they are irritating to the skin. The cosmetic pack sheet disclosed in JP-A-58-167510 contains a small amount of methyl vinyl ether-maleic anhydride copolymer for pH adjustment. However, this pack is also unsatisfactory in terms of poor water retention and shape retention and poor adhesion.

Further, JP-A-55-92306 proposes another cosmetic pack sheet in which the adhesive base is made of water-containing rubber and has improved adhesion to the skin. However, this rubber-based packing agent is
There is a problem that the water contained in the adhesive layer is not continuously dispersed in the layer, so that the effective softening effect by water and the absorption of the active substance into the skin are not achieved so much. Further, since the adhesive layer adheres to the skin too strongly, there is a problem that when the sheet is peeled from the skin, the stratum corneum of the skin is peeled off or the skin is stimulated.

[0007]

Therefore, it has been strongly desired to develop an adhesive pack sheet having not only excellent adhesive strength but also excellent water retention property. Under such circumstances, the present inventors have conducted extensive research to develop an adhesive pack sheet having excellent water retention as well as excellent adhesive strength,
As a result, at least 1 which also contains polyacrylic acid and / or a salt thereof together with a methyl vinyl ether-maleic acid monoalkyl ester copolymer and / or a methyl vinyl ether-maleic anhydride copolymer as an adhesive base.
The present invention has been completed by finding that the above object can be achieved by using two water-based adhesive layers.

Therefore, it is an object of the present invention to provide an adhesive pack sheet having excellent adhesive strength and excellent water retention.

[0009]

That is, the present invention comprises a support layer, a release layer and at least one pressure-sensitive adhesive layer, and the pressure-sensitive adhesive layer comprises an active ingredient, a pressure-sensitive adhesive base, a polyhydric alcohol and a polyvalent metal salt, and a necessary component. In a pressure-sensitive adhesive pack sheet containing a stabilizer, a filler, and a water-soluble or water-swellable polymer, the pressure-sensitive adhesive base is 5 to 20% by weight based on the total weight of the pressure-sensitive adhesive layer. From methyl vinyl-maleic acid monoalkyl ester copolymer and / or methyl vinyl ether-maleic anhydride copolymer, and 2 to 30% by weight of polyacrylic acid and / or its salt based on the total weight of the adhesive layer. It is a sticky pack sheet. Other objects, features and applications of the invention will be apparent to those skilled in the art from the following detailed description of the invention.

In the present invention, the adhesive pack sheet is formed of a support layer, a release layer and at least one adhesive layer,
The adhesive base of the adhesive layer is characterized by containing polyacrylic acid and / or a salt thereof together with a methyl vinyl ether-maleic acid monoalkyl ester copolymer and / or a methyl vinyl ether-maleic anhydride copolymer. . And, in the adhesive layer, in addition to such an adhesive base, an active ingredient, a polyhydric alcohol and a polyvalent metal salt, and further, any stabilizer to be blended as necessary,
It contains a filler, a water-soluble or water-swellable polymer and the like.

When polyacrylic acid or a salt thereof is used alone as an adhesive base for the adhesive layer, the adhesive pack sheet obtained has poor adhesion and shape retention. In order to eliminate such difficulties, if the degree of cross-linking is reduced and the adhesive strength is strengthened, the shape retention of the adhesive pack sheet obtained this time decreases, and when the sheet is peeled from the skin, it becomes sticky to the skin. leave. In particular, when a nonwoven fabric is used as the support layer, the active ingredient contained in the adhesive layer may penetrate into the nonwoven fabric support layer.

Methyl vinyl ether-maleic acid monoalkyl ester copolymer and / or methyl vinyl ether-maleic anhydride copolymer and polyacrylic acid and / or
Alternatively, the combined use with a salt thereof solves such a problem. The combination described above does not deteriorate the properties of each substance,
Rather, they synergistically improve these properties.

