JPH0987155A - Ultraviolet light absorber and skin preparation for external use obtained by blending the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an ultraviolet light absorber having high safety and light stability and excellent ultraviolet absorbing effect. SOLUTION: This ultraviolet light absorber contains a fraction containing Garcinia mangostana Linn., etc., belonging to the genus Garcinia of guttiferous plant as an active ingredient. The fraction containing Garcinia mangostana Linn. is obtained by extracting pericarp of the plant with a solvent (e.g. isopropyl alcohol). The fraction has 319 maximum absorbing wavelength and exhibits excellent ultraviolet absorbing property in UV-A and UV-B areas. This skin preparation for external use having ultraviolet absorbing ability can be prepared in liquid, lotion, cream or stick by including 0.005-30wt.% extract of the plant based on dried material. Garcinia atroviridis Griff. ex T. Anders., Garcinia bancana Miq., Garcinia cambogia Desr., Garcinia dioica Blume., Garcinia globulosa Rindl., Garcinia griffithii T. Anders., is also used in addition to Garcinia mangostana Linn., as the plant.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an ultraviolet absorbent and a skin external preparation containing the same, and more particularly to an ultraviolet absorbent and a skin external preparation containing a plant extract-containing component as a main component.

[0002]

2. Description of the Related Art Ultraviolet rays contained in sunlight are dermatologically long wavelength ultraviolet rays (UV-) of 400 nm to 320 nm.
A), 320 nm to 290 nm medium wavelength ultraviolet light (UV-
B) Classified as short wavelength ultraviolet rays (UV-C) of 290 nm or less. Of these, ultraviolet rays having a wavelength of 290 nm or less are absorbed by the ozone layer and do not reach the surface of the earth.

Ultraviolet rays reaching the surface of the earth have various effects on human skin. Of the ultraviolet rays that reach the ground, UV-
B forms erythema and blisters on the skin and promotes melanin formation. On the other hand, UV-A causes browning of the skin, lowers the elasticity of the skin and promotes the generation of wrinkles, resulting in rapid aging. It can also accelerate the onset of the erythema reaction, or enhance this reaction for some patients, and even cause phototoxicity or even a photoallergic reaction. Various ultraviolet absorbers have been developed to protect the skin from such harmful effects of ultraviolet rays.

As a wide variety of UV absorbers obtained by chemical synthesis, for example, dibenzoylmethane derivatives, benzophenone derivatives, urocanic acid, p-aminobenzoic acid, 2
-Ethylhexyl p-dimethylaminobenzoate and the like are used, and these are used for prevention of ultraviolet rays.

[0005]

However, the conventional sunscreen cosmetics containing a UV absorber by chemical synthesis have a problem in safety to the skin in terms of photosensitization property, and the amount thereof is limited. It is the most problematic drug among cosmetic ingredients. On the other hand, those derived from natural products generally have a mild action and are highly safe, and it is possible to add a large amount thereof, but as an ultraviolet absorber, the absorption wavelength is 270 nm.
UV-A and / or UV-B, which mostly absorbs the following short-wavelength UV rays, and whose effect on the skin is most problematic
Very few have been known to absorb ultraviolet rays having a wavelength in the region, and none have exhibited sufficient ultraviolet ray absorption effect.

[0006] Furthermore, most of the UV absorbers derived from nature have a markedly lacking photostability, and in reality, most of the substances are extremely difficult to use as UV absorbers. That is, since the product containing the ultraviolet absorber is less stored in the dark, and moreover, it is used in a scene where it is irradiated with light during use, it is not possible to simply have an ultraviolet absorbing ability. Can't be an ultraviolet absorber,
Excellent light stability is required. The present invention has been made in view of the problems of the prior art as described above, and the object thereof is excellent safety, a high ultraviolet absorption effect in the UV-A and / or UV-B region, and stable to light. Another object of the present invention is to provide a novel ultraviolet absorber and a skin external preparation containing the same.

[0007]

Means for Solving the Problems As a result of intensive studies for achieving the above-mentioned object, the present inventors have an excellent ultraviolet absorption ability in the extract fraction from the peel of Hypericumaceae plants, especially the asteraceae plants. The existence of substances was found, and the present invention was completed. That is, one feature of the ultraviolet absorbent of the present invention is that it contains mangosteen as an active ingredient.

