JPH10330273A - Production of preparation for external use for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To make it possible to obtain a preparation for external use for skin having an excellent humectant effect and skin roughening preventive effect by extracting bacteria belonging to the genus Sphingomonas with a specific solvent. SOLUTION: This preparation for external use for skin is prepared by extracting bacteria belonging to the genus Sphingomonas with an alcohol or a mixture of alcohol and water after being washed with acetone, separating bacilli from the resultant extract to obtain a sphingoglycolipid-containing composition and then pharmaceutically manufacturing it as it is or by means of mixing with other components. As the extracting solvent, methanol is suitable when an alcohol is independently used, and propanol or butanol is preferable when a mixture of alcohol and water is utilized. This preparation can be prepared as a cosmetic and a medicine directly applicable to skins. When itnprovement for skin roughening and keratin or skin protection is necessitated, it is very effectively usable and shows antiatopic activity too.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a method for producing an external preparation for skin using bacteria belonging to the genus Sphingomonas. The present invention also relates to an external preparation for skin produced by using the production method. Since the external preparation for skin of the present invention has an excellent moisturizing effect and an effect of preventing rough skin, it can be widely used as cosmetics and pharmaceuticals.

[0002]

BACKGROUND OF THE INVENTION Rough skin is caused by excessive loss of moisture from the skin surface when the air is dry or when the skin is washed. In addition, since a wide variety of chemical substances are flooding society today, the function of skin that has been exposed to these chemical substances is inhibited, and the skin often becomes rough due to a decrease in lipid secretion function. For this reason, it is required to prevent skin roughness in advance and provide a skin external preparation having an excellent moisturizing action.

As active compounds having a moisturizing effect, various compounds have been provided so far, mainly water-soluble polyols. Some of them are already in practical use, such as propylene glycol. However, among the moisturizing compounds that have been put to practical use, there are many that cause discomfort when applied, and many have insufficient moisturizing effects, and the development of new moisturizing compounds is still required. .

[0004] Under these circumstances, glycosphingolipids have attracted attention as safe moisturizing compounds. For example, JP-A-1-242690, JP-A-2-485
No. 20, JP-A-4-159203 and JP-B-6-80007 describe that glycosphingolipids have a skin moisture moisturizing effect. However, the methods and structures for obtaining glycosphingolipids used in the examples of these publications are not disclosed.

[0005] JP-A-6-157283 discloses a moisturizing external skin cosmetic comprising a glycosphingolipid represented by a specific general formula as one component. However, there is no mention of a method for obtaining the glycosphingolipid represented by the general formula or a composition having a high activity.

On the other hand, Japanese Patent Application Laid-Open No. 61-28 discloses a specific glycosphingolipid having a moisturizing effect.
No. 6307. This publication describes that ganglioside has a skin moisturizing effect and a skin softening effect, and discloses a skin cosmetic containing ganglioside and a salt thereof. Gangliosides are glycosphingolipids characterized by containing amino sugars and sialic acid in addition to neutral sugars. Also, JP-A-5-39485, JP-A-7-133217 and JP-A-7-285827
Japanese Patent Application Publication No. JP-A-2003-115139 discloses an external preparation for skin using cerebroside. Cerebroside is a glycosphingolipid consisting of a fatty acid, a sphingosine base, and a neutral sugar (galactose or glucose) each of 1 mol.

[0007] As described above, glycosphingolipids are generally known to have a moisturizing effect, and some active compounds have been identified. However, glycosphingolipids having a specified structure cannot be said to have a sufficiently high moisturizing effect, and are difficult to use because of poor solubility. In addition, since separation and purification of glycosphingolipids generally requires labor and cost, it is hard to say that even if an active ingredient is specified, it is not necessarily suitable for practical use. Therefore, there is a need to develop a method for obtaining a glycosphingolipid-containing composition having extremely high moisturizing activity by a simple method.

[0008]

In view of the above problems of the prior art, the present inventors obtain a glycosphingolipid-containing composition having a strong moisturizing effect and a skin roughening preventing effect by a simple method. The research was conducted with the task of developing a method. That is, an object of the present invention is to provide a method for producing a glycosphingolipid-containing composition having an excellent moisturizing effect and a skin roughness preventing effect, and to provide an external preparation for skin containing the composition produced by the method. And

[0009]

Means for Solving the Problems As a result of intensive studies to solve the above problems, the present inventors have found that by extracting bacteria belonging to the genus Sphingomonas with a specific solvent, an extremely high moisturizing effect can be obtained. And found that a composition having an effect of preventing rough skin can be obtained, and the present invention has been completed.

