JPH09119809A - 毛管電気泳動装置のための光学的整合方法及び装置 - Google Patents

毛管電気泳動装置のための光学的整合方法及び装置

Info

Publication number: JPH09119809A
Authority: JP; Japan
Prior art keywords: capillary; array; center; detector; column
Prior art date: 1995-08-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP8240021A

Other languages

English (en)

Japanese (ja)

Inventor

Jr Stephen L Pentoney

エルペントニージュニアスティーヴン

Clarence Y Lew

ワイリュークラレンス

David Rakestraw

レイクストローデイヴィド

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Corp

Original Assignee

SmithKline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-23

Filing date

1996-08-23

Publication date

1997-05-06

1996-08-23 Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp

1997-05-06 Publication of JPH09119809A publication Critical patent/JPH09119809A/ja

Status Pending legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims abstract description 23
238000005251 capillar electrophoresis Methods 0.000 title description 16
230000003287 optical effect Effects 0.000 title description 9
230000005855 radiation Effects 0.000 claims abstract description 26
230000005670 electromagnetic radiation Effects 0.000 claims description 33
230000008859 change Effects 0.000 claims description 2
238000000926 separation method Methods 0.000 description 16
238000001514 detection method Methods 0.000 description 12
239000000499 gel Substances 0.000 description 12
238000001228 spectrum Methods 0.000 description 9
238000004458 analytical method Methods 0.000 description 8
230000035945 sensitivity Effects 0.000 description 8
239000000523 sample Substances 0.000 description 7
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238000010586 diagram Methods 0.000 description 4
238000005516 engineering process Methods 0.000 description 4
230000005284 excitation Effects 0.000 description 3
238000001917 fluorescence detection Methods 0.000 description 3
229920002521 macromolecule Polymers 0.000 description 3
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238000013480 data collection Methods 0.000 description 2
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238000005286 illumination Methods 0.000 description 2
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VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
108091034117 Oligonucleotide Proteins 0.000 description 1
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JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
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230000005540 biological transmission Effects 0.000 description 1
238000012790 confirmation Methods 0.000 description 1
238000013500 data storage Methods 0.000 description 1
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239000007850 fluorescent dye Substances 0.000 description 1
238000001502 gel electrophoresis Methods 0.000 description 1
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108020004707 nucleic acids Proteins 0.000 description 1
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150000007523 nucleic acids Chemical class 0.000 description 1
229920002401 polyacrylamide Polymers 0.000 description 1
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102000004196 processed proteins & peptides Human genes 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
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Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6402—Atomic fluorescence; Laser induced fluorescence
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Immunology (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Optics & Photonics (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Electrochemistry (AREA)
Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Investigating Or Analysing Materials By Optical Means (AREA)
Length Measuring Devices By Optical Means (AREA)

JP8240021A 1995-08-23 1996-08-23 毛管電気泳動装置のための光学的整合方法及び装置 Pending JPH09119809A (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/518,283 US5545901A (en)	1995-08-23	1995-08-23	Automated optical alignment using a galvometric scanner
US08/518,283		1995-08-23

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2006070876A Division JP4463228B2 (ja)	1995-08-23	2006-03-15	毛管電気泳動装置のための光学的整合方法及び装置

Publications (1)

Publication Number	Publication Date
JPH09119809A true JPH09119809A (ja)	1997-05-06

Family

ID=24063311

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
JP8240021A Pending JPH09119809A (ja)	1995-08-23	1996-08-23	毛管電気泳動装置のための光学的整合方法及び装置
JP2006070876A Expired - Lifetime JP4463228B2 (ja)	1995-08-23	2006-03-15	毛管電気泳動装置のための光学的整合方法及び装置
JP2009238100A Expired - Lifetime JP5145309B2 (ja)	1995-08-23	2009-10-15	毛管電気泳動装置のための光学的整合装置

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
JP2006070876A Expired - Lifetime JP4463228B2 (ja)	1995-08-23	2006-03-15	毛管電気泳動装置のための光学的整合方法及び装置
JP2009238100A Expired - Lifetime JP5145309B2 (ja)	1995-08-23	2009-10-15	毛管電気泳動装置のための光学的整合装置

Country Status (4)

Country	Link
US (1)	US5545901A (de)
EP (2)	EP1431748A3 (de)
JP (3)	JPH09119809A (de)
DE (1)	DE69635296T2 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2003254896A (ja) *	2002-02-28	2003-09-10	Kokusai Gijutsu Kaihatsu Co Ltd	試料カートリッジ、試料分析装置及び方法
JP2007212449A (ja) *	2006-01-16	2007-08-23	Hitachi High-Technologies Corp	キャピラリ電気泳動装置及び電気泳動方法

