JPH0971602A5 - - Google Patents
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- Publication number
- JPH0971602A5 JPH0971602A5 JP1996139405A JP13940596A JPH0971602A5 JP H0971602 A5 JPH0971602 A5 JP H0971602A5 JP 1996139405 A JP1996139405 A JP 1996139405A JP 13940596 A JP13940596 A JP 13940596A JP H0971602 A5 JPH0971602 A5 JP H0971602A5
- Authority
- JP
- Japan
- Prior art keywords
- hyaluronic acid
- molecular weight
- present
- skin softening
- acetyl groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Description
【発明の名称】皮膚柔軟化剤[Name of invention] Skin softener
【０００１】
【産業上の利用分野】
本発明は皮膚柔軟化剤、特にヒアルロン酸のアルコール性水酸基にアセチル基を高率で結合させたアセチル化ヒアルロン酸を主成分とする皮膚柔軟化剤に関する。[0001]
[Industrial application field]
The present invention relates to a skin softening agent , and more particularly to a skin softening agent whose main component is acetylated hyaluronic acid in which acetyl groups are bonded to the alcoholic hydroxyl groups of hyaluronic acid at a high rate.
【０００３】
【発明が解決しようとする課題】
しかしながら、前述したようにヒアルロン酸は高い曳糸性を有しており、このためヒアルロン酸の大量の添加は製品の使用性を著しく害する場合があった。
また、ヒアルロン酸は強水溶性であり、このため有機溶媒系あるいは油性基剤中での保湿剤としては使用できないものであった。
本発明は前記従来技術の課題に鑑みなされたものであり、その目的はヒアルロン酸の有する曳糸性などの欠点を改善しつつ、優れた皮膚柔軟化効果を発揮し得る低分子量アセチル化ヒアルロン酸を主成分とする皮膚柔軟化剤を提供することにある。[0003]
[Problem to be solved by the invention]
However, as mentioned above, hyaluronic acid has a high degree of stringiness, and therefore the addition of a large amount of hyaluronic acid can significantly impair the usability of the product.
In addition, hyaluronic acid is highly water-soluble, and therefore cannot be used as a moisturizing agent in organic solvents or oily bases.
The present invention has been made in consideration of the problems of the prior art, and its purpose is to provide a skin softening agent containing low molecular weight acetylated hyaluronic acid as its main component, which can improve the shortcomings of hyaluronic acid, such as its spinnability, while exhibiting excellent skin softening effects .
【０００４】
【課題を解決するための手段】
前記目的を達成するために本発明者が鋭意検討した結果、特定の極限粘度及びアセチル基置換数、即ち、特定の分子量及び疎水性を有するアセチル化ヒアルロン酸が、曳糸性の点で大幅に改善され、しかも高度の皮膚柔軟化効果を発揮し得ることを見いだし、本発明を完成するに至った。[0004]
[Means for solving the problem]
In order to achieve the above object, the present inventors have conducted extensive research and have found that acetylated hyaluronic acid having a specific intrinsic viscosity and number of acetyl group substitutions, i.e., a specific molecular weight and hydrophobicity, can significantly improve spinnability and also exhibit a high level of skin softening effect, thereby completing the present invention.
【０００５】
本出願の皮膚柔軟化剤は、下記特性を有することを特徴とする低分子量アセチル化ヒアルロン酸を主成分とする。
極限粘度：５０〜２００ cm ３ /g
アセチル基置換数：２．６〜３．６個（ただし、Ｎ−アセチル基は含まず）
以下、本発明の構成についてさらに詳細に説明する。
本発明にかかる低分子量アセチル化ヒアルロン酸は、下記化１に示すような構造を有する。
【化１】
本発明にかかる低分子量アセチル化ヒアルロン酸を皮膚柔軟化剤として用いる場合、分子量を極限粘度で示すと、前述したとおり５０〜２００cm３/gであることが必要である。なお、アセチル化ヒアルロン酸の分子量を直接明示することは困難であるので、本願明細書においては温度２５℃において、０．２Ｍリン酸緩衝液（ｐＨ=７．３）中で測定した極限粘度の測定値を用いている。[0005]
The skin softening agent of the present application is based on low molecular weight acetylated hyaluronic acid, which is characterized by the following properties :
Intrinsic viscosity: 50-200 cm3 / g
Number of acetyl groups substituted: 2.6 to 3.6 (excluding N-acetyl groups)
The configuration of the present invention will be described in further detail below.
The low molecular weight acetylated hyaluronic acid of the present invention has the structure shown in Chemical Formula 1 below.
