JPH09503924A - 非侵襲性グルコースモニター - Google Patents
非侵襲性グルコースモニターInfo
- Publication number
- JPH09503924A JPH09503924A JP7504544A JP50454495A JPH09503924A JP H09503924 A JPH09503924 A JP H09503924A JP 7504544 A JP7504544 A JP 7504544A JP 50454495 A JP50454495 A JP 50454495A JP H09503924 A JPH09503924 A JP H09503924A
- Authority
- JP
- Japan
- Prior art keywords
- glucose
- patient
- collection medium
- skin
- reservoir
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 108
- 239000008103 glucose Substances 0.000 title claims abstract description 108
- 238000000034 method Methods 0.000 claims abstract description 31
- 239000008280 blood Substances 0.000 claims abstract description 17
- 210000004369 blood Anatomy 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 238000001514 detection method Methods 0.000 claims description 9
- 238000004458 analytical method Methods 0.000 claims description 8
- 239000003623 enhancer Substances 0.000 claims description 7
- 239000000411 inducer Substances 0.000 claims description 6
- 238000012544 monitoring process Methods 0.000 claims description 6
- 230000035699 permeability Effects 0.000 claims description 6
- 239000000853 adhesive Substances 0.000 claims description 3
- 230000001070 adhesive effect Effects 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims 6
- 108090000790 Enzymes Proteins 0.000 claims 6
- 210000003491 skin Anatomy 0.000 abstract description 16
- 210000003722 extracellular fluid Anatomy 0.000 abstract description 9
- 239000000126 substance Substances 0.000 abstract description 6
- 210000000434 stratum corneum Anatomy 0.000 abstract description 5
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 4
- 230000005611 electricity Effects 0.000 abstract description 3
- 238000012806 monitoring device Methods 0.000 abstract description 2
- 210000004243 sweat Anatomy 0.000 description 5
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000013043 chemical agent Substances 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 108010015776 Glucose oxidase Proteins 0.000 description 2
- 239000004366 Glucose oxidase Substances 0.000 description 2
- 239000012790 adhesive layer Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
- 239000007933 dermal patch Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 229940116332 glucose oxidase Drugs 0.000 description 2
- 235000019420 glucose oxidase Nutrition 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 210000000106 sweat gland Anatomy 0.000 description 2
- 238000004832 voltammetry Methods 0.000 description 2
- 229920000298 Cellophane Polymers 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000002457 bidirectional effect Effects 0.000 description 1
- 239000003833 bile salt Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001713 cholinergic effect Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000000835 electrochemical detection Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000004955 epithelial membrane Anatomy 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 150000002303 glucose derivatives Chemical class 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229910052741 iridium Inorganic materials 0.000 description 1
- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- HWLDNSXPUQTBOD-UHFFFAOYSA-N platinum-iridium alloy Chemical compound [Ir].[Pt] HWLDNSXPUQTBOD-UHFFFAOYSA-N 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Optics & Photonics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9297593A | 1993-07-16 | 1993-07-16 | |
| US08/092,975 | 1993-07-16 | ||
| PCT/US1994/006684 WO1995002357A1 (fr) | 1993-07-16 | 1994-06-14 | Glucometre non invasif |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH09503924A true JPH09503924A (ja) | 1997-04-22 |
Family
