JPH0848616A - Hair tonic - Google Patents

Abstract

PURPOSE:To provide a hair tonic containing a component selected from a Japanese green gentian extract, ginseng extract, duke extract, etc., and hydrogenated bisabolol in combination and capable of manifesting an excellent hair-growing effect by their synergetic effect. CONSTITUTION:This hair tonic contains one or more kinds of components selected from a Japanese green gentian extract, ginseng extract, duke extract, a capsicum tincture, diisopropylamine dichloroacetate, gamma-aminobutyric acid, hinokitiol, a vitamin E derivative, a pantothenic acid derivative, a nicotinic acid derivative and a glycyrrhizic acid derivative and hydrogenated bisabolol expressed by the formula in combination. The amount of blended compound of the formula is preferably about 0.01 to 20wt.%. In addition, the amount of Japanese green gentian extract, ginseng extract and duke extract is preferably about 0.01 to 5.0wt.% on dry residue base. The amount of a component from a capsicum tincture to a glycyrrhizic acid derivative is recommendably 0.01 to 2.0wt.%.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing cosmetic composition excellent in hair-growth effect and hair loss prevention effect.

[0002]

BACKGROUND OF THE INVENTION Hair nourishing cosmetics containing a blood circulation promoting substance such as capsicum tincture and a nicotinic acid derivative, and amino acids and vitamins which are nutritional components of hair have been known. Has been.
In addition, a large number of medical hair nourishing agents and hair nourishing cosmetics containing a component having an effect of preventing sebaceous gland hypertrophy and a component having an inhibitory effect on male hormones have been proposed.

However, the blood circulation-promoting substances that have been conventionally used have strong skin irritation and have a limited amount to be mixed,
It has a shortcoming that the duration of blood circulation promotion is short. Also,
There is a problem that the nutritional component of hair has low permeability to the skin at a low concentration, and the effect cannot be sufficiently exerted by itself.

By the way, male pattern baldness is said to be caused by an excessive action of androgen, but phenomena such as poor blood circulation, decreased activity of hair matrix cells, hypertrophy of sebaceous glands, and fibrosis of scalp are caused. It is presumed that they are complicatedly intertwined.

However, in order to suppress the decrease in the activity of hair mother cells and the enlargement of the sebaceous glands, which are said to be caused by the excessive action of male hormones, even when male hormone agents are simply used as hair-growing agents, until the hair-growing action is exhibited. It is the current situation that it does not reach. Moreover, even if a hair matrix activating agent or a blood circulation promoting agent is used alone, good results cannot be obtained.

As means for solving the above-mentioned problems, a large number of hair nourishing and hair-growth agents have been proposed, including JP-A-5-58850, JP-A-5-1399336 and JP-A-5-170625. However, even if a substance that promotes peripheral blood flow and activates hair matrix cells is used alone, no remarkable hair-growth effect was found.

[0007] In view of such circumstances, the inventors of the present invention have conducted extensive studies on substances that promote peripheral blood flow in the scalp and activate hair matrix cells. As a result, the assembly extract, ginseng extract, and duke Hair nourishing makeup containing an active ingredient such as extract, capsicum tincture, diisopropylamine dichloroacetate, γ-aminobutyric acid, hinokitiol, vitamin E derivative, pantothenic acid derivative, nicotinic acid derivative, glycyrrhizic acid derivative, and hydrogenated bisabolol at the same time. The present invention has been completed by finding that the materials exhibit excellent hair-growth and hair-growth effects by a synergistic effect.

[0008]

[Means for Solving the Problems] That is, the present invention is to be used for the assembly extract, ginseng extract, duke extract, capsicum tincture, diisopropylamine dichloroacetate, γ-aminobutyric acid, hinokitiol, vitamin E derivative, pantothenic acid derivative, nicotinic acid derivative. And one or more components selected from the group consisting of glycyrrhizic acid derivatives and the following structural formula 2

Embedded image The present invention provides a hair nourishing cosmetic comprising a compound represented by:

The structure of the present invention will be described in detail below.

The senburi extract used in the present invention is an extract obtained by digesting the dried and crushed whole plant of senburi (Swertia Japonica Makino) in ethanol or hydrous ethanol and filtering.

