JPH0966100A - Artificial dialysis equipment sterilization cleaning method for instruments - Google Patents
Artificial dialysis equipment sterilization cleaning method for instrumentsInfo
- Publication number
- JPH0966100A JPH0966100A JP7246620A JP24662095A JPH0966100A JP H0966100 A JPH0966100 A JP H0966100A JP 7246620 A JP7246620 A JP 7246620A JP 24662095 A JP24662095 A JP 24662095A JP H0966100 A JPH0966100 A JP H0966100A
- Authority
- JP
- Japan
- Prior art keywords
- artificial dialysis
- instruments
- artificial
- dialysis equipment
- equipment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- External Artificial Organs (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
(57)【要約】
【目的】 人工透析装置器具類に対する殺菌洗浄作用を
高め、器具類の内面に付着する炭酸カルシウムの除去作
業を軽減し、且つ廃液の中和処理を必要としない処理方
法を提供する。
【構成】 人工透析装置器具類にクロロイソシアヌル酸
あるいはその塩を含む水溶液を接触させる。(57) [Summary] [Objective] A treatment method that enhances the sterilization and cleaning action on artificial dialysis equipment instruments, reduces the work of removing calcium carbonate adhering to the inner surfaces of instruments, and does not require neutralization of waste liquid. provide. [Structure] An artificial dialysis device instrument is brought into contact with an aqueous solution containing chloroisocyanuric acid or a salt thereof.
Description
【０００１】[0001]
【産業上の利用分野】この発明は、人工透析装置器具類
の殺菌洗浄法に関するものであり、詳しくは人工透析に
おいて使用される容器、チューブ、フィルター、備品な
どの殺菌及び洗浄処理に係るものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for sterilizing and cleaning artificial dialysis equipment, and more particularly to a method for sterilizing and cleaning containers, tubes, filters and equipment used in artificial dialysis. is there.
【０００２】[0002]
【従来の技術】従来の人工透析装置器具類の殺菌洗浄処
理は、人工透析に使用される容器、チューブ、フィルタ
ー、備品等に次亜塩素酸ナトリウム水溶液あるいは界面
活性剤を接触させる方法がとられている。この種の器具
類には、使用時にその内面に炭酸カルシウムが付着しス
ケールを生じるので、これを除去するため２〜３日毎に
酢酸などの酸性物質を用いて、洗浄することを余儀なく
されている。特開平７−３９８５８号公報には、医療機
関等において発生する感染性の廃棄物を処理するに当た
り、クロロシアヌル酸系化合物を用いる発明が開示され
ている。2. Description of the Related Art The conventional sterilizing and cleaning treatment for artificial dialysis equipment is carried out by contacting an aqueous sodium hypochlorite solution or a surfactant with a container, tube, filter, equipment, etc. used for artificial dialysis. ing. Calcium carbonate adheres to the inner surface of these kinds of equipment during use to form scales, so it is unavoidable to wash them with an acidic substance such as acetic acid every 2-3 days to remove the scales. . Japanese Unexamined Patent Publication (Kokai) No. 7-39858 discloses an invention using a chlorocyanuric acid-based compound for treating infectious waste generated in medical institutions.
【０００３】[0003]
【発明が解決しようとする課題】人工透析装置器具類の
殺菌洗浄処理において、次亜塩素酸ナトリウム水溶液あ
るいは界面活性剤を用いる場合、処理薬液のｐＨは通常
１０〜１３の範囲にありアルカリ性であるため、透析器
具類の内面に炭酸カルシウムが固着し、スケールが発生
する。また、次亜塩素酸ナトリウム、界面活性剤等を含
む廃液あるいは酢酸などの酸性物質を含む処理液を排出
する際には、それぞれ中和処理が行われている。When a sodium hypochlorite aqueous solution or a surfactant is used in the sterilizing and cleaning treatment of artificial dialyzer instruments, the pH of the treatment chemical is usually in the range of 10 to 13 and is alkaline. Therefore, calcium carbonate adheres to the inner surface of the dialysis equipment and scale is generated. Further, when discharging a waste liquid containing sodium hypochlorite, a surfactant or the like or a treatment liquid containing an acidic substance such as acetic acid, a neutralization treatment is performed respectively.