Further, one feature of the ultraviolet absorbent of the present invention is that it contains a mangosteen-containing fraction of a plant of the family Hypericum ( Guttiferae AL de Juss). In addition, one of the UV absorbers of the present invention is that the plant of the family Hypericumaceae ( Guttiferae AL de Juss) belongs to the genus Garcinia Lin.
n.) It is characterized by being a plant.

[0009] The ultraviolet absorbent of the present invention, in part mangosteen belonging to the hypericaceae plants (Guttiferae AL deJuss) is Garcinia (Garcinia Linn.) (Garci
nia mangostana Linn.), Garcinia atrovirid
is Griff.ex T. Anders.), Bangka Manggis ( Garcinia b )
ancana Miq.), Kobano Manggis ( Garcinia brevirostris )
Scheff.), Goraka ( Garcinia cambogia Desr.), Celebes Mangosteen ( Garcinia celebica Linn.), Kowa Gamboji ( Garcinia cowa Roxb.), Mumunjin ( Garcinia d )
ioica Blume.), Obana mangosteen ( Garcinia dulci
s. Kurz.), Akamikanjisu (Garcinia forbesii Kin
g.), Kanjisu (Garcinia globulosa Rindl.), Kiminomangisu (Garcinia griffithii T. Anders.), Ganboji (G
arcinia hauburyi Hook. f.), Hama Mangosteen ( Garci
nia hombroniana Pierre), Merugikanjisu (Garcinia
merguensis Wight), Indogamuboji (Garcinia morell
a Desr.), Tsunomimangisu (Garcinia nigrolineata Pla
nch.ex T. Anders.), Covanocandis ( Garcinia parvif )
olia Miq.), button mangosteen ( Garcinia prainiana
King), Fukugi ( Gardinia subelliptica Merrill), and Carrot ( Gardinia xanthochymus Hook f.), Which is at least one kind of plant extract.

The ultraviolet absorber of the present invention includes, in part, the mangosteen ( Garci ) belonging to the genus Garcinia Linn., Which is a plant of the family Hypericumaceae ( Guttiferae AL de Juss).
nia mangostana Linn.). Further, one feature of the ultraviolet absorbent of the present invention is that the mangosteen-containing fraction of the Hypericumaceae plant ( Guttiferae AL de Juss) is an extracted fraction from the pericarp of the plant. The ultraviolet-absorbing external skin preparation of the present invention is characterized in that, in part, the above-mentioned ultraviolet-absorbing agent is blended, and in one, mangosteen ( Garcinia mangostana).
Linn.) Extract was added.

The embodiments of the present invention will be described in detail below. From the viewpoint of the safety of the ultraviolet absorber, the present inventors have extensively studied the natural substance, particularly the extract thereof centering on plants,
We searched for substances that have ultraviolet absorption ability. as a result,
The maximum absorption wavelength is 31 in a specific fraction of Hypericum plants
It was found that there is an excellent UV absorption ability in the UV-A and UV-B regions at 9 nm, and the effective component is specified, and the stability and the UV absorption ability are excellent, and the UV absorption is also excellent in the light stability. Preparation and external preparation for skin were completed.

Here, as a plant of the family Hypericum ( Guttiferae AL de Juss) used in the present invention, Garcin
ia Linn.) Garcinia mangostana
Linn.), Round (Garcinia atroviridis Griff.ex T.
Anders.), Bangka Manggis ( Garcinia bancana Miq.),
Kobanomangisu (Garcinia brevirostris Scheff.), Goraka (Garcinia cambogia Desr.), Celebes mangosteen (Garcinia celebica Linn.), Kowaganboji (Garcini
a cowa Roxb.), Mumunjin (Garcinia dioica Blume.),
Oba Roh mangosteen (Garcinia dulcis. Kurz.), Akamikanjisu (Garcinia forbesii King.), Kanjisu (Garc
inia globulosa Rindl.), Kimino Manggis ( Garcinia gr
iffithii T. Anders.), Garcinia hauburyi H
ook. f.), Hama Mangosteen ( Garcinia hombroniana Pi
erre), Merugikanjisu (Garcinia merguensis Wigh
t), Indogamuboji (Garcinia morella Desr.), Tsunomimangisu (Garcinia nigrolineata Planch.ex T. Ander
s.), Kobanokanjisu (Garcinia parvifolia Miq.), button mangosteen (Garcinia prainiana King), Garcinia
(Garcinia subelliptica Merrill), Kiyanimomo (Garcin
ia xanthochymus Hook f.) and the like, and among them, mangosteen ( Garcinia mangostana Linn.) is preferable.
Further, as a part used by these plants, the peel is particularly preferable.

