JPH10307192A - Chemical time indicator - Google Patents

Abstract

(57) [Summary] (Corrected) [Purpose] Can be installed in any place, and the time can be easily recognized by a clear change in color tone. Provide a chemical time indicator to display the target. A container divided into two or more chambers by a partition wall dissolvable in a reagent having a specific solubility contains a reagent having a specific solubility and a detection reagent which develops a color with the reagent. [Effect] Since there is no change in color tone such as a coloring reaction until the partition walls are dissolved, whether or not the set time has passed is clearly visualized.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a simple display device for managing the quality of articles stored at a certain temperature or lower for a certain period of time from both the storage time and the storage temperature. It is useful in fields such as management, expiration date management, expiration date management of pharmaceuticals, germination and flowering management of agricultural products, and management of cooking time.

[0002]

2. Description of the Related Art A mechanical or electric timer such as a stopwatch is used to measure elapsed time.
In order to measure the long-term elapsed time, a method relying on memory such as marking a calendar, or a chemical time indicator applying color development or discoloration due to a chemical reaction is used. The chemical time indicator includes a pH indicator, an alkaline substance, and a humectant which are impregnated into paper or non-woven fabric, and change the color tone by absorbing carbon dioxide gas in the air (Japanese Patent Publication No. 4-66518). Is visualized by penetration of a thermoplastic rubber (Japanese Patent Application Laid-Open No. 56-13338), a time consisting of a thermally inactive compound comprising a leuco base and a photosensitive compound which produces an acid activated by actinic radiation. -Temperature indicating material (Japanese Unexamined Patent Publication No.
2 -163965), and a first layer: an oil-soluble resin having a cyanine dye and a carboxyl group / phenol group,
Second layer: emulsion composed of resin having a pH of 7 or more, third layer
Layer: discoloration time indicator consisting of a hygroscopic polymer soluble in water or alcohol (JP-A-5-12696)
9) A time display material in which the layers each carrying a radical generator and a radical reactive dye are brought into a non-contact state via a spacer and an external pressure is applied to bring the two layers into contact with each other and start time measurement (Japanese Patent Application Laid-Open No. 9-54174). Etc. have been devised. A food-like state indicator (JP-A-8-15251), which is a slide-like substance holding a fat film and a pigment, which dissolves and changes the color of the lipid film due to bacterial contamination. What to display (Japanese Patent Application Laid-Open No. 58-50192)
0) is also considered as a kind of chemical time indicator.

[0003]

Problems to be Solved by the Invention A mechanical or electric timer is excellent in absolute accuracy of time measurement,
Due to its complex structure, it cannot be installed in places with high levels of vibration or humidity. In addition, these timers are relatively expensive, and it is economically burdensome to install a large number of timers simultaneously for the purpose of separately managing various types of articles. Absolute accuracy of time measurement is necessary, but not always sufficient, in storage management of articles that are susceptible to changes in the environment of the installation location such as temperature. In general, an expiration date and a storage temperature are added to a perishable article, and if the article is placed in an environment exceeding this temperature, the quality will deteriorate even within the expiration date. Therefore,
It is important to manage an article having an expiration date, not just an elapsed time, but to manage an integrated amount of time and temperature (referred to as a time-temperature integrated value). Most of the quality deterioration can be considered to be caused by a kind of chemical reaction, and a chemical time indicator using a chemical reaction displays a time-temperature integrated value. Although the chemical time indicator is not absolutely accurate in measuring time, it is more valuable than a mechanical timer as a means of storing and managing articles. However, the conventional chemical time indicators are not necessarily widely used. For example, a device that requires circulation of outside air or a device that requires light irradiation is naturally subject to restrictions on installation locations. Furthermore, it has been pointed out that a common problem is that it is difficult to determine which time point has reached the end of timekeeping due to slow discoloration.

[0004]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a sealed structure that can be attached to an object to be managed with a small volume and that does not contaminate the outside, so that the time-temperature integrated value can be easily managed. And to provide a chemical time indicator which changes color almost instantly immediately after a set time has elapsed and is easy to determine. It is another object of the present invention to provide a gradual display chemical time indicator capable of recognizing an intermediate stage of the elapsed time.