The methyl vinyl ether-maleic acid monoalkyl ester copolymer and the methyl vinyl ether-maleic anhydride copolymer not only provide excellent tensile strength and adhesive strength to the adhesive pack sheet, but are also excellent. It also imparts film-forming ability. Polyacrylic acid and its salts provide excellent water retention, adhesion and a pronounced thixotropy effect during the formation of the adhesive layer.

The amount of polyacrylic acid or its salt blended in the adhesive layer is in the range of 2 to 30% by weight based on the total weight of the adhesive layer. The molecular weight of this polyacrylic acid or its salt is within the range of 1 × 10 ^{3 to} 5 × 10 ⁷ . When the molecular weight is higher than the upper limit of the above range, the adhesive force to the skin becomes low.
As a salt of polyacrylic acid, an ammonium salt and a sodium salt are typically mentioned, but it is not limited to these.

The amount of the methyl vinyl ether-maleic acid monoalkyl ester copolymer or methyl vinyl ether-maleic anhydride copolymer blended in the adhesive layer is in the range of 5 to 20% by weight based on the total weight of the adhesive layer. Is. The molecular weight of these copolymers is 1 × 10 ^{3 to} 5 × 10 ^6.
The stoichiometric neutralization degree is in the range of 1 to 100% (in the case of a methyl vinyl ether-maleic anhydride copolymer, the neutralization degree of the hydrolyzed form). The alkyl group contained in the copolymer is a methyl group,
Examples thereof include ethyl group, propyl group, isopropyl group, butyl group, isobutyl group and the like. Most preferred is a methyl vinyl ether-maleic anhydride copolymer.

Polyacrylic acid or a salt thereof and a methyl vinyl ether-maleic acid monoalkyl ester copolymer or a methyl vinyl ether-maleic anhydride copolymer are used in the form of an aqueous solution. The adhesive layer contains 40 to 85% by weight of water, based on its total weight.

When the pack sheet is used for the purpose of beauty, it is possible to mix a substance having cosmetic activity with the adhesive layer, but the kind and amount of the substance having cosmetic activity are not particularly limited, and those skilled in the art can use it. Can be selected as appropriate. Examples include hyaluronic acid, amino acids, proteins, hormones, natural substances such as placenta extract, surface-active substances, skin-whitening substances, vitamins, etc. These may be used alone or in combination. You can

When the pack sheet is used for medical purposes, a water-soluble or water-dispersible drug such as an analgesic, an anesthetic, an antihistamine, a skin stimulant, an anti-inflammatory drug is used for the adhesive layer.
Antiviral agents, stroids, vitamins and the like can be added, and these can be used alone or in combination.

The pack sheet adhesive layer of the present invention has a water retention property,
Contains polyhydric alcohols to increase flexibility and gel strength. Examples of the type of this polyhydric alcohol include glycerin, sorbitol, propylene, glycol, diethylene glycol, 1,3-dibutylene glycol, polyethylene glycol and polypropylene glycol, but are not limited thereto.
Moreover, these can be used individually or in mixture. The amount of the polyhydric alcohol blended in the adhesive layer is 0.1 to 50% by weight based on the total weight of the adhesive layer.

The cross-linking agent for polyacrylic acid or a salt thereof and a methyl vinyl ether-maleic acid monoalkyl ester copolymer or a methyl vinyl ether-maleic anhydride copolymer is a polyvalent metal salt. , The polyvalent metal salt that can be used for this purpose is typically an alkali metal aluminum sulfate (alka
line metal aluminum sulfates), aluminum chloride, aluminum hydroxide, aluminum sulfate, aluminum acetate, aluminum glycinate, aluminum tartrate, etc., zinc salts such as zinc chloride, zinc hydroxide, zinc sulfate, Examples thereof include magnesium salts and calcium salts, but are not limited to these. These are used alone or as a mixture, and the amount thereof is 0.005 to the total weight of the adhesive layer.
It is within the range of 5.0% by weight.

