JPH1017459A - Agent for reinforcing improvement in ununiformity of skin and composition containing the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin ununiformity improvement-reinforcing agent containing the essence of a plant and capable of improving the ununiformity of skin and improving the preventing skin darkness caused by ageing, etc., and to obtain a cosmetic containing the skin ununiformity improvement-reinforcing agent. SOLUTION: This skin ununiformity improvement-reinforcing agent contains the essences of one or more kinds of plants selected from among Ligusticum wallichi Fr., Curcuma longa L., Luffa cylindria Roem., Rhemania glutinosa Lib., Carthamus tinctorius L., Panax ginseng C. A. Meyer, Scutellaria baicalensis Geo., and Purnus persica Bat. The reinforcing agent and the essence of a plant selected from among Purnus persica Bat., Zizyphus jujuba Mill., Rosa multiflora Thun., Hypericum erectum Thun., Hypericum perforatum L., Salvia officinalis L., NelumbonaceaeNelumbo, Paeonia lactiflora Pall, and Paeonia lactiflora Pall are added to a percutaneous administration composition such as a cosmetic. The essence includes the plant itself, the processed product and/or the solvent extract or its solvent-removed product of the plant, and their fractions. The cosmetic having both the skin ununiformity-improving action and the skin darkness improvement-reinforcing action exhibits a remarkable skin darkness-improving effect.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a non-uniform skin improving agent, a skin non-uniformity improving agent suitable for preventing and preventing dullness due to aging and the like, and a skin non-uniformity improving agent. It relates to the cosmetics contained.

[0002]

2. Description of the Related Art Everyone has a desire to be seen more beautifully than others. For this reason, the mechanism for making it look beautiful has been studied, and various cosmetics based on the results have been developed. For example, a cosmetic containing a moisturizing component such as sodium hyaluronate can improve the moisture retention of the skin and prevent the formation of wrinkles, and a cosmetic containing an ascorbic acid derivative suppresses the production of melanin. It can prevent the skin color from becoming black. Among such technical innovations, the mechanism of what is called "dullness" has not been clarified yet, and at present, cosmetics to improve it have not been developed yet. The term `` dullness '' as used herein refers to a condition in which the color of the skin appears darker with a decrease in redness, and there is no vivid feeling of sagging.It has already increased with poor physical condition and age. Known and no one wants to be in this state. Treatment with the cosmetics developed so far can improve the "dullness", but the moisturizing cosmetics can improve or prevent wrinkles, or the whitening cosmetics may produce melanin. The effect is not so great as to suppress the whiteness. It is said that this is because "dullness" causes these physiological phenomena to differ in type and cause.

Under such circumstances, the present inventors have considered "dullness"
As a result of diligent research for the cause of the skin, we found that dullness was caused by unevenness of the fine structure of the skin. However, at present, there is no known material for improving such skin unevenness. Also, there is no known substance which enhances the effect of improving the unevenness of the skin by a substance which improves the unevenness of the skin.

On the other hand, the plant essence shown in the following (a) improves such unevenness of skin, and the plant essence shown in (b) enhances the action of improving such unevenness of skin. It has not been known at all that it does and significantly improves the "dullness". (A) Birch family birch (Betula pendula Roth.), Jujube family daisies (Zizyphus jujuba Mill.), Rose family Eijitsu (Rosa multiflora Thun.), Hypericum pericaceae (Hypericum erectum Thun.), Hypericum perforatum (Hypericum perforatum)
L.), Labiatae sage (Salvia officinalis L.), Paeonia lactiflora Pall, Nettle family Urtica (Urtica thunbergiana Sie. Or Urtica)
dioica L.), Lotus Lotus (NelumbonaceaeNelumbo) (b) Apiaceae Senkyu (Ligusticum wallichi F)
r.), Ginger family turmeric (Curcuma longa L.), Cucurbitaceae luffa (Luffa cylindria Roem.), Scrophulariaceae Jio (Rhemania glutinosa Lib.), Asteraceae cyca (Car
thamus tinctorius L.), Carrot (Panax gi)
nseng CA Meyer), Umbelliferae (Scutellaria b)
aicalensis Geo.) Rosaceae Tonin (Purnus persica Ba)
t.)

[0005]

DISCLOSURE OF THE INVENTION The present invention has been made under such circumstances, and has been developed to provide a material for improving the unevenness of the skin, a material for enhancing the effect of improving the unevenness of the skin, and a cosmetic for improving the dullness. The task is to provide.