The method for producing the plant extract used in the present invention is carried out by using the plant as a solvent, for example, lower alcohols such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol and isobutanol, or hydrous lower alcohols, propylene glycol, 1 It can be obtained by extracting with a polyhydric alcohol such as 3,3-butylene glycol or a water-containing polyhydric alcohol, various organic solvents such as acetone and ethyl acetate, and distilling off the solvent. Then, mangosteen represented by the structural formula of the following chemical formula 1 was confirmed as an active ingredient exhibiting the ultraviolet absorbing ability in these plant extracts.

Embedded image

Mangosteen is a known substance, but its suitability as a UV absorber has not been known at all until now, and of course, it has been blended as an UV-absorbing active ingredient in a skin external preparation or the like for the purpose of UV-shielding effect. Was never used. The present inventors have found that the substance having a high ultraviolet absorption capacity that was present in the extract fraction from Hypericumaceae plants was mangosteen, and also found that its photostability was extremely excellent, and mangosteen It has been clarified for the first time that has excellent suitability as an ultraviolet absorber. When this mangosteen or a plant extract fraction containing mangosteen is blended as an ultraviolet absorber, a skin external preparation having a high ultraviolet absorption ability and excellent safety and photostability can be obtained.

As the mangosteen used in the present invention, the extract of Hypericumaceae plant obtained by the above extraction method can be used. In addition, the extract may be purified by using activated carbon, column chromatography or the like so as not to impair the effects of the present invention in order to remove the color and odor and make it easier to use. Such an extracted and purified product can also be used in the ultraviolet absorbent and the external skin preparation of the present invention. Of course, mangosteen isolated by further purification may be used. Also,
It is also possible to produce mangosteen by synthesis and use it.

The content of the plant extract in the total amount of the external preparation for skin of the present invention is preferably 0.005 to 30% by weight as a dried product. If the blending amount is less than 0.005% by weight, the ultraviolet ray absorbing effect is not sufficiently exerted, and if it is blended in an amount of 30% by weight or more, the cost becomes high, which is not realistic.

In addition to the above-mentioned essential components, the ultraviolet-absorbing external preparation for skin of the present invention is generally used in cosmetics, quasi-drugs, pharmaceuticals, etc., if necessary, within a range not impairing the effects of the present invention. Various components used, an aqueous component, a moisturizer, a thickener, an antiseptic, an antioxidant, a fragrance, a coloring agent, a drug and the like can be added. For example, solid or liquid paraffin, crystal oil, ceresin, ozokerite, hydrocarbons such as montan wax, silicone oils, olive oil, ground wax,
Vegetable or animal fats and oils such as carnauba wax and lanolin, and fatty acids such as stearic acid, palmitic acid, oleic acid, glycerin monostearate, glycerin monooleate, isopropyl isopropyl myristate, and isopropyl stearate. Or esters thereof, esters of monohydric alcohols or polyhydric alcohols of branched fatty acids, alcohols such as ethyl alcohol, isopropyl alcohol, cetyl alcohol and palmityl alcohol, polyhydric alcohols such as glycol, glycerin and sorbitol, or esters thereof. And surfactants such as nonionic surfactants, anionic surfactants, and cationic surfactants.

In addition, the following plant extracts and medicines can be appropriately added to the present invention. For example, capsicum, youtei, aloe, wolfberry, mugwort, mustard, rice, mankeishi, mannen wax, kossai ho, nishida, gentian,
Tanjin, loofah, kyoto, pine, kujin, safflower, barberry, areca, eucalyptus, Kagosou, mokuro, goshitsu, psycho, cha, shinui, wasabi, joteishi, netherlands senchini, gardenia, usabasaicin, garlic, mint, Yokuinin, giraffe, coconut, burdock, licorice, hops, chrysanthemum, rakkyo, leek, leek, onion, senega, armchadul, mannoke mushroom, dio, monoammonium glycyrrhetinic acid, glycyrrhetinic acid, glycyrrhizinate, sesame, senkyu, kashi and the like.

