JPH1057351A - Blood-collecting tube - Google Patents

Abstract

(57) [Summary] [Problem] To provide a blood collection container that can be operated easily, reliably, and safely. SOLUTION: An independent opening 4 is provided at one end of the bottomed tube 2 along the tube axis direction on the inner wall surface of the bottomed tube 2 having an opening 21.
An exhaust passage 3 having an opening 21 is provided, and the exhaust passage 3 is provided with a ventilation hole 5 communicating with the inside of the bottomed tube 2. And exhaust path 3
Can be integrally sealed with the opening 4 and a self-closing plug 6 is fitted into the puncture hole.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a blood collection container.

[0002]

2. Description of the Related Art Conventionally, in blood collection, a vacuum blood collection method using a vacuum blood collection tube has been adopted. This vacuum blood collection method will be specifically described with reference to FIG. After attaching a multiple injection needle as the blood collection needle 140 and piercing the distal end 150 of the blood collection needle 140 into the blood vessel, the vacuum blood collection tube 110 is inserted into the blood collection tube holder 170, and the blood collection tube 140 is inserted at the rear end 160 of the blood collection needle 140. 1
By piercing the plug 130 fitted into the bottomed tube 120 of FIG. 10, the blood vessel is directly connected to the inside of the bottomed tube 120, blood is sucked into the bottomed tube 120 in a reduced pressure state, and blood collection is performed. It has become.

[0003] In the above-mentioned vacuum blood sampling, since the suction speed cannot be adjusted, in a patient with a thin vein, blood collection is difficult because the blood vessels are crushed and blocked by abrupt suction, and the blood collector may be in pain. In addition, since blood is rapidly collected, hemolysis due to physical stress occurs, and a correct test may not be obtained. Further, there is a possibility that storage cannot be performed for a long period of time due to a decrease in the degree of decompression over time, or that a normal blood collection amount cannot be secured.

[0004] On the other hand, there is a blood sampling method using a syringe as a method other than the above-mentioned vacuum blood sampling, but this method does not cause the above-described problem of the vacuum blood sampling, but immediately after the blood sampling, the test container (compatible with an analytical instrument). To use a special container, a normal blood collection tube, or a vacuum blood collection tube).

When a vacuum blood collection tube is used as the test container, the same problem as described above occurs. When another test container is used, the lid of the container is once opened and the blood is dispensed. There is a problem that medical errors such as scattering and accompanying infection occur. Furthermore, in the above-mentioned blood sampling method, there is a problem that the operation is complicated because one operation is added.

[0006] As a method for solving the problems of the conventional blood collection method as described above, a blood collection container compatible with an analytical instrument is used. What is possible is desired. Japanese Patent Application Laid-Open No. Sho 55-55
An example of the blood collecting apparatus is described in Japanese Patent Application Laid-Open No. 1-25849.

In the blood collection using this blood collection apparatus, one end of a blood collection needle is pierced into a plug, and the other end is pierced into a vein to connect a blood collection tube and a vein. Pierce another part of the blood collection tube to allow the blood collection tube to communicate with the outside. Thereafter, when air in the blood collection tube is sucked from the hollow needle, the inside of the blood collection tube is depressurized, and blood is sucked into the blood collection tube due to a difference from the pressure in the vein.

[0008]

However, in the blood sampling by the blood sampling apparatus described in Japanese Patent Application Laid-Open No. 55-125849, an opening for sucking air in a closed blood collection tube is provided with another hollow needle. Limited to the pierced tip. At this time, the sucked blood reaches the tip of the hollow needle, and if sucked, the blood may leak to the outside.If the blood is scattered, adheres to the human body or clothes, etc. There is a risk of malpractice such as infection with pathogenic bacteria.

The present invention has been made in view of the above-mentioned problems, and an object of the present invention is to solve these problems and to make operation simple, reliable and safe. It is intended to provide a blood collection container which can be used.

