JPH09176030A - Sebum secretagogue - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the above stimulating medicine containing the extract of BYAKUSI (root of Angellca dahurica) as an essential ingredient, having a sebum secretion-stimulating action for recovering a weakened sebum-secreting function and continuously supplying the sebum to skins, and useful for preventing and treating xeroderma, atopic dermatitis, etc. SOLUTION: This sebum secretion-stimulating medicine contains the extract of BYAKUSI (root of angellca dahurica) as an active ingredient. The BYAKUSI is originated from Angelica dahurica and its variety, and the extract is obtained by grinding the plant as such or after dried, and subsequently extracting the ground product with a solvent. The extract may be used as such or prepared into a concentrated extract, a diluted solution, etc. The solvent for the extraction is especially preferably a lower alcohol such as methanol or ethanol, water- containing methanol, etc. When the stimulating medicine is used as a preparation for external use for skin, the extract is preferably compounded in an amount of 0.01-30wt.%, preferably 0.1-10wt.%, based on the preparation for external use for skin.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a sebum secretagogue containing a juniper extract. The sebum secretagogue of the present invention is useful for the prevention and treatment of various diseases thought to be caused by a decrease in sebum secretion, for example, xerosis, atopic dermatitis, dry skin, cracks, cracks and the like. It can be used for a wide range of applications such as medicines, quasi drugs, and cosmetics.

[0002]

In the skin, sebum prevents evaporation of water,
It is necessary to maintain the smoothness of the skin, and also has the role of preventing foreign matter from entering the body. Also, sebum is necessary on the scalp to maintain the beauty of hair. However, when the function of sebum secretion declines due to aging, smoothness and moisture of the skin are lost. Oil such as creams, lotions, and emulsions, quasi-drugs, and cosmetics are replenished to the skin having a decreased sebum secretion function.

[0003]

However, although such an external oil replenishment formulation temporarily coats the oil on the skin surface, the oil is gradually lost due to friction and the like, and the effect is poor in sustainability.

It is an object of the present invention to provide a sebum secretagogue which restores the deteriorated sebum secreting function and promotes continuous oil supply to the skin.

[0005]

Means for Solving the Problems In view of the above circumstances, the present inventor has conducted diligent research to develop a sebum secretagogue, and as a result, the juniper extract restores the deteriorated sebum secreting function to the original, They have found that they have a sebum secretion promoting action that promotes continuous supply of oil to the skin, and completed the present invention. That is, the invention according to claim 1 of the present invention is
A sebum secretagogue, which comprises a juniper extract as an active ingredient.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION
Dahurica and its varieties) as the source plant, and the roots are used in Kampo for the purposes of antipyretic, analgesic, detoxifying, and draining. The juniper extract used in the present invention is obtained by solvent extraction of a dried or crushed plant body, and the extract may be used as it is, or may be a diluted solution, or may be a concentrated extract. It may be made into a dry powder by freeze-drying or the like, or may be prepared as a paste. Solvent extraction can be carried out by using water, a hydrophilic organic solvent, a water-containing hydrophilic organic solvent, other organic solvent, etc., in particular, lower alcohols such as methanol and ethanol, water-containing methanol, water-containing ethanol, propylene glycol, etc. It is desirable to extract using.

The sebum secretagogue of the present invention is useful for the prevention and treatment of various diseases thought to be caused by a decrease in sebum secretion, such as xeroderma, atopic dermatitis, dry skin, cracks and cracks. It is useful and can be used in a wide range of applications such as pharmaceuticals, quasi-drugs, and cosmetics. The dosage form of the sebum secretagogue of the present invention is arbitrary, and it may be a dosage form suitable for oral administration such as tablets, capsules, powders, oral liquids, fine granules and granules, and a liniment agent It is also possible to use a dosage form suitable for an external preparation for skin such as a lotion, an ointment and the like, and it can be used in any dosage form.

