JPH10194917A - Antimicrobial and low-irritating cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic, having excellent antimicrobial action, not exhibiting primary irritating property or sensitizing property to skin and further, not imparting discomfort feeling such as stabbing pain, irritating feeling or prickling feeling to skin when used. SOLUTION: This cosmetic is obtained by combinedly using an ethanol extract of a plant of the genus Symphytum, especially leaf of comfrey (Symingtonia officinale L.) and one or two or more kinds of compounds selected from a polyhydric alcohol and an alkyl ether of the polyhydric alcohol. A polyhydric alcohol having <=4 hydroxyl groups in the molecule is preferably used as the polyhydric alcohol. Mono or dialkyl ether of ethylene glycol, diethylene glycol or triethylene glycol, mono- or dialkyl ether of propylene glycol or dipropylene glycol or mono- di- or trialkyl ether of glycerol is preferably used as the alkyl ether of polyhydric alcohol.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic composition which has excellent antibacterial properties, is not contaminated by microorganisms such as bacteria and mold, is stable and has low skin irritation. More specifically, the present invention relates to a highly antibacterial and hypoallergenic cosmetic composition obtained by using one or more kinds selected from polyhydric alcohols and alkyl ethers of polyhydric alcohols in combination with an extract of a plant of the genus Valerian.

[0002]

2. Description of the Related Art Conventionally, cosmetics containing water, such as lotions, emulsions, creams, etc., have various antiseptic and antifungal agents in order to prevent deterioration due to the incorporation of microorganisms such as bacteria and mold during production and use. Agents have been used. Examples of such preservatives include phenols such as isopropylmethylphenol, paraoxybenzoate, phenoxyethanol and hinokitiol; benzoic acid and its salts; salicylic acid and its salts; dehydroacetic acid and its salts; sorbic acid and its salts; Quaternary ammoniums such as benzalkonium, benzethonium chloride and alkyltrimethylammonium chloride, amphoteric surfactants such as alkylaminoethylglycine hydrochloride and sodium stearylhydroxyethylbetaine chloride, and photosensitizers are used.

However, many of the above-mentioned preservatives and fungicides have been reported to have primary irritation, sensitization or photosensitization to the skin, and the amount of the preservative and fungicide is regulated based on the standard of cosmetic raw materials from the viewpoint of safety. In many cases, it is not possible to incorporate an amount showing an effective antibacterial activity. Further, even when the cosmetic does not show a stimulating or sensitizing reaction such as redness, rash, or edema to the skin, it may cause discomfort such as stinging, burning, or tingling when using the cosmetic. Are known. In addition, due to the interaction with the base of the cosmetic or other compounding components, there may be cases where sufficient antibacterial activity is not exhibited.

For example, isopropylmethylphenol,
When oil-soluble preservatives and fungicides such as paraoxybenzoate and sorbic acid are added to cosmetics containing a polymer thickener or powder, the antibacterial activity is reduced by adsorption or the like. Further, in cosmetics containing a surfactant, the antibacterial activity is also reduced due to incorporation into surfactant micelles.
On the other hand, if a large amount is added in anticipation of a sufficient antibacterial activity, problems such as crystal precipitation at low temperatures and the like arise in product stability.

Water-soluble preservatives such as benzoate, salicylate and dehydroacetate are not effective unless the pH of the cosmetic is weakly acidic. As it becomes stronger, its solubility in water decreases,
Crystal precipitation may occur.

[0006] Further, quaternary ammoniums and amphoteric surfactants are irritating to the skin and mucous membranes of the eyes, and are liable to foam, and the antibacterial activity decreases on the acidic side.
There are practical problems such as interaction with anionic substances.

[0007]

Accordingly, in the present invention, an effective antibacterial action is exhibited without deteriorating the antibacterial activity by a cosmetic base or other compounding components, and a preservative or fungicide is added as much as possible. To obtain cosmetics that not only do not show primary irritation and sensitization to the skin but also do not cause discomfort such as stabbing pain, tingling or tingling when using cosmetics by reducing the amount Aimed at.