The basic form of the chemical time indicator according to the present invention comprises a closed container having two chambers, a dissolution chamber and a discoloration chamber. The two chambers are adjacent to each other, and a part or the whole of the partition is made of a material that can be dissolved by a reagent having a specific solubility (dissolution reagent) (hereinafter, the partition is referred to as a dissolution wall). The dissolution chamber is filled with a liquid (dissolution liquid) containing a dissolution reagent, and the discoloration chamber is filled with a liquid (detection liquid) containing a reagent (detection reagent) for detecting contamination of the dissolution liquid. In order to know the reaction result of the detection reagent, the entire container or a part of the detection chamber has a transparent portion (hereinafter, referred to as a transparent window). The measurement of the time-temperature integrated value starts when the lysis solution injected into the lysis chamber comes into contact with the lysis wall. The dissolving wall is gradually dissolved by the dissolving solution, and when the integrated value of time and temperature exceeds a certain amount, the dissolving wall dissolves to the discoloration chamber side and the dissolution chamber communicates with the discoloration chamber. The color development or change in color tone caused by the reaction between the solution leached into the color changing chamber and the detection reagent is observed through the transparent window. The detection reagent need not be a liquid but may be a solid, as long as it contains a component that changes color depending on the solution.

[0006] The time until the dissolution of the dissolving wall can be determined in advance by the amount of the dissolving solution at the start, the concentration of the dissolving reagent, and the thickness of the dissolving wall. If the amount of the lysis solution and the concentration of the lysis reagent are fixed and the thickness of the lysis wall is reduced, measurement can be performed in a short time, and by making the lysis wall thicker, a longer time can be measured. . In either case,
The amount of the lysing solution and the concentration of the lysing reagent need to be in excess to sufficiently dissolve the lysing wall. Conversely, the dissolution time can be determined by keeping the thickness of the dissolution wall constant and changing the amount of the dissolution solution or the concentration of the dissolution reagent.

[0007] The time measurement in the basic mode is started by injecting a lysis solution into a lysis chamber. If an injection port which can be opened is provided in a part of the dissolution chamber, the dissolution chamber can be easily sealed after the injection of the dissolution solution and the injection. The injection operation is further facilitated by separately preparing an injection device in which a required amount of the dissolving solution is filled in a disposable dropper or a syringe for injection. The solution is stored in a chamber different from the dissolution chamber in the chemical time indicator, and the solution is transferred to the dissolution chamber at the start of measurement. It is more preferable because there is no property. The chamber containing the solution is adjacent to the solution chamber, and the partition between the two chambers is a thin film made of a material resistant to the solution. This partition can be broken by applying pressure from the outside, but if a projection is provided in advance on the opposite side of the partition of the chamber containing the solution, the projection can break through the partition by strongly pressing the opposite side with a finger. Transfer of the lysis solution can be easily achieved.
When the dissolution chamber is empty, the volume of the dissolution chamber must be reduced as much as possible because air in the dissolution chamber remains and the contact area between the dissolution wall and the dissolution liquid decreases. If a liquid (referred to as a diluent) that does not dissolve the dissolving wall and does not impair the dissolving ability of the dissolving solution is stored in the dissolving chamber in advance, no air remains in the dissolving chamber. The lysis solution is diluted, but there is no problem if the concentration of the lysis solution is increased.

[0008] Since the chemical time indicator reflects the temperature change during the time measurement in the result, all of the lysis reagent, the detection reagent and the material of the lysis wall are resistant to a sudden high temperature and the reaction is not temperature-dependent. must not.
Polylactic acid, which is a biodegradable resin material, is supplied as processed products such as films, fibers, or containers, and has the property of dissolving relatively quickly in an alkaline solution, although heat resistance and strength do not hinder practical use. . This is the melting wall,
If an aqueous solution of sodium hydroxide or potassium hydroxide is used for the solution, a combination satisfying the above conditions is obtained. In this case, a basic pH indicator such as phenolphthalein or thymol blue can be used as the detection reagent. In particular, phenolphthalein is neutral and colorless, and alkaline and red, and thus has high recognition of the completion of the reaction. A combination of an aqueous solution containing a trace amount of magnesium chloride, which should be detected, is added to the solution of the alkaline aqueous solution by adding xylidyl blue, which is a magnesium detector and easily soluble in alkali, from red to purple-red. The remarkable discoloration makes it easy to recognize. A combination of a metal such as an aluminum foil for the partition, an acidic solution for the dissolving solution, and an acidic pH indicator such as methyl orange or methyl red as the detection reagent can also be used. However, dissolution of metal by acid involves generation of hydrogen gas,
Care must be taken, such as using a very thin metal foil as an indicator for a short time, using a metal only for a very small part of the partition wall, or avoiding sealing of the container.

When a nitrocellulose film is used for the partition walls, an equal volume mixture of acetone and ethanol is used for the dissolving solution, and a dye suspension that is readily soluble in alcohol is used for the detection solution, the color changes due to the dissolution of the dye in alcohol. Can be identified. In any case, the reaction involving the detection reagent does not proceed at all as long as the partition wall is present.
Subsequent determination is very easy. With the chemical time indicator of the present invention, a method is also possible in which discoloration due to the detection reagent is not used as a criterion. For example, if a dissolving solution in which the dye is dissolved in advance is used, and the discoloration chamber is filled with only the diluent without using the detection solution, the dye is diffused due to the temporal collapse of the partition walls, and the colored area increases. Thus, the elapsed time can be determined by the length as in an alcohol thermometer.

