JPH0833463A - Health food containing calsium as main ingredient - Google Patents

Health food containing calsium as main ingredient

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Publication number
JPH0833463A
JPH0833463A JP6172412A JP17241294A JPH0833463A JP H0833463 A JPH0833463 A JP H0833463A JP 6172412 A JP6172412 A JP 6172412A JP 17241294 A JP17241294 A JP 17241294A JP H0833463 A JPH0833463 A JP H0833463A
Authority
JP
Japan
Prior art keywords
unicellular
alga
health food
algae
calcium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6172412A
Other languages
Japanese (ja)
Other versions
JP2656448B2 (en
Inventor
Hiroyuki Takenaka
裕行 竹中
Teruo Shiraishi
照雄 白石
Yuji Yamaguchi
裕司 山口
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MICRO ARUJIE CORP KK
Original Assignee
MICRO ARUJIE CORP KK
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Filing date
Publication date
Application filed by MICRO ARUJIE CORP KK filed Critical MICRO ARUJIE CORP KK
Priority to JP6172412A priority Critical patent/JP2656448B2/en
Publication of JPH0833463A publication Critical patent/JPH0833463A/en
Application granted granted Critical
Publication of JP2656448B2 publication Critical patent/JP2656448B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Edible Seaweed (AREA)

Abstract

PURPOSE:To obtain a health food containing the algal bodies of unicellular calciphilous alga and enabling to simultaneously ingest various mineral ingredients including calcium and various nutritive ingredients. CONSTITUTION:This health food contains the algal bodies of a unicellular calciphilous alga (preferably an alga belonging to the genus Haptophyceae) such as an alga belonging to the genus Pleurochrysis, Gephyrocapsa, Emiliania, etc. A culture solution containing the bodies of the unicellular calciphilous alga artificially cultured under charging carbon dioxide (-enriched air) is concentrated, weakly acidified with acetic acid, etc., mixed with cyclodextrin and chitosan, vacuum-dried or lyophilized into powder, and subsequently processed into a tablet or capsule food.

Description

【発明の詳細な説明】Detailed Description of the Invention

【0001】[0001]

【産業上の利用分野】本発明は健康食品に係り、殊にカ
ルシウムを主成分とする健康食品に係る。
BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to health foods, and more particularly to health foods containing calcium as a main component.

【0002】[0002]

【従来の技術】高齢化社会における重大な問題として、
所謂「寝たきり老人」の増加を挙げることができる。そ
の要因がカルシウムの摂取不足による骨粗鬆症にあるも
のとされ、又食生活の変化により若年層においてもカル
シウムの摂取不足が原因で骨折等が多発する傾向があ
る。そこで骨類、卵殻又は貝殻を主成分とする錠剤状の
ものが健康食品の一つとして種々市販されている。
2. Description of the Related Art As a serious problem in an aging society,
An increase in the so-called "bedless elderly" can be cited. The cause is attributed to osteoporosis due to insufficient calcium intake, and fractures and the like tend to occur frequently due to insufficient calcium intake even in young people due to changes in dietary habits. Therefore, various tablets having bones, egg shells or shells as main components are commercially available as one of the health foods.

【0003】一方、近年、クロレラやデュナリエラのよ
うな単細胞藻類 (微細藻類) が健康食品として利用され
ている。これは、微細藻類が植物の一種であり、藻体全
部を食用に供し得るので健康乃至自然食指向にマッチし
ているからである。
On the other hand, in recent years, single-cell algae (microalgae) such as chlorella and Dunaliella have been used as health foods. This is because microalgae are a type of plant and the whole algae can be used for food, which is suitable for healthy or natural diet.

