JPH10263375A - Permselective hollow fiber membrane - Google Patents
Permselective hollow fiber membraneInfo
- Publication number
- JPH10263375A JPH10263375A JP7326397A JP7326397A JPH10263375A JP H10263375 A JPH10263375 A JP H10263375A JP 7326397 A JP7326397 A JP 7326397A JP 7326397 A JP7326397 A JP 7326397A JP H10263375 A JPH10263375 A JP H10263375A
- Authority
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- Japan
- Prior art keywords
- hollow fiber
- fiber membrane
- breaking strength
- porosity
- present
- Prior art date
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- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Artificial Filaments (AREA)
Abstract
(57)【要約】
【課題】 高い破断強力を有し、高い除水性能を有する
血液透析等に適した選択透過性中空糸膜を提供する。
【解決手段】 内径が１００〜３００μｍ、膜厚が１５
〜６０μｍ、空孔率が５０〜９０％である選択透過性を
有する中空糸膜において、純水の限外濾過係数が３００
ml／mmHg・hr・ｍ2 以上であり、且つ該中空糸膜の破断
強力が２０ｇ以上である選択透過性中空糸膜。PROBLEM TO BE SOLVED: To provide a selectively permeable hollow fiber membrane having high breaking strength and high water removal performance suitable for hemodialysis and the like. SOLUTION: The inner diameter is 100 to 300 μm and the film thickness is 15
In a selectively permeable hollow fiber membrane having a porosity of 50 to 90% and a porosity of 50 to 90%, the ultrafiltration coefficient of pure water is 300.
A permselective hollow fiber membrane having a ml / mmHg · hr · m 2 or more and a breaking strength of the hollow fiber membrane of 20 g or more.
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、選択透過性中空糸
膜に関するものである。更に詳しくは、高い限外濾過係
数（ＵＦＲ）を有し、ポーラス性が高いにもかかわらず
中空糸膜の破断強度に優れた良好な取扱性能を有するも
のであり、血液透析、血液濾過透析等の血液処理に適
し、特に中高分子量領域の有害物質を除去するのに適し
た選択透過性中空糸膜を提供するものである。TECHNICAL FIELD The present invention relates to a selectively permeable hollow fiber membrane. More specifically, it has a high ultrafiltration coefficient (UFR) and has good handling performance with excellent breaking strength of the hollow fiber membrane despite its high porosity, such as hemodialysis, hemofiltration dialysis, etc. The present invention provides a selectively permeable hollow fiber membrane which is suitable for blood treatment, especially for removing harmful substances in the medium-high molecular weight region.
【０００２】[0002]
【従来技術】選択透過性中空糸膜は、逆浸透や血液透析
等において従来より実用的に使用されてきている。特に
腎不全患者の血液を浄化するために、現在では中空糸型
血液透析器がよく使用されている。これは筐体の中に透
析膜、例えば、中空糸の膜を多数本収納し、その中空内
部に患者の血液を流し、外部、即ち中空糸間隙部に透析
液を流して、中空糸膜壁を介して透析することによっ
て、血液中の老廃物を除去し電解質濃度を是正するとと
もに、中空糸内外に圧力差を与えて限外濾過によって血
液中の余剰水分を除去するものである。更に、血液中か
ら血漿のみを分離し、あるいは、その血漿の中から特定
成分を除去して自己免疫疾患などを治療するために、中
空糸が使用されることもある。また最近になってタンパ
ク透過性血液透析やタンパク透過性血液濾過透析に中空
糸を用いることによって治療効果が得られることが確認
されるようになってきている。2. Description of the Related Art Permselective hollow fiber membranes have been practically used in reverse osmosis and hemodialysis. In particular, hollow fiber hemodialyzers are often used at present for purifying blood of patients with renal failure. In this case, a dialysis membrane, for example, a large number of hollow fiber membranes, is housed in a housing, a patient's blood is allowed to flow inside the hollow, and a dialysate is allowed to flow outside, that is, a hollow fiber gap portion, and a hollow fiber membrane wall is formed. The dialysis removes wastes in the blood and corrects the electrolyte concentration, and applies a pressure difference between the inside and outside of the hollow fiber to remove excess water in the blood by ultrafiltration. Furthermore, hollow fibers are sometimes used to separate plasma alone from blood or to remove specific components from the plasma to treat autoimmune diseases and the like. Recently, it has been confirmed that a therapeutic effect can be obtained by using hollow fibers in protein-permeable hemodialysis or protein-permeable hemofiltration dialysis.
