JPH093348A - Method for suppressing discoloration of dye and composition containing dye - Google Patents

Abstract

(57) [Summary] [Structure] Polyvinylpyrrolidone and / or polyvinyl alcohol and a dye are uniformly mixed with other components of a solid composition or a liquid composition, or a dye, polyvinylpyrrolidone and / or polyvinyl alcohol are coated. The coating composition containing the agent is used to coat a solid material composed of other components of the solid composition to suppress discoloration of the pigment in the solid composition or the liquid composition. [Effect] Discoloration of the dye can be prevented by a simple pharmaceutically method without being restricted by the dosage form of the composition such as solid or liquid. Therefore, in solid compositions or liquid compositions in the fields of pharmaceuticals, foods, cosmetics, cosmetics, etc., it is possible to effectively suppress discoloration or fading of the pigments incorporated therein.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for suppressing discoloration of a dye incorporated in a solid composition or a liquid composition in the fields of pharmaceuticals, foods, cosmetics, cosmetics, etc., and a dye-containing composition in which discoloration of the pigment is suppressed. Regarding

[0002]

2. Description of the Related Art Generally, solid compositions or liquid compositions in the fields of pharmaceuticals, foods, cosmetics, cosmetics and the like have a high commercial value regardless of their dosage forms and applications. A dye is often added for the purpose. For example, in the case of a solid composition in the form of tablets or granules, a pigment or a metal lake thereof is added to the coating composition, and uncoated tablets or granules are coated with the coating composition to color these. If the solid composition is a capsule skin, it is possible to distinguish the capsule by color by adding a pigment to the composition, and further enhance the appearance and enhance the commercial value of the coating. Are being carried out. Further, also in a liquid composition using water, an organic solvent or the like as a medium, a dye is blended for the same reason.

However, when the dye is blended in the composition as described above, it may cause discoloration or fading due to light or heat depending on the dye to be used, and the commercial value of the composition may be significantly impaired. As a method for preventing discoloration or fading of such a dye, for example, as a dye to be blended, a method of selecting a dye that hardly causes discoloration even under light or heat conditions to which the composition is expected to be exposed, A method of using a packaging container in which light transmission is controlled for packaging, a method of encapsulating a dye with cyclodextrin (J. Chem. So.
c. Faraday Trans. , 1994, 90
(16), 2331-2336) and the like have been proposed, but the effect of suppressing discoloration by these methods is not always sufficient.

The present invention has been made in view of the above circumstances, and a method for suppressing discoloration of a dye and a dye that can be used for solid compositions or liquid compositions in a wide range of fields such as pharmaceuticals, foods, cosmetics and cosmetics. It is an object of the present invention to provide a dye-containing composition in which discoloration of the above is suppressed.

[0005]

Means and Action for Solving the Problems The present inventors have
As a result of earnestly studying to achieve the above object,
For the dyes used in the fields of foods, cosmetics, cosmetics, etc., it was found that coexistence of polyvinylpyrrolidone and polyvinyl alcohol, which are specific polymer substances, suppress discoloration and fading, and the present invention It came to eggplant.

That is, the present invention is a method for suppressing the discoloration of a dye compounded in a solid composition or a liquid composition, which is characterized in that polyvinylpyrrolidone and / or polyvinyl alcohol coexists in the dye. Disclosed is a method for suppressing discoloration, and a solid composition or a liquid composition containing a dye, wherein the dye contains a polyvinylpyrrolidone and / or polyvinyl alcohol coexisting therein. Hereinafter, the present invention will be described in more detail. The present invention is a solid composition, or a liquid composition including not only a liquid composition but also a composition such as paste, jelly, cream and ointment, and polyvinylpyrrolidone and a pigment. The colorant and / or polyvinyl alcohol coexist to suppress discoloration or fading of the dye, and the dye and polyvinylpyrrolidone and / or polyvinyl alcohol preferably coexist in the same phase. Here, the dye of the present invention is not particularly limited in its kind as long as it is approved to be mixed in the fields of pharmaceuticals, foods, cosmetics and the like, and such dyes include, for example, Red No. 2 , Red No. 3, Red No. 102, Red No. 104,
Red No. 105, Red No. 106, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1, Blue No. 2, Daidai No. 203, Yellow No. 202, Green No. 201, Blue No. 205, Red 506
No., Daidai No. 402, Yellow No. 406, Green No. 401, etc., metal lakes of these dyes and Red 201
No. etc. are mentioned, and these can be used individually by 1 type or in combination of 2 or more types.