[0010] That is, the present invention provides a method for producing an external preparation for skin, characterized in that bacteria belonging to the genus Sphingomonas are washed with acetone and extracted with alcohol or an alcohol / water mixture. The present invention also provides a skin external preparation produced by this production method.

The bacterium used in the present invention is a bacterium belonging to the genus Sphingomonas. Bacteria belonging to the genus Sphingomonas are characterized by having various components including glycosphingolipids. In the present invention, any kind of bacteria belonging to the genus Sphingomonas can be used. Therefore, sphingomyelin Mona spa cattle Mobility scan (Sphingomonas paucimobilis), Sphingomonas cusp Villadorata (Sphingomonas capsulata), Sphingomonas address flies Sheba (Sphingomonas adhaesiv
Bacteria belonging to any classification such as a ) can be used.

Specifically, Sphingomonas paucimobilis FERM BP-
3631, Sphingomonas sp. Mobilis FERM
BP-3632, Sphingomonas paucimovilis FE
RM BP-3633, Sphingomonas sp. Mobilis FERM BP-3634, Sphingomonas capsulata FERM BP-
3709 and Sphingomonas adhaeshiba ( Sphing
omonas adhaesiva ) FERM BP-3710, but many other bacteria belonging to the genus Sphingomonas can also be used.

In the present invention, a single bacterium may be used,
A plurality of bacteria may be used in combination. There is no particular limitation on the combination and mixing ratio when combining a plurality of bacteria.
All known sphingomonas bacteria are colored bacteria. In general, many have a yellow color, but some have an orange color. When such a colored bacterium is used, the same color is obtained in the resulting glycosphingolipid-containing composition. For this reason, it is necessary to decolorize before use, especially when used in fields where aesthetics are required, such as cosmetics. However, this decolorization operation is not always easy, and often it is not possible to completely decolorize. For this reason, there is a problem that it is difficult to use the glycosphingolipid-containing composition for products requiring aesthetics.

Therefore, when it is intended to be used for products requiring aesthetics, it is preferable to use a white mutant of a colored bacterium of the genus Sphingomonas. Since the white mutant bacterium does not initially contain a coloring component that causes a problem, the resulting glycosphingolipid-containing composition does not color. Therefore, there is no need to perform a complicated decolorization step after obtaining the composition, which is extremely advantageous in industry.

[0015] Such a white mutant bacterium can be obtained by culturing a bacterium belonging to the genus Sphingomonas several times with replacing the medium. For example, it can be obtained by repeating culturing 10 or more times on a mixed medium of glucose, yeast extract and sodium glutamate. As a white mutant obtained by such a method,
Sphingomonas sp. Mobilis KFC-W-1 ( Sphi
ngomonas paucimobilis KFC-W-1; accession number F
ERM P-16238). This white bacterium is a colored bacterium belonging to the genus Sphingomonas (IA).
M 12576). In the production method of the present invention, all the white bacteria of the genus Sphingomos obtained by mutating in this manner can be used.

In the production method of the present invention, acetone is added to the microorganism of the genus Sphingomonas to sufficiently remove water from the cells, and then the cells are removed by a method such as filtration. Acetone may be mixed with an aqueous solvent, but it is preferable to use acetone as a single solvent. The amount of acetone to be added is in the range of 0.1 to 1000 liters, preferably 1 to 10 liters per kg of wet cells. After the addition of acetone, the contents contained in the cells are sufficiently contacted with acetone. The contact efficiency may be increased by applying physical stress to the cells. Although the contact time is not particularly limited, it is necessary that the contact time is long enough to sufficiently remove the water in the cells. Although it depends on the relationship with the physical stress, it is usually about 20 seconds to 2 hours. afterwards,
The acetone solution and the cells are separated by a method such as filtration.

The separated cells are then extracted with an alcohol or an alcohol / water mixture. The alcohol used here is selected from hydrocarbon compounds having a hydroxyl group, and is preferably an alkanol having 1 to 8 carbon atoms. Preferred when using alcohol alone,
Methanol, propanol and butanol are most preferred, and methanol is most preferred. Propanol and butanol may be any structural isomers,
(N-) propanol, isopropanol and (n
-) Butanol is preferred. If an alcohol / water mixture is used, a propanol / water mixture and a butanol /
It is preferred to use a water mixture. When using a propanol / water mixture, the mixing weight percentage of propanol is preferably at most 90%, more preferably at most 75%. When a butanol / water mixture is used, the mixed weight percentage of butanol is 95%.
It is preferably the following, more preferably 80 to 95%.

