JPH09249541A - Dentifrice - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a dentifrice exhibiting such actions as to smooth the mucous membrane in the oral cavity, neutralize the lactic acid produced in the oral cavity, suppress developing dental caries and adjust the pH in the oral cavity, by using a specific natural substance beneficial to human health. SOLUTION: This dentifrice contains pref. 0.01-10.00 (esp. 0.10-1.00)wt.% of chitosan of the formula ((n) is 2-4500 on average) [specifically, low-molecular weight chitosan with (n) being 2-150 and/or high-molecular weight chitosan with (n) being 150-4500]. The chitosan is obtained by treating chitin widely found in crustacean and others with a concentrated alkali solution to effect deacetylation (pref. 70-85% or so in deacetylation degree). The chitosan, which has antimicrobial effect and germicidal effect, exhibits a wide antimicrobial spectrum against bacteria.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention is capable of smoothing the mucous membrane in the oral cavity, neutralizing lactic acid and the like generated in the oral cavity by a chemical reaction, and reducing or eliminating a direct factor that corrodes teeth, and The present invention relates to a new type of dentifrice (including mouthwash) having features such as adjusting the internal pH.

[0002] The present invention relates to a dentifrice which has, in addition to such characteristics, the characteristics such that the growth of oral bacteria can be suppressed by a natural substance which is beneficial to human health.

[0003]

2. Description of the Related Art Dentifrices include dentifrices mainly having a cleaning action and dentifrices having a cleaning action and a pharmacological effect. The dentifrice is used in a broad sense to include a mouthwash (used alone) in addition to a general dentifrice used in combination with a toothbrush.

[0004] Dentifrices are classified into powder toothpaste (abrasive content of 95% or more), moisturizing toothpaste (abrasive content of around 70%), and toothpaste according to the shape of the toothpaste. Distinguishing agents (abrasives 60% or less), liquid dentifrices (low viscosity liquid formulations) and liquid dentifrices (no abrasives added) (Mitsui Takeo ed .: New Cosmetics (Nanzandou, 1994)) p49
9-501).

The cleaning action of the dentifrice is mainly to cleanse the oral cavity by removing various deposits in the oral cavity, and in addition to that, it whitens the teeth and imparts a refreshing feeling to the oral cavity. Is also added. The deposits in the oral cavity include deposits on teeth and oral mucosa. The former includes plaque, tartar, and colored deposits, and the latter includes deposits on the gingiva and buccal mucosa (edited by Takeo Mitsui: New Cosmetics (Nanzando, 1
994) p501). In a conventional dentifrice, deposits (typically, plaque) in the oral cavity are physically removed by an abrasive (a main component of the dentifrice) which is a dentifrice component.

In the conventional dentifrice, a foaming agent or the like is used in combination to further improve the physical plaque removing function of the abrasive. Abrasive, which is the main component of dentifrice, is a powder of an inorganic substance, which is (a) tasteless and odorless and white, and (b) a hardness that does not damage the enamel of teeth (that is, 3 or less). Hardness), (c) a small particle size of about 1 to 20 μm, (d) a pH in the range of weakly acidic to weakly alkaline, (e) water-insoluble, and (f) toothpaste. It satisfies conditions such as good compatibility with other components of the agent (foaming agent, flavoring agent, wetting agent, binder, sweetening agent and preservative). In practice,
Calcium carbonate, magnesium carbonate, dicalcium phosphate, silicic acid anhydride, aluminum hydroxide, calcium pyrophosphate, insoluble sodium metaphosphate and others have been used as abrasives.

On the other hand, the presence of various types of oral bacteria has been confirmed, and it is known that oral bacteria, food residues and salivary organic substances are mutually involved in the formation of deposits in the oral cavity. It is also established that oral bacteria influence the development of caries teeth, alveolar pyorrhea and gingivitis and the deposition of tartar.

[0008] In particular, a mucus tooth is found in the plaque attached to the tooth.
Streptococcus m, the causative fungus of tooth decay
utans (streptococcus mutans) produces a glucan, which is a water-insoluble and sticky substance from sucrose by a glucose transferase that is localized on the surface layer of the cells, and firmly adheres to teeth. It has been established that lactic acid is produced by energy metabolism and that lactic acid is produced by demineralization of tooth enamel (see Takeo Mitsui, Shin Cosmetics (Nanzandou, 1994) p701, etc.).