The present invention suppresses discoloration and fading of the dye, and is extremely effective particularly for dyes having poor light resistance and heat resistance. Therefore, the dye of the present invention is
Among the above dyes, Red No. 3, Red No. 104, Red No. 106, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1, metal lakes of these dyes, and Red No. 201 are particularly preferable. is there. Here, the kind of metal of the metal lake is not particularly limited, and examples of such metal include aluminum, barium, zirconium, and the like. The dye of the present invention, it is also possible to use a natural dye, such as carotene, anato dye, paprika dye, carotenoid dye such as gardenia yellow pigment, safflower yellow pigment, safflower red pigment Chalcone pigments such as chlorophyll, copper chlorophyll,
Porphyrin-based pigments such as spirulina blue pigments, diketone-based pigments such as turmeric pigments, betacyanine-based pigments such as beet red, red yeast rice red pigments, azaphylon pigments such as red yeast rice pigments, gardenia blue pigments, gardenia red pigments You can list elementary and so on.

The blending amount of the above-mentioned dye in the present invention is not particularly limited and can be appropriately adjusted depending on the purpose of coloring, the kind of the dye, etc. In general, in the case of a liquid composition, the composition is 0.00001-0.
1% by weight / volume, especially 0.00005-0.01% by weight /
Volume% is preferred. If it is less than 0.00001% by weight / volume, the purpose of blending the dye may not be achieved, and
When the content exceeds the weight / volume%, the color tone becomes extremely dark, which may substantially impair the commercial value. In the case of a solid composition, for the same reason, the whole solid composition when other components are mixed, and the whole coating composition (when the coating composition is used, the solvent does not include a solvent formed after the coating operation, The same), 0.0001 to 1% by weight, and particularly 0.0005 to 0.1% by weight are preferable.

In the present invention, either or both of polyvinylpyrrolidone and polyvinyl alcohol coexist in the above dye. Here, the polyvinylpyrrolidone of the present invention, although its molecular weight is not particularly limited,
Weight average molecular weight of 10,000 to 1,200,000,
Particularly, 25,000 to 40,000 polyvinylpyrrolidone is preferably used. If it is less than 10,000, the viscosity becomes excessive, which may cause a problem in handling the composition. If it exceeds 1,200,000, the compatibility with other components is deteriorated, and a stable composition can be produced. It can be difficult.

The blending amount of polyvinylpyrrolidone in the present invention can be appropriately selected depending on the kind of composition, purpose and the like. For example, in the case of a solid composition coated with a coating composition containing a pigment and polyvinylpyrrolidone, 0.05 to 90% by weight, particularly 0.
It is preferably 1 to 20% by weight. By setting the blending amount within this range, a dispersion viscosity that does not hinder the coating operation can be obtained.

The degree of saponification of the polyvinyl alcohol of the present invention is not particularly limited. For example, when the composition is a solid composition coated with a coating composition containing a dye and polyvinyl alcohol, it is 60 to 60%. 100 mol%,
Particularly, 78 to 96 mol% is preferable. When the saponification degree of polyvinyl alcohol is within the above range, the solubility of polyvinyl alcohol in a solvent that can be used for dispersing the coating composition is suitable. The degree of polymerization is also not particularly limited, but in the case of the solid composition, the degree of polymerization is preferably 300 to 3,000.
If it is less than 300, stickiness may occur, and 3,000
If it exceeds 0, the viscosity may be adversely affected.

The blending amount of polyvinyl alcohol in the present invention can be appropriately selected depending on the kind of composition, purpose and the like. For example, in the case of a solid composition coated with the above coating composition, the total amount of the coating composition is To 0.05-9
It is preferably 0% by weight, particularly preferably 0.1 to 20% by weight. By setting the blending amount within this range, a dispersion viscosity that does not hinder the coating operation can be obtained.