ID=22236062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7504544A Pending JPH09503924A (ja) | 1993-07-16 | 1994-06-14 | 非侵襲性グルコースモニター |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0708615A4 (fr) |
| JP (1) | JPH09503924A (fr) |
| AU (1) | AU7107394A (fr) |
| CA (1) | CA2167393A1 (fr) |
| WO (1) | WO1995002357A1 (fr) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7497940B2 (en) | 2003-09-02 | 2009-03-03 | Koji Sode | Glucose sensor and glucose level measuring apparatus |
| US8747316B2 (en) | 2008-07-31 | 2014-06-10 | Sysmex Corporation | In vivo component measurement method, data processing method for in vivo component measurement, in vivo component measurement apparatus and collection member |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5890489A (en) * | 1996-04-23 | 1999-04-06 | Dermal Therapy (Barbados) Inc. | Method for non-invasive determination of glucose in body fluids |
| US5954685A (en) * | 1996-05-24 | 1999-09-21 | Cygnus, Inc. | Electrochemical sensor with dual purpose electrode |
| US6139718A (en) | 1997-03-25 | 2000-10-31 | Cygnus, Inc. | Electrode with improved signal to noise ratio |
| US8287483B2 (en) | 1998-01-08 | 2012-10-16 | Echo Therapeutics, Inc. | Method and apparatus for enhancement of transdermal transport |
| US7066884B2 (en) | 1998-01-08 | 2006-06-27 | Sontra Medical, Inc. | System, method, and device for non-invasive body fluid sampling and analysis |
| CA2265119C (fr) | 1998-03-13 | 2002-12-03 | Cygnus, Inc. | Biocapteur et systeme d'echantillonnage iontophoresique et methodes d'utilisation de ceux-ci |
| CA2330629C (fr) | 1998-05-13 | 2007-04-03 | Cygnus, Inc. | Procede et dispositif permettant de prevoir des valeurs de mesures physiologiques |
| ATE220936T1 (de) | 1998-05-13 | 2002-08-15 | Cygnus Therapeutic Systems | Sammelvorrichtungen für transdermale probennahmesysteme |
| PT1077634E (pt) | 1998-05-13 | 2003-12-31 | Cygnus Therapeutic Systems | Monitorizacao de substancias fisiologicas a analisar |
| DE69914319T2 (de) | 1998-05-13 | 2004-11-18 | Cygnus, Inc., Redwood City | Signalverarbeitung zur messung von physiologischen analyten |
| US6180416B1 (en) | 1998-09-30 | 2001-01-30 | Cygnus, Inc. | Method and device for predicting physiological values |
| CA2346055C (fr) | 1998-09-30 | 2004-06-29 | Animas Technologies Llc | Procede et dispositif de prediction de valeurs physiologiques |
| WO2000024455A1 (fr) | 1998-10-28 | 2000-05-04 | Cygnus, Inc. | Necessaire et procede permettant de controler la qualite d'un systeme de prelevement par ionophorese |
| US20040171980A1 (en) | 1998-12-18 | 2004-09-02 | Sontra Medical, Inc. | Method and apparatus for enhancement of transdermal transport |
| WO2000047109A1 (fr) | 1999-02-12 | 2000-08-17 | Cygnus, Inc. | Dispositifs et procedes permettant d'effectuer des mesures frequentes d'un analyte present dans un systeme biologique |
| WO2000064533A1 (fr) | 1999-04-22 | 2000-11-02 | Cygnus, Inc. | Procedes et dispositifs pour enlever les especes interferentes |
| US6251083B1 (en) | 1999-09-07 | 2001-06-26 | Amira Medical | Interstitial fluid methods and devices for determination of an analyte in the body |
| WO2003000127A2 (fr) | 2001-06-22 | 2003-01-03 | Cygnus, Inc. | Procedes d'amelioration de l'efficacite d'un systeme de controle d'analyte |
| US8010174B2 (en) | 2003-08-22 | 2011-08-30 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| US9247901B2 (en) | 2003-08-22 | 2016-02-02 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| US8260393B2 (en) | 2003-07-25 | 2012-09-04 | Dexcom, Inc. | Systems and methods for replacing signal data artifacts in a glucose sensor data stream |