Contrary to the above, the detection time is sealed in a small container made of a material soluble in a specific reagent, and the lysis solution is stored in a large container as a main body, so that the chemical time can be further simplified. It can be an indicator. For example, phenolphthalein is sealed in a container made of polylactic acid having a capacity of several ml or less, and a NaOH solution, which is a dissolving solution, is placed in a transparent plastic container that is used daily. To start the time measurement, simply throw the polylactic acid container into the transparent plastic container.

In the basic form, there is only one discoloration chamber,
By providing a plurality of them, stepwise time measurement can be performed. If the discoloration chambers are continuously adjacent to each other and the partition walls are used as dissolution walls, the dissolution liquid injected into the dissolution chamber dissolves in the dissolution wall between the discoloration chamber adjacent to the dissolution chamber (hereinafter referred to as the first discoloration chamber). I do. The dissolution proceeds and the solution is diffused into the first discoloration chamber and discolored. The lysis reagent has a concentration diluted by the volume of the first color changing chamber. If the concentration is sufficient to further dissolve the dissolution wall, the dissolution wall between the next discoloration chamber adjacent to the first discoloration chamber (hereinafter referred to as the second discoloration chamber) starts to dissolve. That is, the combined area of the melting chamber and the first color changing chamber functions as a melting chamber. When the dissolution wall between the first color changing chamber and the second color changing chamber dissolves to the second color changing chamber, the solution diffuses to the second color changing chamber and the second color changing chamber changes color. Similarly, if the third and fourth discoloration chambers are provided, multi-stage discoloration occurs with the passage of time, and stepwise time measurement can be performed. The concentration of the lysis reagent in the lysis solution needs to be high enough to dissolve all the lysis walls in advance, but if the thickness of the lysis wall at each concentration is adjusted, each Free time settings can be made in the stages. Transparent windows for observing the discoloration state must be installed in all discoloration rooms.

The discoloration after the lapse of the set time may be changed as long as the color changes when the solution enters the discoloration chamber.
Any of discoloration from coloring to colorless, coloring to another color, and deepening of coloring may be used. Further, a method may be used in which a solution containing a dye reagent having a concentration sufficient for recognition even when diluted in all the color changing chambers is used without using the detection reagent. In addition to the action of the components on one side of the melting wall, the components on both sides may come into contact with each other and discolor by the action of both components. Any method may be used as long as the discoloration chamber undergoes a clear change in appearance before and after the end of timing. In principle, the discoloration is carried out quickly before and after the end of the time measurement. However, if a gradual change is required, the cross-sectional area of the dissolving wall may be reduced so that the diffusion of the dissolving solution occurs slowly. If the time when the melting wall is completely melted is set as the end of the timekeeping, it is possible to know that the end of the timekeeping is near from the gradual change in the color tone of the discoloration chamber immediately before the end of the timekeeping. To make the color change faster,
The dissolution chamber may be pressurized or the discoloration chamber may be depressurized. When a hole is formed in the dissolution wall, the two liquids are rapidly mixed due to the pressure difference between the two chambers, and the color can be changed almost instantaneously.

The chemical time indicator of the present invention comprises: The dissolution chamber and the discoloration chamber (the dissolution chamber and the discoloration chamber may be common) are adjacent to each other, and all or a part of the boundary acts as a dissolution wall. 2. The lysis reagent in the lysis chamber is in contact with the lysis wall after the start of the timing. 3. The dissolved component is in contact with the dissolved wall at the end of the timing. 4. The lysis reagent in the lysis solution is at a concentration sufficient for the lysis wall to dissolve to the side of the discoloration chamber (the final discoloration chamber in the case of the multi-stage type). 5. The amount of the lysing solution is sufficient to dissolve the dissolving wall to the discoloration chamber side (the final discoloration chamber in the multi-stage type). 6. The amount of the detection reagent is such that the discoloration in the discolored area can be sufficiently recognized. 7. The detection reagent may be in any room as long as there is a region that changes color when the dissolution wall dissolves until it reaches the next room (it may change color due to the interaction of two components). 8. After a set time, the melting wall has a thickness enough to melt until it reaches the discoloration chamber. 9. The material of the main part of the container is not dissolved by the dissolving liquid, and when sealing is required, it only has the mechanical strength to cover the dissolving solution and the detection liquid (diluent) inside and maintain the sealing. Having a thickness of 1
0. A transparent window is provided so that the discolored state can be observed.
Any shape may be used as long as the above conditions are satisfied.