【0004】[0004]

【発明が解決しようとする課題乃至発明の目的】上記の
錠剤状カルシウム健康食品は一般に主としてカルシウム
を、副次的には他のミネラル成分の補給用に過ぎない。
一方、単細胞藻類を主体とする健康食品は蛋白質やビタ
ミン類に富んでいるが、他の栄養成分は乏しい。従っ
て、本発明の目的は、カルシウムを含む各種のミネラル
成分や種々の栄養成分を同時に摂取し得る健康食品を提
供することにある。
DISCLOSURE OF THE INVENTION Problems to be Solved by the Invention The above-mentioned tablet-like calcium health food is generally for supplementing mainly calcium and secondarily other mineral components.
On the other hand, health foods mainly composed of unicellular algae are rich in proteins and vitamins, but poor in other nutritional components. Therefore, an object of the present invention is to provide a health food capable of simultaneously ingesting various mineral components including calcium and various nutritional components.

【0005】[0005]

【課題を解決し、目的を達成する手段及び作用】本発明
者等は上記の課題を解決し、目的を達成するために種々
検討を重ねた結果、単細胞石灰藻類を食品化するのが好
適であると判断するに至った。即ち、単細胞石灰藻類は
細胞の周りにカルシウムを恰かも鎧のように固定する性
質を有しており、又蛋白質、脂質 (殊に EPA、DHA 等の
高度不飽和脂肪酸)、糖質、ビタミン類、カルシウム以
外のミネラル類等を豊富に含有しているからである。そ
こで、単細胞石灰藻類の藻体を食品化するに当り、当該
藻類の培養方法、カルシウム成分を吸収し易くする方
法、高度不飽和脂肪酸等の栄養成分を損なうことなく加
工する方法、保存安定性を向上させる方法等について鋭
意検討を重ね、斯くて単細胞石灰藻類の食品化に成功
し、本発明を完成した。
[Means and Actions for Solving the Problems and Achieving the Purpose] The inventors of the present invention have made various studies to solve the above problems and achieve the objects, and as a result, it is preferable to turn single-cell lime alga into food. I came to judge that there is. In other words, single-celled lime algae have the property of fixing calcium around cells as if they are armor, and proteins, lipids (especially highly unsaturated fatty acids such as EPA and DHA), carbohydrates, and vitamins And minerals other than calcium. Therefore, in making algae bodies of single-cell lime algae into food, the method of culturing the algae, the method of facilitating absorption of calcium components, the method of processing without losing nutrient components such as polyunsaturated fatty acids, and the storage stability are described. The present inventors have conducted intensive studies on methods for improving the properties, and thus succeeded in converting single-cell lime algae into food, thereby completing the present invention.

【0006】本発明による健康食品は単細胞石灰藻類の
藻体を含有しており、カルシウムを主成分としている。
本発明による健康食品は錠剤状を呈していることがで
き、この場合には単細胞石灰藻類の藻体と、造粒剤と、
滑沢剤と、抗酸化剤とを含有している。又、本発明によ
る健康食品はカプセル状を呈していることができ、この
場合には単細胞石灰藻類の藻体と、抗酸化剤と、栄養強
化植物油とを含有している。
The health food according to the present invention contains algal cells of unicellular lime algae and contains calcium as a main component.
The health food according to the present invention can be in the form of tablets, in which case algae of unicellular lime algae, a granulating agent,
It contains a lubricant and an antioxidant. Further, the health food according to the present invention may be in the form of a capsule, and in this case, it contains algae of unicellular lime algae, an antioxidant, and a nutrient-enriched vegetable oil.