[0018] The extraction using these solvents can be carried out according to a method usually used in this technical field.
For example, the extraction operation can be performed once or several times using about 1 to 50 liters of solvent per 1 kg of wet bacterial cells. By distilling the obtained extract according to a well-known method, a residual solution from which the solvent has been removed can be obtained. By further drying the remaining liquid, a solid composition can be obtained. Alternatively, acetone can be added to the remaining liquid to form a precipitate, and the precipitate can be removed by a method such as filtration to obtain a solid composition.

The glycosphingolipid-containing composition obtained by the method of the present invention has an excellent moisturizing effect and an effect of preventing rough skin, and has been confirmed to provide an appropriate amount of moisture to the skin surface and maintain smoothness. I have. Such an effect is considerably superior to ganglioside and galactocerebroside, which are glycosphingolipids that have been confirmed to be moisturizing. Therefore, the external preparation for skin of the present invention can be used very effectively when improvement of rough skin, improvement of keratin or protection of skin is required. These glycosphingolipid-containing compositions also have an anti-atopic effect. Glycosphingolipid-containing composition obtained by the method of the present invention,
It can be used as it is as an external preparation for skin. In addition, by mixing with other components, it can be used as a skin external preparation having various functions.

The form of the external preparation for skin of the present invention is not particularly limited. Therefore, it may be in any state of solid, liquid, paste, jelly, powder and the like. In order to form such a state, for example, solidification can be performed using a gelling agent, or dispersion can be performed using a liquid. Further, a solution can be prepared by adding a solvent, or a powder can be formed by spray drying.

For example, the external preparation for skin of the present invention can be used as cosmetics and pharmaceuticals. For example, toilet soap,
Shampoo, face wash, rinse, ice cream, eyeshadow, cream / emulsion, lotion, perfume, whitening, cosmetic oil, hair cosmetics, condensed perfume, powder, pack, shaving cream, shaving lotion, tanning oil, Sunscreen oil, suntan lotion, sunscreen lotion, foundation, powdered perfume, blusher, mascara, eyebrows, nail cream, beautiful nail enamel, beautiful nail enamel remover, hair wash, bath cosmetics, lipstick, lip balm, eyeliner, toothpaste , A deodorant agent, a hair restorer and a hair restorer. Further, the external preparation for skin of the present invention can also be used as an ointment, a poultice or the like.

Various components can be added to the external preparation for skin of the present invention according to the purpose of use. As such additional components, for example, fats and oils components, phospholipids,
UV absorbers, IR absorbers, emulsifiers, surfactants, preservatives, fungicides, antioxidants, whitening agents, polysaccharides, fluorescent materials, pigments, dyes, fragrances, sequestering agents, binders, extenders, Antibiotics, blood circulation promoters, anti-inflammatory agents, cell activators, and the like can be appropriately added according to the purpose of use. Further, a moisturizing component other than the glycosphingolipid-containing composition obtained by the production method of the present invention can be further added.

Fatty oils (eg, oleic acid, behenic acid, isostearic acid) and ester oils (eg, pentaerythritol-tetra-2-ethylhexanoate, isopropylmilli) can be used in the skin external preparation of the present invention. State), animal and vegetable oils (eg, olive oil, tallow, evening primrose oil, rice bran oil, squalane), mineral oils (eg, hydrocarbon oils, liquid paraffin), vitamins (eg, vitamin A, vitamin B, vitamin D, vitamin K), Silicone oils (eg, methylphenyl silicon, dimethyl silicon), higher alcohols (eg, oleyl alcohol, cetyl alcohol,
2-octyldodecanol, 2-decyltetradecanol) and derivatives thereof.

Examples of the phospholipid which can be used in the external preparation for skin of the present invention include monoacylester glycerophospholipids and diacylester glycerophospholipids. Specific examples include lysophosphatidylcholine, lysophosphatidylethanolamine, lysophosphatidylinositol, phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, and phosphatidic acid. Naturally-derived lecithin (eg, egg yolk) and the hydrogenated products of the above specific examples can also be used.