【０００３】ところで、近年、透析患者の長期合併症と
関連し、透析アミロイドシスの原因物質と考えられるβ
2-マイクログロブリン（β2-ＭＧ、分子量：１１，８０
０）、掻痒感、高脂血症と関係すると考えられる副甲状
腺ホルモン（分子量：約９，５００）、貧血に関与する
赤芽球抑制因子、関節痛、骨痛に係わると考えられる分
子量２〜４万の物質など、比較的中高分子量領域の有害
物質の除去の必要性が叫ばれている。一方、人体に必須
のアルブミン（分子量：６６，０００）の損失は極力避
けなければならない。すなわち、分子量４〜５万以下の
物質の透過性に優れ、分子量６万以上の物質の阻止性の
よい分画分子量のシャープカット性の良好な選択透過性
膜が望まれている。[0003] In recent years, β-β, which is considered to be a causative substance of dialysis amyloidosis, is associated with long-term complications of dialysis patients.
2- microglobulin (β 2 -MG, molecular weight: 11,80
0), parathyroid hormone (molecular weight: about 9,500) considered to be associated with pruritus and hyperlipidemia, erythroblast inhibitory factor involved in anemia, molecular weight thought to be related to arthralgia and bone pain 2 to 2 There is a demand for the removal of harmful substances in a relatively medium-high molecular weight region such as 40,000 substances. On the other hand, the loss of albumin (molecular weight: 66,000) essential for the human body must be avoided as much as possible. That is, there is a demand for a permselective membrane having excellent permeability for substances having a molecular weight of 40,000 to 50,000 or less and good cutoff of the molecular weight of the fraction having good blocking properties for substances having a molecular weight of 60,000 or more.
【０００４】このように血液処理用の中空糸は目的に応
じて特定の物質を選択的に透過させなければならない。
その性能は、中空糸の素材、ポロシテイ（孔の大きさ、
数など）、膜厚などによって決定される。[0004] As described above, the hollow fiber for blood treatment must selectively allow a specific substance to permeate according to the purpose.
Its performance is based on hollow fiber material, porosity (pore size,
Number, etc.), film thickness and the like.
【０００５】上述の特性を得るには、かなり高いＵＦＲ
を有する膜構造が必要であり、従来から、ポリスルホン
などの合成高分子では、例えば特公平２−１８６９５号
や特公平５−５４３７３号に見られるように、比較的上
記要求を満たしたものが得られている。しかし、該合成
高分子の膜は高いポロシティを有している為か、又膜構
造に起因するかどうかは不明であるが、中空糸膜の破断
強度が低く、取扱いが大変難しいものであった。[0005] To obtain the above characteristics, a rather high UFR
Conventionally, synthetic polymers such as polysulfone have relatively satisfied the above requirements as seen in Japanese Patent Publication No. 2-18695 and Japanese Patent Publication No. 5-54337. Have been. However, it is unknown whether the membrane of the synthetic polymer has a high porosity or whether it is due to the membrane structure, but the breaking strength of the hollow fiber membrane is low and handling is very difficult. .
【０００６】また、セルロース誘導体、特にセルロース
トリアセテートでは、例えば特公昭５８−２４１６５号
に見られるように、中空糸を湿式紡糸するときの芯剤に
流動パラフィン、高級アルコール、イソプロピルミリス
テートなど、セルローストリアセテート紡糸原液に対し
凝固性のないものを使用するために、紡糸原液における
セルローストリアセテート濃度を高め、紡糸時の曳糸性
を高くせざるを得ない。また、紡糸原液をノズルから出
糸後、中空糸外面から凝固液で固化させるために、中空
糸外面に緻密構造の層が形成される。As for cellulose derivatives, especially cellulose triacetate, for example, liquid paraffin, higher alcohol, isopropyl myristate, etc. as a core agent for wet spinning of hollow fibers as shown in JP-B-58-24165. In order to use a material having no coagulation property with respect to the spinning dope, the concentration of cellulose triacetate in the spinning dope must be increased to increase the spinnability during spinning. In addition, a layer having a dense structure is formed on the outer surface of the hollow fiber in order to solidify the spinning stock solution from the nozzle and then solidify the outer surface of the hollow fiber with the coagulating liquid.
