JPH1045538A - Trichogen - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a trichogen containing the extract of Aristolochia debilis Sieb.et. Zucc, high in safety and excellent in the trichogenous effect. SOLUTION: This trichogen contains the whole grass extract of Aristolochia debilis Sieb.et Zucc, a glabrous perennial liane herb belonging to the genus Aristolochia in the family Aristolochiaceae in an amount of 0.001-10wt.%. The extract is obtained by drying or grinding the plant bodies, extracting the dried or ground plant bodies with a water-soluble organic solvent such as ethanol or acetone or with a water-containing water-soluble organic solvent containing the alcohol, the acetone or THF preferable in a concentration of >=50wt.% for 7-10 days at room temperature or for 4-8hr at a higher temperature, and subsequently subjecting the extract to a suction filtration treatment and a vacuum concentration treatment. The addition of a skin peripheral vasodilator (e.g. carpronium chloride) to the agent expresses a more preferable trichogenous effect. The trichogen is excellent in safety, because a skin trouble, etc., caused by the long period employment of the trichogen is not recognized.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel hair growth / hair restoration material, and more particularly, to provide a hair growth / hair restoration material having excellent hair growth / hair growth effects and having sufficient safety to withstand long-term use. To do.

[0002]

2. Description of the Related Art Various herbal medicine extracts or various compounds have been blended with hair growth and hair-growth materials that have been provided so far. For example, as herbal extracts, extracts such as Yokuinin, Kashi, etc. (see Japanese Patent Publication No. 1-14511, JP-A No. 2-48514, etc.), and compounds include vitamin E, alloxazine, pyridine N-oxide, adenosine-3. ', 5'-cyclic monophosphate, etc. (JP-A-64-56608, JP-A-
1-261321, JP-A-2-204406, etc.).

[0003]

However, the hair-growth / hair-growth agents provided so far are as follows.
Various herbal extracts and various compounds have been applied, but few have a remarkable effect, and those having a certain effect have strong irritation to cause dermatitis,
There are drawbacks such as difficulty in continuous use.

[0004] The present invention has been made in view of such circumstances, and provides a hair growth and fostering material that is excellent in hair growth and fostering effects and has sufficient safety to withstand long-term use. That is the task.

[0005]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies to solve the above-mentioned problems, and as a result, an extract obtained from a specific plant belonging to the family Echinacea has excellent hair growth and hair growth effects. In addition, they have found that there is no safety problem during use, and have completed the present invention based on such findings.

[0006] That is, the present invention provides an extract preferably obtained by extracting from a whole plant of Echinacea purpurea preferably with a water-soluble organic solvent or a water-containing water-soluble organic solvent.
Hair growth characterized by containing in the range of 10% by weight
Regarding hair restoration materials.

[0007] The present invention also relates to a hair growth and fostering material further comprising a skin peripheral vasodilator in the above hair growth and fostering material.

The present invention will be described in detail below. First, the horse-tailed weed (scientific name: Aristolochia d) applied to the present invention.
ebilis Sieb.et Zucc) is a hairless perennial vine that belongs to the genus Echinacea, which belongs to the genus Echinacea, distributed in the southern and southern parts of Honshu, Kyushu, and the central and southern parts of the Chinese mainland. Until now, in Chinese medicine, the whole plant (ground stem) such as stems and leaves is called Tensento and used for gestational edema and stomach medicine, and the fruit is called horse helmet bell and used for cough deterrent and expectorant, and root ( The dried material of the rhizome is called incense Aoki and is known to be used for detoxification, enteritis, diarrhea, and abdominal pain. Of these, Kaoru Aoki has been found to have some hair-growth effects and has been proposed to be applied as a hair material (Japanese Patent Application Laid-Open No. 7-215826).
Tensento and horse bells have never been used as a hair material, and it was discovered by the present inventor for the first time that Tensenfuji has a remarkable hair growth and hair-growth effect.