【0007】本発明による健康食品を製造するために使
用される単細胞石灰藻類としてはプレオクリシス (Pleu
rochrysis) 属、ゲフィロカプサ (Gephyrocapsa) 属、
エミィリアニア (Emiliania) 属等の藻類であって、円
石藻或いはハプト藻と称されているものが好ましい。造
粒剤としては乳糖が好ましく、滑沢剤としてはタルク、
蔗糖脂肪酸エステル等を例示することができるが後者が
好ましく、結合剤としては糖類、殊に還元麦芽糖が好ま
しく、又抗酸化剤としてはビタミン C や E が好まし
い。尚、乳糖やビタミン C はカルシウムの吸収を促進
する作用も有している。
[0007] The unicellular calcareous algae used for producing the health food according to the present invention include Pleu lysis ( Pleu
rochrysis ), Gephyrocapsa ,
Algae of the genus Emiliania and the like, which are called coccoid algae or haptophytes, are preferable. Lactose is preferred as a granulating agent, talc as a lubricant,
Saccharose fatty acid esters and the like can be exemplified, but the latter is preferred, and the binder is preferably a saccharide, particularly reduced maltose, and the antioxidant is preferably vitamin C or E. Lactose and vitamin C also have the effect of promoting calcium absorption.

【0008】栄養強化物質としてはビタミン E、レシチ
ン、ビール酵母 (ビタミン D の前駆体を含有)、クロレ
ラ藻体 (蛋白質に富んでいる)、米胚芽発酵エキス [ス
ーパー・オキサイド・ディスムターゼ (SOD) 様物質を
含有] 等を例示することができ、これらの物質は錠剤状
食品とする場合にも配合することができる。
[0008] Fortifying substances include vitamin E, lecithin, brewer's yeast (containing a precursor of vitamin D), chlorella alga body (rich in protein), fermented rice germ extract [like superoxide dismutase (SOD) Containing a substance], and these substances can also be blended in the case of a tablet food.

【0009】単細胞石灰藻類は、基本的には植物の仲間
であり、二酸化炭素を吸収して光合成を行なって自らの
エネルギーとしている。空気中の二酸化炭素は 0.03%
程度であるので、単細胞石灰藻類を人工的に培養する場
合には二酸化炭素を富化して増殖を促進させることが肝
要である。この場合に 1 - 5% の二酸化炭素を含有する
空気を送気し、或いは 100% 二酸化炭素ガスを導入す
る。しかしながら、この二酸化炭素源として産業排ガ
ス、例えば火力発電等で燃焼により大量に発生する二酸
化炭素含有排ガスを冷却して利用することができ、これ
により公害の防止をもたらすことも可能である。
[0009] The unicellular calcareous algae is basically a member of plants, and absorbs carbon dioxide to perform photosynthesis to generate its own energy. 0.03% carbon dioxide in the air
Therefore, it is important to enrich carbon dioxide to promote growth when artificially cultivating single-cell lime algae. In this case, air containing 1-5% carbon dioxide is supplied, or 100% carbon dioxide gas is introduced. However, an industrial exhaust gas, for example, a carbon dioxide-containing exhaust gas generated in large quantities by combustion in thermal power generation or the like can be cooled and used as the carbon dioxide source, thereby preventing pollution.

【0010】藻体含有培養液については濃縮し、例えば
酢酸を添加して弱酸性となし、サイクロデキストリン及
びキトサンを添加する。このサイクロデキストリンは藻
類の細胞表面に固定されているカルシウムと多糖類を包
接するためであり、各種タイプのもの、即ちα-、β-、
γ-、δ-、ε- 及びポリマーサイクロデキストリン又は
サイクロデキストリン糖 (粉飴) を使用することがで
き、一方キトサンは藻類のフロックを作るための助剤及
び微生物等による汚染を除去するために使用される。
尚、錠剤状食品の場合には後にカルシウムの吸収を促進
する物質例えば乳糖を造粒剤として配合することができ
るが、カプセル状食品の場合には封入量が限定されるた
めに、この時点で乳酸を添加し、吸収性の良好な乳酸カ
ルシウムの形にできるだけ近づけることが好ましい。得
られた藻体含有液を真空又は凍結乾燥して粉末化する。
この乾燥粉末を主原料として錠剤状又はカプセル状食品
に加工する。
The alga body-containing culture solution is concentrated, for example, acetic acid is added to make it weakly acidic, and cyclodextrin and chitosan are added. This cyclodextrin is for inclusion of calcium and polysaccharides fixed on the cell surface of algae, various types, namely α-, β-,
γ-, δ-, ε- and polymer cyclodextrins or cyclodextrin sugars (candy powder) can be used, while chitosan is used to remove algal floc and microbial contamination. Is done.
In the case of a tablet food, a substance that promotes the absorption of calcium, such as lactose, can be added as a granulating agent.However, in the case of a capsule food, the amount to be enclosed is limited. It is preferable to add lactic acid to make the form of calcium lactate having good absorbability as close as possible. The obtained alga body-containing liquid is vacuum- or freeze-dried to powder.
The dry powder is used as a main raw material to be processed into a tablet or capsule food.