Therefore, a dentifrice for the prevention of caries teeth has (a) a function of removing deposits (typically plaque) of teeth,
(B) A function of preventing tooth decalcification due to contact with lactic acid to enhance acid resistance of teeth, (c) A bactericidal function of causative bacteria of caries teeth,
(D) It is necessary to have a function of inhibiting the decomposition of glucan produced from sucrose and the biosynthesis of glucan. The function of removing the deposits such as plaque in (a) is based on the physical polishing action of the abrasive compounded in the dentifrice. To increase the acid resistance of the tooth in (b), the fluorine ion of the fluorine compound contained in the dentifrice is replaced with a part of the structure of the hydroxyapatite of the tooth enamel, so that the tooth enamel is highly acid resistant fluoroapatite. This is due to The fluorine compound compounded in the dentifrice is sodium fluoride, sodium monofluorophosphate, tin fluoride or the like. The sterilization of the cavities causing cavities in (c) is with a chlorhexidine gluconate, cetylpyridinium chloride or isopropylmethylphenol sterilant (see Takeshi Mitsui, Shin Cosmetics (Nanzandou, 1994) p171, etc.). . The inhibition of glucan degradation and biosynthesis in (d) is inhibited by a degrading enzyme such as dextranase incorporated into a dentifrice. The main purpose of oral hygiene with dentifrice is this strep
It is the prevention of caries teeth caused by the presence of bacteria such as tococcus mutans.

Bacteroids are used as oral bacteria.
es, Bacterionema, Eikenell
a, Fusobacterium, Actinomyc
es, Trepoema, Stoptococcu
s, Stephlococcus, Stoptoco
The presence of cci, Veillnella and other cells has also been confirmed.

Since the main cause of periodontal disease and other diseases is plaque adhering to teeth, a bactericide or the like for suppressing plaque is added to the dentifrice to prevent periodontal disease. Has been done.

[0012]

The conventional dentifrices have various problems such as the following (1) to (3) from the viewpoint of effective oral hygiene. (1) Conventional bactericides for dentifrices (chlorhexidine gluconate, cetylpyridinium chloride or isopropylmethylphenol) are allowed to be added to dentifrices, but from the viewpoint of maintaining human health, There was a problem that it should be refrained from use on the human body. (2) Production of glucan (water-insoluble and viscous substance) and lactic acid due to the activity of fungus tooth-causing bacteria, food residues, and salivary organic matter in dental plaque, etc. According to a dentifrice, there is only a method of inhibiting glucan by decomposing it with an enzyme such as dextranase. Therefore, once lactic acid due to glucan decomposition is generated in the oral cavity, it is impossible to prevent tooth corrosion, and the pH in the oral cavity becomes abnormal. (3) Depending on the conventional dentifrice, even if some plaque or the like is physically removed by the abrasive, glucan is produced in the remaining plaque due to the activity of the fungus causing the tooth decay. If this happens, there is a problem in that the probability that the tooth decay will increase.

Therefore, an object of the present invention is to solve the above problems and provide a dentifrice (that is, a new type of dentifrice) having the following characteristics (a) to (e). . (A) A toothpaste component neutralizes a hydroxy acid (typically lactic acid) generated from dental plaque or the like, thereby directly and immediately removing factors that cause tooth corrosion, thereby preventing tooth corrosion. (B) features such as (b) neutralization of organic acids such as hydroxy acids generated in the oral cavity to adjust the pH in the oral cavity, (c) oral cavity due to substances that are beneficial to human health Features such as the ability to prevent the growth of internal bacteria, (d) features such as smoothing and moisturizing the mucous membrane in the oral cavity, and (e) the whole dentifrice can be composed of natural products Etc.

[0014]

Means for Solving the Problems The first invention (claim 1)
In the dentifrice according to the present invention described in 1), one or two or more kinds of chitosan having an average value of the number n of repeating units represented by the following formula (1) is in the range of 2 to 4,500. Agent, toothpaste, liquid dentifrice, or one mixed with a liquid dentifrice.

[0015]

Embedded image The dentifrice according to the second invention (the invention according to claim 2) is a low molecular weight chitosan having an average value of the number n of repeating units represented by the following formula (1) in the range of 2 to 150: It is characterized by being mixed with a moisturizing dentifrice, a toothpaste, a liquid dentifrice or a liquid dentifrice.

[0016]

Embedded image The dentifrice according to the third invention (the invention according to claim 3) has a high molecular weight in which the average value of the number n of repeating units represented by the following formula (1) is more than 150 and 4,500 or less. Chitosan is characterized by being incorporated into a moisturizing dentifrice, a toothpaste, a liquid dentifrice or a liquid dentifrice.