[0008]

In order to solve the above problems, an antiseptic / fungicidal system having high stability and low irritation to the skin was examined, and as a result, a polyhydric alcohol and an alkyl ether of a polyhydric alcohol were selected. By combining the seed or two or more species with the extract of the genus Valeriana, not only synergistically improved antibacterial activity but also significantly reduced irritation and discomfort to the skin were found. The invention has been completed.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, any polyhydric alcohol which is usually used as a raw material for cosmetics can be used. In particular, those having 4 or less hydroxyl groups in the molecule have a synergistic antibacterial activity. It is preferable for obtaining. For example, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, 3-methyl-1,3-butanediol (isopropylene glycol), hexylene glycol, glycerin, diglycerin, etc. And one or more of these are selected and used.

As the alkyl ether of a polyhydric alcohol used in the present invention, glycols or alkyl ethers of glycerin can be preferably used.
Ethylene glycol monomethyl ether, ethylene glycol monoethyl ether (ethyl eserosolve), ethylene glycol monobutyl ether (butyl cellosolve), ethylene glycol dimethyl ether, diethylene glycol monomethyl ether (methyl carbitol), diethylene glycol monoethyl ether (ethyl carbitol), diethylene glycol monobutyl ether , Diethylene glycol dimethyl ether, diethylene glycol diethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monoisopropyl ether, dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, glyceryl monopalmityl Ether (Kimi alcohol),
Glyceryl monostearyl ether (batyl alcohol), glyceryl monooleyl ether (serakyl alcohol) and the like are exemplified as preferable ones, and one or more of these are selected and used.

These polyhydric alcohols or alkyl ethers of the polyhydric alcohols alone exhibit antibacterial activity at 5.0% by weight or more, but when added to complex systems such as cosmetics, have a sufficient antibacterial activity. Is often not recognized. However, in the present invention, synergistic enhancement of the antibacterial activity is recognized, and a sufficient antibacterial effect is exhibited at a blending ratio of about 5.0 to 10.0% by weight.

In the present invention, the extract of the genus Valeriana used in combination with the polyhydric alcohol or the alkyl ether of the polyhydric alcohol may be obtained by removing the whole plant of the valerian plant or any of its leaves, stems, roots, seeds and flowers. Used alone or in combination of two or more. Further, it can be extracted as is or in a dry state. Comfrey ( Symi)
ngtonia officinale L.) leaves or ethanol extract containing water.

Although the extraction solvent is not particularly limited,
Water, ethanol, methanol, 1,3-butylene glycol, glycerin, diglycerin, polyglycerin, alcohols such as isopropyl alcohol, organic solvents such as acetone, ether and tetrahydrofuran, and the like.
These can be used alone or in combination of two or more. Further, a surfactant may be added to enhance the extraction efficiency. Among these extraction solvents, ethanol,
Particularly effective antibacterial activity is obtained when polar solvents such as 1,3-butylene glycol and their aqueous solutions are used. The ratio of the Valerian plant to the solvent at the time of extraction is not particularly limited, but the solvent is 2 to 1000 times by weight relative to the Valerian plant 1, especially 5 to 1 in terms of extraction operation and efficiency.
00 weight times is preferred.

[0014] Further, as the extraction method, a method of extraction by impregnation at room temperature, in a cooled or heated state, a method of extraction using a distillation method such as steam distillation, an extract by pressing from a raw plant of the genus Valerian And the like. Extraction is performed using these methods alone or in combination of two or more.

The extract of the plant of the genus Valerian can be used as such, and the extract may be subjected to deodorization, purification, etc. within a range that does not lose the antiseptic and fungicidal action. It may be blended, and further, may be used as a fraction using column chromatography or the like.
Further, these extracts, deodorized, purified, and fractionated products can be dried by removing the solvent therefrom, and further provided in the form of a solution solubilized in a solvent such as alcohol or in the form of an emulsion. can do. A low amount of about 0.01 to 10% by weight is sufficient for the compounding amount in the cosmetic.

The cosmetic according to the present invention can be in any form such as cream, ointment, lotion, emulsion, solid, powder, etc., and basic cosmetics such as lotion, emulsion, serum, moisturizing cream, etc. Sun care products such as sunscreen creams, sunscreen lotions, suntan oils, carmine lotions, foundations, makeup cosmetics such as eyeliner, mascara, eye color, cheek color, lipstick, face wash, body shampoo, hair shampoo, etc. Hair cosmetics such as cleaning agents, rinses, treatments, hair creams, hair oils, hair styling agents, perfumes,
It can be provided in the form of a deodorant and antiperspirant.

