JPH09175948A - Hair tonic cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare a hair tonic cosmetic, comprising a tartaric acid nicotinic alcohol and a eugenol glycoside and having hair growth effects and preventing effects on alopecia and dandruff. SOLUTION: This hair tonic cosmetic comprises 0.001-15wt.% tartaric acid nicotinic alcohol and 0.001-15wt.% eugenol glycoside. The tartaric acid nicotinic alcohol is a well-known substance and has promoting actions on peripheral bloodstream. The eugenol glycoside is a compound obtained by bonding saccharides to eugenol through O-glycoside bonds and suitably decomposed into the eugenol having inhibiting activities for 5α-reductases and a saccharide part with a scalp normal bacterial flora and has sustained release hair growth effects and preventing effects on alopecia and dandruff. The cosmetic is prepared as a hair tonic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a rinse, a hair gel, a hair mist, a hair foam, etc., for use.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a hair nourishing composition comprising nicotinic alcohol tartrate and eugenol glycoside, and more specifically, to blood circulation promoting action of nicotinic alcohol tartrate and eugenol glycoside to normal scalp. The present invention relates to a hair nourishing cosmetic composition which has the ability to inhibit the activity of 5α reductase by eugenol released by bacteria and is excellent in the hair growth effect, hair loss prevention effect and dandruff prevention effect.

[0002]

BACKGROUND OF THE INVENTION Conventionally, a hair nourishing cosmetic composition containing a scalp blood circulation-promoting substance such as capsicum tincture, assembly extract, ginseng extract, nicotinic acid, methyl nicotinate, etc. has hitherto been known. Are known.
However, a substance that is effective enough to exert effects such as hair growth, hair loss prevention and dandruff prevention has not yet been developed. Furthermore, in recent years, it has been suggested that hormones are involved in hair growth. In other words, in the hair follicle containing hair matrix cells,
Male hormone (testosterone), due 5α- reductase (delta ^4-3-keto steroid 5α- oxidoreductase), is activated to active androgen (dihydrotestosterone), and further coupled to the receptor, it is incorporated into the nucleus, Transmits information at the DNA level. The transmitted information controls enzyme synthesis involved in keratin synthesis, suppresses keratin synthesis in hair, reduces hair growth, and finally promotes hair loss. Therefore, in the development of a hair restorer, attention has been paid to research on an activity inhibitor of 5α-reductase, which is an androgen activating enzyme in hair and scalp.

However, androgenetic alopecia is said to be one of the causes of excess action of androgen, but it is caused by phenomena such as poor circulation, decreased activity of hair matrix cells, hypertrophy of sebaceous glands, and fibrosis of scalp. It is presumed that they are complicatedly intertwined.

[0004] In order to suppress the decrease in the activity of hair mother cells and the enlargement of the sebaceous glands, which are said to be caused by the excessive action of male sex hormones, even when male sex hormone preparations and the like are simply used as hair nourishing agents, the hair growth effect is not exhibited. The current situation is that there are none. In addition, good results cannot be obtained even when the hair matrix activator or the blood circulation promoter is used alone.

Further, conventionally used blood circulation promoting substances have drawbacks that they are strongly irritated to the skin and the amount thereof is limited, and the duration of blood circulation promotion is short. Further, there is a problem in that the nutritional component of hair has a low permeability to the skin at a low concentration, and the effect alone is not sufficiently exerted.

As means for solving the above-mentioned problems, a large number of hair-growth and hair-growing agents have been proposed, including Japanese Patent Application Laid-Open Nos. 5-58850, 5-139336 and 5-170625. However, no remarkable hair-growth effect was found even when a substance that promotes peripheral blood flow and activates hair matrix cells was used alone.

In view of such circumstances, the inventors of the present invention have conducted extensive studies on a substance having an action of promoting peripheral blood flow in the scalp and activating hair matrix cells. As a result, nicotinic tartrate, and For the purpose of the present invention, a hair nourishing cosmetic composition containing both eugenol glycosides, which are released from the scalp indigestible eugenol having the ability to inhibit the activity of 5α-reductase, is obtained by the synergistic effect of each component. The present invention has been completed by discovering that a certain excellent hair nourishing and hair-growing effect is exhibited.