[0006]

In view of this situation, the present inventors have conducted intensive studies for the cause of "dullness" and have found that unevenness of the skin is a major factor. Based on this finding, as a result of further research for substances that have the effect of improving skin unevenness, the following (a)
Such an effect was found in the essence of the plant shown in Fig. 1. Further studies have revealed that the essence of the following plant (b) has an effect of enhancing the dullness-improving effect resulting from such an effect of improving the unevenness of the skin. As a result of repeated studies, it was confirmed that a cosmetic containing the essence (a) and the essence (b) had an excellent effect of improving "dullness" and completed the invention. Hereinafter, the present invention will be described in detail focusing on embodiments of the invention. (A) Birch family birch (Betula pendula Roth.), Jujube family daisies (Zizyphus jujuba Mill.), Rose family Eijitsu (Rosa multiflora Thun.), Hypericum pericaceae (Hypericum erectum Thun.), Hypericum perforatum (Hypericum perforatum)
L.), Labiatae sage (Salvia officinalis L.), Paeonia lactiflora Pall, Nettle family Urtica (Urtica thunbergiana Sie. Or Urtica)
dioica L.) (b) Apiaceae Senkyu (Ligusticum wallichi F)
r.), Ginger family turmeric (Curcuma longa L.), Cucurbitaceae luffa (Luffa cylindria Roem.), Scrophulariaceae Jio (Rhemania glutinosa Lib.), Asteraceae cyca (Car
thamus tinctorius L.), Carrot (Panax gi)
nseng CA Meyer), Umbelliferae (Scutellaria b)
aicalensis Geo.) Rosaceae Tonin (Purnus persica Ba)
t.)

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION

(1) The agent for improving skin non-uniformity of the present invention The agent for improving skin non-uniformity used in the present invention comprises the essence of a plant shown in the following (A). Here, the essence means a plant itself, a processed product obtained by drying, pulverizing, shredding, or the like, a part or all of the plant, a part or all of the plant, or a solvent extract of the processed product or removal of the solvent. It is a general term for products and their fractions. The most preferred of these essences is a solvent extract of a part or all of a plant, or a processed product thereof, or a solvent-removed product thereof. As the solvent used for the solvent extraction, a polar solvent is preferable.Examples of the polar solvent include alcohols such as methanol and ethanol, esters such as ethyl acetate and methyl formate, nitriles such as acetonitrile, and ethers such as diethyl ether and tetrahydrofuran. And halogenated hydrocarbons such as chloroform and methylene chloride; ketones such as acetone and methyl ethyl ketone; polyhydric alcohols such as 1,3-butanediol and glycerin; and water. These may be used alone or in combination of two or more. Among these, more preferred is a method of extracting using one or more selected from alcohols, polyhydric alcohols, and water. The extraction method is
What is necessary is just to carry out according to a normal method, for example, adding a 1-10-fold solvent to a plant or a processed product of a plant, and immersing it for several days at room temperature and several hours at a temperature near the boiling point. Stirring can be added as appropriate. The extract thus obtained may be used as it is, or the solvent may be removed by distillation under reduced pressure or purified by silica gel column chromatography or liquid-liquid extraction before use. Hereinafter, a production example will be described. (A) Birch family birch (Betula pendula Roth.), Jujube family daisies (Zizyphus jujuba Mill.), Rose family Eijitsu (Rosa multiflora Thun.), Hypericum pericaceae (Hypericum erectum Thun.), Hypericum perforatum (Hypericum perforatum)
L.), Labiatae sage (Salvia officinalis L.), Paeonia lactiflora Pall, Nettle family Urtica (Urtica thunbergiana Sie. Or Urtica)
dioica L.)

[Production Example 1] Birch leaves, bark, xylem 1
After adding 1 kg of 1,3-butanediol to Kg and heating at 90 ° C. for 3 hours, insoluble materials were filtered off to obtain 0.8 kg of skin unevenness improving agent 1.

[Production Example 2] Birch leaves, bark, xylem 1
10 g of a 50% ethanol aqueous solution was added to Kg, and the mixture was refluxed for 2 hours. Insolubles were removed by filtration, and the solvent was distilled off to obtain 68 g of a skin nonuniformity improving agent 2.

[Production Example 3] 1K dried product of Chinese pine
10 g of a 50% aqueous ethanol solution was added to the g, and the mixture was refluxed for 2 hours. Insolubles were removed by filtration, and the solvent was distilled off to obtain 430 g of a skin nonuniformity improver 3.

