JPH09194334A - Hair nourishing agent - Google Patents

Abstract

(57) [Summary] [Objective] To provide a hair nourishing and hair-growth agent which is excellent in the effect of converting the resting phase of the hair cycle to the growing phase, is effective in preventing hair loss, is effective in hair-growth and hair-growth, and is excellent in safety. [Composition] Haran, Ukiwa, Angelica, Amomun, Allium, Ce
A hair nourishing and hair-growth agent containing at least one kind of plant extract selected from the group consisting of ntella and Spilanthes, or a mixture of two or more kinds thereof. [Effect] The above extract has a hair-growth / hair-growth effect.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION The present invention is directed to
ation Blume), Ukiwa (Lemna polyrrhiza L.), Angelica
sinensis, Amomun krervanh pierre, Alliumsativu
m, Centella asiatica urban, Spilanthes acmella
A highly safe hair nourishing hair that contains an extract extracted from Murr.'S water or / and an organic solvent and is highly safe.
Regarding hair restorer.

[0002]

2. Description of the Related Art Hair has a great influence on appearance,
It occupies a very important position in beauty. Alopecia is a deeply worrisome, with no established cure. There are alopecia and congenital types of alopecia, and many studies have been conducted to date on the cause of onset and the mechanism of development, but there are many unclear points. Nevertheless, there are many hair nourishing agents on the market, but the current situation is that few have sufficient effects.

Currently, the causes of hair loss are endocrine abnormalities, hair cycle abnormalities, autonomic nerve disorders, poor blood circulation, nutritional disorders, and others (hereditary, aging, etc.). Conventional hair-growth ingredients include hormones such as estrogen (JP-A-60-38313),
Vitamin E, B ₂ , B ₆ , vitamins such as biotin and pantothenic acid, other amino acids (peptide substance: JP 61-7209 A), crude drug extracts such as assembly extract, anti-inflammatory agents such as diphenhydramine hydrochloride, glycerin. And the like, scalp stimulants such as Photosensitizer No. 301, bactericides such as hinokitiol, and cooling agents such as ethanol. In addition, recently, 5 which is an androgen activating enzyme
Glycyrrhetinic acid, randic acid and the like are used as α-reductase activity inhibitors, and pentadecanoic acid and the like are used as a nutritional supplement.

However, very few of the above-mentioned effect substances exhibit a sufficient effect, and those having a certain degree of effect have strong skin irritation, and there are some which cause a restriction on the compounding amount and some which hinder continuous use. The current situation is that there are still problems.

Due to the above-mentioned background, recently, it has been widely seen that various natural products are extracted and the extract is mixed with a hair nourishing / hair-growing agent.

[0006] For example, Zui Zui [Euphorbia lathyris L.]
Seeds or daikon [Knoxia corymbosa WILLD. Or E
uphorbia sieboldiana MORR. et DECENE.], a water-soluble organic solvent alone or an active ingredient extracted with these water-containing organic solvents from the root herbal medicine (JP-A-63-198612),
Seeds of sesame [Ricinus communis L.] or Kamala [M
allotus philippinensis MULL.-ARG.] fruit epidermis glandular hair and tufted hair herb crude drug extracted with a water-soluble organic solvent alone or with these water-containing organic solvents (JP-A-63)
-198614), a tea leaf extract (Japanese Patent Application Laid-Open No. 63-28009) heat-treated under anaerobic conditions, an extract from Shikimi (Japanese Patent Application Laid-Open No. 63-303915),
Seed or bamboo leaves of Beninasa hispida Cogn.
[Lophatherum gracile Brongh] Leaves or carrot [Pla
ntago asiatica L.] seed crude drug, the active ingredient extracted by a water-soluble organic solvent alone or these water-containing organic solvents (JP-A-64-38011). The active ingredients derived from various natural products are said to be used as they are, or after being dissolved, dispersed and diluted with an appropriate solvent or the like, and blended in a base.

The hair-growth / hair-growth agent is used by expecting a local effect by combining the above-mentioned hair-growth ingredients singly or in combination, and is used for hair-growth, promotion of hair growth, dandruff, itch, inflammation, and thinning hair.・ We try to prevent hair loss, and aim to achieve a comprehensive hair-growth and hair-growth effect.

[0008]

[Problems to be Solved by the Invention]
A wide variety of substances having a hair-growth effect have been proposed, but these conventional hair-growth / hair-growth causes side effects, and hair-growth and hair-growth are not always sufficient. The development of agents is desired.

Recently, attention has been paid to the action of converting the resting phase of the hair cycle into the growing phase, and attempts have been made to utilize the active substance as a hair-growth / hair-growth agent.