[0008]

That is, the object of the present invention is achieved by a hair nourishing cosmetic containing nicotinic alcohol tartrate and eugenol glycoside.

[0009]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The configuration of the present invention will be described below in detail. The nicotinic alcohol tartrate used in the present invention is a known substance, and is used as a drug having a peripheral blood flow promoting action, as a therapeutic drug for Meniere's disease and Meniere's disease syndrome, or as a therapeutic drug for various peripheral circulatory disorders.
The chemical properties of this compound are as follows. Chemical name: 3-pyridinemethanol d- Tatoreito molecular _{formula: C 6 H 7 NO · C} 4 H 6 O 6 Molecular weight: 259.22 mp: 145-150 ° C. (decomposition) above tartaric nicotinyl nick alcohol is a known substance Although it is easily available, it can be easily prepared by the following method. That is, 1 to 30% by weight of nicotinic alcohol and 1 to 10% by weight of d-tartaric acid.
Dissolve in ethyl alcohol. Next, both solutions are mixed at room temperature so as to be equimolar and left for about 1 hour. After that, the generated crystals can be filtered to obtain the desired nicotinic tartrate alcohol.

The content of the nicotinic tartrate alcohol used in the present invention was 0 based on the total amount of the hair nourishing cosmetics as a result of examining the ranges showing the hair-growth effect and the hair loss prevention effect, which are the objects of the present invention. 0.001-15.0% by weight
(Hereinafter, abbreviated as “wt%”), and more preferably 0.01 to 5.0 wt%.

The eugenol glycoside referred to in the present invention is a monosaccharide such as glucose, galactose, mannose, rhamnose, xylose, glucosamine or galactosamine,
It is a compound in which saccharides such as disaccharides such as lactose, maltose, and sucrose and eugenol are O-glycoside-bonded. These eugenol glycosides can be easily synthesized by a known method. For example, U.S. S. P.
According to the method for synthesizing arbutin described in No. 3201385, eugenol glycoside as a mixture of α-form and β-form can be obtained. Also, the Flavor and Fragrance Journal (14, 163-167, 1989).
Years) β-based on the method of synthesizing glucovanillin
You can synthesize only the body. Among these eugenol glycosides, glucose glycosides are preferable in terms of the degree of their effects, and specifically, eugenyl α-D-glucoside and / or eugenyl β-D-glucoside. In this case, the β-form is preferred, but the effect is not particularly problematic even if the α-form is contained. Then, these eugenol glycosides are appropriately decomposed into eugenol and sugar moieties by the scalp resident bacteria, and exhibit a sustained release hair growth effect, hair loss prevention effect, and dandruff prevention effect.

The content of the eugenol glycoside used in the present invention was determined by studying the ranges showing the hair growth effect, hair loss prevention effect and dandruff prevention effect, which are the objects of the present invention. As a reference, it may be 0.001 to 15.0% by weight (hereinafter abbreviated as wt%), and more preferably 0.01 to 5.0% by weight.

The hair nourishing cosmetic composition of the present invention can be prepared according to a conventional method, for example, a hairnic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a conditioner.
It can be manufactured and used in dosage forms such as hair gel, hair mist, and hair foam.

The hair nourishing cosmetic composition of the present invention is applied or sprayed to a desired topical region (scalp) according to its dosage form for the purpose of preventing hair nourishment, hair growth and / or hair loss.

The hair nourishing cosmetic composition of the present invention may appropriately contain a dye, a fragrance, a bactericide, an antiseptic agent, a keratolytic agent, an antioxidant and the like within a range to achieve the object of the present invention.

[0016]

The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to these examples. The test method used in the present invention is as follows.