【０００７】これらの理由により、従来、セルロース誘
導体中空糸は、合成ポリマーの膜に比し、構造の緻密層
と多孔層の密度差が小さく、全体として均一層に近く、
中空糸膜の破断強力は高いが、物質の透過性能は十分と
は言えなかった。For these reasons, conventionally, the cellulose derivative hollow fiber has a smaller density difference between the dense layer and the porous layer of the structure than the synthetic polymer membrane, and is close to a uniform layer as a whole.
Although the breaking strength of the hollow fiber membrane was high, the permeability of the substance was not sufficient.
【０００８】[0008]
【発明が解決しようとする課題】本発明は、このような
従来技術の問題点を解決することを目的とするものであ
って、薄い緻密層で物質の高い選択性をもたせると共に
均質なポーラスな多孔層で膜全体の高い破断強力をもた
せる構造を有する選択透過性中空糸膜を提供することを
目的としている。SUMMARY OF THE INVENTION An object of the present invention is to solve the above-mentioned problems of the prior art. The object of the present invention is to provide a thin dense layer having a high material selectivity and a uniform porous structure. It is an object of the present invention to provide a permselective hollow fiber membrane having a structure in which a porous layer has a high breaking strength of the whole membrane.
【０００９】[0009]
【課題を解決するための手段】本発明者は、かかる目的
を達成するために鋭意研究した結果、特定のＵＦＲ、破
断強度を有する中空糸を用いた血液浄化器が、優れた分
離及び取扱い性能を発揮することを見い出し、本発明に
到達した。Means for Solving the Problems The present inventors have made intensive studies to achieve the above object, and as a result, a blood purifier using a hollow fiber having a specific UFR and breaking strength has excellent separation and handling performance. And reached the present invention.
【００１０】即ち、本願発明は、内径が１００〜３００
μｍ、膜厚が１５〜６０μｍ、空孔率が５０〜９０％で
ある選択透過性を有する中空糸膜において、純水の限外
濾過係数が３００ml／mmHg・hr・ｍ2 以上であり、且つ
該中空糸膜の破断強力が２０ｇ以上であることを特徴と
する選択透過性中空糸膜を提供するものである。That is, according to the present invention, the inner diameter is 100 to 300.
μm, a membrane thickness of 15 to 60 μm, a porosity of 50 to 90%, a permselective hollow fiber membrane, an ultrafiltration coefficient of pure water of 300 ml / mmHg · hr · m 2 or more, and The present invention provides a selectively permeable hollow fiber membrane characterized in that the breaking strength of the hollow fiber membrane is 20 g or more.
【００１１】また、本願発明は、該選択透過性中空糸膜
が、少なくとも内面に緻密層を有する選択透過性中空糸
膜、更には、該選択透過性中空糸膜が、実質的にセルロ
ース誘導体からなる選択透過性中空糸膜を提供するもの
である。[0011] The present invention also relates to a permselective hollow fiber membrane in which the permselective hollow fiber membrane has a dense layer at least on an inner surface, and further, the permselective hollow fiber membrane is substantially composed of a cellulose derivative. The present invention provides a selectively permeable hollow fiber membrane.
【００１２】[0012]
【発明の実施の形態】本発明における中空糸膜は、選択
透過性を有するものであり、その素材としては、ポリス
ルホン系、ポリアクリロニトリル系、ポリアミド系等の
合成高分子やセルロース誘導体等が挙げられ、その中で
もセルロース誘導体が好ましい。BEST MODE FOR CARRYING OUT THE INVENTION The hollow fiber membrane in the present invention has selective permeability, and examples of the material include synthetic polymers such as polysulfone, polyacrylonitrile, and polyamide, and cellulose derivatives. Among them, cellulose derivatives are preferred.
【００１３】更にその中でも特にアセチルセルロースが
好ましく、一般的に使用されるものとしては、実質的に
セルロースジアセテート、セルローストリアセテートか
らなる高分子である。なお、実質的とは、このセルロー
ス誘導体の特性を損わない範囲で、他の高分子、添加物
などを含有してもよいことを意味する。[0013] Among them, acetylcellulose is particularly preferable, and generally used polymers are substantially composed of cellulose diacetate and cellulose triacetate. Note that “substantially” means that other polymers, additives, and the like may be contained as long as the properties of the cellulose derivative are not impaired.