The reason why the above-mentioned effect of converting from the resting period to the growing stage is used as a hair-growth / hair-growth agent is that alopecia has a large proportion of hair in the resting period during hair growth process. Because. Therefore, focusing on the hair cycle of hair, we aimed to develop a hair nourishing and hair-growing agent that is effective in stimulating hair roots in the resting period and accelerating the transition to the growth stage, and was excellent in promoting hair regeneration in the resting period. We have been conducting research to find effective substances.

[0011] Therefore, the present inventors have an excellent effect of shifting a resting period to a growing period from a natural product which is generally considered to be safe on the basis of the above background, and is effective in preventing hair loss and hair-fostering and hair-growing effects and is safe. As a result of searching for and testing various substances, it was found that substances extracted from water or / and organic solvents of various plants can solve this problem, and completed the present invention.

[0012]

In view of the above situation,
As a result of diligent research, the present inventors have found that the lily family Halan, the duckweed buoyancy, the umbilical family Angelica sinensis, the ginger family Amomun krervanh pierre, and the lily family Allium sativu
m, Centella asiatica urban of Apiaceae, Spi of Asteraceae
It was clarified that the extract group of lanthes acmella Murr. extracted with water or / and an organic solvent transforms the resting phase of the hair cycle into the growing phase, and exhibits excellent effects on hair growth and hair growth. did it.

The extract of the present invention can be used as a dried product after removing the solvent, or can be used in a state of being dissolved in the solvent. Then, a hair nourishing / hair growth agent can be prepared by mixing at least one kind or two or more kinds of this extract.

Since the various plant extracts described above are not toxic to the human body and are safe to the skin and scalp, the amount to be added to the hair nourishing / hair-growth agent is not particularly limited and may be in a wide range. Can be selected with. Amount of extract (dry matter equivalent)
Is appropriately used within the range of 0.01 to 10% by weight, and optimally within the range of 0.1 to 3% by weight. This is because when the amount is 0.1% by weight or less, the hair-growth effect is weak, and even when the amount is 3% by weight or more, a significant difference in effect is hardly recognized and it is not efficient.

The raw material used in the present invention may be a raw product or a dried product of the various plants described above. Then, various active ingredients are extracted from the various plant bodies with water and / or an organic solvent.

Solvents used for extracting the active ingredient from the various plants mentioned above include water, lower monohydric alcohols (eg methanol, ethanol, n-butanol, etc.), lower polyhydric alcohols (eg ethylene). Glycol, propylene glycol, 1,3-butylene glycol, glycerin, etc.), ethers (eg, diethyl ether etc.), ketones (eg, acetone, ethyl methyl ketone etc.), esters (eg ethyl acetate), halogenated alkanes ( (Eg, dichloromethane, chloroform, etc.), and other solvents selected from the group consisting of aromatic hydrocarbons such as benzene and toluene.

These solvents can be used alone, but a mixed solution of two or more kinds, for example, a 20-80% ethanol aqueous solution, a benzene: ethyl acetate (4: 1) mixed solution, 1,
It can also be used as an aqueous solution of 3-butylene glycol.

Further, the hair nourishing / hair-growing agent of the present invention contains at least one kind of extract extracted from the plant body with water or / and an organic solvent in various cosmetic bases or the like to give a hair tonic, It can be applied to cosmetics such as hair cream, hair liquid, hair gel, hair blow, hair mousse, hair lotion, pomade, hair shampoo, hair rinse and emulsion. Further, the cosmetics can be applied in various shapes such as a solution, a sol, a gel, an emulsion, an ointment, an oil, a wax and a spray.

Further, the hair nourishing and hair-growing agent of the present invention can be used in combination with other known hair nourishing and hair-growing agents, and an excellent synergistic effect can be expected. Further, after confirming that the hair nourishing and hair-growing agent of the present invention is stable against various surfactants, solvents, pigments, fragrances, preservatives, antioxidants, moisturizers and other various additives, It is also possible to use together with various additives of the above.

The plant extract of the present invention can be expected not only to shift the resting phase of the hair cycle to the growing phase, but also to have secondary effects such as moisturizing effect.

The present invention will be described in more detail below with reference to examples, but the present invention is not limited thereto.

[0022]

【Example】

[Preparation of Various Extracts from Plants] 50 parts of an extraction solvent is added to 1 part of each dried product of the above plants, and extraction is performed at room temperature for about 3 days. After extraction, the supernatant is collected and filtered. Water or / and an organic solvent are distilled off from this extract under reduced pressure to obtain extracts from each plant with various solvents.