At this time, various components generally used in cosmetics, for example, avocado oil, palm oil, peanut oil, rice bran oil, jojoba oil, orange roughy oil, macadamia nut, so long as the effects of the present invention are not impaired. Oil, squalane, evening primrose oil, sesame oil, sunflower oil, safflower oil, carola oil, carnauba wax, paraffin wax, lanolin, diisostearyl malate, isostearyl alcohol, oils such as liquid paraffin, collagen, hyaluronic acid Humectants such as vitamin A oil, retinol, vitamin A such as retinol acetate, vitamin B ₂ such as riboflavin and riboflavin butyrate, vitamin B ₆ such as pyridoxine hydrochloride, L-ascorbic acid and magnesium L-ascorbyl phosphate C, such as sodium and sodium L-ascorbate , Calcium pantothenate, D-pantothenyl alcohol, pantothenic ethyl ether, acetyl pantothenyl ethyl ether, etc., pantothenic acids such as ergocalciferol, cholecalciferol, etc., nicotinic acid, nicotinamide, benzyl nicotinate Nicotinic acids such as α-tocopherol,
Vitamin E such as tocopherol acetate, vitamin P, vitamins such as biotin, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-
Sulfonic acid, 2-hydroxy-4-methoxybenzophenone-
Benzophenone derivatives such as sodium 5-sulfonate; paraaminobenzoic acid derivatives such as paraaminobenzoic acid, ethyl paraaminobenzoate, octyl paradimethylaminobenzoate; 2-ethylhexyl paramethoxycinnamate; mono-2-ethylhexanoic acid diparamethoxycinnamate Methoxycinnamic acid derivatives such as glyceryl; salicylic acid derivatives such as octyl salicylate and myristyl salicylate; urocanic acid;
4-tert-butyl-4'-methoxydibenzoylmethane, 2- (2'-
UV absorbers such as (hydroxy-5'-methylphenyl) benzotriazole, natural plant polysaccharides such as guar gum, locust bean gum, carrageenan, quince seed, pectin, mannan, and microorganisms such as xanthan gum, dextran, curdlan, hyaluronic acid, etc. Animal natural polymers such as gelatin, casein, albumin, collagen, etc., methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose,
Cellulose-based semi-synthetic polymers such as carboxymethyl cellulose, starch-based semi-synthetic polymers such as soluble starch, carboxymethyl starch, and methyl starch; alginic acid-based semi-synthetic polymers such as propylene glycol alginate and alginate; polyvinyl alcohol; polyvinyl pyrrolidone , Carboxyvinyl polymers, synthetic polymers such as sodium polyacrylate and polyethylene oxide; water-soluble polymers such as bentonite, laponite and colloidal alumina; and dibutylhydroxytoluene, butylhydroxyanisole and gallic acid esters. Antioxidants, higher fatty acid soaps, alkyl sulfates, polyoxyethylene alkyl ether sulfates, acyl methyl taurine salts, alkyl ether phosphate salts, a Anionic surface active agents such as an arylamino acid salts, alkyl trimethyl ammonium chloride, dialkyl dimethyl ammonium chloride, cationic surfactants such as benzalkonium chloride, alkyl dimethyl amino acetic acid betaine, alkylamido betaine, 2-
Amphoteric surfactants such as alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene alkyl Ether, polyoxyalkylene fatty acid glycerin ester, polyoxyalkylene sorbitan ester, sorbite oligomeric tetraester, sorbite oligomeric hexaester, polyethylene glycol ester, glycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, alkylolamide, Nonionic surfactants such as fatty acid amides,
Sodium ethylenediaminetetraacetate, sodium polyphosphate, citric acid, sodium metaphosphate, succinic acid,
Sequestering agents such as gluconic acid, placental extracts, soybean arbor extract, glutathione, kojic acid and derivatives thereof, whitening agents such as hydroquinone and its derivatives such as hydroquinone glycosides, glycyrrhizic acid, glycyrrhetinic acid, alantoin, azulene , Hydrocortisone, ε
-Anti-inflammatory agents such as aminocaproic acid, astringents such as allantoin hydroxyaluminum, aluminum chloride, tannic acid, citric acid, and lactic acid; fresheners such as menthol and camphor; antihistamines such as diphenhydramine hydrochloride and chlorpheniramine maleate; estradiol ,
Sebum depressants such as estrone and ethinyl estradiol, exfoliants and dissolving agents such as salicylic acid and resorcinol, α
-Hydroxy acids and the like can be blended.

[0018]

EXAMPLES Further, the features of the present invention will be described in detail with reference to examples. First, a method for producing an extract of the genus Valeriana used in the present invention will be described below.