[0014]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS FIG. 1 shows an example of a basic form of a chemical time indicator according to the present invention, in which 1 is a container body having two rooms, 2 is a melting room, 3 is a discoloration room, 4 is a dissolution wall. The container body 1 is made of a synthetic resin that is transparent and resistant to a solution. A dissolving solution containing a component for dissolving the dissolving wall 4 is injected into the dissolving chamber 2.
The color changing chamber is filled with a detection solution containing a detection reagent for detecting the lysis solution. Examples of the dissolving solution, the dissolving wall 4, and the detecting solution include an alkaline solution such as an aqueous solution of sodium hydroxide and potassium hydroxide as the dissolving solution, a pH indicator such as phenolphthalein as the detecting solution, and polylactic acid as the dissolving wall 4. And materials that dissolve under alkaline conditions. Time measurement is started from the time when the dissolving solution is injected into the dissolving chamber 2, and after a certain period of time, when the dissolving of the dissolving wall proceeds to the discoloring chamber side, the dissolving solution enters the discoloring chamber and changes color. In the combination of the sodium hydroxide solution and the phenolphthalein solution, the color changes from colorless to red after the elapse of the measurement time.

A specific example of this embodiment and a preparation procedure will be described. The container body 1 is made of a transparent polyvinyl chloride pipe (inner diameter 10 mm, thickness 1 mm, height 20 mm), the melting wall 4 is made of a polylactic acid disk (outer diameter 10.2 mm, thickness 0.5 mm), the container body 1
The top and bottom are made of a PVC disc (outside diameter 10.
2 mm, thickness 1 mm). The disk of the melting wall is pressed into the container body horizontally to the center (height: 10 mm) of the container body. Stand vertically with the bottom part up, add about 0.7 ml of phenolphthalein solution (100 ml of water and 2-3 drops of ethanol solution containing 1% phenolphthalein), Press the bottom disk horizontally until there is no step with the edge of the pipe of the container body. The container body is turned upside down, 0.7 ml of 5N-NaOH solution is injected as a dissolving solution, and the disk on the top is press-fitted in the same manner as the lower disk. The timing is started from the time when the 5N-NaOH solution is injected.

FIG. 2 shows an example of a time indicator in which the solution chamber is integrated, and FIG. 3 simulates the color change over time. In FIG. 2, 1 is a container body divided into three chambers, 2 is a dissolution chamber, 3 is a discoloration chamber, 4 is a dissolution wall as a part of a partition between the dissolution chamber and the discoloration chamber, 5 is a dissolution liquid chamber, and 6 is a dissolution chamber. A thin film partition separating the liquid chamber and the dissolving chamber, 7 is a projection for breaking the thin film 6, and 8 is a movable part at the root of the projection 7 which is a part of the container body. The container body 1 is made of a synthetic resin that is transparent and resistant to the dissolving solution. The dissolving chamber 3 is filled with a diluent that does not have the dissolving ability of the dissolving wall and does not hinder the dissolving ability of the dissolving solution. There is a dissolving wall 4 filled with a detecting solution containing a detecting reagent which reacts with and discolors with the solution, and is dissolved by the dissolving solution between the dissolving chamber 2 and the discoloring chamber 3. It has been adjusted to communicate.
The lysis solution chamber 5 is filled with a lysis solution containing a lysis reagent having a concentration capable of sufficiently dissolving the lysis wall in a state diluted with the diluting solution.
Is a hard synthetic resin, and the movable portion 8 is made of a flexible and elastic synthetic resin.

At the start of time measurement, the movable part 8 is pushed in until the projection 7 breaks through the thin film 6 (FIG. 3A). Movable part 8
Returns to its original state due to the internal pressure and elasticity, and the thin film 6 is opened. The lysis solution in the lysis solution chamber 8 diffuses into the lysis chamber 2 and contacts the lysis wall 4 in a state diluted with the diluent (FIG. 3-B). The dissolution of the dissolution wall 4 proceeds from the dissolution chamber 2 side to the discoloration chamber 3 side (FIG. 3-C). When the set time has elapsed and the dissolving wall 4 has melted to the discoloration chamber 3 side, the dissolution chamber 2 and the discoloration chamber 3 communicate with each other. (FIG. 3-D).