UV absorbers which can be used in the external preparation for skin of the present invention include oxybenzone (2-hydroxy-4-methoxybenzophenone), oxybenzonesulfonic acid, oxybenzonesulfonic acid (trihydrate), guaiazulene, ethylene glycol salicylate Octyl satylate, dipropylene glycol salicylate, phenyl salicylate, homomenthyl salicylate, methyl salicylate, methyl diisopropyl cinnamate, sinoxate (2-ethoxyethyl p-methoxycinnamate), di-p
Glyceryl mono-2-ethylhexyl methoxycinnamate, dihydroxymethoxybenzophenone, sodium dihydroxymethoxybenzophenone disulfonate,
Dihydroxybenzophenone, tetrahydroxybenzophenone, p-aminobenzoic acid, ethyl p-aminobenzoate, glyceryl p-aminobenzoate, amyl p-dimethylaminobenzoate, p-dimethylaminobenzoic acid 2-
Ethylhexyl, p-hydroxyanisole, 2-ethylhexyl p-methoxycinnamate, isopropyl p-methoxycinnamate, diisopropylcinnamate,
-(2-hydroxy-5-methylphenyl) benzotriazole, sodium hydroxymethoxybenzophenonesulfonate, 4-tert-butyl-4'-methoxybenzoylmethane, 2-ethylhexyl salicylate,
Glyceryl-p-minobenzoate, methyl orthoaminobenzoate, 2-hydroxy-4-methoxybenzophenone, amyl-p-dimethylaminobenzoate, 2-
Phenylbenzimidazole-5-sulfonic acid, 2-
Hydroxy-4-methoxybenzophenone-5-sulfonic acid, dicaroyltrioleate, 2-ethoxyethyl p-methoxysilicate, butylmethoxybenzoylmethane, glyceryl-mono-2-ethylhexanoyl-
Di-p-methoxybenzophenone, 2-ethylhexyl-2-cyano-3,3-diphenylacrylate, 2,
Examples thereof include 2-dihydroxy-4-methoxybenzophenone and ethyl-4-bishydroxypropylaminobezoate.

The emulsifier and the surfactant which can be used in the external preparation for skin of the present invention include a nonionic surfactant, an anionic surfactant and a cationic surfactant. As nonionic surfactants, sorbitan esters (eg, sorbitan monolaurate, sorbitan monooleate, sorbitan monoisostearate), polyoxyethylene sorbitan esters (eg, polyoxyethylene sorbitan monoisostearate,
Polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monooleate, glycerol ether (eg, glycerol monoisostearate, glycerol monomyristate), polyoxyethylene glycerol ether (eg, polyoxyethylene glycerol monoisostearate, poly) Oxyethylene glycerol monomyristate), polyglycerin fatty acid ester (for example, diglyceryl monostearate,
Decaglyceryl decaisostearate, diglyceryl diisostearate), glycerin fatty acid ester (eg, glyceryl monomyristate, glyceryl monooleate, glyceryl monostearate), polyoxyethylene glycerin fatty acid ester (eg, polyoxyethylene glyceryl monomillilate) State, polyoxyethylene glyceryl monooleate, polyoxyethylene glyceryl monostearate), polyoxyethylene branched alkyl ether (eg, polyoxyethylene octyl dodecyl alcohol, polyoxyethylene-2-decyltetradecyl alcohol), polyoxyethylene alkyl Ethers (eg, polyoxyethylene oleyl alcohol ether, polyoxyethylene cetyl alcohol ether), polyoxyethylene Tylene hydrogenated castor oil fatty acid esters (eg, polyoxyethylene hydrogenated castor oil, polyoxyethylene dihydrocholesterol ether, polyoxyethylene hydrogenated castor oil isostearate), polyoxyethylene alkyl aryl ethers (eg, polyoxyethylene octyl phenol ether), etc. can do.

As the anionic surfactant, salts of higher fatty acids (eg, oleic acid, stearic acid, isostearic acid, barmitic acid, myristic acid, behenic acid) (eg, diethanolamine salt, triethanolamine salt, amino acid salt, potassium salt) Salts, sodium salts), alkali salts of ether carboxylic acids, N-acyl amino acid salts, N-
Examples thereof include acyl sarcon salts and higher alkyl sulfonates. Further, examples of the cationic surfactant or the amphoteric surfactant include an alkyl quaternary ammonium salt, a polyamine, and an alkylamine salt.

As powders that can be used in the external preparation for skin of the present invention, talc, kaolin, fuller's earth, rubber,
Examples include starch, silica, silicic acid, aluminum silicate hydrate, sodium polyacrylate, tetraalkylarylammonium snukite, trialkylarylammonium snukite, ethylene glycol monostearate, sodium carboxymethylcellulose, and carboxyvinyl polymer. Can be.