[Production Example] Comfrey extract 30 g of dried and crushed comfrey leaves and 300 ml of a 50% by weight aqueous ethanol solution are mixed and refluxed for 1 hour.
After removing the solid content by filtration with a filter, the solvent is distilled off to obtain a dried product. The obtained extract was dissolved in 300 ml of a 20% by weight aqueous ethanol solution.

Example 1 Lotion (1) Ethanol 7.0 (% by weight) (2) 1,3-butylene glycol 10.0 (3) Glycerin 2.0 (4) Polyoxyethylene hydrogenated castor oil 0 0.6 (5) Comfrey extract 1.0 (6) Fragrance 0.06 (7) Purified water 79.34 Production method: Add each component of (1) to (6) to (7) in order, and uniformly Prepare by mixing.

Example 2 Emulsion (1) Squalane 4.0 (% by weight) (2) Glyceryl tri-2-ethylhexanoate 2.0 (3) Cetyl 2-ethylhexanoate 3.0 (4) Cetanol 0.6 (5) Stearyl alcohol 0.4 (6) Sorbitan monostearate 1.2 (7) 1,3-butylene glycol 6.0 (8) Dipropylene glycol 4.0 (9) Polyoxyethylene ( (20EO) Sorbitan 0.8 monostearic acid ester (10) Purified water 75.9 (11) Comfrey extract 2.0 (12) Fragrance 0.1 Production method: First, the oil phase of (1) to (6) Mix, heat melt and maintain at 75 ° C. On the other hand, the aqueous phases (7) to (10) are mixed and dissolved by heating to 75 ° C., and the oil phase is added thereto with stirring to emulsify. After cooling, add (11) and (12) at 40 ° C and mix.

Example 3 Cream (1) Stearyl alcohol 6.0 (% by weight) (2) Stearic acid 2.0 (3) Hydrogenated lanolin 4.0 (4) Squalane 9.0 (5) Octyldodeca Knol 10.0 (6) polyoxyethylene (25EO) cetyl alcohol ether 3.0 (7) glyceryl monostearate 2.0 (8) 1,3-butylene glycol 6.0 (9) diethylene glycol monoethyl ether 4 0.0 (10) Purified water 50.9 (11) Comfrey extract 3.0 (12) Fragrance 0.1 Production method: Mix the oil phase components (1) to (7) and heat to 75 ° C. . On the other hand, the aqueous phase components (8) to (10) were mixed and heated to 7
The temperature was adjusted to 5 ° C., and the oil phase was added to the mixture and emulsified.
Add (11) and (12) at 0 ° C.

Example 4 Makeup Base Cream (1) Stearic acid 12.0 (% by weight) (2) Cetanol 2.0 (3) Self-emulsifying glyceryl monostearate 2.0 (4) Propylene glycol 10.0 (5) Glycerin 3.0 (6) Potassium hydroxide 0.3 (7) Purified water 67.6 (8) Comfrey extract 1.5 (9) Fragrance 0.1 (10) Titanium dioxide 1 0.0 (11) Bengala 0.1 (12) Yellow iron oxide 0.4 Production method: (10) to (12) are kneaded with (4), and this is added to the aqueous phase of (5) to (7). Mix and heat to 70 ° C. On the other hand, (1)-
The oil phase component of (3) is mixed and heated to 70 ° C., and this is added to the aqueous phase with stirring to emulsify. After emulsification, cool and add (8) and (9) at 40 ° C.

Example 5 Emulsion Foundation (1) Stearic acid 2.4 (% by weight) (2) Propylene glycol monostearate 2.0 (3) Cetostearyl alcohol 0.2 (4) Liquid lanolin 0 (5) Liquid paraffin 3.0 (6) Isopropyl myristate 8.5 (7) Glyceryl monostearyl ether 3.5 (8) Sodium carboxymethyl cellulose 0.2 (9) Bentonite 0.5 (10) Isoprene glycol 4 3.0 (11) Triethanolamine 1.1 (12) Purified water 53.5 (13) Comfrey extract 1.0 (14) Fragrance 0.1 (15) Titanium oxide 8.0 (16) Talc 4. 0 (17) Bengala 3.0 (18) Yellow iron oxide 2.5 (19) Black iron oxide 0.5 Production method: After mixing the pigments of (15) to (19), the mixture is pulverized by a pulverizer. (12) is heated to 70 ° C., (9) is added to swell well, to which is added (8) previously dispersed in (10), and (11) is further added and dissolved. The oil phases (1) to (7) are mixed, heated and melted to 80 ° C. The pigment is added to the aqueous phase with stirring, the mixture is heated to 75 ° C. through a colloid mill, and the oil phase is added with stirring to emulsify.
(13) and (14) are added at ° C.