A specific example of a form in which the solution chamber is integrated and a preparation procedure will be described. The container body 1 is made of a hard transparent PVC pipe (inner diameter 10 mm, thickness 1 mm, height 20).
mm), the dissolution wall 4 is a polylactic acid disk (outside diameter 10.2 mm, thickness 0.5 mm), the bottom of the container body 1 is a hard polyvinyl chloride disk (outside diameter 10.2 mm, thickness 1 mm), a thin film 6 is a soft vinyl chloride disk (outer diameter 11 mm, thickness 0.1 mm), the surrounding wall of the solution chamber 5 is a hard transparent polyvinyl chloride pipe (inner diameter 10 mm, thickness 1 mm, height 5 mm), movable part Reference numeral 8 denotes a soft PVC disk (outer diameter 12 mm, thickness 1 mm), and protrusion 7 is a rigid PVC column having a conical point on one side (cylinder outer diameter 2 mm, cone length 2 mm, full length 4 mm). It is the same as the above-described basic mode until the dissolving wall 4 is inserted into the container body 1, the detection liquid (phenol phthalein liquid) is filled, and the bottom is press-fitted.

The solution chamber 5 is created in the following procedure. The non-conical side of the protrusion 7 is vertically bonded to the center of the movable portion 8 using an adhesive (for example, a tetrahydrofuran-based adhesive). Further, a pipe for the outer wall of the solution chamber 5 is bonded with an adhesive such that the bonded projection 7 is on the inside, and the circumference of the movable section 8 and the circumference of the pipe coincide. After the adhesive portion has dried, place the opening (the side where the outer peripheral pipe is not adhered) up with 0.3 ml of a solution 5N-NaOH aqueous solution.
, The thin film 6 is placed so that the center of the circle is substantially coincident with the center of the pipe, and the thin film 6 is welded in a ring shape by an ultrasonic welding machine. Check that the solution is not spilled around the welded area (if spilled, wipe off, wash, etc. to remove the outside solution). The bottomed container main body 1 is placed with the bottom facing up, 0.7 ml of water is put therein, and the assembled solution chamber 5 is placed on the thin film 6 down so that the outer circumferences of both pipes coincide. And then welded with an ultrasonic welding machine.

FIG. 4 shows an example of a time indicator for performing stepwise time measurement, and FIG. 5 shows the change over time. In FIG. 4, 9 is a container body having five chambers, 10 is a dissolution chamber, 11, 18, and 20 are first, second, and third color changing chambers, respectively, 12, 17, and 19 are first, second, and second, respectively. 3 dissolving wall, 13 is a dissolving chamber, 14 is a thin film at the boundary between the dissolving chamber and the dissolving chamber, 15 is a projection, and 16 is a movable part. The properties of the materials are the same as in the previous section, except that the lysis solution chamber contains a lysis solution containing a lysis reagent in an amount that can dissolve all the lysis walls, and the discoloration chamber contains a detection solution. (If the amount of the detection reagent contained in the first discoloration chamber 3 is sufficient to discolor the entire container, the second discoloration chamber 18
The third discoloring chamber 20 may be filled with a diluent.) Each dissolving wall has a thickness sufficient to dissolve to the next discoloring chamber after a lapse of a set time under the condition when each dissolution starts. Having

The first time measurement starts when the movable portion 16 is pushed and the thin film 14 is pierced by the projection 15. 1
After the elapse of the second set time, the first dissolving wall 12 dissolves to the first discoloring chamber 11 side, the dissolving liquid and the detection liquid are mixed, and the dissolving liquid chamber 13, the dissolving chamber 10, and the first discoloring chamber 11 are discolored ( FIG.
-A). Subsequently, the second dissolution wall 17 begins to dissolve, and a second timing is started. When the set time for dissolution of the partition walls 17 has elapsed, the color changes to the second color changing chamber 18 (FIG. 5-B). Similarly, when the third set time elapses, the third color changing chamber 20 changes color and the time measurement ends. In this example, the time is set in three stages. However, by adding the fourth, fifth,... Discoloration chambers and dissolving walls, the time can be measured in multiple stages.

A specific example of the type for measuring the time of the multi-step and a method of preparing the time will be described. The solution chamber 13 is formed similarly to the shape in which the solution chamber is integrated. The container body 9 is composed of four transparent hard vinyl chlorides (inner diameter 10 mm, thickness 1 mm, height 10 mm) and a hard polyvinyl chloride disk (outer diameter 10.2 mm, thickness 1 mm). 17 and 19 are three polylactic acid disks (outer diameter 10.2 mm, thickness 0.1 mm).
Press the bottom into the container body as before. 0.7 ml of phenolphthalein solution as a detection liquid is placed with the opening facing upward, and a disk for dissolution walls 12, 17, 19 is placed on the disk so that the center substantially matches the center of the pipe, and another container is placed on top of it. A pipe for the main body 9 is placed so that the outer circumferences thereof coincide with each other, and ultrasonic vibration is applied from above to weld. The injection of the detection liquid and the ultrasonic welding are repeated in the same manner, and finally, the dissolution liquid chamber is ultrasonically welded to obtain the container body 9.