[0010]

In the blood collection container of the present invention, an exhaust port having an independent opening on the end side along the axial direction of the inner wall surface of the bottomed tube having one end opened. A passage is provided, and a vent hole communicating with the inside of the bottomed tube is provided in the exhaust passage, and the opening of the bottomed tube and the opening of the exhaust passage are integrally sealed at the opening of the bottomed tube. Preferably, a plug having a self-closing property is fitted into the puncture hole.

The above means in the blood collection container of the present invention will be described in detail below. The bottomed tube is a vertically elongated tube having one end opened (upper end) and the other end closed (bottom). An exhaust path is provided at an appropriate position of the exhaust path along the pipe axis direction on the inner wall surface of the bottomed pipe, and a ventilation hole communicating with the inside of the bottomed pipe is provided. Is provided with an opening independent of the opening of the bottomed tube.

A cylindrical tube having a bottomed tube having a diameter of 12 to 18 mm and a length of 60 to 110 mm is suitable because it is compatible with general analytical instruments. Further, the diameter of the opening at the upper end of the exhaust path may be any size as long as a hollow needle different from blood sampling can be pierced, and is preferably 2 mm or more. Furthermore,
As the material of the bottomed tube, it is sufficient that blood inside can be confirmed from the outside, and a material made of glass or a transparent synthetic resin material is preferable.

When a synthetic resin is used as the material of the bottomed tube, any general-purpose thermoplastic resin may be used. For example, specifically, polyethylene, polypropylene, polystyrene,
Examples thereof include polyethylene terephthalate, polyacrylonitrile, and the like, and those containing these as main components.

The bottomed tube may be partially colored on the outer surface for identification, and may be provided with a scale for measuring the amount of blood collected.

The bottomed tube described above can be formed by molding using an injection molding method, a blow molding method, a stretch blow molding method, an extrusion molding method, a vacuum molding method, or the like. The above-mentioned molded parts and the like are assembled as a finished product by heat fusion, ultrasonic fusion, or bonding with an adhesive or the like.

An exhaust passage is provided in the vertical axis direction of the bottomed pipe and adjacent to the inner wall surface. Another opening independent of the opening of the bottomed pipe is provided at the upper end of the exhaust path. A vent is provided in a portion other than the opening, and the vent communicates with the inside of the bottomed tube.

When the exhaust path is provided in the vertical axis direction of the bottomed pipe and adjacent to the inner wall surface, a plurality of the ventilation holes are provided along the vertical axis direction of the bottomed pipe. If the entire wall surface of the bottomed tube has a hollow structure and this hollow portion is used as an exhaust path, the vent hole is provided in either the vertical axis direction of the bottomed tube or the circumferential direction of the bottomed tube orthogonal to the bottomed tube. Alternatively, a plurality of pipes are provided in a combination of two directions to communicate the bottomed pipe with the exhaust path.

The position where the above-mentioned ventilation hole is provided is not particularly limited. However, in order to sufficiently exhibit the performance, the ventilation hole is provided at substantially equal intervals and at least over the entire length of the bottomed tube, or at least over the entire circumference. Is preferred. When one row of vents is provided only in the circumferential direction, the vents are provided at a distance of 15 mm or more from the bottom of the bottomed tube in order to prevent the vents from being closed when the separating agent is stored.

The diameter of the ventilation holes is in the range of 0.2 to 2 mm. If it is less than 0.2 mm, installation is technically difficult and not practical. If it exceeds 2 mm, it is not preferable because when the air inside the bottomed tube is sucked through the exhaust path, the blood easily passes against the surface tension.

The number of the ventilation holes is 2 to 10. In the case of one piece, blood may be sucked and leaked to the outside.
If the number is more than 10, no further effect can be expected, and the installation technology becomes difficult, which is not preferable.

The diameter of the opening at the upper end of the exhaust path may be any size as long as another hollow needle can be pierced, and specifically 2 mm
The above is preferred.

The stopper is fitted into the opening of the bottomed tube, and serves to integrally seal the opening of the bottomed tube and the opening of the exhaust passage. At least a part of the stopper is injected into the container. An elastic material that can penetrate the needle, has a self-closing property with respect to the penetrating hole formed at this time even after needle removal, and can maintain airtightness and liquid tightness is used. Further, the piercing portion may be made of an elastic material, and the other portion may be made of a synthetic resin material.