| US7150975B2 (en) | 2002-08-19 | 2006-12-19 | Animas Technologies, Llc | Hydrogel composition for measuring glucose flux |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US20140121989A1 (en) | 2003-08-22 | 2014-05-01 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| WO2005057168A2 (fr) | 2003-12-05 | 2005-06-23 | Dexcom, Inc. | Techniques d'etalonnage pour un capteur de substances a analyser en continu |
| US8423114B2 (en) | 2006-10-04 | 2013-04-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US11633133B2 (en) | 2003-12-05 | 2023-04-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US8792955B2 (en) | 2004-05-03 | 2014-07-29 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US8989833B2 (en) | 2004-07-13 | 2015-03-24 | Dexcom, Inc. | Transcutaneous analyte sensor |
| EP3524142B1 (fr) * | 2004-07-13 | 2021-04-28 | Dexcom, Inc. | Capteur d'analyte transcutanée |
| US20070045902A1 (en) | 2004-07-13 | 2007-03-01 | Brauker James H | Analyte sensor |
| US8886272B2 (en) | 2004-07-13 | 2014-11-11 | Dexcom, Inc. | Analyte sensor |
| US8224414B2 (en) | 2004-10-28 | 2012-07-17 | Echo Therapeutics, Inc. | System and method for analyte sampling and analysis with hydrogel |
| US7432069B2 (en) | 2005-12-05 | 2008-10-07 | Sontra Medical Corporation | Biocompatible chemically crosslinked hydrogels for glucose sensing |
| NZ580997A (en) | 2007-04-27 | 2011-08-26 | Echo Therapeutics Inc | Dermal abrasion device with feedback electrode to deliver data on skin thickness and removable abrasion heads |
| US8597570B2 (en) | 2008-11-04 | 2013-12-03 | Panasonic Corporation | Measurement device, insulin infusion device, measurement method, method for controlling insulin infusion device, and program |
| JP2010271259A (ja) | 2009-05-25 | 2010-12-02 | Sysmex Corp | 生体成分分析方法、生体成分分析装置、生体成分分析用カートリッジおよび生体成分分析用キット |
| KR101666978B1 (ko) | 2014-09-17 | 2016-10-24 | 주식회사 아이센스 | 생체시료 내 분석대상물질의 농도측정방법 및 측정장치 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK8601218A (fr) * | 1984-07-18 | 1986-03-17 | ||
| US5076273A (en) * | 1988-09-08 | 1991-12-31 | Sudor Partners | Method and apparatus for determination of chemical species in body fluid |
| US5139023A (en) * | 1989-06-02 | 1992-08-18 | Theratech Inc. | Apparatus and method for noninvasive blood glucose monitoring |
| US5056521A (en) * | 1989-06-29 | 1991-10-15 | Health Craft International, Inc. | Method for monitoring glucose level |
| US5050604A (en) * | 1989-10-16 | 1991-09-24 | Israel Reshef | Apparatus and method for monitoring the health condition of a subject |
| US5140985A (en) * | 1989-12-11 | 1992-08-25 | Schroeder Jon M | Noninvasive blood glucose measuring device |
| US5036861A (en) * | 1990-01-11 | 1991-08-06 | Sembrowich Walter L | Method and apparatus for non-invasively monitoring plasma glucose levels |
-
1994
- 1994-06-14 AU AU71073/94A patent/AU7107394A/en not_active Abandoned
- 1994-06-14 WO PCT/US1994/006684 patent/WO1995002357A1/fr not_active Ceased
- 1994-06-14 EP EP94920190A patent/EP0708615A4/fr not_active Withdrawn
- 1994-06-14 CA CA 2167393 patent/CA2167393A1/fr not_active Abandoned
- 1994-06-14 JP JP7504544A patent/JPH09503924A/ja active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7497940B2 (en) | 2003-09-02 | 2009-03-03 | Koji Sode | Glucose sensor and glucose level measuring apparatus |
| US8277636B2 (en) | 2003-09-02 | 2012-10-02 | Koji Sode | Glucose sensor and glucose level measuring apparatus |
| US8747316B2 (en) | 2008-07-31 | 2014-06-10 | Sysmex Corporation | In vivo component measurement method, data processing method for in vivo component measurement, in vivo component measurement apparatus and collection member |
Also Published As
| Publication number | Publication date |
|---|---|
| AU7107394A (en) | 1995-02-13 |
| WO1995002357A1 (fr) | 1995-01-26 |
| EP0708615A4 (fr) | 1996-10-16 |
| EP0708615A1 (fr) | 1996-05-01 |
| CA2167393A1 (fr) | 1995-01-26 |
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