As another example of the discoloration pattern, in FIG. 2, 1) a detection reagent is put into a lysis solution chamber 5 together with a lysis reagent. The colorless diluent is put into the dissolution chamber 2 and the discoloration chamber 3. 2)
The detection reagent is put into the dissolution chamber 2. The lysis solution chamber 5 contains a lysis solution, and the discoloration chamber 3 contains a diluent solution. 3) a dissolving reagent for a coloring agent (a pH indicator that changes color when changing from basic to acidic);
In addition, a base component that does not hinder the dissolving ability of the dissolving reagent (not necessary when the dissolving reagent is basic) is placed in the dissolving solution chamber 5. There is an example in which a neutral diluting solution is placed in the dissolving chamber 2 and an acidic solution having a capacity equal to or greater than that of the base in the dissolving chamber is used in the discoloring chamber 3 because the dissolving wall 4 has no dissolving ability.

In the example of 1), the lysis chamber 5 is colored and the lysis chamber 2 and the discoloration chamber 3 are colorless before the start of timing. During the timing, the dissolution chamber 5 and the dissolution chamber 2 are discolored, and the discoloration chamber is colorless. After the end of the timing, the dissolution chamber 5, the dissolution chamber 2, and the discoloration chamber 3 are all discolored. In the example of 2), before the start of the timing, all the colors are non-discolored,
During the timing, the dissolution chamber 5 and the dissolution chamber 2 are discolored, and the discoloration chamber is not discolored. After the end of the timing, the dissolution chamber 5, the dissolution chamber 2, and the discoloration chamber 3 are all discolored. 1) and 2) are the same in the multi-stage timing shown in FIG. 4, and the color of the next color changing chamber is changed in each next timing stage. In the example of 3), the solution chamber 5 before the start of the timing
Shows color in basicity of indicator, dissolution chamber 2 and discoloration chamber 3
Is non-discolored. During the timing, the dissolution solution chamber 5 and the dissolution chamber 2 change color to the basic color of the pH indicator, and the discoloration chamber 3 is non-discolored. Room 3 is p
The color of the H indicator changes to the acidic color.

In the multi-stage timing shown in FIG. 4, if the acidic liquid is introduced into the third discoloration chamber 20 which changes color last, each discoloration chamber similarly changes color to the color of the base at each stage. The whole is discolored to the acidic color of the pH indicator. In the examples up to the preceding paragraph, it is difficult to know that the time is being measured because the color does not change at the start of timekeeping, but in the example given here, it is easy to determine that the time is being measured because the color changes at the time of start of timekeeping. In the previous examples, the entire container body was transparent.However, if one side is made of a transparent window and the back side is made of an opaque material that is colored, if the liquid inside is transparent, the color of the back side will be the color, and the discolored liquid will be The color of the liquid or the color of the back and the color of the liquid is mixed and observed from the transparent surface.

FIG. 6 shows a front view of a bag-shaped chemical time indicator and a sectional view of a central portion thereof. 6 in FIG.
Denotes a bag-shaped container main body, 22 denotes a melting chamber, and 23 denotes a discoloration chamber. 24 is a membrane-like dissolution wall, 25 is a solution chamber, 26
Denotes a thin film that constitutes the solution chamber 25 and serves as a partition wall from the solution chamber 22. 27 is the front side film of the container body, 28 is the back side film of the container body, 29 is the thin film back surface opposite to the thin film 26 of the solution chamber, and 30 is the both sides of the front film 27 and the back side film 28 of the container body. Reference numeral 31 denotes a welded portion of the welded main body side surface, and reference numeral 31 denotes a welded portion (dissolved wall side welded portion) of the melting wall 24 sandwiched and welded to the welding surfaces 30 on the front and back side surfaces of the bag-shaped container body 21. 3
Reference numeral 2 denotes a welded portion of the front side film 27 and the backside film 28 on the upper side of the bag-shaped container main body 21 (upper side welded portion of the main body);
Reference numeral 34 denotes a welded surface of the melting wall 24 sandwiched and welded (welded surface on the upper side of the melting wall). Represents Reference numeral 35 denotes a welding surface of the thin film 26 and the thin film 29 constituting the solution chamber 25 (solution solution welding surface).
36 is a temporary welding surface of the thin film 26 and the thin film 29 constituting the solution chamber 25 (solution solution chamber temporary welding surface), and 37 is a bag-like container main body 2.
A welding surface (an upper surface welding surface of the solution chamber) of the solution chamber which is inserted and welded to the welding portion 34 on the upper side is shown.