[Production Example 4] Dried product of Agetsu fruit 1
10 g of a 50% ethanol aqueous solution was added to Kg, and the mixture was refluxed for 2 hours. Insolubles were removed by filtration, and the solvent was distilled off to obtain 180 g of a skin nonuniformity improver 4.

Production Example 5 1 kg of whole plant of Hypericum perforatum
Then, 10 l of a 50% aqueous ethanol solution was added to the mixture, and the mixture was refluxed for 2 hours. Insolubles were removed by filtration, and the solvent was distilled off to obtain 144 g of a skin nonuniformity improver 5.

Production Example 6 To 1 kg of whole St. John's wort, 10 l of a 50% aqueous ethanol solution was added, and the mixture was refluxed for 2 hours. Insolubles were removed by filtration, and the solvent was distilled off to remove 138 g of the agent for improving skin nonuniformity. 6 was obtained.

[Production Example 7] To 1 kg of the root of a peony was added 10 l of a 50% aqueous ethanol solution, and the mixture was refluxed for 2 hours.
The insoluble matter was filtered off and the solvent was distilled off to obtain 251 g of the skin nonuniformity improving agent 7.

[Production Example 8] 1 kg of nettle leaf is 50
A 10% aqueous solution of ethanol was added, and the mixture was refluxed for 2 hours. Insolubles were filtered off, and the solvent was distilled off to obtain 165 g of the skin nonuniformity improving agent 8.

[Production Example 9] 10 L of 50% ethanol was added to 1 kg of the rhizome of the lotus family, and the mixture was refluxed for 2 hours. The insoluble material was filtered off and the solvent was distilled off to obtain 123 g of the skin nonuniformity improving agent 9. Obtained.

(2) The agent for improving skin unevenness of the present invention The agent for improving skin unevenness of the present invention comprises the following plant essence (b). Here, the essence is
Drying, crushing the plant itself, part or all of the plant,
It is a general term for a processed product obtained by shredding, a part or all of a plant body, a solvent extract of the processed product or a solvent removed product thereof, and a fraction thereof. The most preferred of these essences is a solvent extract of a part or all of a plant, or a processed product thereof, or a solvent-removed product thereof. As the solvent used for solvent extraction, a polar solvent is preferable.Examples of the polar solvent include alcohols such as methanol and ethanol, esters such as ethyl acetate and methyl formate, nitriles such as acetonitrile, and ethers such as diethyl ether and tetrahydrofuran. And halogenated hydrocarbons such as chloroform and methylene chloride; ketones such as acetone and methyl ethyl ketone; polyhydric alcohols such as 1,3-butanediol and glycerin; and water. These may be used alone or in combination of two or more. Among these, more preferred is a method of extracting using one or more selected from alcohols, polyhydric alcohols, and water. The extraction method is
What is necessary is just to carry out according to a normal method, for example, adding a 1- to 10-fold solvent to a plant or a processed product of the plant, and immersing it for several days at room temperature or for several hours at a temperature near the boiling point. Stirring can be added as appropriate. The extract thus obtained may be used as it is, or the solvent may be removed by distillation under reduced pressure or purified by silica gel column chromatography or liquid-liquid extraction before use. Hereinafter, a production example will be described. (B) Apiaceae Senkyu (Ligusticum wallichi F
r.), Ginger family turmeric (Curcuma longa L.), Cucurbitaceae luffa (Luffa cylindria Roem.), Scrophulariaceae family (Rhemania glutinosa Lib.)
thamus tinctorius L.), Carrot (Panax gi)
nseng CA Meyer), Umbelliferae (Scutellaria b)
aicalensis Geo.) Rosaceae Tonin (Purnus persica Ba)
t.)

[Production Example 10] Rhizome 1 of Apiaceae nematode
Add 10 l of 50% ethanol to Kg and reflux for 2 hours,
The insoluble matter was filtered off and the solvent was distilled off to obtain 135 g of the skin nonuniformity improving enhancer 1.

[Production Example 11] Tuberous root of ginger turmeric 1
Add 10 l of 50% ethanol to Kg and reflux for 2 hours,
The insolubles were removed by filtration and the solvent was distilled off to obtain 181 g of the enhancer 2 for improving skin unevenness.