Next, in order to obtain the extracted extract according to the present invention from the above-mentioned whole horsegrass, the plant is dried or ground as it is, and the extract solvent such as methanol,
Monohydric alcohols such as ethanol, propanol and butanol; polyhydric alcohols such as 1,3-butylene glycol and propylene glycol; or water-soluble organic solvents such as acetone, tetrahydrofuran and dioxane; or the above monohydric alcohols, polyhydric alcohols or acetone , Tetrahydrofuran, dioxane, etc., preferably at 50% by weight
Extraction using a water-containing water-soluble organic solvent containing the above, further using a water-insoluble organic solvent such as hexane, heptane, cyclohexane, and ethyl acetate, preferably using a water-soluble organic solvent or a water-containing water-soluble organic solvent. good.

[0010] As a specific method, 100 g of the whole plant of Spodoptera communis is extracted from 0.5 to 5 liters of the extraction solvent at room temperature to the boiling point of the extraction solvent at room temperature for 7 to 10 days and at the heating temperature of 4 to 4.
Extract by digestion once or twice for 8 hours. These extracts are combined, filtered with suction, and then concentrated under reduced pressure to remove the solvent to obtain a viscous or dried extract. The obtained extract is dissolved or dispersed and diluted with an appropriate solvent or the like as it is, and then mixed with a base to obtain the hair growth and hair growth material of the present invention.

[0011] Here, the content of the extract of whole horseshoe clover whole plant extract contained as an active ingredient of the hair growth and fostering agent according to the present invention is preferably 0.001 to 10% by weight, particularly preferably 0.05 to 5% by weight. Is. If the content is less than 0.001% by weight, the hair-growth effect is reduced, and if it exceeds 10% by weight, the stability is reduced.

Next, the hair growth and hair growth agent of the present invention has a more preferable hair growth and hair growth effect when it contains a skin peripheral vasodilator in addition to the above extract of Scutellaria baicalensis. Examples of such skin peripheral vasodilators include carpronium chloride, benzyl nicotinate, vitamin E, vitamin E acetate, vitamin E linoleate,
Vitamin E nicotinate, pepper tincture, and the like, and one or more of these are used.

[0013] The hair growth and fostering composition of the present invention includes, in addition to the extract of the whole plant of Echinacea purpurea, the peripheral vasodilator of the skin, and additives usually used for hair growth and fostering, such as hinokitiol and cationic surfactant. , Sterilizing agents such as parabens, cooling agents such as l-menthol, hydrocarbons, waxes,
Oils such as oils and fats, esters, higher fatty acids, higher alcohols, etc., and other surfactants, fragrances, pigments, antioxidants, ultraviolet protective agents, alcohols, pH adjusters, water and the like can be blended.

The hair growth and hair-growth agent of the present invention includes various dosage forms such as hair tonic, shampoo, conditioner, pomade, hair lotion, hair cream, hair treatment and the like, and they are prepared according to a conventional method.

[0015]

BEST MODE FOR CARRYING OUT THE INVENTION Here, an example of the production of the extract of the whole herbaceae extract according to the present invention will be shown. Production Example 1. 70 g of dried whole plant of Aedes japonicus
% Ethanol at room temperature for 10 days, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness.
An extract was obtained. (Yield 3.1%)

Manufacturing Example 2. Dried whole plant of Aedes japonicus 1
00 g is immersed in 1 L of ethanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, the filtrate was evaporated to dryness,
An extract was obtained. (3.8% yield)

Manufacturing Example 3. Dried whole plant of Aedes japonicus 1
00 g is immersed in 1 liter of acetone, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extracted extract. (Yield 2.7%)

Production Example 4. Dried whole plant 1
00g is immersed in 1 l of butanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue is filtered off with filter paper, the filtrate is evaporated to dryness,
An extract was obtained. (Yield 2.9%)

Production Example 5. Dried whole plant of Aedes japonicus 1
00 g is immersed in 1 liter of an extraction solvent of propylene glycol: distilled water = 1: 1, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 3.2%)

Production Example 6. Dried whole plant of Aedes japonicus 1
00 g was immersed and extracted with 1 L of ethyl acetate at room temperature for 10 days, the residue was filtered off with a filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 1.9%)

Comparative Production Example 1. 100 g of Aoki incense is immersed in 1 liter of ethanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper,
The filtrate was evaporated to dryness to obtain an extract. (Yield 3.1%)

Next, a comparative test was carried out on the effect of the extract of the whole plant of Astragalus vulgaris obtained as described above on hair growth in mice.