Example 6 Cream Foundation (1) Stearic acid 5.0 (% by weight) (2) Lipophilic glyceryl monostearate 2.5 (3) Propylene glycol monolaurate 3.0 (4) Cetostearyl alcohol 1.0 (5) Liquid paraffin 7.0 (6) Isopropyl myristate 8.0 (7) Diglycerin 3.0 (8) Triethylene glycol 2.0 (9) Triethanolamine 1.2 ( 10) Purified water 44.2 (11) Comfrey extract 2.0 (12) Fragrance 0.1 (13) Titanium oxide 8.0 (14) Kaolin 5.0 (15) Talc 2.0 (16) Bentonite 1.0 (17) Bengala 2.6 (18) Yellow iron oxide 2.1 (19) Black iron oxide 0.3 Production method: After mixing the pigments of (13) to (19), pulverize with a pulverizer. Mix and dissolve (7) to (10) and heat. (1) ~
The oil phase of (6) is mixed and dissolved by heating to 80 ° C. The pigment is added to the aqueous phase with stirring, the mixture is heated to 75 ° C. through a colloid mill, the oil phase is added with stirring to emulsify, and after cooling, (11) and (12) are added at 40 ° C.

[Example 7] Emulsifying eye color (1) Stearic acid 8.0 (wt%) (2) White petrolatum 15.0 (3) Isopropyl palmitate 5.0 (4) Lanolin 5.0 (5 ) 1,3-butylene glycol 5.0 (6) Hexylene glycol 5.0 (7) Triethanolamine 2.0 (8) Purified water 50.83 (9) Comfrey extract 2.5 (10) Fragrance 0.15 (11) Red No. 221 0.02 (12) Ultramarine blue 1.50 Production method: The aqueous phases (5) to (8) are mixed, dissolved and heated, and previously mixed and crushed (11) , (12) are added and dispersed, and heated to 75 ° C. (1) to (4), which were previously mixed and heated to make it uniform, were added with stirring to emulsify, and after cooling, (9) and (10) were added and mixed.

Example 8 Emulsion type teak color (1) Beeswax 3.0 (% by weight) (2) Stearic acid 2.0 (3) Cetanol 3.0 (4) Lanolin 3.0 (5) Liquid paraffin 15.0 (6) Isopropyl myristate 7.0 (7) Polyoxyethylene (20EO) sorbitan monostearate 4.2 (8) Sorbitan monostearate 1.8 (9) Glyceryl monostearate 2. 0 (10) Glyceryl monopalmityl ether 2.0 (11) Propylene glycol 5.0 (12) Triethanolamine 0.6 (13) Purified water 46.95 (14) Comfrey extract 2.0 (15) Fragrance 0.15 (16) Red No. 202 0.05 (17) Yellow iron oxide 2.25 Production method: The aqueous phases (11) to (13) were mixed, dissolved, heated, and preliminarily mixed and ground. Add and disperse (16) and (17) and heat to 75 ℃ That. (1) to (10), which were previously mixed and heated to make it uniform, were added with stirring to emulsify, and after cooling, (14) and (15) were added and mixed.

Example 9 Emulsion Type Eyeliner (1) 3.5% by weight of stearic acid (2) Beeswax 2.0 (3) Carnauba wax 0.5 (4) Microcrystalline wax 5.0 (5) 1,3-butylene glycol 7.0 (6) Ethylene glycol monobutyl ether 2.5 (7) Triethanolamine 1.5 (8) Purified water 45.9 (9) Comfrey extract 2.0 (10) Fragrance 0.1 (11) 3.0% by weight bentonite extract 20.0 (12) Titanium oxide 8.0 (13) Carbon black 2.0 Production method: Mix and heat oil phase components (1) to (4) And dissolve. The aqueous phases (5) to (8) are mixed, heated, and added with stirring to emulsify. Next, (11) to (13)
, And dispersed by passing through a colloid mill, followed by cooling.
Add (9) and (10) at 0 ° C.