Polyvinylpyrrolidone for the dye and /
Alternatively, the total amount of polyvinyl alcohol added is 1,000.
-10,000,000% by weight, especially 10,000-
5,000,000 wt% is preferred. If it is less than 1,000% by weight, discoloration of the pigment may not be sufficiently suppressed,
If it exceeds 10,000,000% by weight, the amount of the composition may be substantially excessive, resulting in increased adhesiveness, viscosity, etc., which may impair the handleability of the composition.

The other components of the liquid composition or solid composition of the present invention can be appropriately selected depending on the type of composition, purpose and the like, and the type and amount thereof are not particularly limited.
Examples of such components include polyethylene glycol, propylene glycol, glycerin, cyclodextrin, stearic acid and salts thereof, gelatin, gum arabic powder, carnauba wax, sucrose, trialkyl citrate, sucrose fatty acid ester, silicone resin, polysorbate, and fragrance. And flavoring agents. Further, a substance having any physiologically active action may be added.

When the solid composition of the present invention is a solid composition coated with a coating composition, a known coating agent having a film-forming ability other than polyvinylpyrrolidone and polyvinyl alcohol is appropriately added to the coating composition. As such a coating agent, for example, methyl cellulose, ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl methyl cellulose phthalate, hydroxypropyl methyl cellulose acetate succinate, polyvinyl acetal diethylaminoacetate, carboxymethyl ethyl cellulose, cellulose acetate phthalate, Dextrin, pullulan, aminoalkylmethacrylate copolymer, methacrylic acid copolymer, sodium alginate, shellac It can be mentioned. Also,
In addition to the above-mentioned dyes, inorganic substances generally added to known coating compositions may be appropriately added as needed, and examples of such inorganic substances include titanium oxide, talc, magnesium oxide and the like. You can Further, the above-mentioned other components may be appropriately incorporated in the coating composition.

In order to allow the dye of the present invention and polyvinylpyrrolidone and / or polyvinyl alcohol to coexist, these are mixed uniformly with the above-mentioned other components, or a coating composition containing them and the above-mentioned coating agent is used. It is preferable to coat a solid substance containing other components, but as a more specific method, for example, a uniform solution or dispersion is obtained by dissolving or dispersing polyvinylpyrrolidone and / or polyvinyl alcohol and the above dye in a solvent. Prepare the liquid. The solvent used here may be one that can dissolve and disperse polyvinylpyrrolidone, polyvinyl alcohol and a dye, and examples of such a solvent include water, methanol, ethanol, ether,
Examples thereof include organic solvents such as acetone and isopropanol, and these may be used alone or in combination of two or more. The order of dissolving or dispersing polyvinylpyrrolidone, polyvinyl alcohol and a dye in a solvent is arbitrary.

When the composition of the present invention is a liquid composition,
It is preferable that polyvinylpyrrolidone and / or polyvinyl alcohol and a dye are dissolved in the solvent,
It is preferable to produce a liquid composition by mixing this solution with the other components of the above liquid composition. Here, the mixing order of the other components of the liquid composition is arbitrary, and for example, polyvinylpyrrolidone, polyvinyl alcohol and the dye may be mixed with these components when the dye and the polyvinylpyrrolidone are dissolved in the solvent. After that, these components may be blended. When polyvinylpyrrolidone and / or polyvinylalcohol and a dye are dispersed in the above solvent, it is also preferable that polyvinylpyrrolidone or the like is dissolved in the liquid composition by mixing with other components. Further, in the case of a liquid composition, it can be further diluted before use. In this case, the type of medium used is not particularly limited and can be arbitrarily selected. Examples of such a medium include water, ethanol, polyhydric alcohols, polyalkylene glycols and liquid surfactants. These can be used alone or in combination of two or more.

On the other hand, when the composition of the present invention is a solid composition, the above solution is uniformly mixed with the other components of the above solid composition to produce a solid composition, or the above solid composition is used. The other components of the above are made into solids such as plain tablets and elementary granules, and the solids are sprayed with, for example, a solution or dispersion prepared by further blending the above-mentioned coating agent with the above-mentioned solution or dispersion, and the above-mentioned solids depending on the coating composition. Is preferably coated to produce a solid composition. When other components are mixed with the above-mentioned solution, the compounding order is arbitrary as in the case of the liquid composition. Further, even when other components are solids, the constituent components are not particularly limited as described above,
For example, the derived product can be freely selected from substances and additives having physiological activity. The method for producing the same is not particularly limited, and for example, the method for producing granules, granules, tablets and the like can be carried out according to a conventional method. In the case of a solid composition, the solvent used for preparing the above-mentioned solution or dispersion may be removed by drying after the composition is produced, if necessary.