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5545901A (en) *	1995-08-23	1996-08-13	Beckman Instruments, Inc.	Automated optical alignment using a galvometric scanner
US6225635B1 (en) *	1998-08-07	2001-05-01	The Regents Of The University Of California	System and method for optically locating microchannel positions
JP3613032B2 (ja) *	1998-10-26	2005-01-26	株式会社日立製作所	キャピラリーアレイ電気泳動装置
US6246046B1 (en)	1999-01-21	2001-06-12	University Of Pittsburgh	Method and apparatus for electronically controlled scanning of micro-area devices
US6768812B1 (en) *	1999-05-27	2004-07-27	Cognex Corporation	Method for locating features on an object using varied illumination
US6592733B1 (en)	1999-11-12	2003-07-15	Motorola, Inc.	Capillary electrophoresis devices incorporating optical waveguides
US6932940B2 (en) *	2001-06-22	2005-08-23	Biocal Technology, Inc.	Optical detection in bio-separation device using axial radiation input
AU2002310510A1 (en) *	2001-06-22	2003-01-08	Biocal Technology, Inc.	Optical detection in bio-separation device having axial radiation input and output and widened detection zone
US6929779B2 (en)	2001-06-22	2005-08-16	Biocal Technology, Inc.	Optical detection in bio-separation device using axial radiation output
AU2002357368A1 (en) *	2001-12-19	2003-07-09	Affymetrix, Inc.	Array plates and method for constructing array plates
US6770892B2 (en) *	2002-02-28	2004-08-03	Agilent Technologies, Inc.	Method and system for automated focus-distance determination for molecular array scanners
AU2011203525B8 (en) *	2005-05-19	2014-03-06	Ande Corporation	An apparatus for analyzing/processing a sample of biomolecular analyte, device and method
US8206974B2 (en) *	2005-05-19	2012-06-26	Netbio, Inc.	Ruggedized apparatus for analysis of nucleic acid and proteins
CA3106132C (en)	2011-05-12	2023-08-29	Ande Corporation	Methods and compositions for rapid multiplex amplification of str loci
WO2021095006A1 (en)	2019-11-14	2021-05-20	Dh Technologies Development Pte. Ltd.	Dual mode scanning optical system for capillary electrophoresis

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SE8102772L (sv) *	1981-05-04	1982-11-05	Sven Staffan Folestad	Forfarande for laserinducerad fluoriscensdetektering och anordning for genomforande av forfarandet
US4648715A (en) *	1982-09-07	1987-03-10	Langley-Ford Instruments A Division Of Coulter Electronics Of N.E.	Electrophoretic light scattering with plural reference beams, apparatus and method
JPH0638064B2 (ja) *	1985-01-19	1994-05-18	キヤノン株式会社	粒子解析装置
JPS628038A (ja) *	1985-07-05	1987-01-16	Canon Inc	粒子解析装置
US4837446A (en) *	1988-03-31	1989-06-06	International Paper Company	Apparatus and process for testing uniformity of pulp
JP2745568B2 (ja) *	1988-09-30	1998-04-28	株式会社島津製作所	キャピラリセル検出器の調整方法及び調整機構
JPH02218941A (ja) *	1989-02-18	1990-08-31	Shimadzu Corp	蛍光検出型ゲル電気泳動パターン解析装置
US5274240A (en) *	1990-01-12	1993-12-28	The Regents Of The University Of California	Capillary array confocal fluorescence scanner and method
JP2873884B2 (ja) *	1991-03-22	1999-03-24	日立ソフトウェアエンジニアリング株式会社	多色泳動パターン読み取り装置
DE69221423T2 (de) *	1991-09-30	1998-03-19	Beckman Instruments Inc	Verbesserte Fluoreszenz-Erfassung von Proben in einem Kapillarrohr
US5208466A (en) *	1991-10-08	1993-05-04	Beckman Instruments, Inc.	Apparatus and method for aligning capillary column and detection optics
JP2640704B2 (ja) *	1991-12-30	1997-08-13	日立ソフトウエアエンジニアリング株式会社	蛍光パターン読み取り装置
WO1993019205A1 (en) *	1992-03-19	1993-09-30	The Regents Of The University Of California	Multiple tag labeling method for dna sequencing
EP0654090A4 (de) *	1992-08-10	1998-07-08	Biometric Imaging Inc	Analysenverfahren auf differentieller abtrennung beruhend und testkit.
US5371016A (en) *	1993-04-26	1994-12-06	Becton, Dickinson And Company	Detecting biological activities in culture vials
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US5545901A (en) *	1995-08-23	1996-08-13	Beckman Instruments, Inc.	Automated optical alignment using a galvometric scanner