The ginseng extract used in the present invention is 5 g of Panax ginseng C.A.Meyer.
It is an extract obtained by cold soaking the 6-year-old dried ground product in ethanol or hydrous ethanol and filtering.

The duke extract used in the present invention is
It is an extract obtained from the skin of Randum domestica jack barduke or Randium domestica jack bar lancer by the method described in JP-A-60-243020.

Capsicum tincture used in the present invention,
As diisopropylamine dichloroacetate, γ-aminobutyric acid, and hinokitiol, raw materials used as usual cosmetic raw materials can be used.

As the vitamin E derivative used in the present invention, free vitamin E or ester compounds such as vitamin E acetate, vitamin E succinate, vitamin E linoleate and vitamin E orotate can be used as typical substances. Where Vitamin E is α-,
Any of β-, γ-, and δ-tocopherol can be used.

As the pantothenic acid derivative used in the present invention, free pantothenic acid, pantothenyl alcohol, pantothenyl ethyl ether, acetylpantothenyl ethyl ether, benzoylpantothenyl ethyl ether, D-panthesine, D-pantethine, Examples include a series of compounds such as D-pantothenoyl-L-cysteine and di-D-pantothenoyl-L-cysteine.

As the nicotinic acid derivative used in the present invention, nicotinic acid, nicotinic acid amide, nicotinic acid-
Compounds such as α-tocopherol, benzyl nicotinate, methyl nicotinate and ethyl nicotinate can be used.

As the glycyrrhizic acid derivative used in the present invention, compounds such as glycyrrhizinic acid, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhetinic acid and stearyl glycyrrhetinate can be used.

The hydrogenated product of bisabolol used in the present invention is represented by the above structural formula 2, and the extraction method and the production method are not particularly limited. Further, the compound has stereoisomers, but any one of them may be used alone or a mixture of two or more kinds may be used. This compound can be prepared, for example, by converting α-bisabolol into Z.
Natureforsch. , C: Biosci. , 46
(5-6), 349-356 (1991), can be prepared using the method of Hashidoko et al. The hydrogenated bisabolol used in the present invention is hereinafter referred to as hydrogenated bisabolol.

The amount of hydrogenated bisabolol used in the present invention is not particularly limited, but is 0.01 to 20% by weight (hereinafter abbreviated as wt%) based on the total amount of the hair nourishing cosmetic. Is preferred.

The amount of the assembly extract, ginseng extract and duke extract used in the present invention is converted into a dry residue based on the total amount of the hair nourishing cosmetic,
The amount is preferably 0.001 to 10.0 wt%, more preferably 0.01 to 5.0 wt%.

Capsicum tincture used in the present invention,
The compounding amount of diisopropylamine dichloroacetate, γ-aminobutyric acid, hinokitiol, vitamin E derivative, pantothenic acid derivative, nicotinic acid derivative, glycyrrhizic acid derivative is 0.00 based on the total amount of the hair-care cosmetic.
1 to 5.0 wt% is preferable, more preferably 0.01
~ 2.0 wt%.

The hair nourishing cosmetic composition of the present invention can be prepared according to a conventional method, for example, a hairnic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a conditioner.
It can be manufactured and used in a dosage form such as hair gel, hair mist, and hair foam.

The hair nourishing cosmetic composition of the present invention is applied or sprayed to the intended topical region (scalp) for the purpose of hair nourishment, hair growth and / or hair loss prevention according to its dosage form.

The hair nourishing cosmetic composition of the present invention contains dyes, fragrances, germicides, preservatives, keratolytic agents, antiandrogens,
Antioxidants and the like can be appropriately added within a range that achieves the object of the present invention.

[0025]

The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to these. The test method used in the present invention is as follows.

(1) Test method for mouse hair growth promoting effect C3H mice (male, 8 weeks old, average weight 35 g) were shaved at the center of the back with electric clippers, and then completely shaved by a shaver. From the next day, 0.2 ml per animal of each sample of Example and Comparative Example was applied to the skin of the test site once daily. For each sample, 10 animals were used per group. The base alone was applied as a control group. 14 after the start of the experiment
On day one, the animals were sacrificed and the skin of the test area was photographed. Next, the photograph was taken into an image analysis device, and the area (A) where the hair was first shaved and the hair-growth area (B) were obtained, and the hair-growth rate (%) = [(B) / (A)] × 100 Was calculated for each animal. Finally, a value obtained by dividing the average value of each group of Examples or Comparative Examples by the average value of the control group was used for the determination as the hair growth promoting effect.