【００１４】また、本発明の中空糸膜の膜壁の構造は、
物質の分離透過特性と機械特性を機能分担させるような
極薄緻密層と、機械的に流体圧力に耐えられるが、物質
の透過抵抗には殆んど影響しない多孔層とを合せ持つよ
うな、従来、合成高分子で実現されていた２層又は多層
構造が好ましい。特に、中空糸膜の内面を通して血液を
処理する場合には、少くとも中空糸内面に緻密層がある
のが望ましい。内面に多孔層があると、その部分に血中
蛋白が付着したり、あるいは孔中に侵入したりして、物
質透過の阻害になる懸念がある。Further, the structure of the membrane wall of the hollow fiber membrane of the present invention is as follows:
Such as having an ultra-thin dense layer that shares the function of the separation and transmission properties of the substance and the mechanical properties, and a porous layer that can mechanically withstand fluid pressure but has little effect on the permeation resistance of the substance. Conventionally, a two-layer or multilayer structure realized by a synthetic polymer is preferable. In particular, when blood is processed through the inner surface of the hollow fiber membrane, it is desirable that there is a dense layer at least on the inner surface of the hollow fiber. If there is a porous layer on the inner surface, there is a concern that blood proteins may adhere to that portion or penetrate into the pores, thereby impeding the permeation of substances.
【００１５】中空糸膜の膜厚は、一般に物質の透過性か
らみれば薄いのが望ましいが、本発明に係わるような２
層以上の構造のものでは、多孔層を有するために機械的
強度の点を加味すると１５〜６０μｍであり、好ましく
は２０〜５５μｍ、更に好ましくは３０〜５０μｍであ
る。膜厚が１５μｍ以下では十分な強度が得られず、６
０μｍ以上では透析効率が低下するという問題点が生じ
る。The thickness of the hollow fiber membrane is generally desirably small in view of the permeability of the substance.
In the case of a structure having more than two layers, the thickness is 15 to 60 μm, preferably 20 to 55 μm, more preferably 30 to 50 μm in consideration of mechanical strength due to having a porous layer. If the film thickness is less than 15 μm, sufficient strength cannot be obtained.
If it is 0 μm or more, there is a problem that the dialysis efficiency is reduced.
【００１６】また、本発明の中空糸膜の内径は１００〜
３００μｍ、更には１５０〜２５０μｍが好ましい。内
径が１００μｍ以下では血液の圧損が極端に上がり、溶
血やクロッティングが起こる。また内径が３００μｍ以
上にあると透析効率が低下する問題点が生じる。The hollow fiber membrane of the present invention has an inner diameter of 100 to 100.
It is preferably 300 μm, more preferably 150 to 250 μm. When the inner diameter is 100 μm or less, the pressure loss of blood extremely increases, and hemolysis and clotting occur. When the inner diameter is 300 μm or more, there is a problem that the dialysis efficiency is reduced.
【００１７】また、本発明の中空糸膜の空孔率は５０〜
９０％である。空孔率が５０％以下の場合は、目的とす
る透過性能が得られない。９０％以上では、中空糸膜の
機械強度が低下して、製造時の取扱いによるリーク等の
問題が発生する。The porosity of the hollow fiber membrane of the present invention is 50 to 50%.
90%. If the porosity is 50% or less, the desired transmission performance cannot be obtained. If it is 90% or more, the mechanical strength of the hollow fiber membrane decreases, and problems such as leakage due to handling during production occur.
【００１８】尚、空孔率の測定は、中空糸膜を１時間水
洗した後、中空糸表面及び中空糸管内の水を除き、重量
を測定し（重量Ｗ1 ）、次に中空糸膜を絶乾して重量を
測定し（重量Ｗ2 ）、次式により求める。 空孔率 ＝ （１−Ｗ2／Ｗ1）×１００％ 尚、絶乾とは、１３０℃の熱風乾燥機中で３．５時間乾
燥した状態をいう。The porosity was measured by washing the hollow fiber membrane with water for one hour, removing the water on the surface of the hollow fiber and the hollow fiber tube, measuring the weight (weight W 1 ), and then removing the hollow fiber membrane. After drying completely, the weight is measured (weight W 2 ), and the weight is determined by the following equation. Porosity = (1−W 2 / W 1 ) × 100% Absolutely dry refers to a state dried in a 130 ° C. hot air drier for 3.5 hours.