[0019]

INDUSTRIAL APPLICABILITY According to the present invention, discoloration of a dye can be prevented by a pharmaceutically simple method without being restricted by the dosage form of a composition such as solid or liquid. Therefore, in solid compositions or liquid compositions in the fields of pharmaceuticals, foods, cosmetics, cosmetics, etc., it is possible to effectively suppress discoloration or fading of the pigments incorporated therein.

[0020]

The present invention will be described below in more detail with reference to Examples, but the present invention is not limited to the following Examples.

Example 1 160 g of hydroxypropylmethylcellulose, 16 g of polyvinylpyrrolidone (molecular weight (weight average molecular weight, the same applies hereinafter): about 40,000),
16 g of titanium oxide and 0.03 g of Food Blue No. 1 were added to water, and an aqueous dispersion of the coating composition having a total amount of 1600 g was prepared by a conventional method. Then acetaminophen, lactose,
1000 g of round uncoated tablets made of a crystalline cellulose and magnesium stearate and manufactured by a conventional method were put into a pan coating device (manufactured by Freund Sangyo Co., Ltd.),
While flowing the uncoated tablet while heating the inside of the device, spray an aqueous dispersion of the coating composition into the device, evaporate the water content in the aqueous dispersion, the tablet coated with the coating composition (Solid composition) was obtained. Here, the coating amount of the coating composition was 5% with respect to the uncoated tablet.

[Example 2] In Example 1, the amount of polyvinylpyrrolidone to be added in the aqueous dispersion of the coating composition was changed to 3.2 g, and the edible blue color No. 1 was replaced with 0.03 g. Tablets coated with the above coating composition were obtained in the same manner as in Example 1 except that 03 g was added. The coating amount was the same as in Example 1.

Example 3 In Example 1, the content of polyvinylpyrrolidone in the aqueous dispersion of the coating composition was changed to 28.8 g, and the edible blue color No. 1 was replaced with 0.03 g and the edible yellow color No. 5 was added. Tablets coated with the above coating composition were obtained in the same manner as in Example 1 except that 03 g was added. The coating amount was the same as in Example 1.

Example 4 160 g of hydroxypropylmethylcellulose, 10 g of polyvinyl alcohol (polymerization degree: about 1,000, saponification degree: about 88 mol%), food red No. 3 0.03 g, titanium oxide 16 g, talc 16 g were added to water. And an aqueous dispersion of the coating composition having a total amount of 1600 g was prepared by a conventional method. Then acetaminophen,
1000 g of a round plain tablet made of lactose, crystalline cellulose and magnesium stearate and manufactured by a conventional method is put into a pan coating device (manufactured by Freund Sangyo Co., Ltd.) and the plain tablet is fluidized while heating the inside of the device. Along with, spray an aqueous dispersion of the coating composition into the device,
Moisture in the aqueous dispersion was evaporated to obtain tablets coated with the above coating composition. Here, the coating amount of the coating composition was 8% based on the uncoated tablets.

[Example 5] 160 g of hydroxypropylmethylcellulose, 12 g of polyvinylpyrrolidone (molecular weight: about 40,000), 4 g of polyvinyl alcohol (polymerization degree: about 1,500, saponification degree: about 88 mol%), titanium oxide 16 g and 0.03 g of Food Green No. 3 was added to water to prepare an aqueous dispersion of the coating composition having a total amount of 1600 g by a conventional method. Then consists of acetaminophen, lactose, crystalline cellulose and magnesium stearate,
A round uncoated tablet (1000 g) manufactured by a conventional method was put into a pan coating device (manufactured by Freund Sangyo Co., Ltd.), the uncoated tablet was fluidized while heating the inside of the device, and an aqueous dispersion of the coating composition was added. The tablet was sprayed into the apparatus to evaporate the water content in the aqueous dispersion to obtain a tablet coated with the coating composition. Here, the coating amount of the coating composition was 5% with respect to the uncoated tablet.