【0011】[0011]

【実施例等】次に、製造例及び試験例に関連して本発明
を更に詳細に且つ具体的に説明する。製造例 1 (錠剤状食品) 単細胞石灰藻類であるプレオクリシス・カルテレ (Pleu
rochrysis carterae)をレースウェイ型培養水槽を用い
て培養した。培養液としては海水 0.9 リットルと精製
水 0.1 リットルとを混合し、これに KNO3 50.5mg、K2H
PO4 8.7mg、ビタミン混液 1ml 及び微量金属混液 1ml
の割合で添加された Eppley 培地が用いられた。培養条
件は pH 8.0 - 8.5、温度 25℃、照度 3000 ルックスで
あり、培養に際しては重油を燃焼させて得た排気 (二酸
化炭素ガスを 1% 含有) を冷却して培養水槽に導入し
た。充分に培養した後に、単細胞石灰藻体含有培養液を
遠心分離して水分量 80%まで濃縮し、液が弱酸性を呈す
るまで酢酸水溶液を添加し、次いでサイクロデキストリ
ンとキトサンをそれぞれ 2.5% 及び 0.5% となるように
添加して攪拌した。得られた溶液を真空乾燥して粉末化
した。この乾燥粉末に、硬化ヒマシ油とセラックをエタ
ノールにそれぞれ 0.1% 及び 0.5% 溶解させた溶液を噴
霧して被覆処理を施した。得られた単細胞石灰藻体吸着
物 405g に、乳糖 130g と、還元麦芽水飴 360gと、ビ
タミン C を豊富に含有するアセロラエキスパウダー 20
g と、栄養原料(ビール酵母、クロレラ藻体、米胚芽発
酵エキス及びクエン酸第一鉄ナトリウムを含有) 85g を
添加し、V 型ミキサーにより均一になるまで攪拌混合し
た。次に、95% エタノール 60g 及び食用色素 20g を添
加し、更に攪拌混合した。得られた混合物をローラーコ
ンバクターにより 40 メッシュパスの顆粒状に造粒し、
50℃ で 40 分間乾燥した。得られた乾燥造粒物 (約 10
00g) に滑沢剤としての蔗糖脂肪酸エステル 10g と香料
5g とを添加して攪拌混合し、次いで常法により打錠し
て直径 13mm、重量 700mg の錠剤状食品を得た。
EXAMPLES Next, the present invention will be described in more detail and specifically with reference to production examples and test examples. A Preparation Example 1 (Tablet type food) unicellular lime algae Pureokurishisu-Karutere (Pleu
rochrysis carterae ) was cultivated using a raceway type culture water tank. 0.9 liter of seawater and 0.1 liter of purified water were mixed as a culture solution, and 50.5 mg of KNO 3 and K 2 H
PO 4 8.7mg, vitamin mixture 1ml and trace metal mixture 1ml
Eppley medium supplemented with the following ratio was used. Culture conditions were pH 8.0-8.5, temperature 25 ° C, and illuminance 3000 lux. During culture, the exhaust gas (containing 1% of carbon dioxide gas) obtained by burning heavy oil was cooled and introduced into the culture water tank. After sufficient culture, the culture solution containing the single-cell calcareous algae bodies was concentrated by centrifugation to a water content of 80%, an aqueous acetic acid solution was added until the solution became weakly acidic, and then cyclodextrin and chitosan were added at 2.5% and 0.5%, respectively. % And stirred. The obtained solution was vacuum-dried to powder. The dried powder was coated with a solution prepared by dissolving 0.1% and 0.5% of hydrogenated castor oil and shellac in ethanol respectively. Lactose 130 g, reduced malt syrup 360 g, and vitamin C rich acerola extract powder 20
g and nutrient materials (containing brewer's yeast, chlorella algae, fermented rice germ extract and sodium ferrous citrate) were added, and mixed by stirring with a V-type mixer until uniform. Next, 60 g of 95% ethanol and 20 g of food coloring were added, followed by stirring and mixing. Granulate the resulting mixture into 40 mesh pass granules with a roller compactor,
It was dried at 50 ° C for 40 minutes. The obtained dried granules (about 10
(00g) 10g of sucrose fatty acid ester as a lubricant and fragrance
Then, the mixture was stirred and mixed, and then tableted by a conventional method to obtain a tablet food having a diameter of 13 mm and a weight of 700 mg.

