JPH10314313A - ステント移植組織片 - Google Patents
ステント移植組織片Info
- Publication number
- JPH10314313A JPH10314313A JP36196897A JP36196897A JPH10314313A JP H10314313 A JPH10314313 A JP H10314313A JP 36196897 A JP36196897 A JP 36196897A JP 36196897 A JP36196897 A JP 36196897A JP H10314313 A JPH10314313 A JP H10314313A
- Authority
- JP
- Japan
- Prior art keywords
- stent
- stents
- material layer
- graft
- expandable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000463 material Substances 0.000 claims abstract description 29
- 238000000034 method Methods 0.000 claims abstract description 3
- 239000011888 foil Substances 0.000 claims description 6
- -1 polytetrafluoroethylene Polymers 0.000 claims description 5
- 239000012620 biological material Substances 0.000 claims description 4
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 3
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 3
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 2
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 2
- 210000004204 blood vessel Anatomy 0.000 abstract description 6
- 238000003780 insertion Methods 0.000 abstract description 2
- 230000037431 insertion Effects 0.000 abstract description 2
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 238000004873 anchoring Methods 0.000 description 2
- 206010002329 Aneurysm Diseases 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000003698 laser cutting Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/852—Two or more distinct overlapping stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/89—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
- A61F2002/075—Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/005—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0058—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements soldered or brazed or welded
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0004—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable
- A61F2250/0007—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable for adjusting length
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/006—Additional features; Implant or prostheses properties not otherwise provided for modular
- A61F2250/0063—Nested prosthetic parts
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Laminated Bodies (AREA)
- Footwear And Its Accessory, Manufacturing Method And Apparatuses (AREA)
Abstract
可とう性の膨張可能な材料層(13)が配置されてい
る、同軸的に配置された半径方向に拡張可能な2つのス
テント(11,12)を有するステント移植組織片(1
0)。
Description
であるが、不安定な又は脆弱な又は血栓症の血管壁にお
いて、血管を援助するために使用されるようなステント
移植組織片に関する。
ばレーザ切断により金属管片から製造される半径方向に
拡張可能なステント、及び組織又はフォイルからなるこ
こに縫い付けられた被覆からなる。被覆は、血液流通又
は血液成分の流通又はステント移植組織片の壁を通した
沈着、及びステント移植組織片の内部への壁を通した組
織の固着を阻止するという役割を有する。それによりと
りわけ血圧による血管壁の負荷を逃し、かつステント移
植組織片の内移植個所に塞栓症が生じることがないこと
が保証される。しかしながら従来のステントにおいてス
テントにおける被覆の固定縫い付けに基づいて、結節が
生じ、これら結節は、血栓形成の危険を伴う血管の開い
た流通における渦形成を引起こす。被覆が、編物組織又
はより組織からなる場合、これは、ステントの回りで折
畳まなければならない。その際、ステントの拡張の際に
被覆の折り目のない広げは、常に保証されているわけで
はない。
問題を除去することにある。
に、本発明は、同軸的に配置された半径方向に拡張可能
な2つのステントを有するステント移植組織片を提案
し、その際、両方のステントの間に、可とう性の膨張可
能な材料層、例えば可とう性の膨張可能な生物学的な組
織が配置されている。本発明によるステント移植組織片
において、材料層は、両方の同軸的なステントの間に締
付けられるので、一方のステントにおける材料層の縫い
付けは省略することができる。その上さらに材料層は、
血管内へのステントの挿入の際に、損傷を防止される。
材料層の可とう性のかつ膨張可能な特性に基づいて、こ
の材料層は、両方のステントとともに移植個所において
半径方向に広がることができる。押込む際に両方のステ
ントの相互のずれを防止するために、両方のステント
は、その端部範囲において互いに点状に結合することが
できる。そのために種々の技術を使用することができ
る。両方のステントは、例えば互いに溶接、プレス又は
接着することができる。材料層は、人体に協調性のある
材料又は生物学的な組織からなるフォイル又は組織から
なるホース状の要素によって形成することができる。し
かし材料層は、内側のステントの回りに巻かれたフォイ
ル又は組織テープからなることができる。それによりス
テント移植組織片のとくに経済的な製造が可能である。
材料中間層のための材料としては、例えばポリテトラフ
ルオロエチレン、ポリエチレンテレフタラート、又は自
己又は同種の静脈又は動脈のような生物学的な材料が問
題になる。その際、あらかじめ膨張したポリテトラフル
オロエチレンは、この材料が原線維構造を有するので、
格別の利点を有し、それにより血管壁内へのステント移
植組織片の固着が助長される。それにより時間ととも
に、血管とステント移植組織片との間の固定的な結合が
生じる。
織片の有利な実施例を、図面により詳細に説明する。
及び12を有するステント移植組織片10の一部切り欠
いた斜視図を示しており、これらステントの間に、膨張
可能な材料層13が配置されている。この層13は、人
体に協調性のある合成物質フォイル又は合成物質組織か
ら製造することができる。しかし人体に協調性のある又
は生物学的なその他の材料の使用も可能である。図示し
た例において材料層13は、ステント移植組織片10の
長さの一部にわたってだけ延びている。
テントを有するステント移植組織片を示す一部切り欠か
れた斜視図である。
Claims (10)
- 【請求項1】 同軸的に配置された半径方向に拡張可能
な2つのステントが設けられており、その際、両方のス
テント(11,12)の間に、可とう性の膨張可能な材
