JPH10279432A5 - - Google Patents
Info
- Publication number
- JPH10279432A5 JPH10279432A5 JP1997099813A JP9981397A JPH10279432A5 JP H10279432 A5 JPH10279432 A5 JP H10279432A5 JP 1997099813 A JP1997099813 A JP 1997099813A JP 9981397 A JP9981397 A JP 9981397A JP H10279432 A5 JPH10279432 A5 JP H10279432A5
- Authority
- JP
- Japan
- Prior art keywords
- extract
- lignan
- glycosides
- glycoside
- products
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Description
【０００５】
すなわち、本発明は、次の成分（Ａ）及び（Ｂ）
（Ａ）リグナン配糖体
（Ｂ）皮脂分泌調整剤及び／または殺菌剤から選ばれる薬効剤
を含有することを特徴とする組成物を提供するものである。本発明の好ましい実施態様としては、以下の特徴を有する。
（１）該リグナン配糖体が、下記の構造式（Ｉ）で示されるリグナン配糖体である。
【化５】
（２）該リグナン配糖体が、下記の構造式（ＩＩ−ａ）、（ＩＩ−ｂ）もしくは（ＩＩ−ｃ）で示されるリグナン配糖体の１種または２種以上を主成分とするリグナン配糖体である。
【化６】
【化７】
【化８】
（３）該リグナン配糖体が、ゴマ種子やその加湿物もしくは発芽体、またはそれらの粉砕物、またはそれらの脱脂物の含水低級アルコール抽出物である。
（４）該皮脂分泌調整剤が、ピリドキシン及びその誘導体並びにそれらの塩、ビオチン、酸化亜鉛、塩化アルミニウム、塩化ナトリウム、アルミニウムヒドロキシクロライド、クエン酸及びその塩、海水乾燥物、アロエ抽出物、イブキトラノオ抽出物、オウバク抽出物、クレソン抽出物、メリッサ抽出物、ハマメリス抽出物、紅茶抽出物、緑茶抽出物、ウーロン茶抽出物、スギナ抽出物、ホップ抽出物、ローズマリー抽出物から選ばれる１種または２種以上である。
（５）該殺菌剤が安息香酸及びその誘導体並びにその塩、塩化ベンザルコニウム、イソプロピルメチルフェノール、レゾルシン、ビス（２−ピリジルチオ−１−オキシド）亜鉛、イオウ、ショウガ抽出物、クジン抽出物、ティーツリー抽出物、ユーカリ抽出物及びドクダミ抽出物から選ばれる１種または２種以上である。 [0005]
That is, the present invention provides a composition comprising the following components (A) and (B):
(A) Lignan glycosides
(B) a medicinal agent selected from a sebum secretion regulator and/or a bactericide
A preferred embodiment of the present invention has the following features.
(1) The lignan glycoside is a lignan glycoside represented by the following structural formula (I):
[C5]
(2) The lignan glycoside is a lignan glycoside having as its main component one or more of the lignan glycosides represented by the following structural formula (II-a), (II-b) or (II-c):
[C6]
[Chemical 7]
[Chemical formula 8]
(3) The lignan glycoside is a hydrous lower alcohol extract of sesame seeds, their moistened or germinated products, or their pulverized products, or their defatted products.
(4) The sebum secretion regulator is one or more selected from pyridoxine and its derivatives and salts thereof, biotin, zinc oxide, aluminum chloride, sodium chloride, aluminum hydroxychloride, citric acid and its salts, seawater dried products, aloe extract, Ibuki toranoo extract, Phellodendron bark extract, watercress extract, Melissa extract, Hamamelis extract, black tea extract, green tea extract, oolong tea extract, horsetail extract, hop extract, and rosemary extract.
(5) The disinfectant is one or more selected from benzoic acid and its derivatives and salts, benzalkonium chloride, isopropylmethylphenol, resorcinol, zinc bis(2-pyridylthio-1-oxide), sulfur, ginger extract, lily of the valley extract, tea tree extract, eucalyptus extract, and Houttuynia cordata extract.
【００２８】
参考例３ 高純度リグナン配糖体精製物の製造
参考例２に記載の方法で得られた粗リグナン配糖体を、ＯＤＳを担体とする分配クロマトグラフィーに供した。ＹＭＣ−ＧＥＬ ＯＤＳ−Ａ（山村化学（株）製）６０ｇを直径３ｃｍ、長さ５０ｃｍのガラス製カラムに充填して水を流して平衡化した。これに前記粗リグナン配糖体１ｇをカラムの上部に負荷した。水から順次メタノール濃度を増加させる段階溶出法によって、分画成分を溶出させた。３０〜６０％（ｖ／ｖ）メタノールで溶出する画分を集め、減圧濃縮したところ、約１００ｍｇのカラム分画物が得られた。[0028]
Reference Example 3: Preparation of Highly Purified Lignan Glycosides The crude lignan glycosides obtained by the method described in Reference Example 2 were subjected to partition chromatography using ODS as a carrier. 60 g of YMC-GEL ODS-A (Yamamura Chemical Co., Ltd.) was packed into a glass column 3 cm in diameter and 50 cm in length, and equilibrated with water. 1 g of the crude lignan glycosides was loaded onto the top of the column. The fractionated components were eluted by a stepwise elution method, starting with water and gradually increasing the methanol concentration. The fractions eluted with 30-60% (v/v) methanol were collected and concentrated under reduced pressure, yielding approximately 100 mg of column fractions.
【００３６】
【表１】
[0036]
[Table 1]
【００３７】
（製法）
Ａ．成分（１）〜（７）を混合し、加熱して７０℃に保つ。
Ｂ．成分（１１）と（１３）を混合し、加熱して７０℃に保つ。
Ｃ．ＡにＢを加え、混合した後、冷却する。
Ｄ．Ｃに（８）〜（１０）及び（１２）を加えてクリームを得た。[0037]
(Manufacturing method)
A. Mix ingredients (1) to (7) and heat to 70°C.
B. Mix ingredients (11) and (13) and heat to 70°C.
C. Add B to A, mix, and then cool.
D. C was added with (8) to (10) and (12) to obtain a cream.
【００４２】
【表２】
[0042]
[Table 2]
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9099813A JPH10279432A (en) | 1997-04-01 | 1997-04-01 | Composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9099813A JPH10279432A (en) | 1997-04-01 | 1997-04-01 | Composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH10279432A JPH10279432A (en) | 1998-10-20 |
| JPH10279432A5 true JPH10279432A5 (en) | 2005-03-03 |
Family
ID=14257301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9099813A Pending JPH10279432A (en) | 1997-04-01 | 1997-04-01 | Composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH10279432A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI20021184L (en) | 2002-06-19 | 2003-12-20 | Hormos Nutraceutical Oy Ltd | Lignan preparations |
| WO2004012655A2 (en) * | 2002-08-06 | 2004-02-12 | The Quigley Corporation | Anti-microbial compositions and methods of using same |
| KR101252554B1 (en) * | 2006-03-17 | 2013-04-08 | (주)아모레퍼시픽 | Composition capable of inhibiting sebum secretion |
| FR2906716B1 (en) * | 2006-10-06 | 2013-05-17 | Clarins Lab | USE OF A COSMETIC COMPOSITION FOR THE CARE OF OIL SKIN. |
-
1997
- 1997-04-01 JP JP9099813A patent/JPH10279432A/en active Pending
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