"Mouse hair growth evaluation test" (1) Sample This invention: 70% ethanol aqueous dispersion containing 5% of the extract of the whole plant of Spodoptera frugiperda (Production Example 2) Comparative product 1: Vitamin E 1% 70% ethanol aqueous dispersion containing Comparative product 2: 5 extract of Aoki incense extract (Comparative Production Example 1)
% Aqueous solution containing 70% ethanol Control: 70% aqueous ethanol solution

(2) Test method Using 9-week-old C3H mice, one group consisting of 10 mice was made into 4 groups, and the backs of these groups were shaved to a size of 2.0 × 2.0 cm, and then removed the next day. After applying 0.04g of each sample to the hair part,
On day 16, the density of hair growth at the site was evaluated as the degree of increase in blackness using a color difference meter. Table 1 shows the results.

[0025]

[Table 1]

As is clear from the results shown in Table 1, in the extract of the whole herbaceous extract according to the present invention, the L value is decreased and the blackness is increased as compared with the control. On the other hand, in the vitamin E of the comparative product 1 and the extract of incense Aoki of the comparative product 2, almost no decrease in the L value was observed as compared with the control. This is presumed to be the result of the extract of whole horseshoe clover whole grass extract according to the present invention stimulating hair roots, increasing blood circulation around hair follicles, and activating metabolism.

[0027]

The present invention will be further described with reference to the following examples.
In addition, the compounding amount is a weight part. Examples 1-3. Hair Tonic Using the ingredients and blending composition shown in Table 2 below, each ingredient was dissolved by heating and solubilized to prepare a hair tonic.

[0028]

[Table 2]

"Human hair growth / hair growth evaluation test" (1) Sample The product of the present invention: hair tonic of Examples 1 to 3 Comparative product: Extract of whole plant extract of Echinacea purpurea from the hair tonic of Example 1 (Production Example 2) Removed (increased water) Hair tonic

(2) Test Method Twenty panelists, each complaining of alopecia and alopecia, were divided into 4 groups of 5 each, and a long-term continuous test for 6 months was performed using each sample. As an application method, a method of evenly applying to the head twice a day was used as in the case of using a normal tonic. The evaluation was performed at the third and sixth months after the start of use, and the number of subjects who felt that the amount of downy hair and hard hair had increased was measured. In addition, at the end of the test, they were asked to improve their scalp condition and reduce dandruff. Table 3 shows the results.

[0031]

[Table 3]

As is evident from the results in Table 3, the hair growth and hair growth preparation of the present invention has a hair growth effect because the number of people who have developed alveoli and those who have hard hair have increased. Was given. At the end of the test, the number of persons who reported improvement in scalp condition and reduction of dandruff generation in Example 1 was 4 and in Example 2 was 3. From this, the hair growth / hair growth material of the present invention was also confirmed to have a hair growth effect. Further, it was confirmed that the safety was high because no skin damage such as deterioration of the scalp condition or inflammatory reaction was observed in any panel during the use test period.

Embodiment 4 FIG. Hair tonic (A) Extract of Whole Grassroots Extract (Preparation Example 4) 3.0 Menthol 0.2 Vitamin E 0.05 Carpronium chloride 0.1 (B) Ethanol 50.0 (C) Propylene glycol 5.0 Vitamin B2 0.5 Yeast extract (containing nucleic acid) 0.5 Glycyrrhizin dipotassium 0.3 Hydrochloric acid Diphenhydramine 0.3 Methyl paraben 0.2 (D) Purified water 39.75 (E) Fragrance 0.1

(Production method) (A) was dissolved in (B), and (D) and (E) in which (C) was dissolved were added thereto to prepare a hair tonic.