Further, the dosage form of the ultraviolet absorbent external preparation for skin of the present invention is arbitrary, for example, liquid, emulsion, cream,
It is possible to take a dosage form such as a stick. Hereinafter, the present invention will be described in more detail with reference to an extract from the peel of mangosteen ( garcinia mangostana Linn.).

Extraction Example 1 Raw Material Mangosteen ( Garcinia mangostana Linn.) 100 g of crushed skin peeling Extraction 100 g of the crushed mangosteen skin was added with 400 ml of isopropyl ether, and the temperature was 50 ° C. for 1 hour.
The extraction operation was performed at a rotational stirring number of 100 rpm. Pressure filtration The extract obtained as described above was filtered under a pressure of nitrogen 0.1 kg / cm 2 or less. Filtered by 2.

Concentration The filtrate obtained above was concentrated under reduced pressure at a temperature of 45 to 60 ° C. and a reduced pressure of 35 to 500 torr. Purification 7.7 g of the concentrate was treated with 10 g of activated carbon to remove impurities. Then, using a chromatographic tube having an inner diameter of 5 cm and a length of 50 cm, separation and purification was performed by silica gel column chromatography. As the developing solvent, ethyl acetate-hexane or chloroform-methanol was used. Pressure filtration Similarly to the above, filter paper No. 1 was used under a pressure of 0.1 kg / cm 2 or less of nitrogen. 2 was used and pressure filtration was performed.

As a result, 3.85 g of an extracted and refined product containing mangosteen as a main component was obtained. In addition, the main component having the ultraviolet absorbing effect of the extract is ¹ H-NMR, GC-
It was found to be mangosteen by MS, organic microanalysis, ultraviolet absorption spectrum (shown in FIG. 1), infrared absorption spectrum and the like.

Extraction Example 2 100 g of crushed mangosteen (G. mangostana L.) peeled material 100 g of crushed mangosteen peeled product was added to 4 g of methanol
00 ml was added, and the extraction operation was performed at a temperature of 50 ° C. for a time of 1 hour and a rotational stirring number of 100 rpm. Pressure filtration The extract obtained as described above was filtered under a pressure of nitrogen 0.1 kg / cm 2 or less. Filtered by 2.

Concentration The filtrate obtained above was concentrated under reduced pressure at a temperature of 45 to 60 ° C. and a vacuum degree of 35 to 500 torr. Purification 7.7 g of the concentrate was treated with 10 g of activated carbon to remove impurities. Then, using a chromatographic tube having an inner diameter of 5 cm and a length of 50 cm, separation and purification was performed by silica gel column chromatography. As the developing solvent, ethyl acetate-hexane or chloroform-methanol was used. Pressure filtration Similarly to the above, filter paper No. 1 was used under a pressure of 0.1 kg / cm 2 or less of nitrogen. 2 was used and pressure filtration was performed.

As a result, 3.00 g of an extracted and purified product containing mangosteen as a main component was obtained. In addition, the main component having the ultraviolet absorbing effect of the extract is ¹ H-NMR, GC-
Similar to the case of Extraction Example 1, it was found to be mangostin by analysis of MS, organic trace analysis, ultraviolet absorption spectrum, infrared absorption spectrum, and the like.

Next, the present inventors examined the photostability of mangosteen. That is, mangosteen at a concentration of 1
The solution was dissolved in ethanol to 0 ppm, the ethanol solution was filled in a glass sample bottle, and irradiation with xenon lamp light was performed at 50 ° C. for 30 hours (corresponding to about 10 days in summer). Then, the ultraviolet absorption spectrum was measured as described above. The results are shown in FIGS. 2 and 3. As can be seen from the figure, almost no decrease in absorbance due to irradiation with xenon lamp light was observed in the ultraviolet absorption spectrum, and the basic waveform did not change. As is clear from the above, it was found that mangosteen has excellent photostability and is highly suitable as an ultraviolet absorber.

Next, a compounding example of the external preparation for skin according to the present invention will be shown. Formulation Example 1 Cream A. Oil phase Stearic acid 10.0% by weight Stearyl alcohol 4.0 Glycerin monostearate 8.0 Vitamin E acetate 0.5 Mangosteen peel extract 0.03 Perfume 0.4 Ethylparaben 0.1 Butylparaben 0.1 Propyl Paraben 0.1 B. Aqueous phase 1,3-butylene glycol 10.0 Propylene glycol 8.0 Glycerin 2.0 Potassium hydroxide 0.4 Purified water Residual

<Production Method> Oil phase A and water phase B are each 70 ° C.
The mixture was heated to 100 ° C., completely dissolved, and the phase A was added to the phase B and emulsified with an emulsifier. The emulsion was cooled using a heat exchanger to obtain a cream.