The bag-like container body 21 is made of a rectangular film 2.
It is composed of sheets (front side film 27, back side film 28) and is welded by the main body side welding part 30, the main body upper side welding part 34, and the solution chamber welding part 35. The dissolving wall 24 is a rectangular film, and in a bent state, both sides are dissolving wall side welding portions 31, and the upper surface is dissolving wall upper side welding surface 33, and the front side film 27 and the back side film 28 of the bag-shaped container body 21. It is sandwiched and welded. The solution chamber 25 is composed of two rectangular films, a thin film 26 and a thin film back surface 29, and has three sides on which the solution chamber welding surface 3 is formed.
5 and one side is temporarily welded (welded so as to be partially peeled off when subjected to a strong pressure) by the solution chamber temporary welding portion 36, and the solution solution upper side welding surface 37 on the opposite side of the solution solution chamber temporary welding portion 36. And is welded so as to be sandwiched by the welding portion 32 on the upper side of the main body. A dissolving solution capable of dissolving the dissolving wall 24 is contained in the dissolving solution chamber 25, and a diluent containing a discoloring component is contained in the dissolving chamber 22 surrounded by the dissolving wall 24, and a lower discoloration chamber separated by the dissolving wall 24. 23 contains a diluent. If necessary, a peelable adhesive is applied to the surface of the backside film 28.

A specific example of a form in which the solution chamber 25 is integrated and a preparation procedure will be described. Front membrane 27 of container body 21
The back side film 28 is made of polyethylene rectangular film (thickness 0.1 mm, length 100 mm, width 20 mm), and the thin film 26 of the solution chamber 25 and the thin film back surface 29 are made of polyethylene rectangular film (thickness 0.1 mm). , Length 15mm, width 10m
m) The dissolving wall 24 is a rectangular film of polylactic acid (thickness 0.1 mm, length 40 mm, width 17 mm). The two films (26, 29) constituting the dissolving solution chamber 25 are overlapped, heat-sealed on the three sides of the outer periphery with a width of 2 mm, and a 2N-NaOH aqueous solution is used as a dissolving solution from one unwelded side.
After injecting 5 ml, the unwelded side is temporarily welded with a width of 3 mm. Temporary welding means welding with the welding time shorter than the minimum time for complete welding. The polylactic acid film for the dissolving wall 24 is folded in two, and the opposite side of the fold of the dissolving wall 24 between the front film 27 and the back film 28 of the container body 21 is formed by the front film 27 and the back film 28. Heat seal both sides with a width of 3 mm by sandwiching it at a position inward of about 1.5 mm parallel to the upper side (to the short side), and also at a position of about 1.5 mm parallel to both sides.

After injecting 5 ml of water as a diluent from the opening opposite to the side where the melting wall 24 is welded, the upper side welded portion 34 is heat-sealed. With the opening on the side where the dissolution wall 24 is welded up, 2 ml of phenolphthalein solution is injected between the dissolution walls 24, and the side of the dissolution solution chamber 25 opposite to the dissolution solution chamber temporary welding portion 36 is removed. Heat is applied to the main body upper side welding portion 32, the melting wall upper side welding surface 33, and the melting solution chamber upper side welding surface 37 in a state where they are overlapped with each other so as to be aligned with the non-welded side of the melting wall 24 so as to put the solution chamber 25 inside. Perform sealing. With the opposite side where the melting wall 24 is welded up,
After injecting 5 ml of water as a diluent from the opening, the welded portion 34 on the lower side of the main body is heat-sealed. A double-sided adhesive tape or a peelable adhesive tape having a width of 20 mm is attached to the back film 28.

In the method of use in this example, first, the one having a set time (thickness of the dissolving wall) that matches the expiration date of the object is selected. The lysing solution chamber 25 is crushed from the outside of the bag-shaped container body 21 with a finger or the like at the time of manufacturing, shipping, or purchasing the object. A part of the temporary welding portion (dissolving solution chamber temporary welding surface 36) of the thin film 26 and the thin film back surface 29 is peeled off, and the dissolving solution flows into the dissolving chamber 22, and the inside of the dissolving chamber 22 changes color by the detection reagent. After confirming the discoloration of the melting chamber, the bag-shaped container body 21
Is attached by an adhesive tape on the back film 28. If there is no change in the color changing room 23, it can be determined that the timed object is within the expiration date and can be used. If a change is found in the discoloration room 23, it is better to refrain from using it even within the expiration date. The solution chamber 25 is omitted in the same shape,
One backside film 28 may be integrated with the packaging of the storage object, and a solution may be injected into the melting chamber at the time of packaging the object and then sealed by welding.

[0031]

When the chemical time indicator of the present invention exceeds a preset time-temperature integrated value, it exhibits an almost instantaneous color tone change, so that quality control based on the time-temperature integrated value can be performed very easily. Since it can be provided at a low cost with a high degree of freedom in installation location, it can be applied to various uses.

[Brief description of the drawings]

FIG. 1 shows an example of a basic embodiment of the present invention.