【0012】比較製造例 (錠剤状食品) 貝殻カルシウム粉末と、魚油と、ビタミン C 末とを混
合し、常法により打錠して錠剤状食品を得た。
Comparative Production Example (Tablet Food) A calcium powder of shellfish, fish oil and vitamin C powder were mixed and tableted by a conventional method to obtain a tablet food.

【0013】製造例 2 (カプセル状食品) 製造例 1 と同様の条件でプレオクリシス・カルテレを
培養した。充分に培養した後に、単細胞石灰藻体含有培
養液を遠心分離して水分量 80%まで濃縮し、液が弱酸性
を呈するまで酢酸水溶液を添加し、次いで乳酸とサイク
ロデキストリンをそれぞれ 2.0% 及び 2.5% となるよう
に添加して攪拌し、更に0.5% となるようにキトサンを
添加して充分に攪拌した。得られた溶液を真空乾燥して
粉末化した。この乾燥粉末 500g にアセロラ抽出ビタミ
ン C 末 50g 添加し混合して均一なものとなした。大豆
レシチン 10g と大豆抽出ビタミン E 50g とを添加した
紫蘇油 600g に、上記の粉末を添加し、蜜蝋により粘度
を 6500 - 8500cps に調整し、真空下で攪拌することに
より均一な油性懸濁液を得た。この油性懸濁液を、ゼラ
チンとグリセロールとからなるソフトカプセルに充填封
入することにより所望のカプセル状食品を得た。このソ
フトカプセルはオーバル 5 号 (ラグビーボール型) で
あり、封入量は 350mg である。
Production Example 2 (Capsule Food) Preocrysis cartele was cultured under the same conditions as in Production Example 1. After sufficient culturing, the culture solution containing the single-cell calcareous algae bodies was concentrated by centrifugation to a water content of 80%, an aqueous acetic acid solution was added until the solution became weakly acidic, and then lactic acid and cyclodextrin were 2.0% and 2.5%, respectively. %, And the mixture was stirred. Further, chitosan was added to a further 0.5%, followed by sufficient stirring. The obtained solution was vacuum-dried to powder. To 500 g of the dried powder, 50 g of acerola-extracted vitamin C powder was added and mixed to obtain a uniform product. To 600 g of Shiso oil containing 10 g of soy lecithin and 50 g of soy extract vitamin E, add the above powder, adjust the viscosity to 6500-8500 cps with beeswax, and stir under vacuum to form a uniform oily suspension. Obtained. This oily suspension was filled and sealed in a soft capsule composed of gelatin and glycerol to obtain a desired capsule food. This soft capsule is Oval No. 5 (rugby ball type), and the amount of filling is 350mg.