When used as a skin external preparation, the essential ingredient juniper extract can be blended in any concentration,
Usually, 0.01 to 30% by weight (hereinafter, simply referred to as "%"), preferably 0.1 to 10% in various external preparations for skin.
It is good to mix. The external preparation for skin containing the juniper extract of the present invention includes, in addition to the above-mentioned essential components, raw materials usually used for external preparations for skin, for example, surfactants, oils, alcohols, humectants, thickeners and antiseptics. Agents, antioxidants, chelating agents, pH adjusting agents, fragrances, dyes, ultraviolet absorbing / scattering agents, vitamins, amino acids, water and the like can be added.

Specifically, the surfactants include lipophilic glycerin monostearate, self-emulsifying glycerin monostearate, polyglycerin monostearate, sorbitan monooleate, polyethylene glycol monostearate, polyoxyethylene sorbitan. Monooleate, polyoxyethylene cetyl ether, polyoxyethylene sterol, polyoxyethylene lanolin,
Polyoxyethylene beeswax, nonionic surfactant such as polyoxyethylene hydrogenated castor oil, sodium stearate, potassium palmitate, sodium cetyl sulfate,
Anionic surfactants such as sodium lauryl phosphate, triethanolamine palmitate, sodium polyoxyethylene lauryl phosphate and sodium N-acylglutamate, cationic surfactants such as stearyl dimethylbenzyl ammonium chloride and stearyl trimethyl ammonium chloride, alkyl chlorides Aminoethylglycine solution,
Examples thereof include amphoteric surfactants such as lecithin.

The oil component includes castor oil, olive oil, cacao oil, camellia oil, palm oil, wax, jojoba oil, grape seed oil, vegetable oils such as avocado oil, animal oils such as mink oil and egg yolk oil, and honey. Waxes such as wax, spermaceti, lanolin, carnauba wax, candelilla wax, liquid paraffin, squalane, microcrystalline wax, ceresin wax, paraffin wax, hydrocarbons such as petrolatum, lauric acid, myristic acid, stearic acid, oleic acid , Natural and synthetic fatty acids such as isostearic acid, behenic acid, cetanol, stearyl alcohol,
Examples include natural and synthetic higher alcohols such as hexyldecanol, octyldodecanol, and lauryl alcohol; esters such as isopropyl myristate, isopropyl palmitate, isopropyl adipate, octyldodecyl myristate, octyldodecyl oleate, and cholesterol oleate. Can be.

Examples of moisturizers include polyhydric alcohols such as glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, polyglycerin, polyethylene glycol and dipropylene glycol, and amino acids such as sodium lactate and sodium pyrrolidonecarboxylate.
Examples thereof include MF components, water-soluble polymer substances such as hyaluronic acid, collagen, mucopolysaccharides and chondroitin sulfate.

As the thickener, sodium alginate,
Xanthan gum, aluminum silicate, quince seed extract, tragacanth gum, natural polymer substances such as starch,
Examples include semi-synthetic polymer substances such as methyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, soluble starch and cationized cellulose.

Preservatives include benzoate, salicylate, sorbate, dehydroacetate, paraoxybenzoate, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-. Trichlorocarbanilide, benzalkonium chloride, hinokitiol,
Resorcinol, ethanol and the like can be exemplified.

As the antioxidant, dibutylhydroxytoluene, butylhydroxyanisole, propyl gallate, ascorbic acid, etc., and as the chelating agent, disodium edetate, ethylenediaminetetraacetic acid salt, pyrophosphate salt, hexametaphosphate salt, citrate. Acid, tartaric acid, gluconic acid, etc., as a pH adjuster, sodium hydroxide,
Examples include triethanolamine, citric acid, sodium citrate, boric acid, borax, potassium hydrogen phosphate and the like.