[Production Example 12] 1K above ground part of Cucurbitaceae Luffa
10 g of 50% ethanol was added to the g, and the mixture was refluxed for 2 hours. Insolubles were removed by filtration and the solvent was distilled off to obtain 123 g of the enhancer 3 for improving skin unevenness.

[Production Example 13] 10 kg of 50% ethanol was added to 1 kg of the root portion of Scrophulariaceae, and the mixture was refluxed for 2 hours. The insoluble matter was filtered off, and the solvent was distilled off. I got

[Preparation Example 14] 10 L of 50% ethanol was added to 1 kg of a flower of Asteraceae squid, and the mixture was refluxed for 2 hours. The insoluble material was filtered off, and the solvent was distilled off. I got

[Production Example 15] Root 1 of carrot carrot
Add 10 l of 50% ethanol to Kg and reflux for 2 hours,
The insolubles were removed by filtration and the solvent was distilled off to obtain 185 g of the skin nonuniformity improving enhancer 6.

[Production Example 16] Root 1K of Agonaceae
10 g of 50% ethanol was added to the g, and the mixture was refluxed for 2 hours. The insoluble matter was removed by filtration and the solvent was distilled off to obtain 165 g of the skin nonuniformity improving agent 7.

[Production Example 17] 1 Kg of ronin tonuin
Was added to 10 l of 50% ethanol, and the mixture was refluxed for 2 hours. Insolubles were removed by filtration, and the solvent was distilled off to obtain 105 g of a skin nonuniformity improving enhancer 8.

(3) Cosmetic of the Present Invention The cosmetic of the present invention is characterized by containing the above-mentioned agent for improving skin unevenness and an enhancer for improving skin unevenness. The skin non-uniformity improving agent or the skin non-uniformity improving enhancer may contain only one kind or two or more kinds. The type of the cosmetic of the present invention is not particularly limited as long as it is a generally known cosmetic. For example, basic cosmetics such as creams and emulsions, makeup cosmetics such as foundations and lip colors Hair oils, hair tonics, shampoos, rinses and other hair cosmetics, nail polish such as manicures and pedicures, cleaning agents such as body shampoos and soaps, bath agents such as bath bubbles and bath essences can be preferably exemplified. This is because the skin non-uniformity improving agent of the present invention can improve not only the non-uniformity of the skin but also the non-uniformity of the human body tissue close to the skin, so that a favorable action can be exerted on hair and nails. . In the cosmetic of the present invention, the content of the agent for improving skin non-uniformity is preferably from 0.001 to 10% by weight, more preferably from 0.01 to 5% by weight, and more preferably from 0.0 to 5% by weight.
5 to 1% by weight is more preferred. The preferred content of the enhancer for improving skin heterogeneity in the cosmetic of the present invention is 0.1%.
001 to 10% by weight, more preferably 0.01 to 5% by weight, even more preferably 0.05 to 1% by weight. The preferable ratio of the agent for improving skin unevenness and the enhancer for improving skin unevenness is 1: 9 to 9: 1, more preferably 1: 4 to 4: 1, and further preferably 1: 3 to 3: 1. preferable. The cosmetic of the present invention can contain optional ingredients usually used in cosmetics in addition to the agent for improving skin nonuniformity and the enhancer for improving skin nonuniformity. Such optional components include hydrocarbons such as petrolatum or microcrystalline wax,
Esters such as jojoba oil and gay wax, triglycerides such as tallow, olive oil, higher alcohols such as cetanol and oleyl alcohol, fatty acids such as stearic acid and oleic acid, and polyhydric alcohols such as glycerin and 1,3-butanediol. , Nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, thickeners such as ethanol and carbopol, preservatives, ultraviolet absorbers, antioxidants, pigments, powders, etc. Can be illustrated. The cosmetic of the present invention can be produced by treating these raw materials by a usual method. The cosmetic of the present invention has an effect of improving the unevenness of the skin and improving and preventing dullness. Therefore, the cosmetic of the present invention can make a person to make makeup look younger than the actual age, and is also suitable as a cosmetic for preventing and improving aging.