The adhesive layer may contain an adhesive gel base, a stabilizer for stabilizing the drug or other active substance. EDTA and Na-E as stabilizers
Examples thereof include chelating agents such as DTA, lactic acid, citric acid, tartaric acid, low molecular weight polyacrylic acid, and the like, but are not limited thereto. These are used alone or as a mixture, and the amount thereof is 0.00 based on the total weight of the adhesive layer.
It is within the range of 1 to 15.0% by weight.

The adhesive layer may contain a filler, preferably an inorganic filler. Examples of this filler include, but are not limited to, kaolin, bentonite, acid value titanium, anhydrous silicate, and talc. These can be used alone or as a mixture, and the amount thereof is 0.001 to 3 with respect to the total weight of the adhesive layer.
It is within the range of 0.0% by weight.

Further, a water-soluble or water-swellable polymer may be blended in the adhesive layer. As the water-soluble or water-swellable polymer, sodium carboxymethyl cellulose, polyvinylpyrrolidone, polyvinyl alcohol, gelatin, Examples thereof include, but are not limited to, hydroxymethyl cellulose, hydroxyethyl cellulose, gum arabic, sodium alginate and the like.
These are used alone or as a mixture. The amount is within the range of 0.01 to 15.0% by weight based on the total weight of the adhesive layer.

In the pressure-sensitive adhesive pack sheet of the present invention, the pressure-sensitive adhesive layer can be formed as a single layer or a plurality of layers. The pressure-sensitive adhesive pack sheet of the present invention can be produced by a conventional method, and the types of the support layer and the release layer can be easily selected by those skilled in the art depending on the purpose of use and application of the pack sheet.

For example, the adhesive pack sheet of the present invention having one adhesive layer is manufactured as follows. A methyl vinyl ether-maleic acid monoalkyl ester copolymer or a methyl vinyl ether-maleic anhydride copolymer is dissolved or dispersed in deionized water heated to, for example, 60 ° C., and the resulting solution is stirred for 20 to 60 minutes. Hydrolyze. The solution thus prepared is diluted with polyhydric alcohol. Polyacrylic acid alone or mixed with other water-soluble or water-swellable polymeric substance is dissolved in deionized water, and the resulting solution is added to the solution prepared above and mixed well. . Then, an active substance such as a drug or a substance having cosmetic activity, a stabilizer, a cross-linking agent, a filler, a preservative, a surface-active substance or a fragrance is added to deionized water or a mixture of deionized water and a polyhydric alcohol. The dissolved or dispersed solution is added to the homogeneous mixed solution prepared above with stirring and mixed to prepare an adhesive layer solution.

Next, this adhesive layer solution was applied to the support layer by 0.0
It is evenly applied with a thickness of 5 to 1.0 mm and a release layer is laminated thereon. The pack sheet thus obtained is cut into a desired size and shape and aged at room temperature for about 7 days.

As the support layer, non-woven fabric, lint (lin)
t), knits or plastic films can be used.

As a method for preparing the adhesive pack sheet of the present invention having two adhesive layers, for example, two different or the same adhesive layer solutions are sequentially coated on a support layer (or a release layer), By further laminating a release layer (or a support layer) thereon, or by applying the adhesive layer solution onto each of the two release sheets, the two release sheets coated with these adhesive layer solutions are bonded to each other. It can be manufactured by adhesion by means of adhesion, and in this case, in actual use, one of the release sheets functions as a support layer, and the other release sheet functions as a release layer.

[0029]

EXAMPLES The present invention will be described in more detail based on the following examples, comparative examples and test examples, but the present invention is not limited to these examples, comparative examples and test examples.

Example 1 First, a deionized water of 3 times volume was added to a 50% ethanol or isopropanol solution of methyl vinyl ether-maleic acid monoethyl ester copolymer (supplier: ISP, Gantrez ES Series), and then under reduced pressure. Then, ethanol or isopropanol was evaporated at 70 ° C. to obtain a dispersion liquid or a solution having a solid content concentration of 25%.

Next, 20 g of the obtained 25% methyl vinyl ether-maleic acid monoester copolymer aqueous solution and 20 g of a 20% polyacrylic acid aqueous solution were mixed to prepare an adhesive base solution.