1995
- 1995-08-23 US US08/518,283 patent/US5545901A/en not_active Expired - Lifetime
1996
- 1996-08-20 DE DE69635296T patent/DE69635296T2/de not_active Expired - Lifetime
- 1996-08-20 EP EP04075245A patent/EP1431748A3/de not_active Ceased
- 1996-08-20 EP EP96306071A patent/EP0773438B1/de not_active Expired - Lifetime
- 1996-08-23 JP JP8240021A patent/JPH09119809A/ja active Pending
2006
- 2006-03-15 JP JP2006070876A patent/JP4463228B2/ja not_active Expired - Lifetime
2009
- 2009-10-15 JP JP2009238100A patent/JP5145309B2/ja not_active Expired - Lifetime

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2003254896A (ja) *	2002-02-28	2003-09-10	Kokusai Gijutsu Kaihatsu Co Ltd	試料カートリッジ、試料分析装置及び方法
JP2007212449A (ja) *	2006-01-16	2007-08-23	Hitachi High-Technologies Corp	キャピラリ電気泳動装置及び電気泳動方法

Also Published As

Publication number	Publication date
JP4463228B2 (ja)	2010-05-19
JP2010019853A (ja)	2010-01-28
JP5145309B2 (ja)	2013-02-13
EP1431748A2 (de)	2004-06-23
US5545901A (en)	1996-08-13
EP0773438A2 (de)	1997-05-14
EP0773438A3 (de)	1997-07-23
EP0773438B1 (de)	2005-10-19
DE69635296T2 (de)	2006-07-20
DE69635296D1 (de)	2006-03-02
EP1431748A3 (de)	2004-09-08
JP2006349666A (ja)	2006-12-28

Legal Events

Date	Code	Title	Description
2005-02-22	A131	Notification of reasons for refusal	Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20050222
2005-05-23	A601	Written request for extension of time	Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20050520
2005-05-26	A602	Written permission of extension of time	Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20050525
2005-08-22	A521	Written amendment	Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20050819
2005-11-15	A02	Decision of refusal	Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20051115

Publication	Publication Date	Title
JP5145309B2 (ja)	2013-02-13	毛管電気泳動装置のための光学的整合装置
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EP0284660B1 (de)	1992-07-08	Gerät zur Sequenzanalyse von Basen
EP0401821B1 (de)	1996-02-14	Fluoreszenz-Auswertegerät für elektrophoretische Bilder
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US7170597B1 (en)	2007-01-30	Microplate reader
US5614726A (en)	1997-03-25	Automated optical alignment system and method using Raman scattering of capillary tube contents
JP4489479B2 (ja)	2010-06-23	キャピラリアレイ検出用回転共焦スキャナ
US20070131870A1 (en)	2007-06-14	Multiplexed CE fluorescence system
JP3613032B2 (ja)	2005-01-26	キャピラリーアレイ電気泳動装置
JPH1194798A (ja)	1999-04-09	光検出電気泳動装置
US6630063B1 (en)	2003-10-07	Uniform laser excitation and detection in capillary array electrophoresis system and method
US6762840B1 (en)	2004-07-13	Image information reading apparatus designed to maintain light amount to be detected at uniform level
JPH0778469B2 (ja)	1995-08-23	蛍光パターン読取り装置
US20050161329A1 (en)	2005-07-28	Multiplexed capillary electrophoresis systems
JP2701412B2 (ja)	1998-01-21	ゲル電気泳動装置
EP0275440A2 (de)	1988-07-27	Photodetektionssystem für die DNA-Basen-Analyse
SU629455A1 (ru)	1978-10-25	Устройство дл спектрохимических исследований
WO2021095006A1 (en)	2021-05-20	Dual mode scanning optical system for capillary electrophoresis
JPH10148627A (ja)	1998-06-02	マルチキャピラリー電気泳動装置
Fujii et al.	1992	Automated optical axis adjustment system for fluorescence scanning of electrophoresis gel
JP2000180362A (ja)	2000-06-30	画像情報読取方法および画像情報読取装置
JPH09318600A (ja)	1997-12-12	Ｄｎａ塩基配列決定装置
JP2002182323A (ja)	2002-06-26	共焦点光学系を備えたスキャナのフォーカス位置決定方法およびフォーカス調整方法、共焦点光学系を備えたスキャナならびにフォーカス位置決定用デバイス
CA2607937A1 (en)	2009-04-29	Fragment sizing using short wavelength radiation for biomolecular applications

JPH09119809A - 毛管電気泳動装置のための光学的整合方法及び装置 - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (2)

Related Child Applications (1)

Publications (1)

Family

ID=24063311

Family Applications (3)

Family Applications After (2)

Country Status (4)

Cited By (2)

Families Citing this family (15)

Family Cites Families (17)

Cited By (2)

Also Published As

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