[Example 10] Aqueous suspension type mascara (1) 50% by weight of vinyl acetate emulsion 37.0 (% by weight) (2) Sodium carboxymethylcellulose 1.0 (3) 1,3-butylene glycol 3.5 (4) Ethylene glycol monomethyl ether 3.5 (5) Comfrey extract 3.0 (6) Titanium oxide 8.0 (7) Carbon black 1.6 (8) Bengala 0.4 (9) Purified water 0 Production method; (2) to (5) were added to (9) and dissolved,
(6) to (8) are added and dispersed through a colloid mill. Add (1) to this and disperse uniformly.

Example 11 Cleansing Gel (1) Glycerin 15.0 (% by weight) (2) 1,3-butylene glycol 10.0 (3) Silicic anhydride 7.0 (4) Polyoxyethylene (20EO) ) Lauryl ether 5.0 (5) Polyoxyethylene (50EO) hydrogenated castor oil 2.5 (6) Diethylene glycol monoethyl ether 5.0 (7) Carboxyvinyl polymer 0.5 (8) Potassium hydroxide 0.45 ( 9) Comfrey extract 2.0 (10) Fragrance 0.1 (11) Purified water 52.45 Production method; (3) and (7) were added to (11) to make uniform, and then (1) and ( Dissolve (4)-(6) in 2) and heat to 70 ° C. to dissolve uniformly. Then cool and at 40 ° C (9),
(10) is added, and finally (8) is added for neutralization.

Example 12 Hair Rinse (1) Cetanol 3.0 (% by weight) (2) Stearyltrimethylammonium chloride 0.7 (3) Silicone Oil 3.0 (4) Polyoxyethylene (10EO) Oleyl Ether 1 (5) Glycerin 5.0 (6) Comfrey extract 1.5 (7) Green No. 3 1% by weight aqueous solution 0.2 (8) Fragrance 0.1 (9) Purified water 85.5 Production method; Add (5) and (7) to 9) and heat to 70 ° C. On the other hand, (1) to (4) are mixed and dissolved, and heated to 70 ° C. This oil phase was gradually added to the previously prepared aqueous phase while stirring, and pre-emulsified, homogenized by adding a homomixer, and then cooled,
At 40 ° C., (6) and (8) are added.

Example 13 Hair Treatment (1) Polyoxyethylene (30EO) behenyl ether 4.0 (% by weight) (2) Self-emulsifying glyceryl monostearate 6.0 (3) Isopropyl myristate 0 (4) hexyldecanol 5.0 (5) squalane 3.0 (6) purified lanolin 3.0 (7) stearic acid 5.0 (8) lauryl dimethylaminoacetate betaine 5.0 (9) glycerin 10.0 ( 10) Purified water 52.8 (11) Fragrance 0.2 (12) Comfrey extract 1.0 Production method: Mix and heat the oil phase components (1) to (7) to 80 ° C. On the other hand, the aqueous phase components (8) to (10) were mixed and heated to 8
The temperature was adjusted to 5 ° C., and the oil phase was added to the mixture and emulsified.
At 0 ° C. add (11) and (12).

Example 14 Face Wash (1) Stearic acid 10.0 (% by weight) (2) Palmitic acid 10.0 (3) Myristic acid 12.0 (4) Lauric acid 4.0 (5) Oleyl Alcohol 1.5 (6) Lanolin alcohol 1.0 (7) Potassium hydroxide 6.0 (8) Purified water 44.4 (9) 1,3-butylene glycol 10.0 (10) Fragrance 0.1 (11 ) Comfrey extract 1.0 Production method: After mixing and dissolving the oil phase of (1) to (6) and the aqueous phase of (7) to (9) at 75 ° C., add an aqueous phase to the oil phase. Saponify. After cooling, add (10) and (11) at 40 ° C. and mix.

Example 15 Body Shampoo (1) Lauric acid 5.0 (% by weight) (2) Myristic acid 7.5 (3) Lauroyl diethanolamide 5.0 (4) Glycerin 20.0 (5) Water Potassium oxide (10% by weight aqueous solution) 3.0 (6) Purified water 58.7 (7) Comfrey extract 0.5 (8) Fragrance 0.3 Production method: Oil phase of (1) to (3) and ( After mixing and dissolving each of the aqueous phases 4) to 6) at 75 ° C., the aqueous phase is added to the oil phase for saponification. After cooling, add (7) and (8) at 40 ° C. and mix.