Also, 1 g of glycerin was added to 14 g of deionized water.
5 g, 10 g of a mixture of cosmetic ingredients having the following composition, nonionic surfactant (Tween 80: polyoxyethylene (20)
Sorbita monooleate) 1 g, ammonium aluminum sulfate (0.055% by weight in terms of aluminum) 0.5
g, 0.1 g of methyl paraben and 4.5 g of triethanolamine are dissolved, and kaolin 1 is added.
3 g and titanium dioxide 2 g were dispersed to prepare a dispersion solution containing a cosmetic ingredient. The dispersion solution thus obtained was added to the adhesive base solution and mixed to prepare an adhesive layer solution. All of these mixing operations were performed at about 50 ° C.

[Composition of Beauty Ingredient Mixture] Hyaluronic acid 3.0 g Lactic acid 2.0 g Placenta extract 0.5 g Liquid paraffin 1.0 g Rosehip oil 0.5 g Stearyl alcohol 0.2 g Polyoxyethylene sorbitan monooleate 0.1 g BHT 0.05 g deionized water q. s.

As shown in FIG. 1, the pressure-sensitive adhesive layer solution thus obtained is applied to a support layer 3 made of a non-woven fabric in a thickness of 0.5 mm to form a pressure-sensitive adhesive layer 1, and then a release layer. Two
Were laminated to obtain an adhesive pack sheet of Example 1. Then, the obtained adhesive pack sheet was cut into a required shape and size and aged at room temperature for 7 days.

Example 2 20% polyacrylic acid sodium salt (weight average molecular weight:
An adhesive base solution was prepared by mixing 20 g of an aqueous solution of about 1 × 10 ⁴ ) with a solution obtained by dissolving 12 g of methylbiphenyl ether-maleic anhydride copolymer in 20 g of deionized water.

Hydroxyethylcellulose 1.5 was dissolved in 17 g of deionized water, and 15 g of sorbitol, 10 g of the cosmetic ingredient mixture of Example 1 and a nonionic surfactant (Tween 80: polyoxyethylene) were dissolved in the resulting solution. (20) Sorbita monooleate) 1 g, ammonium aluminum sulfate (0.032% by weight in terms of aluminum) 0.5
g, EDTA-2Na 0.5 g, tartaric acid 1.0 g, urea 1.7 g and methyl paraben 0.1 g were dissolved or dispersed. The obtained dispersion solution was mixed with the above adhesive base solution to prepare an adhesive layer solution. All these mixing operations were carried out at about 50 ° C.

The pressure-sensitive adhesive layer solution thus obtained was added to
A non-woven fabric having a thickness of 5 mm was applied, and a release layer was further laminated thereon to obtain an adhesive pack sheet of Example 2. Then, the obtained adhesive pack sheet was cut into a desired size and shape and aged at room temperature for about 7 days.

Example 3 20% polyacrylic acid sodium salt (weight average molecular weight:
Obtained by dissolving a mixture of 10 g of a methylbiphenyl ether-maleic acid monoethyl ester copolymer and 5 g of a methyl vinyl ether-maleic anhydride copolymer in 20 g of an aqueous solution of about 1 × 10 ⁴ ) and 16 g of deionized water. An adhesive base solution was prepared by mixing with the solution.

3 g of polyvinylpyrrolidone was dissolved in 14 g of deionized water, and 15 g of sorbin, 10 g of the cosmetic ingredient mixture of Example 1 and a nonionic surfactant (Tween 80: polyoxyethylene (20) sorbita) were dissolved in 14 g of deionized water. Monooleate) 1 g, ammonium aluminum sulfate (0.062% by weight in terms of aluminum) 0.4 g, EDTA-2
Na 0.8 g, urea 1.7 and methyl paraben 0.1
g was dissolved or dispersed. The obtained dispersion solution was mixed with the above adhesive base solution to prepare an adhesive layer solution.
All these mixing operations were carried out at about 50 ° C.
Then, an adhesive pack sheet was prepared in the same manner as in Example 2.