[0027]

【Example】

[Example 1] A lotion was prepared according to the following formulation. That is, the formulation components were heated and dissolved at 80 ° C., and then stirred and cooled to obtain a lotion. 1,3-butanediol 5 parts by weight Glycerin 5 parts by weight Sodium hyaluronate 0.1 part by weight Methylparaben 0.1 part by weight Skin non-uniformity improving agent 1 0.1 part by weight Skin non-uniformity improving enhancer 10 0 0.3 parts by weight Benzalkonium chloride 0.1 part by weight Sodium dihydrogen phosphate 0.1 part by weight Ethanol 7 parts by weight POE (60) hydrogenated castor oil 0.1 part by weight Fragrance 0.1 part by weight Water 82 parts by weight

Example 2 A lotion was prepared according to the following formulation. That is, the formulation components were heated and dissolved at 80 ° C., and then stirred and cooled to obtain a lotion. 1,3-butanediol 5 parts by weight Glycerin 5 parts by weight Sodium hyaluronate 0.1 part by weight Methylparaben 0.1 part by weight Skin non-uniformity improving agent 2 0.1 part by weight Skin non-uniformity improving enhancer 20 0.5 parts by weight Benzalkonium chloride 0.1 part by weight Sodium dihydrogen phosphate 0.1 part by weight Ethanol 7 parts by weight POE (60) hydrogenated castor oil 0.1 part by weight Part Perfume 0.1 parts by weight Water 81.7 parts by weight

Example 3 A lotion was prepared according to the following formulation. That is, the formulation components were heated and dissolved at 80 ° C., and then stirred and cooled to obtain a lotion. 1,3-butanediol 5 parts by weight Glycerin 5 parts by weight Sodium chondroitin sulfate 0.1 part by weight Methylparaben 0.1 part by weight Skin non-uniformity improving agent 4 0.5 part by weight Skin non-uniformity improving enhancer 30 0.1 parts by weight Skin enhancer 4 0.1 part by weight Benzalkonium chloride 0.1 part by weight Sodium dihydrogen phosphate 0.1 part by weight Ethanol 7 parts by weight POE (60) hydrogenated castor oil 0.1 Parts by weight Fragrance 0.1 parts by weight Water 81.7 parts by weight

Example 4 A cream was prepared according to the following recipe. That is, the components (a), (b) and (c) were dissolved by heating at 80 ° C., kneaded well with (a), diluted by adding (b), and gradually added and emulsified. This was stirred and cooled to obtain a cream. A 1,3-butanediol 5 parts by weight 70% aqueous maltitol solution 10 parts by weight methyl paraben 0.3 parts by weight butyl paraben 0.1 part by weight triglycerin diisostearate 4 parts by weight b liquid paraffin 7 parts by weight carnauba wax 3 Parts by weight Dimethicone (1 cs) 4 parts by weight C water 65.4 parts by weight Skin non-uniformity improving agent 5 0.5 parts by weight Skin non-uniformity improving agent 6 0.5 parts by weight Skin non-uniformity Improvement enhancer 5 0.1 parts by weight Skin non-uniformity improvement enhancer 6 1 parts by weight Sodium hyaluronate 0.1 part by weight

Example 5 A foundation was prepared according to the following formulation. That is, each component of (a), (b) and (c) was
The mixture was heated and dissolved in, kneaded well with a, diluted with b, diluted with d, dispersed and emulsified by gradually adding c. This was stirred and cooled to obtain a foundation. A 1,3-butanediol 5 parts by weight 70% aqueous maltitol solution 10 parts by weight methyl paraben 0.3 parts by weight butyl paraben 0.1 part by weight triglycerin diisostearate 4 parts by weight b liquid paraffin 7 parts by weight carnauba wax 3 4 parts by weight Dimethicone (1 c.s.) 4 parts by weight C Water 48.9 parts by weight Skin non-uniformity improving agent 7 0.5 part by weight Skin non-uniformity improving enhancer 7 0.1 Sodium hyaluronate 0.1 Parts by weight titanium oxide 8 parts by weight talc 3 parts by weight sericite 2 parts by weight yellow iron oxide 3 parts by weight Bengala 2 parts by weight

Example 6 A hair tonic was prepared according to the following formulation. That is, the prescription components were weighed and solubilized with stirring at room temperature to obtain a hair tonic. Ethinyl estradiol 0.1 parts by weight Pepper tincture 0.1 parts by weight Menthol 0.1 parts by weight Skin non-uniformity improving agent 8 0.1 parts by weight Skin non-uniformity improving enhancer 8 0.1 parts by weight Ethanol 40 parts by weight Part 1,3-butanediol 5 parts by weight water 54.5 parts by weight