Formulation Example 1 Hair Tonic (wt%) [Component] Ethanol 60 Polyoxyethylene hydrogenated castor oil (EO 60 mol) 0.5 Glycerin 3 Menthol 0.2 Orchid extract (dry matter) 3 Fragrance and Dye Appropriate amount Ion-exchange water Total amount is 100

Formulation Example 2 Shampoo (wt%) [Component] Polyoxyethylene alkyl ether sodium sulfate (EO 2 mol) 15 Coconut oil fatty acid diethanolamide 5 Glycerin 3 Floating extract (dry matter) 0.5 Ethanol 5 Fragrances and dyes Appropriate amount Ion-exchanged water Total amount is 100

Formulation Example 3 Hair cream (% by weight) [Component] Liquid paraffin 20 Solid paraffin 3 Polyoxyethylene cetyl ether (EO 15 mol) 2 Sorbitan sesquioleate 1 Angelica extract (dry product) 1 Carboxyvinyl polymer 0 1 Ethanol 10 Potassium hydroxide 0.1 Glycerin 3 Fragrance and antiseptic proper amount Ion-exchanged water Total 100

Formulation Example 4 Hair lotion (% by weight) [Component] Ethanol 20 Glycerin 3 Polyoxyethylene sorbitan monolaurate (EO 20 mol) 1 Amomun extract (dry product) 0.5 Halan extract (dry product) ) 0.5 Fragrance and antiseptic Appropriate amount Ion-exchanged water 100

Formulation Example 5 Ointment (% by weight) [Ingredient] White beeswax 5.0 Purified lanolin 5.0 Allium extract (dry product) 1.0 Vaseline 89.0

The hair growth effect of the present invention will be specifically described with reference to examples. The following experiment was conducted to confirm the effect of the present invention.

[Animal Hair Growth Experiment Method] C3H mouse (male,
Hair (dormant period) on the back of 7 weeks old was shaved with an electric clipper and then completely removed using a hair removing foam. Then, from the day after the hair removal, the sample is removed from the hair removal area by 0.1
It was applied by ml. The sample was adjusted to a concentration of 3 (w / w)% with a 50% (w / w) ethanol aqueous solution. Six mice were used per group for one sample. From the day when the hair regrowth started, it was evaluated with the naked eye according to the criteria shown below, the evaluation points were given one by one, and the evaluation points for six animals were summed to obtain the average evaluation point per group, The speed of reproduction was compared.
Table 1 shows the results of the hair growth evaluation 15 days after the start of application. Student-T test for comparison of control points
Was used.

[Judgment Criteria for Evaluation Points of Hair Growth Effect] Evaluation Points Judgment Criteria 4 ...・ Growth up to 3/4 range of hair removal area 2 ・ ・ ・ ・ ・ ・ ・ ・ Growth up to 2/4 range of hair removal area 1 ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ 1 of hair removal area Growth up to / 4 range ..... No hair growth is observed.

[0031]

[Table 1]

As is clear from the results shown in Table 1, these plant extracts showed a high effect on hair regeneration. See also Student
From the statistical results using the -t test, it was confirmed that various plant extracts had a remarkable hair regeneration promoting effect at a risk rate of 10% or less compared to the control.

[Test Method for Hair Growth Effect] Male pattern baldness patient 13
A name (ages 30 to 63 years old) was used as a subject, and a method of uniformly applying 2 ml of the hair tonic prepared in Formulation Example 1 to the head twice a day was used. For the evaluation, the condition of the hair at the application site was observed 3 months and 6 months after the test period according to the following evaluation criteria.

[Judgment Criteria for Human Hair Growth Effect] Extremely Effective ・ ・ ・ ・ ・ ・ ++ Effectively ・ ・ ・ ・ ・ ・ ・ ・ + Positively Effective・ ・ ・ ・ ・ ・ ・ ± No effect ・ ・ ・ ・ ・ ・ ・ ・ ・

[0035]

[Table 2]

In Table 2 above, a clear hair-growing effect was recognized in the plant extract. In addition, no skin abnormalities such as papules and erythema were observed in this test.

[0037]

EFFECT OF THE INVENTION The extract of the present invention extracted with water or / and an organic solvent has an effect of shifting the resting phase of the hair cycle to a growing phase, that is, an excellent hair-growing / hair-growing effect.

Further, the various extracts mentioned above are products extracted from natural products which are generally considered to be safe, and are excellent in safety for the living body.
The hair nourishing agent has a very excellent hair-growth effect.

Continuation of front page (51) Int.Cl. ⁶ Identification number Office reference number FI Technical indication location A61K 35/78 ADA A61K 35/78 ADA N ADS ADSV (72) Inventor Ryoichi Yokoji 1-11 Ebie, Fukushima-ku, Osaka No. 17 Inside Naris Cosmetics Co., Ltd.

Claims (1)

[Claims] 1. A sprout (Aspidistra elation Blume)
(Lemna polyrrhiza L.), Angelica sinensis, Amomun
krervanh pierre, Allium sativum Centellaasiatic
Hair restorer and hair restorer characterized by containing at least one kind or a mixture of two or more kinds of extracts of a urban and Spilanthes acmella Murr.