Example 4 25% polyacrylic acid sodium salt (weight average molecular weight:
About 5 × 10 ³ ) aqueous solution (15 g) was mixed with 25% methyl vinyl ether-maleic anhydride isopropyl monoester aqueous solution (25 g) to prepare an adhesive base solution.

A solution prepared by dissolving 7 g of sodium alginate in 24 g of deionized water was added with 15 g of sorbine, 10 g of the cosmetic ingredient mixture of Example 1, and a nonionic surfactant (Tween).
80: Polyoxyethylene (20) sorbita monooleate) 1
g, aluminum ammonium sulfate (0.062% by weight in terms of aluminum) 0.4 g, EDTA-2Na0.
5 g, urea 1.7 and methyl paraben 0.1 g were dissolved or dispersed. The obtained dispersion solution was mixed with the above adhesive base solution to prepare an adhesive layer solution.

As shown in FIG. 2, the adhesive layer solution thus obtained was applied to a release sheet (supporting layer 3) in a thickness of 0.5 mm to prepare a first adhesive layer 1 '. . Also,
The same adhesive layer solution as described above was applied to another release sheet (release layer 2) with a thickness of 0.5 mm to prepare a second adhesive layer 1. These release sheets were laminated so that the pressure-sensitive adhesive layers 1, 1 ′ face each other to prepare a pressure-sensitive adhesive pack sheet of Example 4 having two pressure-sensitive adhesive layers 1, 1 ′.

Example 5 25% ammonium polyacrylate (weight average molecular weight:
An adhesive base solution was prepared by mixing 25 g of an aqueous solution of about 5 × 10 ³ ) and a solution obtained by dissolving 10 g of methylbiphenyl ether-maleic anhydride copolymer in 18 g of deionized water.

To a solution prepared by dissolving 3 g of polyvinylpyrrolidone and 1.5 g of polyvinyl alcohol in 19 g of deionized water, 10 g of glycerin and 5 parts of 1,3-butanediol were added.
g, peppermint oil 2.2 g, diclofenac sodium 4%, nonionic surfactant (Tween 80: polyoxyethylene (20) sorbitamonooleate) 1 g, aluminum ammonium sulfate (0.035 in terms of aluminum) % By weight) 0.35 g, ED
TA-2Na (0.85 g) and methylparaben (0.1 g) were dissolved or dispersed. The obtained dispersion solution was mixed with the above adhesive base solution to prepare an adhesive layer solution. At this time, all mixing operations were performed at about 50 ° C. Then, in the same manner as in Example 2, an adhesive pack sheet of Example 5 was obtained.

Example 6 25% polyacrylic acid sodium salt (weight average molecular weight:
An adhesive base solution was prepared by mixing 20 g of an aqueous solution of about 5 × 10 ³ ) and a solution of 10 g of methylbiphenyl ether-maleic anhydride copolymer dissolved in 20 g of deionized water.

To a solution prepared by dissolving 10 g of 40% polyacrylic acid in 19 g of deionized water, 10 g of glycerin, 2.3 g of peppermint oil, and sodium diclofenac 4 were added.
%, Nonionic surfactant (Tween 80: polyoxyethylene (20) sorbitamonooleate) 1 g, aluminum potassium sulfate (0.03% by weight in terms of aluminum)
0.3 g, EDTA-2Na 0.8 g and methyl paraben 0.1 g were dissolved, then kaolin 10 g and titanium dioxide 1.5 g were dispersed. The obtained dispersion solution was mixed with the above adhesive base solution to prepare an adhesive layer solution. Then, in the same manner as in Example 2, an adhesive pack sheet of Example 6 was obtained.

Comparative Example 1 Polyacrylic acid sodium salt (weight average molecular weight: about 1 ×)
10 ⁵ ) 15 g, glycerin 30 g and potassium aluminum sulfate (0.028% by weight in terms of aluminum)
0.3g was mixed well with a kneader so as to be homogeneous, and 15g of 20% polyacrylic acid aqueous solution and 28.5g of water
And 1 g of Tween 80 were added, and then the mixture was sufficiently stirred to form a homogeneous mixture, and 10 g of the cosmetic ingredient mixture of Example 1 was added to the obtained mixture to emulsify,
An adhesive layer solution was obtained. Next, in the same manner as in Example 2, an adhesive pack sheet of Comparative Example 1 was obtained.