【００１９】また、本発明の中空糸膜は次に述べるＵＦ
Ｒを有するが、これらの係数の測定法は、透析医学会誌
２９（８）、１２３１〜１２４５頁、１９９６の「各種
の血液浄化法の機能と適応−血液浄化器の性能評価法と
機能分類」に基づいて行う。Further, the hollow fiber membrane of the present invention has a UF
The method of measuring these coefficients is described in "Functions and Adaptations of Various Blood Purification Methods-Performance Evaluation Methods and Function Classification of Blood Purifiers" in Dialysis Medical Society 29 (8), pp. 1231-1245, 1996. Perform based on.
【００２０】本発明の上記中空糸束を用いて組み立てた
透析器におけるＵＦＲは３００ml／hr・mmHg・ｍ2 以上
で、かつ中空糸膜の破断強度が２０ｇ以上であるが、好
ましくはＵＦＲが４００ml／hr・mmHg・ｍ2 以上で、か
つ中空糸膜の破断強度が２４ｇ以上、更に好ましくは、
ＵＦＲが４５０ml／hr・mmHg・ｍ2 以上で、かつ中空糸
膜の破断強度が２８ｇ以上である。The UFR of the dialyzer assembled using the hollow fiber bundle of the present invention is 300 ml / hr · mmHg · m 2 or more, and the breaking strength of the hollow fiber membrane is 20 g or more, and preferably, the UFR is 400 ml. / Hr · mmHg · m 2 or more, and the breaking strength of the hollow fiber membrane is 24 g or more, more preferably,
The UFR is 450 ml / hr · mmHg · m 2 or more, and the breaking strength of the hollow fiber membrane is 28 g or more.
【００２１】かかる本発明の中空糸膜の製造方法は特に
限定されるものではないが、望ましくはセルロース誘導
体を有機溶剤に溶解した紡糸原液を、芯剤として水溶液
を用いて、チューブインオリフィス状ノズルより吐出さ
せ、気体中を通過後、水溶性凝固液中に通し固化させる
方式が採用される。Although the method for producing the hollow fiber membrane of the present invention is not particularly limited, a tube-in-orifice-shaped nozzle is desirably prepared by using a spinning stock solution obtained by dissolving a cellulose derivative in an organic solvent and using an aqueous solution as a core agent. A method is adopted in which the liquid is discharged more, passes through a gas, and then passes through a water-soluble coagulating liquid and solidifies.
【００２２】[0022]
【実施例】以下本発明について実施例をあげて更に具体
的に説明するが、本発明は、これらの実施例によって何
ら限定されるものではない。EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples, but the present invention is not limited to these examples.
【００２３】尚、本願発明の破断強力は、オリエンテッ
ク社製テンシロンＵＴＭ２５０を用い、糸長２５ｍｍ、
引っ張り速度２０ｍｍ／ｍｉｎの条件で測定した。The breaking strength of the present invention was determined by using Tensilon UTM250 manufactured by Orientec Co., Ltd.
The measurement was performed under the conditions of a pulling speed of 20 mm / min.
【００２４】［実施例１］セルローストリアセテート１
３部とプロピレングリコール２０部を、Ｎ−メチルピロ
リドン６７部に均一溶解したものを紡糸原液として、チ
ューブインオリフィス型ノズルより、Ｎ−メチルピロリ
ドンの水溶液を芯剤として、空気中に吐出させた後、凝
固液の中に導いて固化させ、水洗、グリセリン付着処理
後、捲取った。かかる中空糸の内径は２００μｍ、膜厚
が３５μｍ、空孔率が８０％であり、破断強力は３０ｇ
であった。得られた中空糸膜を乾燥後、束状にして、円
管状の容器内に挿入充填して、両端をポリウレタンで接
着固定し、有効面積が約１．５ｍ2 の血液透析器を作成
した。該透析器のＵＦＲは５００ml／hr・mmHg・ｍ2で
あった。[Example 1] Cellulose triacetate 1
3 parts and 20 parts of propylene glycol were uniformly dissolved in 67 parts of N-methylpyrrolidone as a spinning dope, and discharged into the air from a tube-in orifice type nozzle using an aqueous solution of N-methylpyrrolidone as a core agent. After being introduced into a coagulating liquid and solidified, washed with water and treated with glycerin, and then wound up. The hollow fiber has an inner diameter of 200 μm, a thickness of 35 μm, a porosity of 80%, and a breaking strength of 30 g.
Met. The obtained hollow fiber membranes were dried, bundled, inserted and filled in a cylindrical container, and both ends were adhered and fixed with polyurethane to prepare a hemodialyzer having an effective area of about 1.5 m 2 . The UFR of the dialyzer was 500 ml / hr · mmHg · m 2 .