The cream according to the present formulation example was diluted with ethanol so that the mangosteen peel extract concentration became a 0.001% concentration solution, placed in a quartz cell, and the absorbance at a wavelength of 200 to 600 nm was measured by a spectrophotometer. As a result of the measurement, it was found that, like the ultraviolet absorption spectrum of Extraction Example 1 (FIG. 1), it has a high absorption ability in the wavelength region near 280 to 370 nm and is effective in preventing sunburn. Moreover, the cream of this formulation example was also excellent in moisture retention.

[0030]

EXAMPLES Examples of the present invention will be described below, but the present invention is not limited thereto. In addition, the compounding amount is shown by weight% unless otherwise specified. All of the following external preparations for skin were highly safe and were excellent in ultraviolet absorbing effect, as in the case of the above-mentioned formulation example 1. It was also an external preparation for skin, which was excellent in moisturizing property.

Formulation Example 2 Cream A. Oil phase Cetanol 4.0% Vaseline 7.0 Isopropyl myristate 8.0 Squalane 12.0 Dimethylpolysiloxane 3.0 Glycerin monostearate 2.2 POE (20) Sorbitan monostearate 2.8 Glycyrrhetinate stearate 0.02 ethyl paraben 0.1 butyl paraben 0.1 B. Water phase Mangosteen 0.1 1,3-butylene glycol 7.0 Phenoxyethanol 0.2 L-Ascorbic acid phosphoric acid ester magnesium salt 3.0 Ascorbic acid phosphoric acid ester magnesium salt 1.0 Purified water Residue

<Production Method> Mangosteen was dissolved in the oil phase in advance, and then a cream was obtained according to Formulation Example 1.

Formulation Example 3 Emulsion A. Oil phase Squalane 5.0% Oleyl oleate 3.0 Vaseline 2.0 Sorbitan sesquioleate 0.8 Polyoxyethylene (20) oleyl ether 1.2 2-Ethylhexyl-p-methoxycinnamate 3.0 Mangosteen peel extraction Material 0.2 Perfume 0.12 B. Water phase Dipropyne glycol 5.0 Ethanol 3.0 Carboxyl vinyl polymer 0.17 Sodium hyaluronate 0.1 Potassium hydroxide 0.08 Methylparaben 0.15 Sodium hexamethanephosphate 0.05 Purified water Residual

<Manufacturing Method> The mangosteen peel extract was previously dissolved in the oil phase, and then a milky lotion was obtained according to Formulation Example 1.

Formulation Example 4 Cream A. Oil phase Behenyl alcohol 0.5% 12-Human doxystearic acid cholestanol ester 2.0 Squalane 7.0 Jojoba oil 5.0 Self-emulsifying glyceryl monostearate 2.5 Polyoxyethalene (20) sorbitan monostearate 1 .5 2-Hydroxy-4-methoxybenzophenone 3.0 Mangosteen peel extract 0.05 Ethylparaben 0.2 Butylparaben 0.1 Perfume 0.1 B.I. Aqueous phase 1,3-butylene glycol 6.0 Glycerin 3.5 Zinc oxide 1.5 Kaolin 0.5 Bentonite 0.3 Sodium hexametaphosphate 0.03 Purified water Residual

<Manufacturing Method> After dissolving the mangosteen peel extract in the oil phase, a cream containing powder was obtained by a manufacturing method according to Formulation Example 1.

Formulation Example 5 Essence A. Oil phase Stearic acid 3.0% Cetanol 1.0 Lanolin derivative 3.0 Liquid paraffin 5.0 2-Ethylhexyl stearate 3.0 POE Cetyl alcohol ether 2.0 Glycerin monostearate 2.0 Mangosteen peel extract 10. 0 Preservative Suitable amount Perfume Suitable amount B. Water phase 1,3-butylene glycol 6.0 Triethanolamine 10.0 Purified water Residual

<Production Method> Stearic acid, cetanol, lanolin derivative, liquid paraffin, 2-ethylhexyl stearate, glycerin monostearate are added at 70 to 80 ° C.
After heat-dissolving in, the mangosteen peel extract was added, and further POE cetyl alcohol ether, preservative, and fragrance were sequentially dissolved, and the temperature was raised to 70 ° C. to produce oil phase A. The oil phase A was added to the aqueous phase B with stirring to emulsify, and the emulsion particles were uniformly prepared with a homomixer, followed by degassing and cooling to obtain an essence.