Example 6 In Example 5, the amount of polyvinylpyrrolidone mixed in the aqueous dispersion of the coating composition was changed to 4 g, the amount of polyvinyl alcohol was changed to 12 g, and food green No. 3 was replaced with 0.03 g. Tablets coated with the above coating composition were obtained in the same manner as in Example 5 except that 0.03 g of Food Yellow No. 5 was added. The coating amount was the same as in Example 5.

[Example 7] The same as Example 1 except that 0.2 g of food red No. 3 aluminum lake was added in place of food blue No. 1 0.03 g in the aqueous dispersion of the coating composition. To obtain a tablet coated with the above coating composition. The coating amount was the same as in Example 1.

[Example 8] Aquacoat (trade name; ethyl cellulose aqueous dispersion manufactured by Asahi Kasei Corporation) 200
g, polyvinylpyrrolidone (molecular weight: about 40,000)
15 g, 20 g of talc, 20 g of triethyl citrate and 0.03 g of Food Green No. 3 were added to water to prepare an aqueous dispersion of a coating composition having a total amount of 400 g by a conventional method. Next, spherical elementary granules (particle size: 500, obtained by laminating phenylpropanolamine hydrochloride, corn starch, talc, and hydroxypropyl cellulose on purified sucrose spherical granules (particle size 500
(μm to 710 μm) is put into a centrifugal fluidized granulation coating apparatus, and while the inside of the apparatus is heated, the elementary particles are tumbled, and an aqueous dispersion of the coating composition is sprayed into the apparatus, The water content in the dispersion was evaporated to obtain granules (solid composition) coated with the coating composition. Here, the coating amount of the coating composition was about 12% in terms of solid content based on the elementary particles.

[Example 9] The same as Example 8 except that 0.2 g of food yellow No. 5 aluminum lake was added in place of food green No. 3 0.03 g in the aqueous dispersion of the coating composition. To obtain a tablet coated with the above coating composition. The coating amount was the same as in Example 8.

[Example 10] By a conventional method, 3 g of potassium aluminum sulfate, 50 ml of mint water, 10 g of polyvinylpyrrolidone (molecular weight: about 40,000) and edible red No. 106 0.0002% (weight%, the same shall apply hereinafter), edible Yellow No. 4 was dissolved in water to a concentration of 0.0004% to prepare a mouthwash (liquid composition) having a total amount of 1000 ml.

[Example 11] By a conventional method, sodium polyoxyethylene alkyl ether sulfate 30%, coconut oil fatty acid amide propyl betaine 10%, coconut oil fatty acid diethanolamide 3%, polyvinylpyrrolidone (molecular weight: about 40,000) 1 .2%, cationized cellulose 0.5%, hexylene glycol 3%, sodium benzoate 3%, green No. 3 0.0001%, an appropriate amount of citric acid,
Shampoo (liquid composition) consisting of appropriate amount of fragrance and purified water
Was prepared.

Example 12 By a conventional method, stearyl trimethyl ammonium chloride 1.5%, cetostearyl alcohol 3%, polyvinylpyrrolidone (molecular weight: about 2)
5,000) 1.5%, polyoxyethylene alkylphenyl ether phosphoric acid 0.8%, sorbitan monostearate 0.5%, propylene glycol 6%, red 20
No. 1 0.0003%, an appropriate amount of benzoic acid, an appropriate amount of fragrance, and a hair rinse (liquid composition) comprising purified water were prepared.

Example 13 By a conventional method, sodium polyoxyethylene alkyl ether sulfate 10%, coconut oil fatty acid diethanolamide 0.2%, linear alkylbenzene sulfonate sodium 16%, polyethylene glycol 1%, polyvinylpyrrolidone (molecular weight : About 40,0
00) 2%, ethanol 4%, sodium benzoate 2
%, Blue No. 1, 0.00005%, an appropriate amount of citric acid, an appropriate amount of fragrance, and clean water were prepared as a kitchen detergent (liquid composition).