Polyols that can be used in the external preparation for skin of the present invention include polyglycerin such as glycerin, diglycerin, triglycerin, and tetraglycerin.
Ethylene glycol, propylene glycol, 1,3-
Examples thereof include butylene glycol, 1,4-butylene glycol, dipropylene glycol, polyethylene glycol, sorbitol, erythritol, maltotriose, threitol, sucrose, glucose, maltose, maltose, fructose, and xylitol.

Other materials which can be used in the skin external preparation of the present invention include skin bleaching agents such as arbutin, skin protecting agents such as retinol, retinol ester, retinoic acid, anti-inflammatory agents such as salicylic acid, p Preservatives such as -hydroxybenzoic acid esters; antioxidants such as α-tocopherol; and the like. Materials other than these can also be added to the skin external preparation of the present invention depending on the use. The amount and method of addition of each component can be in accordance with methods well known in the art. The external preparation for skin of the present invention can be widely used when a moisturizing effect or an anti-atopic effect is required.
The amount to be used is determined within a range where the desired moisturizing effect is sufficiently exhibited.

[0031]

The present invention will be described more specifically with reference to the following examples. Components, ratios, operation orders, and the like shown in the following examples can be appropriately changed without departing from the spirit of the present invention. Therefore, the scope of the present invention is not limited to the specific examples shown in the following examples.

Example 1 Preparation of Glycosphingolipid-containing Composition Sphingomonas sp. Mobilis (IAM 12576)
Was cultured at room temperature for 24 hours. The culture was performed using a medium (adjusted to pH 7.0 with citric acid) containing 1.0% glucose, 0.5% yeast extract, and 0.2% sodium glutamate (aeration 0.7 vvm). After sterilizing the obtained culture solution, the pH was adjusted to 5 and the cells were centrifuged. 30 liters of acetone was added to 20 kg of the cells, stirred, and filtered. The filtered cells were extracted three times with 30 liters of each solvent described in the following table, and the solvent was distilled off from the obtained extract using a flash evaporator. 8 liters of acetone was added to 4 liters of the remaining liquid, stirred, and allowed to stand to form a precipitate. The precipitate was taken out, further added with 2 liters of acetone, stirred, and allowed to stand again to form a precipitate. By taking out this precipitate, dehydrating and drying under reduced pressure,
Glycosphingolipid-containing compositions (Samples 1 to 19) were prepared.

[0033]

[Table 1]

Example 2 Preparation of Cosmetic Emulsion A first liquid prepared by mixing each component at 75 ° C. was added to a second liquid prepared by mixing each component at 75 ° C. A cosmetic emulsion was prepared by sufficiently emulsifying the emulsion.

[0035]

[Table 2]

(Example 3) Production of lipstick Each component described in the following table was mixed at room temperature and sufficiently stirred to produce a lipstick.

[Table 3]

(Example 4) Production of lip balm Each of the components shown in the following table was mixed at room temperature and sufficiently stirred to produce a lip balm.

[0038]

[Table 4]

Example 5 Production of Hand Cream Each component described in the following table was mixed at room temperature and thoroughly stirred to produce a hand cream.

[0040]

[Table 5]

(Example 6) Production of shampoo for hair Each component shown in the following table was mixed at room temperature and thoroughly stirred to produce a shampoo for hair.

[0042]

[Table 6]

Example 7 Production of Hair Rinse The components shown in the following table were mixed at room temperature and thoroughly stirred to produce a hair rinse.

[0044]

[Table 7]

(Example 8) Preparation of bath agent The components shown in the following table were mixed at room temperature and thoroughly stirred to prepare a bath agent.

[0046]

[Table 8]

Example 9 Production of Cosmetic Essence A cosmetic serum was prepared by mixing the components shown in the following table at room temperature and stirring thoroughly.

[0048]

[Table 9]

(Example 10) Production of powder foundation Each of the components shown in the following table was mixed at room temperature and thoroughly stirred to produce a powder foundation.

[0050]

[Table 10]

Example 11 Production of Anti-Atopic Ointment Each component described in the following table was emulsified and dispersed at 70 ° C.
An anti-atopic ointment was produced by cooling.

[0052]

[Table 11]

(Test Example 1) Component analysis test The components of the glycosphingolipid-containing composition extracted by the sample 1 (methanol) of Example 1 were analyzed, and the results shown in the following table were obtained.