Formulation 6 Essence A. Ethanol phase Sorbitan monooleate 1.0% Oleyl alcohol 0.5 Vitamin E acetate 0.2 Perfume proper amount Ethanol 10.0 POE sorbitan dilaurate monostearate ester 1.0 Preservative proper amount anti-fading agent proper amount B. Water phase Mangosteen peel extract 0.05 Dipropylene glycol 5.0 Polyethylene glycol 400 5.0 Carboxyvinyl polymer 0.3 Sodium alginate 0.3 Potassium hydroxide 0.15 POE sorbitan dilaurate monostearate 1.0 Placenta extract 0.2 Purified water Residual

<Manufacturing Method> After dissolving the carboxyvinyl polymer in purified water, dipropylene glycol, polyethylene glycol 400 and mangosteen peel extract were successively dissolved to obtain an aqueous phase B. Ethanol POE sorbitan dilaurate monostearate, sorbitan monooleate, oleyl alcohol, vitamin E
Acetate, fragrance, antiseptic, anti-fading agent are sequentially dissolved,
An ethanol phase A was obtained, and the ethanol phase A was added to the aqueous phase B and emulsified. Dissolve potassium hydroxide in a portion of purified water,
This was added, stirred, degassed, and filtered to obtain an essence.

Formulation Example 7 Oil-in-water foundation A. Powder talc 3.0% Titanium dioxide 5.0 Red iron oxide 0.5 Yellow iron oxide 1.4 Black iron oxide 0.1 B. Water phase Bentonite 0.5 Polyoxyethylene sorbitan monostearate 0.9 Triethanolamine 1.0 Propylene glycol 10.0 Mangosteen peel extract 0.1 Purified water 56.4 C.I. Oil phase Stearic acid 2.2 Isohexadecyl alcohol 7.0 Glycerin monostearate 2.0 Liquid lanolin 2.0 Liquid paraffin 8.0 Preservative proper amount Perfume proper amount

<Manufacturing Method> The mangosteen peel extract was partially dissolved in propylene glycol in advance, and bentonite, which is a thickener for the aqueous phase, was dispersed in the rest of propylene glycol. These were added to purified water and subjected to a homomixer treatment at 70 ° C, and then the remaining aqueous phase components were added and sufficiently stirred. Add the powder portion that has been thoroughly mixed and pulverized to this while stirring,
A homomixer treatment was performed at 0 ° C. Next, the oil phase heated and dissolved at 70 ° C. to 80 ° C. was gradually added and subjected to a homomixer treatment at 70 ° C. This was cooled with stirring, a fragrance was added at 45 ° C., cooled to room temperature, finally deaerated and filled in a container to obtain an oil-in-water foundation.

Formulation Example 8 W / O type foundation (cream type) A. Powder sericite 5.36% Kaolin 4.0 Titanium dioxide 9.32 Red iron oxide 0.36 Yellow iron oxide 0.8 Black iron oxide 0.16 B. Oil phase Liquid paraffin 5.0 Mangosteen peel extract 0.08 Decamethylcyclopentasiloxane 12.0 Polyoxyethylene-modified dimethylpolysiloxane 4.0 Purified water 51.9 C.I. Aqueous phase dispersant 0.1 1,3-butylene glycol 5.0 Purified water 51.9 Preservative proper amount D.I. Other stabilizers 2.0 Fragrance suitable amount

<Manufacturing Method> The aqueous phase was heated and stirred at 70 ° C., and the powder portion which had been sufficiently mixed and pulverized was added, and the mixture was treated with a homomixer at 70 ° C. A stabilizer dissolved in a part of purified water was added to this and stirred. Further, the oil phase heated to 70 ° C. was added, and the mixture was treated with a homomixer at 70 ° C. Cool this while stirring 45
A fragrance was added at 0 ° C., the mixture was cooled to room temperature, and finally deaerated and filled in a container to obtain a W / O emulsion type foundation.