Next, the above Examples 1 to 15 were evaluated for antibacterial activity, skin irritation and discomfort during use. At the same time, the comparative examples shown in Table 1 were similarly evaluated for antibacterial activity.

[0036]

[Table 1]

(1) Evaluation of antibacterial activity As bacteria, Escherichia coli and Staphylococc
us aureus ) and Pseudomonas aeruginosa
Using Candida albicans and black mold ( Aspergillus niger ) as fungi, inoculating 10 ⁶ bacteria and 10 ⁵ fungi per gram of the sample, culturing at 37 ° C. and 25 ° C., respectively, for 2 weeks The number of viable bacteria was measured later. In addition, the antibacterial activity was judged to be acceptable when the bacteria died after 2 weeks, and when the viable count of the fungi became 1/1000 or less, the bacteria passed. The results of the antibacterial test
In Tables 2 and 3, those that passed were indicated by “「 ”, and those that failed were indicated by“ x ”.

[0038]

[Table 2]

[0039]

[Table 3]

As is clear from Table 2, in Examples of the present invention, sufficient antibacterial activity against both bacteria and fungi was observed. In contrast, as shown in Table 3, Comparative Example 2 containing only the comfrey extract
In 5,7,9,11,13 and 15, no antibacterial activity was observed for most test bacteria. Comparative Examples 1, 3, 4, 6, 8, 10, 12 and 1 containing only a polyhydric alcohol or its alkyl ether
Also in No. 4, some or all of the test bacteria did not meet the acceptance criteria.

(2) Evaluation of skin irritation For each sample,
Using 30 male panelists, a 48-hour obstruction sticking test was performed, evaluated according to the criteria shown in Table 4, and the average value of the skin irritation index of 30 persons was obtained. In Examples 11 to 15, a 1.0% by weight aqueous solution was used for the test.

[0042]

[Table 4]

(3) Evaluation of discomfort during use Twenty female panelists were divided into one group, and each group was allowed to use each sample.
Stinging pain felt between 30 seconds and 1 minute after application,
Discomfort such as burning and tingling were evaluated. The evaluation results were "very strong; 5 points", "somewhat strong; 4 points", "feeling; 3 points", "slightly feeling; 2 points", "subtle feeling; 1 point", and "not feeling". ; 0
The score was evaluated as “point”, and indicated by the average value of 20 persons. Also in this case, for Examples 11 to 15, a 1.0% by weight aqueous solution was used for the test. Table 5 summarizes the above results.

[0044]

[Table 5]

In Table 5, no skin irritation was observed in any of the examples of the present invention.
Discomfort during use is also subtle.

[0046]

As described above in detail, according to the present invention, the antibacterial action is synergistically enhanced, and not only skin irritation but also discomfort such as stinging, tingling and tingling when used. It was possible to obtain an antibacterial cosmetic which was hardly felt.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 7/06 A61K 7/06 7/075 7/075 7/08 7/08 7/50 7/50

Claims (7)

[Claims] 1. A method comprising using one or more selected from polyhydric alcohols and alkyl ethers of polyhydric alcohols with an extract of a plant of the genus Valerian.
Antibacterial hypoallergenic cosmetic. 2. One or more polyhydric alcohols are:
The antibacterial hypoallergenic cosmetic according to claim 1, wherein the cosmetic is selected from those having 4 or less hydroxyl groups in a molecule. 3. An alkyl ether of a polyhydric alcohol.
The species or two or more species are selected from mono and dialkyl ethers of ethylene glycol, diethylene glycol and triethylene glycol, mono and dialkyl ethers of propylene glycol and dipropylene glycol, and mono, di and trialkyl ethers of glycerin. The antibacterial and hypoallergenic cosmetic according to claim 1 or 2. 4. The antibacterial anti-irritant cosmetic according to claim 1, wherein the extract of the genus Valeriana is a polar solvent extract. 5. The method according to claim 1, wherein the extract of Valerian plant is an ethanol extract.
2. The antibacterial and hypoallergenic cosmetic according to item 1. 6. The plant of the genus Valeriana is comfrey ( Symi
ngtonia officinale L.) An antimicrobial anti-irritant cosmetic according to any one of claims 1 to 5, which is an ethanol extract. 7. The plant of the genus Valeriana is comfrey ( Symi
The antibacterial anti-irritant cosmetic according to any one of claims 1 to 6, wherein the cosmetic is an ethanol extract of leaves of Ngtonia officinale L.)