Embodiment 5 Hair treatment (A) Liquid paraffin 2.0 Methyl polysiloxane (10 cs) 2.0 Cetanol 4.0 Extract of whole bollworm extract (Preparation Example 5) 4.5 (B) Stearyl trimethyl ammonium chloride 3.0 Distearyl dimethyl ammonium chloride 0.5 Propylene glycol 5.0 Pyroctone olamine 0.25 Purified water 40.0 (C) Hydrolyzed collagen 0.5 Hyaluronic acid 0.01 Bovine placenta extract 0.5 Purified water 37.19 Diphenhydramine hydrochloride 0.25 Methyl paraben 0.2 (D) Fragrance 0.1

(Preparation method) (A) and (B) were each heated to 80 ° C.
The mixture is heated to 2 and mixed to emulsify. After that, the mixture was cooled to around 40 ° C., at which point (C) was added, and (D) was further added to prepare a hair treatment.

Embodiment 6 Hair shampoo (A) Triethanolamine lauryl sulfate 10.0 Sodium lauryl sulfate 5.0 coconut oil diethanolamide 2.0 Propylene glycol 5.0 Pyrocton olamine 0.25 Benzyl nicotinate 0.1 Uranus japonicus whole plant extract (Production Example 3) 1.0 (B) Trichlorocarbanilide 0.25 Purified water 76.3 (C) Fragrance 0.1

(Preparation method) (A) was mixed at 80 ° C., then cooled to about 40 ° C., (B) was added, and (C) was further added to prepare a hair shampoo.

Embodiment 7 Hair rinse (A) Liquid paraffin 0.5 Methylpolysiloxane (10 cs) 0.5 Cetanol 2.0 Stearyltrimethylammonium chloride 3.0 Echinacea japonicus whole plant extract (Production Example 2) 2.0 (B) 1,3-butylene glycol 5.0 Purified water 40.0 Diphenhydramine hydrochloride 0.25 (C ) Glycyrrhizin dipotassium 0.25 Purified water 46.4 (D) Fragrance 0.1

(Manufacturing method) (A) and (B) are each at 80 ° C.
The mixture is warmed to, and mixed at that point to emulsify. Then 40 ° C
After cooling to near, (C) was added and then (D) was added to prepare a hair rinse.

Embodiment 8 FIG. Hair cream (A) Extract of whole plant of Paramecium japonicum (Preparation example 1) 2.5 Vaseline 7.0 Beeswax 8.0 Liquid paraffin 37.0 Polyoxyethylene (20E.O.) cetyl ether 3.0 Glyceryl monostearate 2.0 Vitamin E nicotinate 0.1 (B) Purified water 34.6 Propylene glycol 5.0 Diphenhydramine hydrochloride 0.2 Dipotassium glycyrrhizin 0.2 Ethyl paraben 0.3 (C) Fragrance 0.1

(Production method) (A) was mixed and dissolved at 80 ° C., and then (B) which had been heated to 80 ° C. was gradually added to (A) to form a cream. Thereafter, the mixture was cooled to 40 ° C., and (C) was added to prepare a hair cream.

Embodiment 9 Hair tonic (A) Extract of whole plant extract of Aedes japonicus (Preparation Example 6) 0.5 Salicylic acid 0.3 Menthol 0.2 Pepper tincture 0.01 (B) Ethanol 60.0 (C) Glycerin 5.0 (D) Purified water 33.89 (E) Fragrance 0.1

(Production method) (A) was dissolved in (B) and (D) and (E) in which (C) was dissolved were added to this to prepare a hair tonic.

The hair growth and hair growth agents of the present invention obtained in Examples 4 to 9 above were tested for hair growth and hair growth effects by the same method as in Examples 1 to 3 or a similar method. No skin damage such as deterioration of the scalp condition and inflammatory reaction was observed at all.

[0046]

EFFECTS OF THE INVENTION According to the present invention, it is possible to provide a hair-growth / hair-growth material which has an excellent hair-growth / hair-growth effect and which is excellent in safety without causing skin damage due to long-term continuous use.

Claims (4)

[Claims] 1. A hair-growth / hair-growth material containing an extract of the whole plant of Euphausiaceae. 2. The hair growth and fostering composition according to claim 1, wherein the extract is extracted with a water-soluble organic solvent or a water-containing water-soluble organic solvent. 3. The content of the extract is 0.001-10.
3% by weight.
Hair restoration. 4. The hair growth / hair growth material according to claim 1, wherein the hair growth / hair growth material contains a skin peripheral vasodilator.