【０００４】[0004]
【課題を解決するための手段】本発明者らは、人工透析
装置器具類に対する殺菌洗浄作用を高め、器具類の内面
に付着する炭酸カルシウムを除去し、且つ廃液の中和処
理を必要としない方法について鋭意検討を重ねた結果、
人工透析装置器具類にクロロイソシアヌル酸あるいはそ
の塩を含む水溶液を接触させることにより、所期の目的
を達成しうることを見い出し、本発明を完成するに至っ
た。DISCLOSURE OF THE INVENTION The inventors of the present invention enhance the sterilizing and cleaning action on instruments of artificial dialysis equipment, remove calcium carbonate adhering to the inner surface of instruments, and do not require neutralization of waste liquid. As a result of earnestly examining the method,
It has been found that the intended purpose can be achieved by contacting the artificial dialysis device instruments with an aqueous solution containing chloroisocyanuric acid or a salt thereof, and completed the present invention.
【０００５】本発明方法の実施においては、処理すべき
人工透析装置器具類の容器、チューブ、フィルター、備
品類の汚染の度合いに応じて、活性塩素濃度が０．００
５〜０．１％、好ましくは０．０１〜０．０４％の範囲
になるように、クロロイソシアヌル酸あるいはその塩の
水溶液濃度を調整する。処理液を人工透析装置器具類の
容器、チューブ、フィルター、備品類に接触させるに
は、循環、浸漬、清拭、噴霧のいずれの方法も可能であ
る。また処理は常温で行うのが一般的であり、その接触
は汚染の度合いに応じて数秒から数時間の範囲で行われ
る。人工透析装置器具類は、クロロイソシアヌル酸ある
いはその塩を含む水溶液によって処理されたのち、水洗
される。In carrying out the method of the present invention, the active chlorine concentration is 0.00 depending on the degree of contamination of the containers, tubes, filters, and equipment of the artificial dialysis equipment to be treated.
The concentration of the aqueous solution of chloroisocyanuric acid or its salt is adjusted so as to be in the range of 5 to 0.1%, preferably 0.01 to 0.04%. In order to bring the treatment liquid into contact with the container, the tube, the filter, and the equipment of the artificial dialysis equipment, any of circulation, dipping, wiping and spraying can be used. Further, the treatment is generally carried out at room temperature, and the contact is carried out in the range of several seconds to several hours depending on the degree of contamination. The artificial dialyzer instruments are treated with an aqueous solution containing chloroisocyanuric acid or a salt thereof, and then washed with water.
【０００６】本発明の実施に適するクロロイソシアヌル
酸あるいはその塩の代表的なものとしては、トリクロロ
イソシアヌル酸、ジクロロイソシアヌル酸、ジクロロイ
ソシアヌル酸ナトリウム及びジクロロイソシアヌル酸カ
リウムが挙げられる。これらのうち、トリクロロイソシ
アヌル酸及びジクロロイソシアヌル酸は、ジクロロイソ
シアヌル酸アルカリ金属塩に較べて、塩素臭が強く、ま
た水に完全溶解させるのに時間が掛かり過ぎるなど、処
理液の調製が煩雑である。Representative examples of chloroisocyanuric acid or a salt thereof suitable for carrying out the present invention include trichloroisocyanuric acid, dichloroisocyanuric acid, sodium dichloroisocyanurate and potassium dichloroisocyanurate. Of these, trichloroisocyanuric acid and dichloroisocyanuric acid have a strong chlorine odor compared with alkali metal salts of dichloroisocyanuric acid, and it takes too much time to completely dissolve them in water, so that the preparation of the treatment liquid is complicated. .
【０００７】[0007]
【実施例】以下、本発明を実施例及び比較例によって、
具体的に説明する。 〔実施例１及び比較例１〕ジクロロイソシアヌル酸ナト
リウム２８０ｇを精製水７００リットルに溶解して、ｐ
Ｈ６．５、活性塩素濃度２５０ｐｐｍの処理液を調製
し、これを使用済の人工透析装置器具類の容器、チュー
ブに６時間循環接触させた。次いでこの透析装置の循環
ラインに精製水を流し、チューブの最終部位からこの洗
浄水を採取して検体とし、これに含まれる生菌（Ｋｌｅ
ｂｓｉｅｌｌａ Ｐｎｅｕｍｏｎｉａｅ）の数を測定し
た。また比較のために、次亜塩素酸ナトリウム４４００
ｇを精製水７００リットルに溶解して、ｐＨ１２、活性
塩素濃度５００ｐｐｍの処理液を調製し、これを用いて
前記と同様の試験を行い、生菌数を測定した。これらの
試験結果は、表１に示したとおりであった。The present invention will now be described by way of Examples and Comparative Examples.