料層(13)が配置されていることを特徴とする、ステ
ント移植組織片。 - 【請求項2】 材料層(13)が、ステント(11,1
2)の一部だけを覆っていることを特徴とする、請求項
1記載のステント移植組織片。 - 【請求項3】 両方のステント(11,12)が、その
端部範囲において互いに点状に結合されていることを特
徴とする、請求項1又は2記載のステント移植組織片。 - 【請求項4】 材料層(13)が、フォイル又は組織か
らなるホース状の要素によって形成されていることを特
徴とする、請求項1ないし3の1つに記載のステント移
植組織片。 - 【請求項5】 材料層(13)が、内側のステントの回
りに巻かれたフォイル又は組織テープによって形成され
ていることを特徴とする、請求項1ないし3の1つに記
載のステント移植組織片。 - 【請求項6】 材料層(13)が、ポリテトラフルオロ
エチレンからなることを特徴とする、請求項1ないし5
の1つに記載のステント移植組織片。 - 【請求項7】 材料層(13)が、ポリエチレンテレフ
タラートからなることを特徴とする、請求項1ないし5
の1つに記載のステント移植組織片。 - 【請求項8】 材料層(13)が、生物学的な材料から
なることを特徴とする、請求項1ないし5の1つに記載
のステント移植組織片。 - 【請求項9】 生物学的な材料が、自己源であることを
特徴とする、請求項8記載のステント移植組織片。 - 【請求項10】 生物学的な材料が、同種の源であるこ
とを特徴とする、請求項8記載のステント移植組織片。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19720115A DE19720115C2 (de) | 1997-05-14 | 1997-05-14 | Stent-Graft |
| DE19720115.6 | 1997-05-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH10314313A true JPH10314313A (ja) | 1998-12-02 |
| JP3211156B2 JP3211156B2 (ja) | 2001-09-25 |
Family
ID=7829391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP36196897A Expired - Lifetime JP3211156B2 (ja) | 1997-05-14 | 1997-11-21 | ステント移植組織片 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5916264A (ja) |
| EP (1) | EP0878173B1 (ja) |
| JP (1) | JP3211156B2 (ja) |
| AT (1) | ATE195239T1 (ja) |
| CA (1) | CA2224548C (ja) |
| DE (1) | DE19720115C2 (ja) |
| DK (1) | DK0878173T3 (ja) |
| ES (1) | ES2151218T3 (ja) |
| GR (1) | GR3034716T3 (ja) |
| PT (1) | PT878173E (ja) |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9415142B2 (en) | 2006-04-26 | 2016-08-16 | Micell Technologies, Inc. | Coatings containing multiple drugs |
| US9433516B2 (en) | 2007-04-17 | 2016-09-06 | Micell Technologies, Inc. | Stents having controlled elution |
| US9486431B2 (en) | 2008-07-17 | 2016-11-08 | Micell Technologies, Inc. | Drug delivery medical device |
| US9510856B2 (en) | 2008-07-17 | 2016-12-06 | Micell Technologies, Inc. | Drug delivery medical device |
| US9737642B2 (en) | 2007-01-08 | 2017-08-22 | Micell Technologies, Inc. | Stents having biodegradable layers |
| US9789233B2 (en) | 2008-04-17 | 2017-10-17 | Micell Technologies, Inc. | Stents having bioabsorbable layers |
| US9827117B2 (en) | 2005-07-15 | 2017-11-28 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
| US9981072B2 (en) | 2009-04-01 | 2018-05-29 | Micell Technologies, Inc. | Coated stents |
| US10117972B2 (en) | 2011-07-15 | 2018-11-06 | Micell Technologies, Inc. | Drug delivery medical device |
| US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
| US10232092B2 (en) | 2010-04-22 | 2019-03-19 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
| US10272606B2 (en) | 2013-05-15 | 2019-04-30 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
| JP2019118810A (ja) * | 2018-01-10 | 2019-07-22 | エスアンドジー バイオテック、インコーポレーテッド | 内腔拡張用3重構造ステント及びその製造方法 |
| US10835396B2 (en) | 2005-07-15 | 2020-11-17 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
| US11039943B2 (en) | 2013-03-12 | 2021-06-22 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
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| US10117972B2 (en) | 2011-07-15 | 2018-11-06 | Micell Technologies, Inc. | Drug delivery medical device |
| US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
| US11039943B2 (en) | 2013-03-12 | 2021-06-22 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
| US10272606B2 (en) | 2013-05-15 | 2019-04-30 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
| JP2019118810A (ja) * | 2018-01-10 | 2019-07-22 | エスアンドジー バイオテック、インコーポレーテッド | 内腔拡張用3重構造ステント及びその製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE19720115C2 (de) | 1999-05-20 |
| DE19720115A1 (de) | 1998-12-24 |
| PT878173E (pt) | 2000-11-30 |
| DK0878173T3 (da) | 2000-12-27 |
| CA2224548A1 (en) | 1998-11-14 |
| ATE195239T1 (de) | 2000-08-15 |
| CA2224548C (en) | 2005-08-09 |
| GR3034716T3 (en) | 2001-01-31 |
| ES2151218T3 (es) | 2000-12-16 |
| EP0878173B1 (de) | 2000-08-09 |
| EP0878173A1 (de) | 1998-11-18 |
| US5916264A (en) | 1999-06-29 |
| JP3211156B2 (ja) | 2001-09-25 |
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