Comparative Example 2 20 g of kaolin and 3 g of titanium dioxide were added to a solution of 2.0 g of methyl vinyl ether-maleic anhydride copolymer and 0.5 g of citric acid dissolved in 18 g of deionized water.
g, gelatin 5 g, polyacrylic acid sodium salt 3 g,
Sodium carboxymethyl cellulose 1g, natural rubber latex 5g, styrene butadiene latex (SBR
5 g of latex), 2.4 g of polybutene, 10 g of the cosmetic ingredient mixture of Example 1 and 0.1 g of an acid value inhibitor were added to prepare an adhesive layer solution. Next, in the same manner as in Example 2, an adhesive pack sheet of Comparative Example 2 was obtained.

Comparative Example 3 Gelatin 1.5 g, polyvinylpyrrolidone 3 g, methyl paraben 0.1 g and urea 1 g were dissolved in deionized water 18 g at 50 ° C., and 1,3-butylene glycol 5 g and peppermint oil 2.2 g were dissolved therein. 4 g of diclofenac sodium, 50 g of sorbitol and 0.5 g of aluminum hydroxide were added. Add a few more to the resulting mixture.
-Butylene glycol 6.7 g, sodium polyacrylate 4 g and sodium carboxymethyl cellulose 4
The mixture of g was added and mixed to prepare an adhesive layer solution.
Next, in the same manner as in Example 2, an adhesive pack sheet of Comparative Example 3 was obtained.

Test Example 1 The adhesive force and adhesive force of the adhesive pack sheet according to the present invention were evaluated as follows based on PSTC.

Adhesion Test (PSTC-1) Adhesive pack sheets of Examples 1 to 3 and 5 and Comparative Example 1 and two commercially available adhesives [adhesives, trade name of Daiichi Pharmaceutical Co., Ltd. of Korea] : The first pape (JEIL PARF
^(TM) ) and Korea Dale Chemical Co., Ltd. trade name: DAEIL PAS ⁽ TM ⁾ )] were each cut into a size of 0.5 inch × 20 cm. About 10 cm of the release layer is peeled from the adhesive layer, the pack sheet or adhesive is attached on the stainless steel plate, and the rubber roller (2.3 kg) is used.
I went back and forth twice on the board. The force required for peeling the pack sheet or the adhesive from the stainless steel plate by 180 ° was measured with a universal testing machine (ZWICK), and the strength was calculated. Table 1 shows average values obtained by repeating the same test three times.

Adhesion Test (PSTC-6) Adhesive pack sheets of Examples 1 to 3 and 5 and Comparative Example 1 and two commercially available adhesives [adhesives, trade name of Daiichi Pharmaceutical Co., Ltd. of Korea] : The first pape (JEIL PARF
^(TM) ) and Korean Dale Chemicals Co., Ltd. product name: DAEIL PAS ⁽ TM ⁾ )] are each cut into a size of 1.0 inch × 30 cm, and the release layer is peeled off from the adhesive layer. The pack sheet and the adhesive were fixed on a flat glass plate with the adhesive layer facing upward. A TT-10 rolling ball tack tester (Chemsultants International) was fixed to one end of the pack sheet or the adhesive, and a 5/16 inch ball was shot from there. The distance traveled by the ball on the adhesive layer was measured. Table 1 shows the average values obtained by repeating the same test three times.

[0053]

[Table 1]

Experimental Example 2 In order to know the adhesion characteristics of the pack sheet according to the present invention and the effect when it is adhered to the skin, Examples 1 to 4 and Comparative Examples 1 to 1
2 and the commercially available cosmetic pack sheet were cut into an appropriate size that is easily attached to the face, and openings for exposing the eyes, nose, and mouth were formed.