(1) Test method for mouse hair growth promoting effect C3H mice (male, 8 weeks old, average body weight: 35 g) were shaved at the center of the back with electric clippers and then completely shaved by a shaver. From the next day, each sample of Example and Comparative Example was applied to the skin of the test part once a day, 0.2 ml per animal. A group of 10 animals was used for one sample. The base alone was applied as a control. 14 after the start of the experiment
On the day, the animals were sacrificed and the skin of the test area was photographed. Next, the photograph was taken into an image analyzer, and the area (A) of initial shaving and the area of hair growth (B) were determined. Further, the hair growth rate (%) = [(B) / (A)] × 100 Was calculated for each animal. Finally, the value obtained by dividing the average value of each group of the examples or comparative examples by the average value of the control group was used as a hair growth promoting effect in the determination.

(2) Test method for human hair growth promoting effect Male subject 1 in the thirties and forties with a decline in hair growth
The hair at the top of the head was shaved into a circular shape having a diameter of about 7 mm. One and three days after shaving, the method of Hayashi et al. (British Journal of Dermatology, 12
Volume 5, p. 123, 1991), the hair growth rate (growth length / day) was determined for the hair (about 30 to 40 hairs) at the target site, and the average value was calculated (A). Then, about 3 ml of the sample of the Example or Comparative Example was applied to each test subject twice daily in the morning and evening, and massaged well. The hair growth rate at the same site was measured in the same manner 3 months after the start of the test, and the average value (B) was calculated. The effect was determined by comparing the ratio (B) / (A) before and after use of each hair nourishing cosmetic.

(3) Practical test method 20 heads of male pattern baldness were applied to the heads twice daily in the morning and evening, and continuously 6 times.
The effect after applying the sample for a month was evaluated. The test result shows that “hairy hair has become bristle or bristles have increased” for each item of hair growth effect, hair loss prevention effect and dandruff prevention effect.
The number of respondents who said "hair loss has decreased" is shown.

Examples 1 to 13 and Comparative Examples 1 to 4 (Heartonic) In the raw material composition shown in Table 1, the active ingredients were blended as shown in Table 2 to prepare a hairnic, and the above-mentioned tests were carried out. . As the eugenol glycoside, a mixture of α-form and β-form (3: 7) or β-form was used.

[0021]

[Table 1]

[0022]

[Table 2]

(1) Preparation Method After dissolving the component (B) shown in Table 1 in the component (A), the component (C) was added, and the mixture was stirred and dispersed to fill a container. At the time of use, the contents were uniformly shaken and used.

(2) Characteristics Table 2 shows the results of various tests conducted on each heartnic. As shown in Table 2, in Comparative Examples 1 to 4, the mouse hair growth promoting effect and the human hair growth promoting effect were low, and the results of the practical test were also not good.

On the other hand, the hair nourishing cosmetics of the present invention of Examples 1 to 13 show a high mouse hair growth promoting effect and a human hair growth promoting effect, and the results of practical tests are also good.
Clearly good results were obtained over all of the tests.
In addition, when using the hair restoration cosmetics of any of the examples,
No inflammation or other symptoms considered to be side effects occurred in mice and humans, and it was clear that the hair restoration cosmetic of the present invention was also excellent in safety.

[0026]

EFFECTS OF THE INVENTION The hair nourishing cosmetic composition of the present invention has an activity of activating hair mother cells, and is excellent in hair growth effect, hair loss prevention effect, dandruff prevention effect and safety.

 ─────────────────────────────────────────────────── ─── Continuation of front page (72) Hiroyuki Nishio, 5-3 28, Kotobuki-cho, Odawara-shi, Kanagawa Cosmetics Research Institute, Kanebo Co., Ltd. (72) Noriaki Nakagawa 5--3, Shou-cho, Odawara-shi, Kanagawa No. 28 Kanebo Co., Ltd.Cosmetics Research Laboratory

Claims (1)

[Claims] 1. A hair nourishing cosmetic comprising nicotinic tartrate alcohol and eugenol glycoside.