[0017]

[Chemical 6]

[0018]

BEST MODE FOR CARRYING OUT THE INVENTION

[First Dentifrice According to the Present Invention] The first dentifrice according to the present invention has the above-mentioned constitution. The first aspect of the present invention will be specifically described below. < Chitosan > Chitosan is a linear chain in which 2-amino-2-deoxy-D-glucose (compound in parentheses of formula (1)) in which an acetyl group is removed from an acetamide group of chitin is β-1,4 bonded. Is a polysaccharide.

In the formula (2), glucosamine is β-1,4.
It shows the combined state. 2-Amino-2-deoxy-D-glucose is often identified by the trivial name glucosamine. In this specification, the term “glucosamine” which is a common name is used for convenience.

[0020]

Embedded image Chitosan is industrially obtained by treating chitin widely existing in crustaceans and the like with a concentrated alkaline solution to deacetylate it. Chitosan is the degree of deacetylation (that is, the ratio of N-acetylglucosamine to glucosamine)
Is about 60% or more and less than 100% is industrially used. And, in particular, the degree of deacetylation is 70 to
About 85% (that is, the chitosan content is 70-85%
It is actually used a lot.

The chitosan used in the present invention (first to third inventions) has a deacetylation degree of about 60% or more and less than 100%. Therefore, the term “chitosan” of the present invention is used to mean chitosan having a deacetylation degree of about 60% or more and less than 100% in terms of the degree of deacetylation. If the degree of deacetylation is large, the reactivity with organic acids will increase, so
The chitosan used in the present invention has a deacetylation degree of about 70%.
It is preferable that it is above.

In the first aspect of the present invention, dentifrice is blended with chitosan having an average value of the number n of repeating units represented by the formula (1) in the range of 2 to 4,500. In the first aspect of the present invention, even if chitosan having a small number of n, which is sometimes referred to as chitosan oligosaccharide, is used, the effect of the present invention can be enjoyed. Is also included.

It is known that the solubility of chitosan changes depending on the molecular weight, and chitosan having a large molecular weight is
It is insoluble in water, organic solvents and alkaline solutions, and soluble in inorganic and organic acids. The inorganic acid is, for example, dilute hydrochloric acid or dilute nitric acid. The organic acid is, for example, carboxylic acid, substituted carboxylic acid, amino acid, acidic amino acid or ascorbic acid. The substituted carboxylic acid is one in which hydrogen of the carboxylic acid matrix is replaced with a hydroxyl group, an alkoxy group or an oxo group.

Specific examples of organic acids include acetic acid,
Examples include citric acid, malic acid, lactic acid, glutamic acid or ascorbic acid. Chitosan having a small molecular weight is generally soluble in water or the like. Chitosan has the property of a polycation and also functions as a coagulant (Uchida
Yasushi: “Chitosan,” Nisoe Association News, VOL. 7, NO.
8).

Chitosan is industrially obtained by collecting chitosan having a different number of glucosamine (the number n in the formula (1)) in a certain range (that is, an aggregate of chitosan having different molecular weights). Graded chitosan (for example, graded chitosan having an average molecular weight of 10,000).

The grade of chitosan used industrially has a glucosamine number of, for example, 2 to 10 and 15 to 15.
20, 150-370, 500-750, 1,200-
A typical one is 3,200 or 3,200 or more. In the first aspect of the present invention, if the average value of the number of glucosamine (the number n in the formula (1)) is in the range of 2 to 4,500, a chitosan having a single or a plurality of grades is used as a dentifrice. Can be blended with The use of chitosan having an average value of the number of glucosamines (the number n in the formula (1) of 2 or more is because organic acids generated in the oral cavity (typically, when more glucosamines are present in the dentifrice) This is because the neutralization reaction with lactic acid generated from plaque) becomes possible. The use of chitosan in which the average value of the number of glucosamine (the number n in the formula (1)) exceeds 4,500 is excluded because chitosan having a molecular weight exceeding that is a neutralization reaction with an organic acid generated in the oral cavity. Because the speed of will slow down.

Chitosan has antibacterial and bactericidal properties,
It is known to show a broad antibacterial spectrum against bacteria. Regarding the antibacterial property of chitosan, for example, in an experiment examining the effect of chitosan concentration on the growth of Escherichia coli,
It has been reported that growth of Escherichia coli is inhibited at a chitosan concentration of 0.02% or more (see Yasushi Uchida: "Chitosan", Nisso Kyoho, VOL.7, NO.8, etc.). It has been reported that chitosan has a similar growth inhibitory effect on other Gram-negative bacteria and Gram-positive bacteria.

Regarding the bactericidal activity of chitosan, for example, in an experiment in which the bactericidal activity of chitosan against Escherichia coli was examined, it was reported that the bactericidal rate was 91% depending on the conditions (Yasu Uchida: "Chitosan", Japanese Sozo Association Bulletin, VOL.
7, NO. 8 etc.).

Therefore, by blending chitosan, it is possible to impart its antibacterial and bactericidal properties to the dentifrice.

In the first aspect of the present invention, an organic acid salt of chitosan can be used in combination with chitosan. The organic acid salt of chitosan is typically a carboxylic acid, a substituted carboxylic acid, an amino acid, an acidic amino acid, or the like. Specific examples of the organic acid salt of chitosan include salts of acetic acid, citric acid, malic acid, lactic acid, glutamic acid or ascorbic acid. For example, an organic acid salt of high molecular weight chitosan can be used in combination to increase the viscosity and thereby reduce the amount of binder. In the first aspect of the present invention, low molecular weight chitosan may be used, low molecular weight chitosan and high molecular weight chitosan may be used in combination, or high molecular weight chitosan may be used.

However, typical specific examples of the effects of the present invention are the case where one or more low molecular weight chitosans are used and the case where low molecular weight chitosan and high molecular weight chitosan are used in combination.

In the present invention, it is possible to use either a single chitosan or an aggregated chitosan. Further, the chitosan aggregate may be an aggregate of chitosan having the same molecular weight or an aggregate of chitosan having different molecular weights. Therefore, the “one kind” of chitosan of the present invention may consist of a single chitosan, an aggregate of chitosan having the same molecular weight, or an aggregate of chitosan having different molecular weights. Low molecular weight chitosan The low molecular weight chitosan has an average value of the number of glucosamines (the number n in the formula (1)) in the range of 1 to 150.

Chitosan becomes soluble in water due to its low molecular weight. Therefore, in the present invention, a low-molecular weight chitosan is dissolved in water in a dentifrice or blended in a state close thereto, and when the dentifrice is used, the low-molecular weight chitosan easily reacts with an organic acid such as a hydroxy acid. You can Therefore, when lactic acid is produced from glucan in dental plaque,
Immediately, the lactic acid and the low molecular weight chitosan undergo a neutralization reaction, thereby reducing the acidity in the oral cavity and directly reducing the tooth corrosion factor. Therefore, it is possible to obtain a caries tooth preventive effect which cannot be obtained by the conventional dentifrice.

Further, the pH in the oral cavity is normally maintained due to the decrease or disappearance of the organic acid generated in the oral cavity. Moreover, although chitosan has a low molecular weight, it has a certain degree of antibacterial property, so that the low molecular weight chitosan suppresses the growth of oral bacteria.

The low molecular weight chitosan has, for example, a degree of deacetylation of about 80 to about 85% and an average number of glucosamine (ie, the number of n in the formula (1)) of 10 to 20. About 5 is a light yellowish brown powder, 5
The weight% aqueous solution has a viscosity of about 5 to 10 cps. The pH of the aqueous solution in which the small amount is dissolved is about 6 to 8 (measured by the glass electrode method). Further, the purified product has a general viable cell count of 3 × 10 3 / g or less (measured by the standard agar plate culture method), and is adjusted to be negative for the solar bacterium group (measured by the dezoxycholate culture method).

For water solubilization of chitosan, oligomerization by molecular weight cleavage, derivatization (carboxymethyl chitosan etc.), adjustment of deacetylation degree, introduction of hydrophilic group (hydrophilic polyoxyethylene / polyoxypropylene chitosan etc.) Methods such as phosphorylation and sulfation (Japanese Patent Laid-Open No. Sho 62-62).
-221615 gazette). Chitosan, which has become water-soluble due to the reduction in molecular weight, is excellent in reactivity (for example, reaction rate) with the hydroxy acid generated in the oral cavity, and has a good taste imparted to the dentifrice. High molecular weight chitosan In the dentifrice of the present invention, high molecular weight chitosan can be used alone or in combination. The high molecular weight chitosan is one in which the average value of the number of glucosamine (ie, n in the formula (1)) as the repeating unit is in the range of more than 150 and less than 4,500.

The high molecular weight chitosan is poorly soluble or insoluble in water, and becomes more insoluble in water as the number n of repeating units increases (that is, the molecular weight becomes higher in molecular weight).

However, high molecular weight chitosan can be made water-soluble by forming a salt with a water-soluble organic acid (eg, hydroxy acid, acidic amino acid). Therefore, high molecular weight chitosan gradually dissolves in lactic acid produced from glucan in plaque or the like, and completes the neutralization reaction with lactic acid produced from glucan in plaque or the like. Therefore, the compounding of high-molecular-weight chitosan completely prevents the generation of tooth decay. Since the high molecular weight chitosan also has the ability to inhibit bacterial growth, the addition of the high molecular weight chitosan also makes it possible to impart the bacterial growth inhibiting ability to the dentifrice.

In the dentifrice of the present invention, the presence / absence of the high molecular weight chitosan and the quantitative ratio with the high molecular weight chitosan can be determined based on the antibacterial property of the dentifrice, the organic acid scavenging ability and other factors. Regarding the high molecular weight chitosan compounded in the dentifrice of the present invention, when only the high molecular weight chitosan is compounded, the high molecular weight chitosan and the low molecular weight chitosan may be used in combination.

The total amount of chitosan is 0.01.
.About.10.00% by weight (based on the weight of the whole dentifrice), preferably 0.05 to 5.00% by weight, more preferably 0.1.
It is 10 to 1.00% by weight. < Dentifrice > The dentifrice targeted by the present invention is a moisturizing dentifrice,
Toothpaste, liquid dentifrice or liquid dentifrice (so-called,
Mouthwash) etc. The present invention can be applied to various aspects and kinds as long as they are generally recognized as a moisturizing dentifrice, a toothpaste, a liquid dentifrice or a liquid dentifrice. Thus, for example, the “dentifrice” of the present invention includes those generally referred to as semi-dentifrice. Further, as long as the effect of the chitosan blending is not particularly reduced, there is no particular limitation on the kind of the component to be added to the moisturizing dentifrice, toothpaste, liquid dentifrice or liquid dentifrice. Note that the dentifrice can maximize the effects of the present invention when it is a toothpaste.

Further, in the dentifrice of the present invention, in addition to the original effects of chitosan (such as lactic acid neutralizing action and antibacterial action), various other actions of chitosan (for example, as a sweetener) Action and the like) can be added to the dentifrice. A specific effect can be produced in combination with the specific component being blended.

Each dentifrice of the invention can be typically classified by the numerical value of the content of the abrasive. That is, about 70% of an abrasive is a moisturizing dentifrice, 60% or less of an abrasive is a toothpaste, a low-viscosity liquid formulation is a liquid dentifrice, and a non-abrasive formulation is a liquid dentifrice. However, in the dentifrice of the present invention, when water is present, the effect of the present invention can be enjoyed even if the amount of the abrasive is small. Therefore, even if the content of the abrasive exceeds 60%, it can be included in the range of the toothpaste of the present invention.

In the present invention, the dentifrice basically contains various components such as an abrasive, a foaming agent, a binder, a flavoring agent, a wetting agent and a preservative. There are no particular restrictions on the abrasive to be added to the dentifrice of the present invention, and any abrasive that can be used as an abrasive for dentifrice can be used.

As the dentifrice, for example, calcium carbonate, calcium pyrophosphate, dicalcium phosphate, calcium hydrogen phosphate, calcium hydrogen phosphate / anhydrous, calcium hydrogen phosphate / dihydrate, insoluble sodium metaphosphate, precipitation Examples thereof include silica, aluminosilicate, aluminum oxide, magnesium carbonate, and magnesium triphosphate. Particularly in the dentifrice of the present invention,
It has been found in the present invention that chitin can be compounded as an abrasive so that it also acts as a scrubbing agent. or,
It has also been found in the present invention that chitin can be incorporated into dentifrices to give them unique natural sweetness.

The chitin to be added to the dentifrice has the repeating unit number of 150 to 4,500, and if it is 30 to 200 mesh (preferably 80 to 100 mesh), such an effect can be obtained by adding it to the dentifrice. It is also found in the present invention that it is easy to enjoy. The repeating unit of chitin is the one in which the NH2 group in formula (1) is changed to an NHCOCH3 group.

As the foaming agent, a surfactant which is excellent in foaming property, dispersibility, suspension property, penetrability and detergency is generally used. The foaming agent can be used in the dentifrice of the present invention. This is because the effect of chitosan can be further improved by using a foaming agent. As the surfactant, sodium lauryl sulfate, sodium lauroyl sarcosine, sodium alkylsulfosuccinate, sodium coconut oil fatty acid monoglycerin sulfonate, sucrose fatty acid ester and the like are generally used.

In the dentifrice of the present invention, the cleaning effect of the dentifrice is improved by the addition of chitosan, so that it is possible to reduce the addition of the foaming agent. Moreover, the dentifrice of the present invention is a dentifrice that does not contain a foaming agent (so-called,
An excellent cleaning effect is expected even in the case of a dentifrice without a foaming agent and a non-foam toothpaste.

In the dentifrice, a binder is used in order to prevent the powder component and the liquid component from being separated from each other and to impart appropriate viscoelasticity and morphology to the dentifrice. Any dentifrice of the present invention can be used as long as it can be used as a binder for dentifrice. Examples of the binder include methyl cellulose and hydroxyethyl cellulose.
Su, carboxymethyl cellulose alkali salt, carrage
Organic natural binders such as nan, sodium alginate, xanthan gum or tragacanth gum, synthetic high molecular weight binders such as polyvinyl alcohol, sodium polyacrylate, polycarboxyvinyl or polyvinylpyrrolidone, and others.

Since the viscosity of the dentifrice is increased by using the water-soluble organic acid and the high molecular weight chitosan, in such a case, it is possible to reduce the amount of the binder (particularly, the inorganic binder). It is possible.

In the dentifrice of the present invention, one or two or more of these binders can be blended. However, by blending an organic or inorganic natural product binder, the whole dentifrice is naturally formulated. It is possible to compose the object. In addition, it becomes possible to reduce the content of the binder in the dentifrice by blending the high molecular weight chitosan.

In the dentifrice of the present invention, the astringency derived from the raw material of chitosan (in particular, the astringency derived from high molecular weight chitosan)
Can be mitigated by blending a flavoring agent (fragrance and sweetener).

Examples of the fragrance to be added to the dentifrice of the present invention include peppermint, spearmint, menthol, carvone or anethole. Examples of the sweetener include natural sweeteners such as stevioside, glycerin, sorbitol and glutyrrhizinate, and synthetic sweeteners such as saccharin sodium and aspartame. In addition, it is also possible to use a chitin oligomer as an auxiliary agent for a sweetener.

However, since the dentifrice of the present invention contains a natural product, chitosan, the other products are also mixed with the natural product, whereby the whole dentifrice is composed of the natural product. And it becomes possible to exhibit the new function which the conventional dentifrice does not have.

The dentifrice of the present invention includes propylene glycol-
A common wetting agent such as glycerin, glycerin and sorbitol can be added. However, since chitosan itself acts as a wetting agent, it is possible to reduce conventional wetting agents.

A preferred representative example of the dentifrice according to the present invention is a dentifrice in which all the components including chitosan of the dentifrice are natural products. Most abrasives are natural products. Therefore,
Abrasives of natural products, organic natural products or inorganic natural products, natural fragrances such as peppermint, spearmint, menthol, carvone or anethole, stevia powder, stevia extract ( Stevia extract), natural product sweeteners such as glycerin, sorbit and sorbitol, and low molecular weight chitosan of the present invention, chitosan composed of high molecular weight chitosan, and water, etc. to form a dentifrice entirely composed of natural products. be able to.

Moreover, since chitosan has a function as a natural sweetener, for example, salt-containing dentifrice is blended with salt-containing dentifrice (for example, about 8% salt-containing dentifrice). Chitosan can be used to reduce the peculiar saltiness of the dentifrice and improve the feeling of use of the dentifrice. [Dentifrice according to the second invention] In the second invention, the average value of the number of glucosamine (that is, n in the formula (1)) is 2 to.
A dentifrice formulated with a low molecular weight chitosan in the range of 150.

The second aspect of the present invention is a dentifrice having the added advantages of low molecular weight chitosan. Since low molecular weight chitosan has high solubility in water, it is possible to sufficiently mix chitosan even with a dentifrice having a low water content. Further, in a water-based dentifrice (for example, a mouthwash), it is possible to mix an arbitrary amount (for example, a large amount) of chitosan.

The representative dentifrice of the second aspect of the present invention is an aqueous dentifrice such as a mouthwash. The mouthwash is called a toothpaste or mouthwash, and it is used by exhaling after cleaning the inside of the mouth with an appropriate amount contained in the mouth. The mouth rinse is generally composed of water, a solvent, a wetting agent, a solubilizing agent, a flavoring agent, a preservative, a coloring agent, a pH adjusting agent and a medicinal component. Then, the mouthwash can be made to have an effect not found in conventional mouthwashes by blending low molecular weight chitosan. The compounding amount of chitosan can be the same as the above range. [Dentifrice according to the third aspect of the present invention] In the third aspect of the present invention, the average value of the number of glucosamine (that is, n in the formula (1)) exceeds 150, and the dentifrice is 4,50.
It is a dentifrice containing high molecular weight chitosan of 0 or less.

The third aspect of the present invention relates to high molecular weight chitosan or /
And the organic acid salt thereof is added to the dentifrice to which the advantages that they have are added. High molecular weight chitosan is insoluble or sparingly soluble in water but soluble in organic acids (for example, hydroxy acids such as malic acid). The high molecular weight chitosan blended in the dentifrice will react with lactic acid and gradually dissolve. Further, since high molecular weight chitosan and its organic acid salt have great antibacterial properties, they can be made into dentifrices having excellent antibacterial properties.

Next, the dentifrice according to the present invention will be specifically described based on Examples, but the Examples are merely examples and do not limit the present invention.

[0061]

【Example】

Example 1 A standard toothpaste was prepared in order to investigate the effect of chitosan formulation on the toothpaste. The standard toothpaste had the same composition as that of a general toothpaste.

[0062] The pH of an aqueous solution obtained by dissolving 1.5 g of this standard toothpaste in 50 g of purified water was 6.7 (room temperature). 1.5 grams of this standard toothpaste was added to a 50% aqueous solution of 0.01% lactic acid.
The pH of the aqueous solution dissolved in gram was 5.8 (room temperature). The pH of the 0.01% aqueous lactic acid solution was 2.6 (room temperature). <Example 2> Chitosan (average molecular weight 2,500, Ltd.)
Kyowa Technos Flownac S (trade name) 0.7
A chitosan-containing toothpaste was prepared by adding wt% to the formulation of the standard toothpaste of Example 1. It should be noted that instead of adding 0.7% by weight of chitosan, purified water was reduced by 0.7% by weight. The pH of the aqueous solution prepared by dissolving 1.5 g of the toothpaste prepared in Example 2 in 50 g of a 0.01% lactic acid aqueous solution was 6.5 (room temperature). <Example 3> 0.2% by weight of chitosan (average molecular weight 1000, chitosan oligosaccharide) and chitosan (average molecular weight 2,500, Flownac S manufactured by Kyowa Technos Co., Ltd.)
(Trade name)) was added to the composition of the standard toothpaste of Example 1 to prepare a toothpaste containing chitosan. Instead of adding 0.5% by weight of chitosan, the amount of purified water was reduced by 0.5% by weight.

1.5 g of the toothpaste prepared in Example 3 was dissolved in 50 g of a 0.01% lactic acid aqueous solution to prepare an aqueous solution p.
H was 6.4 (room temperature). <Example 4> Chitosan (average molecular weight 2,500, Ltd.)
Kyowa Technos Flownac S (trade name) 0.3
Wt% and chitosan (average molecular weight 100,000,
Flownack HL (trade name) manufactured by Kyowa Technos Co., Ltd.)
Was added to the formulation of the standard toothpaste of Example 1 to prepare a toothpaste containing chitosan. Instead of adding 0.6% by weight of chitosan, the amount of purified water was reduced by 0.6% by weight.

1.5 g of the toothpaste prepared in Example 4 was dissolved in 50 g of a 0.01% lactic acid aqueous solution to prepare an aqueous solution p.
H was 6.3 (room temperature). <Example 5> Chitosan (average molecular weight 300,000,
An agent of FRONAC H (trade name) manufactured by Kyowa Technos Co., Ltd. was prepared. Instead of adding 0.5% by weight of chitosan, the amount of purified water was reduced by 0.5% by weight.

1.5 g of the toothpaste prepared in Example 4 was dissolved in 50 g of a 0.01% lactic acid aqueous solution to prepare an aqueous solution p.
H was 6.2 (room temperature). The toothpaste containing a small amount of chitosan prepared in the above Examples 2 to 5 also neutralizes lactic acid and produces lactic acid even if the average usage amount per general adult (1.5 g) is high. The pH of the aqueous solution when it was absent was approaching 6.7.

It was also found that even high molecular weight chitosan has the ability to neutralize lactic acid, and the ability to neutralize lactic acid is improved by increasing the amount of chitosan compounded. <Example 6> A standard mouthwash was prepared in order to examine the effect of chitosan formulation on the mouthwash. The standard mouthwash had the same composition as the general mouthwash.