【００２５】［比較例１］セルローストリアセテート２
０部とプロピレングリコール２４部を、Ｎ−メチルピロ
リドン５６部に均一溶解したものを紡糸原液として、チ
ューブインオリフィス型ノズルより、流動パラフィンを
芯剤として、空気中に吐出させた後、凝固液の中に導い
て固化させ、水洗、グリセリン付着処理後、捲取った。
かかる中空糸の内径は２００μｍ、膜厚が１５μｍであ
り、破断強力は５０ｇであった。得られた中空糸膜を乾
燥後、束状にして、円管状の容器内に挿入充填して、両
端をポリウレタンで接着固定し、有効面積が約１．５ｍ
2 の血液透析器を作成した。該透析器のＵＦＲは１５５
ml／hr・mmHg・ｍ2 であった。Comparative Example 1 Cellulose Triacetate 2
0 parts and 24 parts of propylene glycol were uniformly dissolved in 56 parts of N-methylpyrrolidone as a spinning solution, and discharged from the tube-in orifice type nozzle into the air using liquid paraffin as a core agent. After being guided into the inside, it was washed, washed with water and adhered with glycerin, and then wound up.
The hollow fiber had an inner diameter of 200 μm, a film thickness of 15 μm, and a breaking strength of 50 g. The obtained hollow fiber membrane is dried, then bundled, inserted and filled into a cylindrical container, and both ends are adhered and fixed with polyurethane, and the effective area is about 1.5 m.
Two hemodialyzers were made. The UFR of the dialyzer is 155
ml / hr · mmHg · m 2 .
【００２６】［比較例２〜５］市販の血液透析器に用い
られている合成膜及びセルローストリアセテート膜につ
いて、ＵＦＲ及び糸破断強力を調べた。セルローストリ
アセテートを素材とするものとしてニプロ社製ＦＢ−１
５０Ｕ（内径１５μｍ、膜厚２００μｍ：比較例２）
を、ポリスルホンを素材とする合成膜として旭メディカ
ル社製ＡＰＳ−１５０（内径４５μｍ、膜厚２００μ
ｍ：比較例３）、東レ社製ＢＳ−１．３（内径４０μ
ｍ、膜厚２００μｍ：比較例４）、ポリアミドを素材と
する合成膜としてガンブロ社製ＰＡ−１７０（内径５０
μｍ、膜厚２００μｍ：比較例５）を用いた。破断強
度、ＵＦＲは実施例１と同様の方法で測定した。[Comparative Examples 2 to 5] UFR and yarn breaking strength of synthetic membranes and cellulose triacetate membranes used in commercially available hemodialyzers were examined. Nipro FB-1 made from cellulose triacetate
50 U (inner diameter 15 μm, film thickness 200 μm: Comparative Example 2)
As APS-150 manufactured by Asahi Medical Co., Ltd. (inner diameter 45 μm, film thickness 200 μm) as a synthetic membrane using polysulfone as a material.
m: Comparative Example 3), Toray's BS-1.3 (40 μm inner diameter)
m, thickness 200 μm: Comparative Example 4), PA-170 (inner diameter 50
μm, thickness 200 μm: Comparative Example 5) was used. The breaking strength and UFR were measured in the same manner as in Example 1.
【００２７】[0027]
【表１】 [Table 1]
【００２８】[0028]
【発明の効果】本発明の中空糸膜は破断強度が高く、そ
の集束体を用いて血液浄化器を組み立てた場合、高い除
水性能を示すなど優れた効果を奏するものである。The hollow fiber membrane of the present invention has a high breaking strength, and when a blood purifier is assembled using the bundle thereof, it exhibits excellent effects such as high water removal performance.
Claims (3)
〜６０μｍ、空孔率が５０〜９０％である選択透過性を
有する中空糸膜において、純水の限外濾過係数が３００
ml／mmHg・hr・ｍ2 以上であり、且つ該中空糸膜の破断
強力が２０ｇ以上であることを特徴とする選択透過性中
空糸膜。1. An inner diameter of 100 to 300 μm and a film thickness of 15
In a selectively permeable hollow fiber membrane having a porosity of 50 to 90% and a porosity of 50 to 90%, the ultrafiltration coefficient of pure water is 300.
A permselective hollow fiber membrane characterized by being at least ml / mmHg · hr · m 2 and having a breaking strength of at least 20 g.