[Chemical formula 1]
When the low molecular weight acetylated hyaluronic acid of the present invention is used as skin softening agent, molecular weight must be expressed as limiting viscosity, as mentioned above, 50-200cm3 /g.In addition, since it is difficult to directly indicate the molecular weight of acetylated hyaluronic acid, in this specification, the measured value of limiting viscosity is measured at 25 ℃ in 0.2M phosphate buffer solution (pH=7.3).
【００４１】
【発明の効果】
以上説明したように本発明にかかる皮膚柔軟化剤は、特定の分子量及びアセチル基置換数を有する低分子量アセチル化ヒアルロン酸を含むため、ヒアルロン酸の有する曳糸性を適度に抑制しつつ、優れた皮膚柔軟効果、保湿効果を発揮することができる。[0041]
[Effects of the Invention]
As explained above, the skin softening agent of the present invention contains low-molecular-weight acetylated hyaluronic acid having a specific molecular weight and acetyl group substitution number, and therefore can exhibit excellent skin softening and moisturizing effects while appropriately suppressing the spinnability of hyaluronic acid.
Claims (1)
極限粘度：５０〜２００ cm ３ /g
アセチル基の置換数：２．６〜３．６個（ただし、Ｎ−アセチル基は含まず） A skin softener containing low molecular weight acetylated hyaluronic acid as its main component, characterized by the following properties :
Intrinsic viscosity: 50-200 cm3 / g
Number of acetyl groups substituted: 2.6 to 3.6 (excluding N-acetyl groups)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13940596A JP3557044B2 (en) | 1995-06-29 | 1996-05-08 | Emollient |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7-186156 | 1995-06-29 | ||
| JP18615695 | 1995-06-29 | ||
| JP13940596A JP3557044B2 (en) | 1995-06-29 | 1996-05-08 | Emollient |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH0971602A JPH0971602A (en) | 1997-03-18 |
| JP3557044B2 JP3557044B2 (en) | 2004-08-25 |
| JPH0971602A5 true JPH0971602A5 (en) | 2004-12-16 |
Family
ID=26472227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13940596A Expired - Lifetime JP3557044B2 (en) | 1995-06-29 | 1996-05-08 | Emollient |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3557044B2 (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10279418A (en) * | 1997-03-31 | 1998-10-20 | Shiseido Co Ltd | Preparation for external use for skin |
| JP3634113B2 (en) * | 1997-03-31 | 2005-03-30 | 株式会社資生堂 | Topical skin preparation |
| JP2004262777A (en) * | 2003-02-27 | 2004-09-24 | Shiseido Co Ltd | Acetylated hyaluronic acid-containing ocular medicinal preparation |
| JP2006349372A (en) * | 2005-06-13 | 2006-12-28 | Shiseido Co Ltd | Method for evaluating flexibility, and elasticity of skin using oxidized protein in horny cell layer as index |
| JP4993890B2 (en) * | 2005-09-15 | 2012-08-08 | ロート製薬株式会社 | Topical skin preparation |
| JP2007186688A (en) * | 2005-12-13 | 2007-07-26 | Shiseido Co Ltd | Method for producing low-molecular weight hyaluronic acid |
| JP2007186689A (en) * | 2005-12-13 | 2007-07-26 | Shiseido Co Ltd | Method for producing low-molecular weight hyaluronic acid |
| JP2008050311A (en) * | 2006-08-25 | 2008-03-06 | Kowa Co | Emulsifying composition with good usability |
| US20100008878A1 (en) * | 2007-08-09 | 2010-01-14 | Foodchemifa Co., Ltd | Propylene glycol hyaluronate, and skincare preparation for external use comprising same |
| JP2010196048A (en) * | 2009-01-30 | 2010-09-09 | Kose Corp | Novel water-soluble polymer, and cosmetic material or skin preparation for external use containing the same |
| JP2010208950A (en) * | 2009-03-06 | 2010-09-24 | Nippon Zettoc Co Ltd | Cosmetic and manufacturing method of the same |
| JP2010254974A (en) * | 2009-03-31 | 2010-11-11 | Kose Corp | Water-soluble copolymer and cosmetic or external preparation for skin obtained by blending the same |
| JP6071123B2 (en) * | 2012-02-10 | 2017-02-01 | 株式会社 資生堂 | Oil-in-water emulsified skin cosmetic |
| US20160250131A1 (en) | 2013-10-09 | 2016-09-01 | Shiseido Company, Ltd. | Low-Stringiness Thickener and Cosmetic Material Admixed with Said Thickner |
| JP2016196430A (en) * | 2015-04-03 | 2016-11-24 | 株式会社ダイセル | Composition for external application comprising equol and humectant |
| GB201703850D0 (en) * | 2017-03-10 | 2017-04-26 | Givaudan Sa | Improvements in or relating to organic compounds |
-
1996
- 1996-05-08 JP JP13940596A patent/JP3557044B2/en not_active Expired - Lifetime
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