FIG. 2 shows an example in which a solution chamber is added to the basic configuration.

FIG. 3 shows an example of color change over time according to the example of FIG. 2;

FIG. 4 Stepwise time indicator

FIG. 5 is an example of a color tone change by a stepwise time indicator.

FIG. 6 is a front view and a sectional view of an example of a bag-shaped time indicator.

[Explanation of symbols]

1. 1. Container body Melting chamber
3. Discoloration room 4. Melting wall 5. Lysis chamber
6. 6. Thin film Protrusion 8. movable part
9. Container body 10. Dissolution chamber 11. 1st discoloration room
12. First melting wall 13. Lysis chamber 14. Thin film
15. Projection part 16. Movable part 17. Second melting wall
18. Second color changing room 19. Third melting wall 20. Third color changing room
21. Bag-shaped container body 22. Dissolution chamber 23. Discoloration room
24. 25. Membranous dissolution wall Dissolution chamber 26. Thin film
27. Front membrane 28. Backside membrane 29. Thin film back
30. Body side welded portion 31. Fusion wall side welded portion 32. Welded part on the top
33. Deposition wall upper surface welding surface 34. Welding part on bottom side of main body 35. Dissolution liquid chamber welding surface
36. Dissolution liquid chamber temporary welding surface 37. Welding surface on the upper side of the solution chamber

Claims (15)

[Claims] Claims: 1. A container divided into at least two chambers by a partition wall partially or wholly made of a material dissolvable in a reagent having a specific solubility, wherein at least one of the containers is provided.
A chemical time indicator for managing a time-temperature integrated value in which a chamber contains a reagent having a specific solubility and another chamber contains a detection reagent for detecting a reagent having a specific solubility. 2. A container partitioned into at least two chambers by a partition wall partially or wholly made of a material dissolvable in a reagent having a specific solubility, wherein at least one of said containers is provided.
A chamber containing reagents and dyes having a specific solubility,
A chemical time indicator for managing a time-temperature integrated value for detecting elapsed time by diffusion of a dye due to dissolution of the partition. 3. The method according to claim 1, wherein after one partition is dissolved, a mixture of a reagent having a specific solubilizing ability and a detection reagent comes into contact, and the next partition is dissolved. 3. The method according to claim 1, further comprising the steps of:
Chemical time indicator described in. 4. The chemical time indicator according to claim 1, wherein a part or all of the chamber containing the detection reagent is transparent. 5. The chemical time indicator according to claim 1, further comprising an inlet for injecting a reagent having a specific solubility. 6. A partition which can be physically broken from the outside in a chamber for accommodating a reagent having a specific dissolving ability, and is capable of dissolving a reagent having a specific dissolving ability in a specific reagent until the start of timing. The chemical time indicator according to claim 1, wherein the chemical time indicator is not brought into contact with the chemical time indicator. 7. The chemical time indicator according to claim 1, wherein the reagent having a specific solubility is an alkaline solution, the detection reagent is a pH indicator, and a part of the material of the partition is polylactic acid. 8. The chemical time indicator according to claim 7, wherein the alkaline solution is sodium hydroxide or potassium hydroxide, and the pH indicator is phenolphthalein. 9. The chemical time indicator according to claim 1, wherein the reagent having a specific solubility is a water-soluble organic solvent, and a part of the material of the partition is a plastic soluble in the organic solvent. 10. The chemical time indicator according to claim 1, wherein an adhesive capable of adhering to an object to be time-controlled is applied to a part of the container. 11. The adhesive according to claim 1, wherein the adhesive is a peelable adhesive.
Chemical time indicator according to 0. 12. The chemical time indicator according to claim 1, wherein a difference is provided in the internal pressure between the chambers partitioned by the partition walls to increase the mixing speed of the two liquids after the partition walls are dissolved. 13. A detection reagent is accommodated in one chamber of a container partitioned by a partition made of a material dissolvable in a reagent having a specific solubility, and a reagent having a specific solubility is injected into another chamber. A method for measuring the elapsed time from a color change reaction caused by mixing a reagent having a specific dissolving ability with a detection reagent by dissolving the partition wall to allow the two chambers to communicate with each other. 14. A reagent and a dye reagent having a specific solubility are injected into one chamber of a container partitioned by a partition made of a material dissolvable in a reagent having a specific solubility, and the other chamber is dissolved by dissolution of the partition. A method of measuring the elapsed time by recognizing the dye that diffuses to the surface. 15. A container in which a reagent or a dye reagent for detecting a reagent having a specific solubility is sealed in a small container made of a material soluble in a reagent having a specific solubility, and a reagent having a specific solubility is accommodated. Elapsed time measurement method to start time measurement by putting it in a filled container.