面に緻密層を有する請求項１に記載の選択透過性中空糸
膜。2. The permselective hollow fiber membrane according to claim 1, wherein the permselective hollow fiber membrane has a dense layer at least on an inner surface.
ロース誘導体からなる請求項１又は２に記載の選択透過
性中空糸膜。3. The selectively permeable hollow fiber membrane according to claim 1, wherein the selectively permeable hollow fiber membrane substantially comprises a cellulose derivative.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7326397A JPH10263375A (en) | 1997-03-26 | 1997-03-26 | Permselective hollow fiber membrane |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7326397A JPH10263375A (en) | 1997-03-26 | 1997-03-26 | Permselective hollow fiber membrane |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH10263375A true JPH10263375A (en) | 1998-10-06 |
Family
ID=13513124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7326397A Pending JPH10263375A (en) | 1997-03-26 | 1997-03-26 | Permselective hollow fiber membrane |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH10263375A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001038169A (en) * | 1999-08-03 | 2001-02-13 | Kuraray Co Ltd | Plasma component separation membrane |
| KR100301607B1 (en) * | 1999-05-27 | 2001-11-14 | 박호군 | Recycling Method of Water-Soluble Cleaner Solutions Using Hydrophilic Membranes |
| WO2004006991A1 (en) * | 2002-07-12 | 2004-01-22 | Kuraray Co., Ltd. | Porous membrane |
| JP2008178814A (en) * | 2007-01-25 | 2008-08-07 | Toyobo Co Ltd | Cellulose acetate asymmetric hollow fiber membrane |
| WO2018139334A1 (en) * | 2017-01-26 | 2018-08-02 | テルモ株式会社 | Heat exchanger and artificial lung |
| EP3290102A4 (en) * | 2015-04-28 | 2018-12-26 | Toray Industries, Inc. | Composite hollow fiber membrane and method for producing same |
| JPWO2018139333A1 (en) * | 2017-01-26 | 2019-11-14 | テルモ株式会社 | Heat exchanger and oxygenator |
| EP4239050A4 (en) * | 2020-10-30 | 2024-10-09 | Toyobo Co., Ltd. | HOLLOW FIBER MEMBRANE FOR CRYOPRESERVATION OF CELLS |
-
1997
- 1997-03-26 JP JP7326397A patent/JPH10263375A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100301607B1 (en) * | 1999-05-27 | 2001-11-14 | 박호군 | Recycling Method of Water-Soluble Cleaner Solutions Using Hydrophilic Membranes |
| JP2001038169A (en) * | 1999-08-03 | 2001-02-13 | Kuraray Co Ltd | Plasma component separation membrane |
| WO2004006991A1 (en) * | 2002-07-12 | 2004-01-22 | Kuraray Co., Ltd. | Porous membrane |
| US7364660B2 (en) | 2002-07-12 | 2008-04-29 | Kuraray Co., Ltd. | Porous membrane |
| JP2008178814A (en) * | 2007-01-25 | 2008-08-07 | Toyobo Co Ltd | Cellulose acetate asymmetric hollow fiber membrane |
| EP3290102A4 (en) * | 2015-04-28 | 2018-12-26 | Toray Industries, Inc. | Composite hollow fiber membrane and method for producing same |
| WO2018139334A1 (en) * | 2017-01-26 | 2018-08-02 | テルモ株式会社 | Heat exchanger and artificial lung |
| CN110099705A (en) * | 2017-01-26 | 2019-08-06 | 泰尔茂株式会社 | Heat exchanger and artificial lung |
| JPWO2018139333A1 (en) * | 2017-01-26 | 2019-11-14 | テルモ株式会社 | Heat exchanger and oxygenator |
| JPWO2018139334A1 (en) * | 2017-01-26 | 2019-11-14 | テルモ株式会社 | Heat exchanger and oxygenator |
| US11471575B2 (en) | 2017-01-26 | 2022-10-18 | Terumo Kabushiki Kaisha | Heat exchanger and oxygenator |
| US11534536B2 (en) | 2017-01-26 | 2022-12-27 | Terumo Kabushiki Kaisha | Heat exchanger and oxygenator |
| EP4239050A4 (en) * | 2020-10-30 | 2024-10-09 | Toyobo Co., Ltd. | HOLLOW FIBER MEMBRANE FOR CRYOPRESERVATION OF CELLS |
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