Example 14 By a conventional method, 85.3% of a soap base (containing 12% by weight of water), 4% of coconut oil fatty acid amidopropyldimethylaminoacetic acid betaine, 2% of squalane, polyvinylpyrrolidone (molecular weight: about 40) , 00
0) 2%, EHPP 0.3%, aloe extract powder 0.2%,
A solid soap (solid composition) comprising 0.2% titanium dioxide, 5% palmitic acid, an appropriate amount of fragrance, and 0.0005% of Red No. 106 was produced.

[Comparative Example 1] Tablets coated with the above coating composition were obtained in the same manner as in Example 2 except that polyvinylpyrrolidone was not added. In addition,
The coating amount was also the same as in Example 2.

Comparative Example 2 A tablet coated with the above coating composition was obtained in the same manner as in Example 8 except that polyvinylpyrrolidone was not added. In addition,
The coating amount was the same as in Example 8.

[Comparative Example 3] Tablets coated with the above coating composition were obtained in the same manner as in Example 7 except that polyvinylpyrrolidone was not added. In addition,
The coating amount was also the same as in Example 7.

Comparative Example 4 A mouthwash was prepared in the same manner as in Example 10 except that polyvinylpyrrolidone was not added.

Comparative Example 5 A hair rinse was prepared in the same manner as in Example 12 except that polyvinylpyrrolidone was not added.

Examples 1 to 9 and 14 and Comparative Examples 1 to 3
For each solid composition obtained in step 1, the degree of discoloration was observed under fluorescent light irradiation (30 W) conditions at room temperature for 8 weeks, or under light-shielded storage conditions at 40 ° C. and 75% relative humidity for 8 weeks. The degree of discoloration of the dye contained in each solid composition was evaluated according to the evaluation criteria. The results are shown in Table 1. <Evaluation criteria>(++); Significant discoloration is recognized (+); Discoloration is recognized (-); Discoloration is not recognized

[0041]

[Table 1]

According to the results shown in Table 1, the discoloration of the dye incorporated in the solid composition of the present invention is suppressed, whereas neither polyvinylpyrrolidone nor polyvinyl alcohol coexists with the dye. Solid composition (Comparative Example 1
In the cases of 3) to 3), it is recognized that the discoloration of the dye in the composition is not suppressed.

Next, the liquid compositions obtained in Examples 10 to 13 and Comparative Examples 4 and 5 were put in a colorless transparent glass bottle, and the above was performed under the conditions of fluorescent lamp irradiation (30 W) for 8 weeks at room temperature. The degree of discoloration of the dye in each liquid composition was observed, and the degree of discoloration of the dye blended in each liquid composition was evaluated according to the same evaluation criteria as above. Table 2 shows the results.

[0044]

[Table 2]

According to the results shown in Table 2, the discoloration of the dye incorporated in the liquid composition of the present invention was suppressed, while neither polyvinylpyrrolidone nor polyvinyl alcohol coexisted with the dye. In the case of the liquid compositions (Comparative Examples 4 and 5), it is observed that the discoloration of the pigment in the composition is not suppressed.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification number Reference number within the agency FI Technical indication location A61K 47/22 A61K 47/22 M 47/32 47/32 K (72) Inventor Etsuo Ogasawara Tokyo Sumida-ku Honsho 1-3-7, Lion Co., Ltd.

Claims (5)

[Claims] 1. A method for suppressing discoloration of a dye blended in a solid composition or a liquid composition, which comprises allowing polyvinylpyrrolidone and / or polyvinyl alcohol to coexist in the dye. 2. A method in which polyvinylpyrrolidone and / or polyvinyl alcohol, a dye and the other components of the solid composition or the liquid composition are uniformly mixed to suppress discoloration of the dye in the solid composition or the liquid composition. 1. A method for suppressing discoloration of a dye according to 1. 3. A coating composition containing polyvinylpyrrolidone and / or polyvinyl alcohol, a dye and a coating agent is used to coat a solid comprising the other components of the solid composition to prevent discoloration of the dye in the solid composition. The method for suppressing discoloration of a dye according to claim 1. 4. The dyes are Red No. 3, Red No. 104, and Red No. 1.
6. One, two or more selected from No. 06, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1 and metal lakes of these dyes, and Red No. 201. Method for suppressing discoloration of dyes in. 5. A solid composition or a liquid composition containing a dye, wherein the dye is mixed with polyvinylpyrrolidone and / or polyvinyl alcohol.