Example 7 A bath agent was prepared according to the following formulation. That is, the ingredients were weighed into a kneader and kneaded well to obtain a bath agent. Sodium sulfate 60 parts by weight Lavender oil 10 parts by weight 1,3-butanediol 10 parts by weight Skin non-uniformity improving agent 91 1 part by weight Skin non-uniformity improving enhancer 1 10 parts by weight Glycerin 9 parts by weight

Example 8 The skin non-uniformity improving agents 1 to 9 of the present invention were prepared in the presence of the skin non-uniformity improving agent 1
The effect of improving the unevenness of the skin was measured. That is, the upper arm of 20 volunteers was irradiated with 0.8 MED ultraviolet B twice, to prepare a non-uniform skin model, to which a sample was administered for 4 weeks, and the form was observed 5 weeks later. The observation items of the morphology were the distribution judgment of the low luminance part, the judgment of the melanin distribution, and the nonuniformity of the horny layer peeling. The distribution of the low-luminance portion is determined by irradiating the skin with light at an angle of 45 degrees and capturing the uniformity of the low-luminance portion when captured as an image by a CCD camera. Score 2: extremely uniform, score 1: uniform, score 0 .5: somewhat uniform, rating 0: non-uniform, judged visually. The distribution of melanin was determined by stripping the stratum corneum with cellophane tape, staining with Fontana-Masson and staining with hematoxylin and eosin, observing the melanin distribution of each cell under the microscope with the naked eye, and determining the following criteria. Rating 2: distribution is extremely uniform, rating 1: distribution is uniform, 0.5: distribution is somewhat uniform,
0: Distribution is non-uniform. At this time, the method of peeling the stratum corneum was also determined based on the following criteria. Rating 2: The way of peeling was extremely uniform, Score 1: The way of peeling was uniform, 0.5: The way of peeling was somewhat uniform, and 0: The way of peeling was uneven. The results are shown in Table 1 as average scores. The specimen was prepared by dissolving each skin heterogeneity improving agent at a concentration of 1% and skin heterogeneity improving enhancer 1 at a concentration of 1% in a 50% aqueous ethanol solution. The control was 50%. An aqueous ethanol solution was used.
No treatment was performed without irradiation with ultraviolet light.
Control 1 does not include the skin non-uniformity improving agent and does not include the skin non-uniformity improving agent 1, and Control 2 does not include the skin non-uniformity improving agent and does not include the skin non-uniformity improving agent 1. Only the one added was used. This indicates that the combination of the agent for improving skin non-uniformity and the enhancer for improving skin non-uniformity according to the present invention is excellent in the effect of improving skin non-uniformity. Furthermore, it is also found that the skin unevenness improvement enhancer alone cannot be used to improve the skin unevenness.

[0035]

[Table 1]

Example 9 The skin non-uniformity improving agents 1 to 8 of the present invention were prepared in the presence of the skin non-uniformity improving agent 1.
The effect of improving the unevenness of the skin was measured. That is, the upper arm of 20 volunteers was irradiated with 0.8 MED ultraviolet B twice, to prepare a non-uniform skin model, to which a sample was administered for 4 weeks, and the form was observed 5 weeks later. The observation items of the morphology were the distribution judgment of the low luminance part, the judgment of the melanin distribution, and the nonuniformity of the horny layer peeling. The distribution of the low-luminance portion is determined by irradiating the skin with light at an angle of 45 degrees and capturing the uniformity of the low-luminance portion when captured as an image by a CCD camera. Score 2: extremely uniform, score 1: uniform, score 0 .5: somewhat uniform, rating 0: non-uniform, judged visually. The distribution of melanin was determined by stripping the stratum corneum with cellophane tape, staining with Fontana-Masson and staining with hematoxylin and eosin, observing the melanin distribution of each cell under the microscope with the naked eye, and determining the following criteria. Rating 2: distribution is extremely uniform, rating 1: distribution is uniform, 0.5: distribution is somewhat uniform,
0: Distribution is non-uniform. At this time, the method of peeling the stratum corneum was also determined based on the following criteria. Rating 2: The way of peeling was extremely uniform, Score 1: The way of peeling was uniform, 0.5: The way of peeling was somewhat uniform, and 0: The way of peeling was uneven. The results are shown in Table 1 as average scores. The sample was prepared by adding the skin non-uniformity improving agent 1 at a concentration of 1% to the skin non-uniformity improving agent 1.
To 8 were dissolved in a 50% aqueous ethanol solution at a concentration of 1%, and a 50% aqueous ethanol solution was used as a control. No treatment was performed without irradiation with ultraviolet light. Control 1 is a skin non-uniformity improving agent 1 without the skin non-uniformity improving agent, and Control 2 is a skin non-uniformity improving agent without the skin non-uniformity improving agent 1. What added only 1 was used. The results are shown in Table 2 as average scores. This indicates that the combination of the agent for improving skin non-uniformity and the enhancer for improving skin non-uniformity according to the present invention is excellent in the effect of improving skin non-uniformity.