This will be specifically described. [Example 1 and Comparative Example 1] 280 g of sodium dichloroisocyanurate was dissolved in 700 liters of purified water.
A treatment liquid having H6.5 and an active chlorine concentration of 250 ppm was prepared, and this was circulated and contacted with a container and a tube of a used artificial dialysis device instrument for 6 hours. Then, purified water is flown through the circulation line of the dialyzer, and the wash water is collected from the final part of the tube to obtain a sample, which is the live bacteria (Kle) contained in the sample.
The number of bsiella Pneumoniae) was measured. For comparison, sodium hypochlorite 4400
g was dissolved in 700 liters of purified water to prepare a treatment liquid having a pH of 12 and an active chlorine concentration of 500 ppm, and the same test as above was carried out using this to measure the viable cell count. These test results were as shown in Table 1.
【０００８】[0008]
【表１】 [Table 1]
【０００９】〔実施例２及び比較例２〕ジクロロイソシ
アヌル酸ナトリウム２８０ｇを精製水７００リットルに
溶解して、ｐＨ６．５、活性塩素濃度２５０ｐｐｍの処
理液を調製し、この処理液を継続して使用中の人工透析
装置器具類の容器、チューブに毎日６時間循環接触さ
せ、この処理を連続して３０日間行い、器具類に発生す
る炭酸カルシウムの状況を観察し、スケールの生成が確
認された際、直ちに酢酸による洗浄処理を行うことにし
て、その発生頻度を調べた。また比較のために、次亜塩
素酸ナトリウム４４００ｇを精製水７００リットルに溶
解して、ｐＨ１２、活性塩素濃度５００ｐｐｍの処理液
を調製し、これを用いて前記と同様の試験を行い、炭酸
カルシウムの発生によるスケールの洗浄頻度を調べた。
これらの試験結果は、表２に示したとおりであった。[Example 2 and Comparative Example 2] 280 g of sodium dichloroisocyanurate was dissolved in 700 liters of purified water to prepare a treatment liquid having a pH of 6.5 and an active chlorine concentration of 250 ppm, and the treatment liquid was continuously used. Circulating contact with the vessel and tube of the artificial dialysis machine equipment for 6 hours every day, this treatment is continuously performed for 30 days, the situation of calcium carbonate generated in the equipment is observed, and when the generation of scale is confirmed. Then, it was decided to immediately carry out a washing treatment with acetic acid, and the occurrence frequency was investigated. For comparison, 4400 g of sodium hypochlorite was dissolved in 700 liters of purified water to prepare a treatment liquid having a pH of 12 and an active chlorine concentration of 500 ppm, and the same test as the above was conducted using the treatment liquid. The frequency of cleaning the scale due to generation was examined.
These test results were as shown in Table 2.
【００１０】[0010]
【表２】 [Table 2]
【００１１】〔実施例３及び比較例３〕ジクロロイソシ
アヌル酸ナトリウム１９０ｇを精製水６００リットルに
溶解して、ｐＨ６．５、活性塩素濃度２００ｐｐｍの処
理液を調製し、この処理液に使用済の人工透析装置器具
類の容器及びチューブを６時間浸漬接触させた。次い
で、この容器及びチューブを透析装置に接続しその循環
ラインに精製水を流し、チューブの最終部位から洗浄水
を採取して検体とし、指標菌としてＰｓｅｕｄｏｍｏｎ
ａｓ Ａｅｒｕｇｉｎｏｓａ菌を調べ、その殺菌洗浄効
果を評価した。また、比較のために次亜塩素酸ナトリウ
ム６０００ｇを精製水６００リットルに溶解して、ｐＨ
１２．２、活性塩素濃度８００ｐｐｍの処理液を調製
し、これを用いて前記と同様の試験を行った。これらの
試験結果は、表３に示したとおりであった。[Example 3 and Comparative Example 3] 190 g of sodium dichloroisocyanurate was dissolved in 600 liters of purified water to prepare a treatment liquid having a pH of 6.5 and an active chlorine concentration of 200 ppm. The container and the tube of the dialysis equipment were immersed and contacted for 6 hours. Then, the container and the tube were connected to a dialysis machine, purified water was flown through the circulation line, and washing water was collected from the final part of the tube to obtain a sample, which was used as an indicator bacterium Pseudomon.
The As aeruginosa bacterium was examined and its bactericidal cleaning effect was evaluated. For comparison, 6000 g of sodium hypochlorite was dissolved in 600 liters of purified water to adjust the pH.