Examples of the ultraviolet absorbing / scattering agent include 2-hydroxy-4-methoxybenzophenone, octyldimethylparaaminobenzoate, ethylhexylparamethoxycinnamate, titanium oxide, kaolin, talc and the like. As vitamins, vitamin A,
Vitamin B group, vitamin C, vitamin D, vitamin E,
Examples thereof include vitamin F, vitamin K, vitamin P, vitamin U, carnitine, ferulic acid, γ-oryzanol, α-lipoic acid, orotic acid and their derivatives. As amino acids, glycine, alanine, valine, leucine, isoleucine, serine, threonine,
Examples thereof include phenylalanine, tyrosine, tryptophan, cystine, cystine, methionine, proline, hydroxyproline, aspartic acid, asparagine, glutamic acid, glutamine, arginine, histidine, lysine and their derivatives.

The optional components are not limited to these. By appropriately blending the above-mentioned essential components and optional components, various skin external preparations, for example, as product forms such as creams, emulsions, lotions, beauty liquids, packs, undermake-ups, foundations, jellies, ointments and the like. Can be used.

Specific examples of the case where the sebum secretagogue of the present invention is used as a skin cosmetic are as follows (1) to (4). (1) For skin cream 0.1-10% of juniper extract, oil 20-70%, surfactant 2-7%, humectant 1-10%, trace amount of preservative, trace amount of fragrance, residual amount of purified water A skin cream containing. (2) In the case of emulsion 0.1-10% of juniper extract, 10-40% of oil content, 0-15% of alcohols, 1-5% of surfactant, 1 moisturizer
Emulsion containing -10%, thickener 0-2%, preservative trace amount, perfume trace amount, purified water remaining amount. (3) For lotions and beauty essences, juniper extract 0.1-10%, alcohols 5-20
%, Surfactant 0-2%, moisturizer 2-8%, thickener 0
2%, antioxidant 0-0.5%, chelating agent 0-0.1
%, PH adjuster 0 to 0.2%, dye 0 to trace amount, preservative trace amount, perfume trace amount, purified water remaining amount, beauty lotion. (4) In the case of a pack, the juniper extract 0.1 to 10%, alcohols 2 to 10
%, Moisturizing agent 2 to 10%, inorganic powder 0 to 20%, film forming agent 1
Packing agent containing 0 to 20%, trace amount of preservative, trace amount of fragrance, and residual amount of purified water.

[0018]

EXAMPLES Next, the present invention will be described specifically with reference to examples, but the present invention is not limited to the following examples.

[Preparation of juniper extract] To 20 g of dried juniper, 10 times amount (w / v) of 30% (v / v) aqueous ethanol solution was added and extracted in a water bath at 40 ° C. for 2 hours. The extract was filtered, ethanol was removed, and then freeze-dried to obtain 4.383 g of the extract. The following test examples were carried out using this juniper extract.

Test Example: Confirmation of sebum synthesis promoting action The method for measuring sebum synthesis is the method of Seki et al.
304-305, 1987). That is, the auricle portion of a male hamster was collected with a punch having a diameter of 10 mm to remove the cartilage portion, and Eagle-MEM medium (containing 10% fetal calf serum) containing [ ¹⁴ C] sodium acetate (2 μCi) was added.
Incubation was carried out at 37 ° C. for 6 hours with shaking. The auricle after the culture was washed with physiological saline and then treated with 2N NaBr to separate the epidermis and the dermis. Lipids were extracted from the obtained dermis with a chloroform-methanol (2: 1) solution, and the radioactivity was measured with a liquid scintillation counter to determine the amount of synthetic lipid. At this time, the left auricle of the same animal was used as the control side in the above medium, and the right auricle was used as the sample side in the above medium containing the juniper extract at a concentration of 500 or 1000 μg / ml. The promotion rate (promotion rate%) was calculated. Table 1 shows the results. The value of the promotion rate (%) in Table 1 is the average value of 5 animals.