[0037]

[Table 2] [Example 10] Using the lotion of Example 1, a use test was conducted using a group of 20 women suffering from dullness. In other words, the sample lotion was applied twice a day in the morning and evening for 2 months, and the improvement of dullness was answered by a questionnaire. Control Group 1 used the skin non-uniformity improving agent 1 of Example 1 replaced with water, Control Group 2 used the skin non-uniformity improving enhancer 1 replaced with water, and Control Group 3 Was obtained by replacing the skin non-uniformity improving agent 1 and the skin non-uniformity improving agent 1 with water. Table 3 shows the results. This shows that the cosmetic of the present invention is excellent in improving dullness.

[0038]

[Table 3]

[0039]

According to the present invention, it is possible to provide a material which improves the unevenness of the skin and the dullness.

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[Procedure amendment]

[Submission date] December 5, 1996

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] Name of invention

[Correction method] Change

[Correction contents]

Patent application title: Skin non-uniformity improving enhancer and composition containing the same

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification number Agency reference number FI Technical display location A61K 35/78 A61K 35/78 M CH Q F ADA ADAN

Claims (5)

[Claims] 1. An enhancer for improving skin heterogeneity comprising an essence of any of the following plants. Umbelliferae (Ligu
sticum wallichi Fr.), Ginger family turmeric (Curcuma l)
onga L.), Cucurbitaceae Luffa (Luffa cylindria Roem.),
Scrophulariaceae (Rhemania glutinosa Lib.),
Asteraceae squid (Carthamus tinctorius L.), Scarfaceae carrot (Panax ginseng CA Meyer), Apiaceae squirrel (Scutellaria baicalensis Geo.) Rosaceae tonnin (Purnus persica Bat.) 2. The enhancer for improving skin heterogeneity according to claim 1, wherein the essence is an extract of a plant using a polar solvent or a solvent-removed product thereof. 3. A cosmetic composition for improving dullness, comprising the enhancer for improving skin non-uniformity according to claim 1 or 2 and a skin non-uniformity improver comprising the essence of a plant shown in the following (a). . (A) Birch family birch (Betula pendula Roth.), Jujube family daisies (Zizyphus jujuba Mill.), Rose family Eijitsu (Rosa multiflora Thun.), Hypericum pericaceae (Hypericum erectum Thun.), Hypericum perforatum (Hypericum perforatum)
L.), Lamiaceae sage (Salvia officinalis L.), Paeonia lactiflora Pall., Nettle family Nettle (Urtica thunbergiana Sie. Or Urtica)
dioica L.), Lotus Lotus (Nelumbonaceae Nelumbo) 4. One or more species selected from the essences of plants of any family shown in the following (A) and one or more species selected from essences of plants of any family shown in (B). And a cosmetic for improving dullness. (A) Birch family birch (Betula pendula Roth.), Jujube family daisies (Zizyphus jujuba Mill.), Rose family Eijitsu (Rosa multiflora Thun.), Hypericum pericaceae (Hypericum erectum Thun.), Hypericum perforatum (Hypericum perforatum)
L.), Labiatae sage (Salvia officinalis L.), Paeonia lactiflora Pall, Nettle family Urtica (Urtica thunbergiana Sie. Or Urtica)
dioica L.), Lotus Lotus (NelumbonaceaeNelumbo) (b) Apiaceae Senkyu (Ligusticum wallichi F)
r.), Ginger family turmeric (Curcuma longa L.), Cucurbitaceae luffa (Luffa cylindria Roem.), Scrophulariaceae Jio (Rhemania glutinosa Lib.), Asteraceae cyca (Car
thamus tinctorius L.), Carrot (Panax gi)
nseng CA Meyer), Umbelliferae (Scutellaria b)
aicalensis Geo.) Rosaceae Tonin (Purnus persica Ba)
t.) 5. The cosmetic for improving dullness according to claim 4, wherein the essence of the plant in (a) or (b) is an extract of the plant with a polar solvent.