(2) Practical test method The heads of 20 male pattern baldness patients were exposed to the head twice daily in the morning and evening, 6 times in a row.
The effect after applying the sample for a month was evaluated. The test results, for each item of hair growth effect and hair loss prevention effect,
The number of respondents who responded that "downy hair was bristled or bristles increased" and "hair loss decreased" was shown.

(3) Method for Producing Each Active Ingredient The method for producing the assembly extract, ginseng extract and duke extract used in the examples is not specified, but the outline of each method is described below.
As the components of capsicum tincture, hinokitiol, etc., those used as usual cosmetic raw materials were used as samples.

[Production method of assembly extract] 50 g of the assembly product was hydrous ethanol (ethanol 50 wt%) 2
After digestion in 50 ml at a temperature of 40 to 50 ° C., the residue was digested again in the same manner to obtain 1.5 liters of the extract. This was concentrated under reduced pressure and 100 ml of purified water was added to the residue.
In addition, after aging for 1 week, the extract obtained by filtering off the insoluble portion was concentrated under reduced pressure, and then ethanol was added to adjust the ethanol content of the extract to 50 wt%,
Obtained ml assembly extract.

[Production method of Korean carrot extract] 50 g of dried ginseng roots of 5 to 6 years old were cold soaked in 200 ml of water-containing ethanol (50 wt% ethanol) for 1 week, and ethanol of the extract obtained by filtration was distilled off. Then, purified water was added to adjust the ethanol content of the extract to 50 wt%, and the extract was aged in a cold place for 7 to 10 weeks and then filtered to obtain 100 ml of a ginseng extract.

[Production Method of Duke Extract] Duke extract was prepared by crushing 50 g of the skin of Randium Domesticum Jack Burduke and immersing it in 200 ml of ethanol.
It was left at room temperature for a week. Further, the mixture was filtered and concentrated under reduced pressure to obtain 5.2 g of an oily substance.

In the following text, the compounding amount is indicated on the basis of the pure content of the extract obtained by extraction with the 50% aqueous ethanol solution as described above (calculated as the dry residue).

Examples 1 to 13 and Comparative Examples 1 to 13 (Heartonic) In the raw material composition of Table 1, the active ingredients were blended as shown in Table 2 to prepare a hairnic, and the above-mentioned tests were carried out. . In the table,% means% by weight.

[0034]

[Table 1]

[0035]

[Table 2]

(1) Preparation Method After dissolving the component (B) shown in Table 1 in the component (A), the component (C) was added, and the mixture was stirred and dispersed to fill a container. At the time of use, the content was uniformly dispersed by shaking before use.

(2) Characteristics Table 2 shows the results of various tests conducted on each hairnic. As shown in Table 2, in Comparative Examples 1 to 13, the mouse hair growth promoting effect and the human hair loss improving effect were low, and the results of the practical test were also not good.

On the other hand, the hair nourishing cosmetics of the present invention of Examples 1 to 13 show a high mouse hair growth promoting effect and a human hair loss improving effect, and the results of practical tests are also good. Showed good results. It should be noted that when using the hair nourishing cosmetic of any of the examples, no symptoms considered to be inflammation or other side effects are expressed in mice and humans, and it is clear that the hair nourishing cosmetic of the present invention is also excellent in safety. Met.

[0039]

EFFECTS OF THE INVENTION The hair nourishing cosmetic composition of the present invention has an activity of activating hair mother cells, and is excellent in hair growth effect, hair loss prevention effect and safety.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical indication C07C 31/133 9155-4H

Claims (1)

[Claims] 1. An assembly extract, a Korean carrot extract,
At least one component selected from the group consisting of Duke extract, capsicum tincture, diisopropylamine dichloroacetate, γ-aminobutyric acid, hinokitiol, vitamin E derivative, pantothenic acid derivative, nicotinic acid derivative, and glycyrrhizic acid derivative, and the following structure Formula [1] A hair nourishing cosmetic comprising a compound represented by: