JPH0930954A - Beautifying and whitening dermal preparation for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a beautifying and whitening dermal preparation for external use, having suppressing actions on melanogenesis and inhibiting actions on tyrosinase activities, capable of manifesting excellent effects on color lightening, beautifying and whitening of pigmentation, dermal stains, ephelides, chloasma, etc., after the sunburn and having high safety. SOLUTION: This beautifying and whitening dermal preparation for external use contains 0.005-20wt.%, preferably 0.01-10wt.% extract of a plant belonging to the genus Eleutherin of the family Iridaceae (e.g. Eleutherin americana Mevr. et Heyne) of extract of a plant belonging to the genus Iris (e.g. Iris pallida) as an active ingredient. The extract, as necessary, is suitably further blended with a beautifying and whitening agent, a humectant, an antioxidant, an oily ingredient, an ultraviolet absorber, a surfactant, a thickening agent, alcohols, a powdery ingredient, a colorant, an aqueous ingredient, water, various dermal nutrients, etc., and prepared into an ointment, a cream, a milky lotion, a lotion, a pack, a bathing agent, etc. Furthermore, the extract is obtained by immersing or refluxing a leaf, a stem, a fruit, etc., of the plant, the whole herb, etc., thereof together with an extracting solvent (e.g. ethanol) under heating, then filtering the resultant extract and concentrating the prepared filtrate.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to the family Iridacea.
The present invention relates to an external preparation for whitening skin, which is effective in preventing melanin production and preventing and improving pigmentation, spots, freckles, chloasma, etc. after sunburn by incorporating the plant extract of e).

[0002]

2. Description of the Related Art Although there are some unclear points about the mechanism of the occurrence of skin spots and the like, melanin pigments are generally formed due to hormonal abnormalities and stimulation of ultraviolet rays from sunlight. It is believed to be abnormally deposited within. This melanin pigment, which causes skin coloring, is produced in melanin-producing granules (melanosomes) in melanocytes (melanocytes) between the epidermis and dermis,
The generated melanin diffuses into adjacent cells by the osmotic effect. The biochemical reaction in this melanocyte is presumed to be as follows. That is, tyrosine, which is an essential amino acid, is converted into dopaquinone by the action of the enzyme tyrosinase, and the process in which it is converted to black melanin via a red pigment and a colorless pigment by an enzymatic or non-enzymatic oxidative action is a melanin pigment production process. Therefore, suppressing the action of tyrosinase, which is the first step of the reaction, is important for suppressing melanin production.

[0003]

However, compounds that suppress the tyrosinase action, except for hydroquinone, have very slow onset of their effects, so that the effect of improving skin pigmentation is not sufficient. On the other hand, although hydroquinone is recognized as having an effect, its use is generally restricted because of its sensitizing properties. Therefore, in order to improve its safety, attempts have been made to use higher fatty acid monoesters or alkyl monoethers (JP-A-58-154507), but the esters are decomposed by a hydrolase in the body. Therefore, it is not always safe, and ethers have not been sufficiently satisfactory in terms of safety.

[0004]

The inventors of the present invention investigated the melanin production inhibitory effect of various substances as a solution to these problems, and found that the iris family (Iridac)
It was found that the plant extract of eae) has a melanin production inhibitory action and a tyrosinase inhibitory action, and completed the present invention. There has been no report on the melanin production inhibitory action of a plant extract of Iridaceae, and its application to a whitening agent has not been known at all. The present inventors have completed the present invention based on the above findings.

That is, the present invention relates to the family Iridacea.
An external preparation for whitening skin, characterized by containing the plant extract of e).

The structure of the present invention will be described in detail below. The plant of the iris family (Iridaceae) used in the present invention is a plant of the genus Eleutherin or the genus Iris.
is) plants are preferred. Eleutherin (El
eutherin) plants include Hong Kong (Eleutherin ame
ricana Mevr.et Heyne), Eleutherin bulbosa (Miller)
Urb. And Eleutherin subaphylla. In addition, as a plant of the genus (Iris),
pallida) and white iris (Iris florentina).

Iridacea used in the present invention
The plant e) is a plant that is widely distributed all over the world, and is a plant that grows in the dry grass and grass. The plant extract used in the present invention, such as leaves and stems or fruits of these plants, after soaking or heating and refluxing the whole plant with an extraction solvent,
Obtained by filtration and concentration. The extraction solvent used in the present invention may be any solvent used in ordinary extraction,
In particular, alcohols such as methanol and ethanol, hydroalcohols, organic solvents such as acetone and ethyl acetate can be used alone or in combination.

The amount of the plant extract of the family Iridaceae used in the present invention is 0.005 to 20.0% by weight, preferably 0.01 to 1% by weight, based on the total weight of the external preparation.
0.0% by weight. When it is less than 0.005% by weight,
The effect of the present invention is not sufficiently exerted and 20.0% by weight
If it exceeds, it is not preferable because formulation is difficult. Also, 1
Even if it is added in an amount of 0.0% by weight or more, the effect is not significantly improved.

In addition to the above-mentioned essential components, the external whitening agent for skin whitening of the present invention also contains components that are usually used in external skin external agents such as cosmetics and pharmaceuticals, such as other whitening agents and moisturizers.
Antioxidants, oily components, UV absorbers, surfactants, thickeners, alcohols, powder components, coloring materials, aqueous components, water,
Various skin nutrients and the like can be appropriately compounded as needed.

In addition, sequestering agents such as disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, caffeine, tannin, verapamil, tranexamic acid and its derivatives, licorice extraction Substance, glabridin, hot water extract of fruits of fire thorns, various crude drugs, tocopherol acetate,
Drugs such as glycyrrhizic acid and its derivatives or salts thereof, vitamin C, magnesium ascorbate phosphate,
Other whitening agents such as ascorbic acid glucoside, arbutin, kojic acid, glucose, fructose, mannose,
Sugars such as sucrose and trehalose can also be appropriately blended.

The external preparation for whitening skin of the present invention includes, for example, ointments, creams, emulsions, lotions, packs, bath agents and the like.
Any conventional skin external preparation may be used,
The dosage form is not particularly limited.

[0012]

Next, the present invention will be described in more detail by way of examples. Note that the present invention is not limited by this. The blending amount is% by weight. Prior to Examples, test methods and results of the melanin suppressing effect, tyrosinase activity inhibiting effect and whitening effect of the plant extract of the present invention will be described.

Test Method and Results 1. Preparation of Sample 50 g of stem and branch of Iridaceae plant was immersed in ethanol at room temperature for 1 week, and the extract was concentrated to obtain 5.2 g of ethanol extract. This extract was dissolved in DMSO at 1%, the concentration was adjusted by diluting this solution, and the following experiment was performed using this.

2. Cell culture method B16 melanoma cultured cells derived from mice were used. 1
0% FBS and theophylline (0.09 mg / ml)
The cells were cultured in an Eagle MEM medium containing C. in a CO ₂ incubator (95% air, 5% carbon dioxide) at 37 ° C. After 24 hours of culturing, the sample solution was added so as to have a final concentration (concentration of extracted dry matter) of 10 ^-2 to 10 ^-5 % by weight, culturing was continued for another 3 days, and the melanin production amount was visually sensed by the following method. The determination and the tyrosinase activity inhibitory effect were measured.

3. Visual measurement of melanin amount Place a diffusion plate on the lid of the well plate, observe the intracellular melanin amount with an inverted microscope, and compare with the sample (standard) to which Iridaceae plant extract is not added did. The results are shown in Table 1. In addition, as a reference example, the same test as above was carried out on an extract of Kaigai (Lamiaceae, Odorikosou Subfamily), which is already known to have an action of suppressing melanin production. Table 1 also shows the results.

<Criteria> ○: White (amount of melanin) Δ: Slightly white (amount of melanin) ×: Reference (amount of melanin)

4. Measurement of tyrosinase activity Before measurement, the medium in the wells is removed and washed twice with 100 μl of PBS. 45 μl of 1% Triton-X in each well
(Rohm and Haas product name, surfactant) containing PBS is added. Shake the plate for 1 minute, break the cell membrane well, and use a microplate reader for 475n.
The absorbance at m was measured, and this was taken as the absorbance at 0 minutes. Then, 5 μl of 10 mM L-DOPA solution was quickly added, and the mixture was transferred to an incubator at 37 ° C. and reacted for 60 minutes. The plate was shaken for 1 minute, and the absorbance (475 nm) at 60 minutes was measured. The tyrosinase activity inhibition rate was calculated based on the decrease in the absorbance difference of the sample containing Iridaceae plant extract relative to the difference in absorbance at 0 minutes and 60 minutes in the case of the sample (control) to which the plant extract of Iridaceae was not added ( %). Table 1 shows the results.

Further, as a reference example, the same test as above was carried out on an ethanol extract of mussel, which is already known to have a tyrosinase activity inhibitory action. Table 1 also shows the results. In addition,-in a table | surface means that the significant difference was not recognized within 5% of the risk ratio compared with the control.

[0019]

[Table 1] ─────────────────────────────────── Test Melanin production Visual evaluation Tyrosinase activity inhibition rate ( %) ──────── ──────────────────────── concentration (wt%) 10 ^-5 10 ^-4 10 ^-3 10 ^{- 2} 10 ^-5 10 ^-4 10 ^-3 10 ^-2 ─────────────────────────────────── Hong Kong extraction Extract × × × ○ − − 35 94 E. bulbosa extract × × × ○ − − 33 97 E. subaphylla extract × × × ○ − − 36 95 Iris pallida extract × × ○ ◎ − 9 31 62 Iris florentina extract Material × × △ ○ − 5 24 52 Clam shell extract × × × × − − − 55 ─────────────────────────────── ─────

[5] Whitening test [Test method] 136 subjects exposed to sunlight in summer for 4 hours (2 hours per day for 2 days) each sample from 5 days after the day of sun exposure to the skin of the upper arm inner skin Was applied once each morning and evening for 4 weeks. The panel is divided into 8 groups and 17
The group was tested with the formulation shown below. (Alcohol phase) 95% Ethyl alcohol 55.0% by weight Polyoxyethylene (25 moles) hydrogenated castor oil ether 2.0 Antioxidant / preservative proper amount Fragrance proper amount drug (listed in Table 2) (water phase) glycerin 5.0 Sodium hexametaphosphate Suitable amount Ion-exchanged water Residue <Production method> An aqueous phase and an alcohol phase are prepared, respectively, and then both are mixed and solubilized.

[Evaluation Method] The lightening effect after use was judged based on the following judgment criteria. <Judgment criteria> ：: When the ratio showing significant effect and effectiveness among the subjects is 80% or more 割 合: The ratio showing significant effect and effectiveness among the subjects is 50% or more
Less than 80% △: The proportion of the test subjects showing excellent and effective is 30% or more
When less than 50% x: When the ratio of markedly effective or effective among the subjects is less than 30%

Samples having the blending composition described in the above test method were prepared and the whitening effect was compared using the agents shown in Table 2.
The results are shown in Table 2.

[0023]

[Table 2] ────────────────────────── Drug compounding amount (% by weight) Effect ────────── ──────────────── Additive- × Hydroquinone 1.0 △ Hong Kong extract 0.1 ○ Hong Kong extract 1.0 ○ Hong Kong extract 10.0 ◎ E. bulbosa extract Material 0.1 ○ E.bulbosa extract 1.0 ○ E.bulbosa extract 10.0 ◎ E.subaphylla extract 0.1 ○ E.subaphylla extract 1.0 ○ E.subaphylla extract 10.0 ◎ Iris pallida extract 0.1 ○ Iris pallida extract 1.0 ○ Iris pallida extract 1.0 ◎ Iris florentina extract 0.1 ○ Iris florentina extract 1.0 ○ Iris florentina extract 1.0 ◎ ── ────────────────────────

The Hong Kong extract of Table 2 and E. bulbosa
The extract, E. subaphylla extract, Iris pallida extract, and Iris florentina extract were obtained by heating and reducing whole plants of these plants in ethanol, filtering, and concentrating and drying.

As is clear from Table 2, the effect after exposure to sunlight is to prevent excessive melanin pigment deposition and prevent darkening by adding a plant extract of Iridaceae. Was recognized.

Example 1 Cream (formulation) Stearic acid 5.0% by weight Stearyl alcohol 4.0 Isopropyl myristate 18.0 Glycerin monostearate 3.0 Propylene glycol 10.0 Hong Kong methanol extract 0.01 Caustic potash 0 .2 Sodium bisulfite 0.01 Preservative proper amount Perfume proper amount Ion-exchanged water Residue (production method) Dissolve propylene glycol, Hong Kong methanol extract and caustic potash in ion-exchanged water, heat and keep at 70 ° C (water phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is gradually added to the water phase, and after the addition is completed, the temperature is maintained for a while to cause a reaction. Then, it is uniformly emulsified with a homomixer and cooled to 30 ° C. with thorough stirring.

Example 2 Cream (formulation) Stearic acid 2.0% by weight Stearyl alcohol 7.0 Hydrogenated lanolin 2.0 Squalane 5.0 2-Octyldodecyl alcohol 6.0 Polyoxyethylene (25 mol) cetyl alcohol ether 3.0 Glycerin monostearate 2.0 Propylene glycol 5.0 E. bulbosa ethanol extract 0.05 Sodium hydrogen sulfite 0.03 Ethylparaben 0.3 Perfume suitable amount Ion-exchanged water Residue (production method) Propylene in ion-exchanged water Add glycol,
Heat and maintain at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is added to the aqueous phase to carry out preliminary emulsification, and the mixture is uniformly emulsified with a homomixer and then cooled to 30 ° C. with thorough stirring.

Example 3 Cream (Formulation) Solid paraffin 5.0% by weight Beeswax 10.0 Vaseline 15.0 Liquid paraffin 41.0 Glycerin monostearate 2.0 Polyoxyethylene (20 mol) sorbitan monolaurate 2 .0 soap powder 0.1 borax 0.2 E. subaphylla acetone extract 0.05 Hong Kong ethanol extract 0.05 sodium bisulfite 0.03 ethylparaben 0.3 perfume proper amount ion-exchanged water residual (production method) ion-exchanged water Soap powder and borax are added to the mixture, heated and melted and kept at 70 ° C (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is gradually added to the aqueous phase while stirring to carry out the reaction. After the reaction is completed, the mixture is uniformly emulsified with a homomixer, and after emulsification, the mixture is cooled to 30 ° C. with thorough stirring.

Example 4 Emulsion (formulation) Stearic acid 2.5 wt% Cetyl alcohol 1.5 Vaseline 5.0 Liquid paraffin 10.0 Polyoxyethylene (10 mol) monooleate 2.0 Polyethylene glycol 1500 3. 0 triethanolamine 1.0 carboxyvinyl polymer 0.05 (trade name: Carbopol 941, BFGoodrich Chemical company) E.bulbosa acetic acid ethyl ester extract 0.01 sodium bisulfite 0.01 ethylparaben 0.3 perfume proper amount ion Exchanged water Residue (production method) A carboxyvinyl polymer is dissolved in a small amount of ion exchanged water (phase A). Polyethylene glycol 1500 and triethanolamine are added to the remaining ion-exchanged water, dissolved by heating, and kept at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is added to the water phase to perform preliminary emulsification, the phase A is added, and the mixture is uniformly emulsified with a homomixer. After the emulsification, the mixture is cooled to 30 ° C. while stirring well.

Example 5 Emulsion (Formulation) Microcrystalline wax 1.0% by weight Beeswax 2.0 Lanolin 20.0 Liquid paraffin 10.0 Squalane 5.0 Sorbitan sesquioleate 4.0 Polyoxyethylene (20 mol) ) Sorbitan monooleate 1.0 Propylene glycol 7.0 E. subaphylla acetone extract 10.0 Sodium hydrogen sulfite 0.01 Ethylparaben 0.3 Perfume proper amount Ion-exchanged water Residue (production method) Propylene glycol is added to ion-exchanged water In addition,
Heat and maintain at 70 ° C. (aqueous phase). The other components are mixed, heated and melted and kept at 70 ° C. (oil phase). While stirring the oil phase, the aqueous phase is gradually added thereto, and the mixture is uniformly emulsified with a homomixer. After emulsification, cool to 30 ° C with good stirring.

Example 6 Jelly (formulation) 95% ethyl alcohol 10.0% by weight dipropylene glycol 15.0 polyoxyethylene (50 mol) oleyl alcohol ether 2.0 carboxyvinyl polymer 1.0 (trade name: Carbopol) 940, BFGoodrich Chemical company) Caustic soda 0.15 L-Arginine 0.1 Hong Kong 50% ethanol aqueous solution extract 7.0 2-Hydroxy-4-methoxybenzophenone sodium sulfonate 0.05 Ethylenediaminetetraacetate ・ 3 sodium ・ 2 water 0 .05 Methylparaben 0.2 Fragrance Suitable amount Ion-exchanged water Residual (production method) Carbopol 940 was uniformly dissolved in ion-exchanged water, while 95% ethanol was extracted with a 50% ethanol solution in Hong Kong and polyoxyethylene (50 mol) oleyl. alcohol Dissolve the ether and add to the aqueous phase.
Next, after adding other components, the mixture is neutralized with caustic soda and L-arginine to increase the viscosity.

Example 7 Serum (formulation) (Phase A) Ethyl alcohol (95%) 10.0% by weight Polyoxyethylene (20 mol) Octyldodecanol 1.0 Pantothenyl ethyl ether 0.1 E.bulbosa methanol Extract 1.5 Methylparaben 0.15 (Phase B) Potassium hydroxide 0.1 (Phase C) Glycerin 5.0 Dipropylene glycol 10.0 Sodium bisulfite 0.03 Carboxyvinyl polymer 0.2 (trade name: Carbo Pole 940, BFGoodrich Chemical company) Purified water Residue (production method) Phases A and C are uniformly dissolved, and A is added to phase C
Add phases and solubilize. Next, after adding the phase B, filling is performed.

Example 8 Pack (formulation) (Phase A) 5.0% by weight dipropylene glycol Polyoxyethylene (60 mol) hydrogenated castor oil 5.0 (Phase B) E. subaphylla methanol extract 0.01 Olive oil 5 0.0 Tocopherol acetate 0.2 Ethylparaben 0.2 Perfume 0.2 (Phase C) Sodium hydrogen sulfite 0.03 Polyvinyl alcohol 13.0 (Saponification degree 90, degree of polymerization 2,000) Ethanol 7.0 Purified water Residue (Manufacturing method) Phase A, phase B, and phase C are uniformly dissolved,
Add phase B to phase and solubilize. Next, this is added to the C phase and then filled.

Example 9 Solid foundation (formulation) Talc 43.1% by weight Kaolin 15.0 Sericite 10.0 Zinc white 7.0 Titanium dioxide 3.8 Yellow iron oxide 2.9 Black iron oxide 0.2 Squalane 8 0.0 isostearic acid 4.0 POE sorbitan monooleate 3.0 isocetyl octoate 2.0 Hong Kong ethanol extract 1.0 preservative appropriate amount perfume appropriate amount (manufacturing method) Talc to black iron oxide powder components are thoroughly mixed with a blender. Then, an oily component of squalane to isocetyl octoate, a Hong Kong ethanol extract, an antiseptic and a fragrance are added, and the mixture is well kneaded and then filled into a container and molded.

Example 10 Emulsion type foundation (cream type) (Formulation) (Powder part) Titanium dioxide 10.3% by weight Sericite 5.4 Kaolin 3.0 Yellow iron oxide 0.8 Bengala 0.3 Black iron oxide 0.2 (oil phase) decamethylcyclopentasiloxane 11.5 liquid paraffin 4.5 polyoxyethylene-modified dimethylpolysiloxane 4.0 (water phase) purified water 50.0 1,3-butylene glycol 4.5 E .bulbosa ethanol extract 1.5 sorbitan sesquioleate ester 3.0 preservative proper amount perfume proper amount (manufacturing method) After the water phase is heated and stirred, the powder portion thoroughly mixed and pulverized is added and treated with a homomixer. Further, the oil phase mixed by heating is added, and the mixture is treated with a homomixer. Then, a fragrance is added with stirring, and the mixture is cooled to room temperature.

Example 11 Cream (Formulation) Stearic acid 5.0% by weight Stearyl alcohol 4.0 Isopropyl myristate 18.0 Glycerin monostearate 3.0 Propylene glycol 10.0 Iris pallida Methanol extract 0.01 Caustic potash 0.2 Sodium bisulfite 0.01 Preservative Suitable amount Perfume Suitable amount Ion-exchanged water Residual (production method) Ion-exchanged water with propylene glycol and Iris p
Add allida methanol extract and potassium hydroxide to dissolve and heat to maintain at 70 ° C (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). Add the oil phase gradually to the water phase,
After all the ingredients have been added, the temperature is maintained for a while to cause a reaction. Then, it is uniformly emulsified with a homomixer and cooled to 30 ° C. with thorough stirring.

Example 12 Cream (formulation) Stearic acid 2.0% by weight Stearyl alcohol 7.0 Hydrogenated lanolin 2.0 Squalane 5.0 2-Octyldodecyl alcohol 6.0 Polyoxyethylene (25 mol) cetyl alcohol ether 3.0 Glycerin monostearate 2.0 Propylene glycol 5.0 Iris florentina Ethanol extract 0.05 Sodium bisulfite 0.03 Ethylparaben 0.3 Fragrance Ion-exchanged water Residual (production method) Propylene glycol on ion-exchanged water And add
Heat and maintain at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is added to the aqueous phase to carry out preliminary emulsification, and the mixture is uniformly emulsified with a homomixer and then cooled to 30 ° C. with thorough stirring.

Example 13 Cream (formulation) Solid paraffin 5.0% by weight Beeswax 10.0 Vaseline 15.0 Liquid paraffin 41.0 Glycerin monostearate 2.0 Polyoxyethylene (20 mol) sorbitan monolaurate 2 .0 soap powder 0.1 borax 0.2 Iris pallida acetone extract 0.05 Iris florentina ethanol extract 0.05 sodium bisulfite 0.03 ethylparaben 0.3 perfume proper amount ion-exchanged water residual (production method) ion-exchanged water Soap powder and borax are added to the mixture, heated and melted and kept at 70 ° C (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is gradually added to the aqueous phase while stirring to carry out the reaction. After the reaction is completed, the mixture is uniformly emulsified with a homomixer, and after emulsification, the mixture is cooled to 30 ° C. with thorough stirring.

Example 14 Emulsion (formulation) Stearic acid 2.5% by weight Cetyl alcohol 1.5 Vaseline 5.0 Liquid paraffin 10.0 Polyoxyethylene (10 mol) monooleate 2.0 Polyethylene glycol 1500 3. 0 Triethanolamine 1.0 Carboxyvinyl polymer 0.05 (Brand name: Carbopol 941, BFGoodrich Chemical company) Iris pallida Acetic acid ethyl ester extract 0.01 Sodium hydrogen sulfite 0.01 Ethyl paraben 0.3 Perfume Ion exchange Water Residue (Production Method) A carboxyvinyl polymer is dissolved in a small amount of ion-exchanged water (phase A). Polyethylene glycol 1500 and triethanolamine are added to the remaining ion-exchanged water, dissolved by heating, and kept at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is added to the water phase to perform preliminary emulsification, the phase A is added, and the mixture is uniformly emulsified with a homomixer. After the emulsification, the mixture is cooled to 30 ° C. while stirring well.

Example 15 Emulsion (formulation) Microcrystalline wax 1.0 wt% Beeswax 2.0 Lanolin 20.0 Liquid paraffin 10.0 Squalane 5.0 Sorbitan sesquioleate 4.0 Polyoxyethylene (20 mol) ) Sorbitan monooleate 1.0 Propylene glycol 7.0 Iris florentina Acetone extract 10.0 Sodium hydrogen sulfite 0.01 Ethyl paraben 0.3 Fragrance suitable amount Ion-exchanged water Residual (production method) Add propylene glycol to ion-exchanged water ,
Heat and maintain at 70 ° C. (aqueous phase). The other components are mixed, heated and melted and kept at 70 ° C. (oil phase). While stirring the oil phase, the aqueous phase is gradually added thereto, and the mixture is uniformly emulsified with a homomixer. After emulsification, cool to 30 ° C with good stirring.

Example 16 Jelly (formulation) 95% ethyl alcohol 10.0% by weight dipropylene glycol 15.0 polyoxyethylene (50 mol) oleyl alcohol ether 2.0 carboxyvinyl polymer 1.0 (trade name: Carbopol) 940, BFGoodrich Chemical company) Caustic soda 0.15 L-arginine 0.1 Iris pallida 50% ethanol aqueous solution extract 7.0 2-Hydroxy-4-methoxybenzophenone sulfonate sodium 0.05 Ethylenediaminetetraacetate ・ 3 sodium ・ dihydrate 0 .05 Methylparaben 0.2 Fragrance Appropriate amount Ion-exchanged water Residual (production method) Carbopol 940 is uniformly dissolved in ion-exchanged water, while Iris pallida 50% ethanol aqueous solution extract and polyoxyethylene (50 mol) oleyl in 95% ethanol Arcor Ruether is dissolved and added to the aqueous phase. Next, after adding other ingredients, caustic soda,
Thicken by neutralizing with L-arginine.

[0042]

Industrial Applicability As described above, the whitening skin external preparation of the present invention has a melanin production inhibitory action and a tyrosinase activity inhibitory action, and is effective in treating pigmentation, stains, freckles, melasma, etc. after sunburn. It is an external preparation for whitening skin, which has excellent effects on lightening and whitening, and is also excellent in safety.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Yuki Shibata 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Inside Shiseido Daiichi Research Center, Inc. (72) Inventor Masako Naganuma 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Shiseido Daiichi Research Center Co., Ltd.

Claims (4)

[Claims] 1. An external preparation for whitening skin, comprising a plant extract of the family Iridaceae. 2. The external preparation for whitening skin according to claim 1, wherein the plant extract of the family Iridaceae is a plant extract of the genus Eleutherin. 3. A plant extract of the family Iridaceae belongs to the genus Iri.
The external preparation for whitening skin according to claim 1, which is the plant extract of s). 4. The blending amount of the iris family plant extract is 0.0.
The external preparation for whitening skin according to any one of claims 1 to 3, which is 05 to 20.0% by weight.