Formulation Example 9 W / O type cream type sunscreen cosmetic A. Aqueous phase Purified water 54.95% 1,3-Butylene glycol 7.0 Titanium dioxide 5.0 Disodium edetate 0.05 Ethanol 2.0 Gecchi root extract 0.5 B.I. Oil phase Oxybenzone 2.0 Octyl paramethoxycinnamate 5.0 Vaseline 5.0 Stearyl alcohol 3.0 Mangosteen peel extract 14.95 Stearic acid 3.0 Glyceryl monostearate 3.0 Polyethyl acrylate 1.0 Antioxidant Appropriate amount Preservative Appropriate amount Perfume Appropriate amount

<Manufacturing Method> The radix root extract was previously dissolved in ethanol. Oil phase and water phase are 70 ℃
It was heated to and dissolved. Titanium dioxide was sufficiently dispersed in the water phase portion, the oil phase portion was added, and the mixture was emulsified using a homogenizer. The emulsion was cooled using a heat exchanger to obtain a W / O cream type sunscreen cosmetic.

Formulation Example 10 O / W type emulsion type sunscreen cosmetic A. Aqueous phase Purified water 68.3% Dipropylene glycol 6.0 Ethanol 3.0 Hydroxyethyl cellulose 0.3 Mangosteen peel extract 0.005 B.I. Oil phase Octyl paramethoxycinnamate 6.0 Glyceryloctyl diparamethoxycinnamate 2.0 4-tert-Butyl 4′-methoxybenzoylmethane 2.0 Oxybenzone 3.0 Oleyloleate 5.0 Dimethylpolysiloxane 3. 0 Vaseline 0.5 Cetyl alcohol 1.0 Sorbitan sesquioleate ester 0.8 POE (29) oleyl alcohol ether 1.2 Antioxidant proper amount Preservative proper amount Perfume proper amount

<Manufacturing Method> The mangosteen peel extract is dissolved in ethanol in advance, and it is further combined with other aqueous phase components at 70 ° C.
The mixture was heated to 1, and an aqueous phase was prepared. Then, the oil phase portion was heated and dissolved at 70 ° C. The oil phase part was added to the water phase part and emulsified using a homogenizer. The emulsion was cooled using a heat exchanger.

Formulation Example 11 W / O type cream type sunscreen cosmetic A. Aqueous phase Purified water 36.5% 1,3-butylene glycol 6.0 B.I. Oil phase Octyl paramethoxycinnamate 5.0 Oxybenzone 3.0 4-tert-Butyl 4'-methokidibenzoylmethane 1.0 Hydrophobized titanium dioxide 3.0 Squalane 40.0 Mangosteen peel extract 1.0 Diisostearin Acid glycerin 3.0 Organically modified montmorillonite 1.5 Preservative Suitable amount Perfume Suitable amount

<Production Method> The oil phase part and the water phase part are each 70 ° C.
It was heated to dissolve. Titanium dioxide was sufficiently dispersed in the oil phase portion, and the water phase portion was added while performing the homogenizer treatment. The emulsion was cooled using a heat exchanger.

Formulation Example 12 Lotion Purified water 40.0% Dipropylene glycol 5.0 1,3-butylene glycol 10.0 Polyethylene glycol 400 10.0 Ethyl alcohol 20.0 Polyoxyethylene (60) hydrogenated castor oil 3. 0 Octyl paramethoxycinnamate 1.0 Mangosteen peel extract 5.0 Triethanolamine 5.0 Fragrance Suitable amount

<Production Method> Polyoxyethylene (60) hydrogenated castor oil, octyl paramethoxycinnamate and a fragrance were dissolved in ethyl alcohol (alcohol phase). on the other hand,
The Geckitz root extract was dissolved in 1,3-butylene glycol in advance, and purified water and other polyhydric alcohols were further added and sufficiently dissolved (aqueous phase). The alcohol phase was added to the aqueous phase, and the mixture was thoroughly stirred.