[0067] The pH of this standard mouthwash was 6.8 (room temperature). <Example 7> Chitosan (average molecular weight 2,500, Ltd.)
Kyowa Technos Flownac S (trade name) 0.5
A chitosan-containing mouthwash was prepared by adding wt% to the blend composition of the standard mouthwash of Example 6. Chitosan is 0.5
Instead of adding wt%, purified water was reduced by 0.5 wt%. The pH of the aqueous solution prepared by mixing 10 g of the mouthwash prepared in Example 7 with 40 g of a 0.01% lactic acid aqueous solution was 6.5 (room temperature). <Example 8> 0.2% by weight of chitosan (average molecular weight 1000, chitosan oligosaccharide) and chitosan (average molecular weight 2,500, Flownac S manufactured by Kyowa Technos Co., Ltd.)
(Trade name)) was added to the compounding composition of the standard mouthwash of Example 6 to prepare a chitosan-containing mouthwash. Instead of adding 0.5% by weight of chitosan, the amount of purified water was reduced by 0.5% by weight. The pH of the aqueous solution prepared by mixing 10 g of the mouthwash prepared in Example 8 with 40 g of a 0.01% lactic acid aqueous solution was 6.5 (room temperature). <Example 9> Chitosan (average molecular weight 2,500, Ltd.)
Kyowa Technos Flownac S (trade name) 0.3
% By weight, and chitosan (average molecular weight 100,000,
Flownack HL (trade name) manufactured by Kyowa Technos Co., Ltd.)
And 0.2% by weight of a 1: 1 mixture of L-ascorbic acid were added to the compounding composition of the standard mouthwash of Example 6 to prepare a mouthwash containing chitosan.

Instead of adding 0.5% by weight of chitosan, the amount of purified water was reduced by 0.5% by weight. 10 g of the mouthwash prepared in Example 9 was added to a 0.01% aqueous lactic acid solution 4
The pH of the aqueous solution mixed with 0 gram was 6.2 (room temperature). <Example 10> The chitosan-containing toothpaste prepared in Examples 2 to 5 and the chitosan-containing mouthwash prepared in Examples 7 to 9 were subjected to a sensory test for feel and taste.

The sensory test was conducted on a panel of 50 men and women (subjects to be evaluated). For the panel, a person was selected who could identify the slight difference in taste and feel of toothpaste and mouthwash. A sensory test on toothpaste was conducted using a typical commercially available 5
This was done in contrast to different types of toothpaste. Many dentifrices of Examples 1 to 8 containing low molecular weight chitosan had the same taste as the standard combination. The dentifrice of Example 9 containing a high molecular weight chitosan was often said to be slightly astringent. Many respondents answered that the dentifrices of Examples 1 to 9 had the same feel as the standard formulation.

[0070]

EFFECTS OF THE INVENTION According to the first aspect of the present invention, a factor that corrodes teeth is neutralized by a neutralization reaction with organic acids such as hydroxy acids that corrode teeth, and the pH in the oral cavity is normal. Acting to become, in addition to, bacteria (typically
It is possible to obtain a dentifrice in which the growth inhibitory action of (oral bacteria) is obtained from natural products.

Furthermore, according to the first aspect of the present invention, it is possible to obtain an effect which has not existed in conventional dentifrices, such as the fact that the whole dentifrice can be a natural dentifrice.

According to the second aspect of the present invention, the same effects as those of the first aspect of the present invention can be easily obtained even for an aqueous dentifrice such as a mouthwash.

According to the third aspect of the present invention, a dentifrice having the same effects as those of the first aspect of the present invention and excellent antibacterial properties can be obtained.

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[Procedure amendment]

[Submission date] April 26, 1996

[Procedure 3]

[Document name to be amended] Statement

[Name of item to be corrected] 0045

[Correction method] Change

[Correction contents]

The chitin to be added to the dentifrice has the repeating unit number of 150 to 4,500, and if it is 30 to 200 mesh (preferably 80 to 100 mesh), such an effect can be obtained by adding it to the dentifrice. It is also found in the present invention that it is easy to enjoy. In addition, the repeating unit of chitin is a unit in which the NH ₂ group of the formula (1) is changed to an NHCOCH ₃ group.

Claims (3)

[Claims] 1. The number n of repeating units represented by the following formula (1):
One or two or more types of chitosan having an average value of 2 to 4,500 are blended with a moisturizing dentifrice, a toothpaste, a liquid dentifrice or a liquid dentifrice. Agent. Embedded image 2. The number n of repeating units represented by the following formula (1):
A low molecular weight chitosan having an average value of 2 to 150 is incorporated in a moisturizing dentifrice, a toothpaste, a liquid dentifrice or a liquid dentifrice. Embedded image 3. The number n of repeating units represented by the following formula (1):
The dentifrice is characterized in that a high molecular weight chitosan having an average value of more than 150 and 4,500 or less is blended with a moisturizing dentifrice, a toothpaste, a liquid dentifrice or a liquid dentifrice. Embedded image