【0014】試験例 製造例 1 及び比較製造例により得た錠剤状食品 (本発
明品及び対照品) を温度 40℃、相対湿度 75% に保たれ
た試験器内において 3 ケ 月間にわたり保存し、経時的
に採取してカルシウム量、酸価、過酸化物価及び生菌数
を測定した。結果は下記の表 1 に示される通りであ
り、本発明による錠剤状食品は安定性において著しく優
れており、生菌数も減少する傾向を示した。
Test Example The tablet-shaped food products (the present invention product and the control product) obtained in Production Example 1 and Comparative Production Example were stored for 3 months in a tester kept at a temperature of 40 ° C. and a relative humidity of 75%, It was collected with time and the calcium amount, acid value, peroxide value and viable cell count were measured. The results are as shown in Table 1 below. The tablet-like food according to the present invention was remarkably excellent in stability and showed a tendency to decrease the number of viable bacteria.

【0015】[0015]

【表1】 上記の表中において、カルシウム量は試験開始前におけ
るカルシウム含有量を100% とした場合の残存量を % 値
で示している。
[Table 1] In the above table, the amount of calcium indicates the residual amount as a% value when the calcium content before the start of the test is 100%.

【0016】[0016]

【発明の効果】本発明による健康食品は単細胞石灰藻類
が豊富に有しているカルシウムを主体とするミネラル
類、蛋白質、高度不飽和脂肪酸を含む脂質、糖質、ビタ
ミン類を何等損なうことなく含有しており、栄養価が高
い。錠剤状の食品とする場合には造粒剤として乳糖を、
又抗酸化剤としてビタミン C が配合されるが、これら
はカルシウムの吸収性を向上させる。本発明による食品
は高度不飽和脂肪酸等の脂質を含有しているが、錠剤状
に加工された場合にも保存安定性に優れている。
EFFECTS OF THE INVENTION The health food according to the present invention contains calcium-based minerals, proteins, lipids containing polyunsaturated fatty acids, lipids, sugars and vitamins, which are rich in unicellular lime algae, without any loss. It has high nutritional value. Lactose as a granulating agent when making a tablet-like food,
Vitamin C is also included as an antioxidant, which improves calcium absorption. Although the food according to the present invention contains lipids such as highly unsaturated fatty acids, it has excellent storage stability even when processed into tablets.

Claims (3)

【特許請求の範囲】[Claims] 【請求項1】 単細胞石灰藻類の藻体を含有しているこ
とを特徴とする、カルシウムを主成分とする健康食品。
1. A health food containing calcium as a main component, which contains algal cells of unicellular lime algae.
【請求項2】 単細胞石灰藻類の藻体と、造粒剤と、滑
沢剤と、結合剤と、抗酸化剤とを含有しており、錠剤状
を呈していることを特徴とする、カルシウムを主成分と
する健康食品。
2. Calcium characterized in that it contains an algal body of unicellular lime algae, a granulating agent, a lubricant, a binder, and an antioxidant, and has a tablet form. A health food containing as a main ingredient.
【請求項3】 単細胞石灰藻類の藻体と、抗酸化剤と、
栄養強化植物油とを含有し、ソフトカプセルに封入され
ていることを特徴とする、カルシウムを主成分とする健
康食品。
3. An algal body of unicellular lime algae, and an antioxidant,
A health food containing calcium as a main component, which contains nutrient-enriched vegetable oil and is enclosed in a soft capsule.
JP6172412A 1994-07-25 1994-07-25 Health foods mainly composed of calcium Expired - Lifetime JP2656448B2 (en)

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JP2656448B2 JP2656448B2 (en) 1997-09-24