Adhesion to the skin by attaching each pack sheet excluding the commercially available ones to the faces of 10 applicants for 3 hours,
Remaining stickiness, pain at peeling, irritation to skin, and cosmetic effect (softness and water retention effect) were evaluated in three grades, that is, ◯: excellent, Δ: good, and x: ineffective. The commercially available product was applied for 30 minutes. Further, the pack sheet was left at 60 ° C. for 2 hours to evaluate its shape retention. Regarding the degree of cross-linking, the pack sheet is immersed in water at 60 ° C. for 3 hours and stirred,
When the sheet was dissolved in water under these conditions, it was judged to be poor, and when the sheet was dispersed and swollen, the degree of crosslinking was evaluated to be good. Table 2 shows the results.

[0056]

[Table 2]

As is known from the results of Table 2, the pack sheet of Comparative Example 2 containing gelatin, less than 5% by weight of methyl vinyl ether-maleic anhydride copolymer, and polyacrylic acid had an adhesive force to the skin. It was very bad.

Experimental Example 3 In order to examine the hard skin permeability of the active ingredient of the pack sheet of the present invention, the hair of the abdomen of a guinea pig of about 350 g in weight was removed with a clipper, and the removed site was cut off. Frozen at 20 ° C. Franz type (Frantz typ
The skin sample was placed on a glass slide of a diffusion cell of e) with the stratum corneum facing upward. The storage part of the cell is filled with a buffer solution (storage part solution),
The cell was maintained at 37 ° C.

The pack sheets of Examples 5 and 6 and Comparative Example 1 were applied on the skin, and the solution in the container was set to 600 rp.
It was stirred at m. When a predetermined time had elapsed, a part of the solution in the receiving part was periodically discharged and the same amount of fresh solution was replenished.
High-performance liquid chromatography (HPLC) was carried out on the solution in the housing portion ingested from the cell to measure the concentration of the drug contained therein. The conditions of HPLC were as follows. Column: C _18U (Waters Chromatography, Milton, Mas
s) Mobile phase: methanol: 0.5 M sodium acetate buffer (30:70, V / V) Flow rate: 1.2 ml / min Detector: UV280 nm The results are shown in Table 3.

[0060]

[Table 3]

Although the present invention has been described with reference to its preferred embodiments, it is obvious that various modifications and changes can be made without departing from the spirit of the present invention.

[Brief description of drawings]

FIG. 1 is a cross-sectional explanatory view showing an example of a pack sheet having one adhesive layer according to the present invention.

FIG. 2 is a cross-sectional explanatory view showing an example of a pack sheet having two adhesive layers according to the present invention.

[Explanation of symbols]

 1, 1 '... Adhesive layer, 2 ... Release layer, 3 ... Support layer.

Claims (3)

[Claims] 1. A stabilizer comprising a support layer, a peeling layer and at least one pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises an active ingredient, a pressure-sensitive adhesive base, a polyhydric alcohol and a polyvalent metal salt, and a stabilizer optionally blended, In an adhesive pack sheet containing a filler and a water-soluble or water-swellable polymer, the adhesive base comprises 5 to 20% by weight of methyl vinyl-monoalkyl maleic acid maleate copolymer based on the total weight of the adhesive layer. Adhesive pack sheet comprising a polymer and / or a methyl vinyl ether-maleic anhydride copolymer and 2 to 30% by weight of polyacrylic acid and / or a salt thereof, based on the total weight of the adhesive layer. . 2. The molecular weight of polyacrylic acid or a salt thereof is
The pressure-sensitive adhesive pack sheet according to claim 1, which is in the range of 1 × 10 ^{3 to} 5 × 10 ⁷ . 3. A methyl vinyl ether-maleic acid monoalkyl ester copolymer or methyl vinyl ether-
The molecular weight of the maleic anhydride copolymer is 1 × 10 ^{3 to} 5 ×.
The pressure-sensitive adhesive pack sheet according to claim 1 or 2, which is in the range of 10 ⁶ .