[0021]

[0022]

[Table 1]

From the results shown in Table 1, it was confirmed that the extract of Juniperus japonicus has a sebum secretion promoting action. Next, Examples 1 to 4 will be shown as formulation examples of the juniper extract which has an action of promoting sebum secretion.

Example 1: Toner Lotion (Ingredient) 1. 1. Glycerin monostearate 1.0% by weight 2. Isopropyl palmitate 3.0 Lanolin 1.0 4. Glycerin 5.0 5. 5. Paraoxybenzoic acid methyl ester 0.1 Stearylcholaminoformylmethylpyridium chloride 1.5 7. Juniper extract 0.5 8. Ethanol 10.0 9. Fragrance, dye trace 10. Purified water Remaining amount (manufacturing method and application) Ingredients 1 to 8 were added to ingredient 10 and dissolved, and ingredient 9 was further added to prepare a lotion. This lotion is used for the prevention and treatment of various diseases thought to be caused by a decrease in sebum secretion such as xerosis, atopic dermatitis, dry skin, cracks, and cracks.

Example 2: Emulsion (blending component) 1. 1. Glyceryl ether 1.5% by weight 2. Polyoxyethylene (20) hydrogenated castor oil 1.5 3. Sorbitan monostearate 1.0 Squalane 10.0 5. Dipropylene glycol 5.0 6. Juniper extract 0.5 7. Fragrance trace amount 8. Purified water Remaining amount (production method and application) Components 1 to 5 were heated and dissolved at 70 ° C. On the other hand, component 6 is added to component 8 and heated at 70 ° C., the oil and fat solution (components 1 to 5) is added and emulsified, and then, while cooling, component 7 is added and cooled to room temperature to obtain an emulsion. Was prepared. This emulsion is used for the prevention and treatment of various diseases thought to be caused by a decrease in sebum secretion such as xerosis, atopic dermatitis, dry skin, cracks, and cracks.

Example 3: Ointment (blending component) 1. Solid paraffin 10.0% by weight 2. Beeswax 10.0 3. Squalane 10.0 4. Salicylic acid 0.3 5. Zinc white 0.56. Juniper extract 0.5 7. Fragrance trace amount 8. Vaseline balance (manufacturing method and application) Mix ingredients other than 7 above, and mix at 70 ℃
The mixture was heated to 100 ° C., gradually cooled, Component 7 was added and mixed on the way, and the mixture was cooled to room temperature to prepare an ointment. This ointment is used for the prevention and treatment of various diseases thought to be caused by a decrease in sebum secretion such as xerosis, atopic dermatitis, dry skin, cracks, and cracks.

Example 4: Bath agent (blending component) 1. Sodium sulfate 40.0% by weight 2. Sodium hydrogen carbonate 49.0 3. Extract of juniper extract 10.0 4. Fragrance, Dye 1.0 (Production method and application) The above components 1 to 4 were mixed to prepare a bath agent. This bath agent contains 30 g /
About 200 L is added and melted, and it is used for the prevention and treatment of various diseases thought to be caused by a decrease in sebum secretion such as xerosis, atopic dermatitis, dry skin, cracks, and cracks.

(Embodiment) A preferred embodiment of the present invention will be described. (1) A sebum secretagogue, which comprises 0.01 to 30% by weight, preferably 0.1 to 10% by weight, of a juniper extract as an active ingredient. (2) A skin external preparation for promoting sebum secretion, which comprises a juniper extract as an active ingredient.

[0029]

Industrial Applicability As described above, the sebum secretagogue of the present invention contains a juniper extract as an essential component, and various diseases thought to be caused by a decrease in sebum secretion, such as xeroderma It is useful for the prevention and treatment of atopic dermatitis, dry skin, cracks, cracks, etc., pharmaceuticals, quasi-drugs,
It can be used in a wide range of cosmetic applications.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical display area A61K 9/06 A61K 9/06 G

Claims (1)

[Claims] 1. A sebum secretagogue, which comprises a juniper extract as an active ingredient.