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11302183A (en) * 1998-04-17 1999-11-02 Fancl Corp Chitosan composition and method for producing the same
JP2003250487A (en) * 2002-02-27 2003-09-09 Fancl Corp Powder-containing tablets
WO2005027941A1 (en) * 2003-09-19 2005-03-31 Shinichi Kitasaki Skin preparation for external use
JP2008031225A (en) * 2006-07-26 2008-02-14 Bio Marine Kk Inclusion body of a mixture of metal ion compounds from seawater and cyclodextrin
JP2008127304A (en) * 2006-11-18 2008-06-05 Tokyo Dental College Agent for enhancing dental quality, oral composition containing the same, food and drink and method for producing them
JP2012036112A (en) * 2010-08-05 2012-02-23 Sankyo:Kk Method for manufacturing product for improving bioavailability, and the product
JP2020043850A (en) * 2018-09-12 2020-03-26 エムジーファーマ株式会社 Antiobestic composition
WO2021177247A1 (en) * 2020-03-02 2021-09-10 株式会社シクロケムバイオ Mineral absorption enhancer
JP2023018662A (en) * 2021-07-27 2023-02-08 奥野製薬工業株式会社 Method for producing brewed vinegar and acetic acid fermentation aid used in the method

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JPH02174652A (en) * 1989-09-04 1990-07-06 Jun Nasu Alkaline agent for food
JPH0427352A (en) * 1990-05-22 1992-01-30 Fuji Capsule Kk Enteric soft capsule for health food
JPH04112824A (en) * 1990-09-01 1992-04-14 Taisho Pharmaceut Co Ltd Sofalcone-containing solid preparation
JPH0549446A (en) * 1991-08-22 1993-03-02 Kankyo Hozen Kenkyusho:Kk Calcium-containing food
EP0588539A1 (en) * 1992-09-18 1994-03-23 Teva Pharmaceutical Industries, Ltd. Stabilized pharmaceutical compositions containing derivatives of vitamins D2 and D3
US5330760A (en) * 1992-08-27 1994-07-19 Sterling Winthrop Inc. Effervescent antacid

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02174652A (en) * 1989-09-04 1990-07-06 Jun Nasu Alkaline agent for food
JPH0427352A (en) * 1990-05-22 1992-01-30 Fuji Capsule Kk Enteric soft capsule for health food
JPH04112824A (en) * 1990-09-01 1992-04-14 Taisho Pharmaceut Co Ltd Sofalcone-containing solid preparation
JPH0549446A (en) * 1991-08-22 1993-03-02 Kankyo Hozen Kenkyusho:Kk Calcium-containing food
US5330760A (en) * 1992-08-27 1994-07-19 Sterling Winthrop Inc. Effervescent antacid
EP0588539A1 (en) * 1992-09-18 1994-03-23 Teva Pharmaceutical Industries, Ltd. Stabilized pharmaceutical compositions containing derivatives of vitamins D2 and D3

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11302183A (en) * 1998-04-17 1999-11-02 Fancl Corp Chitosan composition and method for producing the same
JP2003250487A (en) * 2002-02-27 2003-09-09 Fancl Corp Powder-containing tablets
WO2005027941A1 (en) * 2003-09-19 2005-03-31 Shinichi Kitasaki Skin preparation for external use
JP2008031225A (en) * 2006-07-26 2008-02-14 Bio Marine Kk Inclusion body of a mixture of metal ion compounds from seawater and cyclodextrin
JP2008127304A (en) * 2006-11-18 2008-06-05 Tokyo Dental College Agent for enhancing dental quality, oral composition containing the same, food and drink and method for producing them
JP2012036112A (en) * 2010-08-05 2012-02-23 Sankyo:Kk Method for manufacturing product for improving bioavailability, and the product
JP2020043850A (en) * 2018-09-12 2020-03-26 エムジーファーマ株式会社 Antiobestic composition
WO2021177247A1 (en) * 2020-03-02 2021-09-10 株式会社シクロケムバイオ Mineral absorption enhancer
JPWO2021177247A1 (en) * 2020-03-02 2021-09-10
JP2023018662A (en) * 2021-07-27 2023-02-08 奥野製薬工業株式会社 Method for producing brewed vinegar and acetic acid fermentation aid used in the method

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