Formulation Example 13 O / W type emulsion type sunscreen cosmetic A. Oil phase Liquid paraffin 3.0% Isopropyl myristate 2.0 Oleyl oleate 4.0 Vaseline 2.0 Stearyl alcohol 1.0 Stearic acid 2.0 Glyceryl monostearate 2.0 Mangosteen peel extract 0.1 Vitamin E Acetate Proper amount Preservative Proper amount Perfume Proper amount B. Water phase Purified water 77.8 1,3-Butylene glycol 6.0 Carboxyvinyl polymer 0.2 Triethanolamine Appropriate amount

<Production method> The oil phase part and the water phase part are each 70 ° C.
It was heated to dissolve. The oil phase was added to the aqueous phase, and the mixture was emulsified using a homogenizer. The emulsion was cooled using a heat exchanger.

[0055]

As described above, according to the ultraviolet absorbent and the external skin preparation containing the same according to the present invention, the safety and photostability can be improved by adding mangosteen or a plant extract containing it as a main component. It has high properties and can obtain an excellent ultraviolet absorbing effect.

[Brief description of drawings]

FIG. 1 shows a mangosteen ( Garcini) according to an embodiment of the present invention.
FIG. 3 is an ultraviolet absorption spectrum diagram of an isopropyl ether extract (Extraction Example 1) of the skin of a mangostana Linn.).

FIG. 2 is an ultraviolet absorption spectrum diagram of mangosteen before irradiation with a xenon lamp.

FIG. 3 is an ultraviolet absorption spectrum diagram of mangosteen after irradiation with a xenon lamp.

 ─────────────────────────────────────────────────── ─── Continued Front Page (72) Inventor Kazuyo Taniguchi 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Shiseido Daiichi Research Center Co., Ltd. (72) Toyoyuki Nishi, Oyazaka, Yamashina-ku, Kyoto-shi, Kyoto 39 Tsunomachi, Nippon Shinyaku Co., Ltd.

Claims (8)

[Claims] 1. An ultraviolet absorber containing mangosteen as an active ingredient. 2. The ultraviolet absorber according to claim 1, wherein
An ultraviolet absorber comprising a mangosteen-containing fraction of a plant of the family Hypericum ( Guttiferae AL de Juss). 3. The ultraviolet absorber according to claim 2, wherein
An ultraviolet absorber characterized in that the Hypericumaceae plant ( Guttiferae AL de Juss) is a plant of the genus Garcinia Linn. 4. The ultraviolet absorber according to claim 2 or 3, wherein the Hypericumaceae plant ( Guttiferae AL de Juss) is used.
There mangosteen belonging to the Garcinia (Garcinia Linn.) (Gar
cinia mangostana Linn.), round (Garcinia atrovir
idis Griff.ex T. Anders.), Bankamangisu (Garcinia
bancana Miq.), Cobano Manggis ( Garcinia brevirostr )
is Scheff.), Goraka ( Garcinia cambogia Desr.), Celebes Mangosteen ( Garcinia celebica Linn.), Kowa Gamboji ( Garcinia cowa Roxb.), Mumunjin ( Garcinia )
dioica Blume.), Obana mangosteen ( Garcinia dul)
cis. Kurz.), Akamikanjisu (Garcinia forbesii Kin
g.), Kanjisu (Garcinia globulosa Rindl.), Kiminomangisu (Garcinia griffithii T. Anders.), Ganboji (G
arcinia hauburyi Hook. f.), Hama Mangosteen ( Garci
nia hombroniana Pierre), Merugikanjisu (Garcinia
merguensis Wight), Indogamuboji (Garcinia morell
a Desr.), Tsunomimangisu (Garcinia nigrolineata Pla
nch.ex T. Anders.), Covanocandis ( Garcinia parvif )
olia Miq.), button mangosteen ( Garcinia prainiana
King), Fukugi ( Gardinia subelliptica Merrill), and peach ( Gardinia xanthochymus Hook f.) At least one or more kinds of plant extract selected from the ultraviolet absorber characterized by the above-mentioned. 5. The ultraviolet absorber according to claim 2, wherein
Mangosteen belonging to hypericaceae plant (Guttiferae AL deJuss) is Garcinia (Garcinia Linn.) (Garcinia
Mangostana Linn.) UV absorber. 6. The ultraviolet absorber according to claim 2, wherein the Hypericumaceae plant ( Guttiferae AL) is used.
de Juss) mangosteen-containing fraction is an extract fraction from the pericarp of the plant. 7. An external preparation for skin, comprising the ultraviolet absorbent according to claim 1 incorporated therein. 8. A mangostin ( garcinia mangostana Lin
An ultraviolet-absorptive external preparation for skin, comprising the extract of n.).