12.2, a treatment liquid having an active chlorine concentration of 800 ppm was prepared, and the same test as the above was conducted using the treatment liquid. The results of these tests were as shown in Table 3.
【００１２】[0012]
【表３】 [Table 3]
【００１３】[0013]
【発明の効果】本発明において使用のクロロイソシアヌ
ル酸系化合物は、次亜塩素酸ナトリウムに較べて、１／
２以下の活性塩素濃度で充分な殺菌力並びに洗浄力を有
しており、且つこれらを含む水溶液はｐＨ６〜７の弱酸
性ないし中性であり、人工透析装置器具類に付着の炭酸
カルシユムが容易に溶解するので、スケール発生による
洗浄作業が軽減され、また廃液を中和処理することなく
排出しうるなど実施上の効果は顕著である。The chloroisocyanuric acid-based compound used in the present invention is 1/100% less than sodium hypochlorite.
It has sufficient sterilizing power and detergency at an active chlorine concentration of 2 or less, and the aqueous solution containing these is weakly acidic to neutral at pH 6 to 7, and calcium carbonate easily adheres to artificial dialysis equipment instruments. Since it dissolves in water, the cleaning work due to scale generation is reduced, and the waste liquid can be discharged without being neutralized, and the practical effects are remarkable.
Claims (2)
ル酸あるいはその塩を含む水溶液を接触させることを特
徴とする人工透析装置器具類の殺菌洗浄法。1. A method for sterilizing and cleaning an artificial dialysis device, which comprises contacting the artificial dialysis device with an aqueous solution containing chloroisocyanuric acid or a salt thereof.
ヌル酸アルカリ金属塩を含む水溶液を接触させることを
特徴とする人工透析装置器具類の殺菌洗浄法。2. A method for sterilizing and cleaning an artificial dialyzer device, which comprises contacting the artificial dialyzer device with an aqueous solution containing an alkali metal salt of dichloroisocyanuric acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP07246620A JP3078209B2 (en) | 1995-08-30 | 1995-08-30 | Sterilization cleaning method for artificial dialysis equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP07246620A JP3078209B2 (en) | 1995-08-30 | 1995-08-30 | Sterilization cleaning method for artificial dialysis equipment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0966100A true JPH0966100A (en) | 1997-03-11 |
| JP3078209B2 JP3078209B2 (en) | 2000-08-21 |
Family
ID=17151121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP07246620A Expired - Fee Related JP3078209B2 (en) | 1995-08-30 | 1995-08-30 | Sterilization cleaning method for artificial dialysis equipment |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3078209B2 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6623695B2 (en) | 1997-12-04 | 2003-09-23 | Steris Corporation | Chemical modification of electrochemically activated solutions for improved performance |
| JP2009112551A (en) * | 2007-11-07 | 2009-05-28 | Kao Corp | Sterilization method for food processing equipment |
| JP2013529125A (en) * | 2010-04-14 | 2013-07-18 | ハイポ−ストリーム・リミテッド | Device for preparing diluted disinfectant solution |
| CN115845168A (en) * | 2022-12-15 | 2023-03-28 | 王俊 | Disinfection device of dialysis machine and using method |
-
1995
- 1995-08-30 JP JP07246620A patent/JP3078209B2/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6623695B2 (en) | 1997-12-04 | 2003-09-23 | Steris Corporation | Chemical modification of electrochemically activated solutions for improved performance |
| JP2009112551A (en) * | 2007-11-07 | 2009-05-28 | Kao Corp | Sterilization method for food processing equipment |
| JP2013529125A (en) * | 2010-04-14 | 2013-07-18 | ハイポ−ストリーム・リミテッド | Device for preparing diluted disinfectant solution |
| JP2016163886A (en) * | 2010-04-14 | 2016-09-08 | ハイポ−ストリーム・リミテッド | Device for preparing disinfectant solution which is diluted |
| US9492352B2 (en) | 2010-04-14 | 2016-11-15 | Hypo-Stream Limited | Device for preparing dilute disinfectant solution |
| US10188111B2 (en) | 2010-04-14 | 2019-01-29 | Hypo-Stream Limited | Pharmaceutically acceptable composition comprising dilute sodium hypochlorite solution |
| CN115845168A (en) * | 2022-12-15 | 2023-03-28 | 王俊 | Disinfection device of dialysis machine and using method |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3078209B2 (en) | 2000-08-21 |
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