[Table 12]

(Test Example 2) Moisturizing effect and skin roughness preventing effect test 9-week-old male hairless mouse (Skh: hr-1, Japan S)
LC) was prepared and placed in a 2.5 cm diameter circle on the back.
5% Triton X150 (50 μl) was applied uniformly. The application was performed once a day for 5 days. 6
From the day, ultraviolet rays in the middle wavelength range are irradiated at 0.15 J / cm ² using an SE lamp (manufactured by Toshiba Medical Instruments Co., Ltd.), and then a 0.7% solution ( solvent:
0.5% Triton X150) and a control (0.5% Triton X150) were applied. This operation was performed once a day and continued until the tenth day.

When the irradiation of the medium-wavelength region with ultraviolet rays on the tenth day and the application of the sample were completed, the amount of transepidermal water loss was measured using Hydrograph AMU-3 (manufactured by Forshon Co., Ltd.) and compared with the control. For comparison, the same test was performed using a 0.7% solution of ganglioside and galactocerebroside.

As a result, ganglioside and galactocerebroside showed slightly better moisturizing effect and skin roughness preventing effect than the control. On the other hand, Samples 1 to 18 were found to have a uniform moisturizing effect and an effect of preventing rough skin.
Showed a particularly strong moisturizing effect and a rough skin preventing effect.

[0057]

According to the production method of the present invention, an external preparation for skin having a remarkable moisturizing effect and a skin roughness preventing effect can be produced by a simple procedure. Therefore, the production method of the present invention is expected to have high industrial applicability as an economically practical method. Further, the external preparation for skin produced by the production method of the present invention is extremely useful as a humectant and a skin roughness inhibitor. For this reason, the skin external preparation of the present invention can be widely used for various products including cosmetics and pharmaceuticals directly applied to the skin.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 7/075 A61K 7/075 7/08 7/08 7/15 7/15 7/40 7/40 7/48 7/48 7/50 7/50 9/06 9/06 G

Claims (13)

[Claims] 1. A method for producing an external preparation for skin, which comprises a step of washing bacteria belonging to the genus Sphingomonas with acetone and extracting the same with alcohol or an alcohol / water mixture. 2. The method according to claim 1, wherein the extraction solvent is methanol. 3. The method according to claim 1, wherein the extraction solvent is a propanol / water mixture or a butanol / water mixture.
Manufacturing method. 4. The method according to claim 3, wherein the extraction solvent is a propanol / water mixture, and the propanol in the mixture is 75% by weight or less. 5. The method according to claim 3, wherein the extraction solvent is a butanol / water mixture, and the butanol in the mixture is 95% by weight or less. 6. The method according to claim 3, wherein the extraction solvent is a butanol / water mixture, and the butanol in the mixture is 80 to 95% by weight or less. 7. An external preparation for skin produced by the production method according to any one of claims 1 to 6. 8. A blood circulation promoting agent, a whitening agent, a surfactant, a pigment,
Fragrances, preservatives, pigments, fungicides, antioxidants, UV absorbers,
8. The composition according to claim 7, further comprising a component selected from the group consisting of an infrared absorbing agent, a fluorescent material, a sequestering agent, a binder, a bulking agent, an anti-inflammatory agent, a blood circulation promoter, a cell activator, and an antibiotic. External preparation for skin. 9. The external preparation for skin according to claim 7, wherein the external preparation for skin is a cosmetic. 10. The external preparation for skin is a toilet soap, shampoo,
Facial cleanser, rinse, ice cream, eyeshadow, cream / emulsion, lotion, perfume, whitening, cosmetic oil, hair cosmetics, condensate, powder, pack, shaving cream, shaving lotion, tanning oil, sunscreen Oil, suntan lotion, sunscreen lotion, foundation, powdered perfume, blusher, mascara, eyebrow ink,
It is a cosmetic selected from the group consisting of nail cream, nail enamel, nail enamel remover, hair wash, bath cosmetics, lipstick, lip balm, eyeliner, toothpaste, deodorant, hair restorer and hair restorer. The external preparation for skin according to claim 9, wherein 11. The external preparation for skin according to claim 7, wherein the external preparation for skin is a medicine. 12. The external preparation for skin according to claim 11, which is selected from the group consisting of an ointment, a compress and a medicated lip balm. 13. The external preparation for skin according to claim 11, wherein the external preparation for skin is an anti-atopic agent.