Examples of the elastic material include synthetic rubbers such as natural rubber, isoprene rubber, styrene butadiene rubber and silicone rubber, ethylene-propylene rubber, polyester elastomer, nylon elastomer, styrene-isoprene block copolymer, styrene-butadiene. A thermoplastic elastomer such as a block copolymer, polybutadiene, thermoplastic polyurethane, or hydrogenated styrene-butadiene block copolymer, or a mixture of at least two or more of these is used.

As the synthetic resin material, polyethylene, polypropylene, polystyrene, polyethylene terephthalate, polyacrylonitrile and the like and those containing these as main components are used.

The plug body has a skirt portion which is fitted independently with the bottomed tube and the open end of the exhaust passage. Further, a recess may be provided in the piercing portion to facilitate piercing. Further, the whole or a part may be colored for identification.

In the above plug, when the portion other than the piercing portion is made of synthetic resin and the container body is made of synthetic resin, the portion other than the piercing portion and the above-described bottomed tube can be easily connected. It can be integrally formed by being connected by a thin hinge structure that can be bent into two pieces, or can be simultaneously injection-molded by a two-color molding method.

The plug is preferably formed by a vulcanization molding method when the elastic material is natural rubber or synthetic rubber, or by injection molding when the elastic material is a thermoplastic elastomer. In addition, when only the piercing portion is made of an elastic material, the piercing portion formed in advance at the time of molding the plug is insert-molded,
Alternatively, injection molding can be performed simultaneously by a two-color molding method.

In the blood collection container of the present invention, as a means for preventing blood from leaking out in the event that blood enters the exhaust passage, it is fitted to the inner periphery of the exhaust passage near the opening at the upper end of the exhaust passage. Preferably, a liquid tight filter is fitted. The liquid-tight filter has fine vents that are permeable to air and substantially impermeable to blood when in contact with blood. The thickness of the liquid-tight filter is preferably 2 mm or more in order to ensure sufficient liquid-tightness.

Examples of the material of the liquid-tight filter include glass sinter, metal sinter such as aluminum and stainless steel, non-woven fabric, felt, knitted fabric and woven fabric.
Nonwoven fabrics are preferred because of their fit and ease of manufacture. As this material, polyethylene, polypropylene, polystyrene, polyethylene terephthalate, polyacrylonitrile and the like, and those containing these as a main component, and natural fibers made of cellulose and the like are preferable. The weight of the nonwoven fabric is preferably 150 g / m ² or more from the viewpoint of maintaining airtightness.

At the time of blood collection, a thixotropic gel-like composition for separating serum or plasma is used as the separating agent contained in the bottomed tube. As the above composition,
Any of those conventionally used as a composition for separating serum or plasma can be used and is not particularly limited. For example, the composition may be prepared by adding a thixotropy-imparting agent (for example, a condensate of sorbitol and an aromatic aldehyde, polyoxyethylene, polyoxyethylene, or the like) to a synthetic resin (eg, an oligomer of dicyclopentadiene) having fluidity at normal temperature. Oxypropylene block copolymer), specific gravity adjuster (eg, silica) and viscosity adjuster (eg,
It can be obtained by adding and kneading an additive such as phthalic acid ester).

The specific gravity of the composition is 1.03 to 1.1, which is an intermediate specific gravity between serum (or plasma) and clot (or blood cell).
08 and its viscosity at 25 ° C. is preferably 1,000,000 centipoise or less.

As the drug, a blood anticoagulant, a blood coagulation promoter and the like are contained in the bottomed tube and used. Examples of the blood anticoagulant include sodium dipotassium ethylenediaminetetraacetate, sodium tripotassium ethylenediaminetetraacetate, sodium disodium ethylenediaminetetraacetate, sodium heparin, sodium fluoride, and citric acid.

As the blood coagulation accelerator, any of those conventionally used can be used, and examples thereof include finely divided silica. The above drug, after containing the separating agent,
It is used by being applied to the inner surface of a bottomed tube, laminated on the upper surface of a separating agent, or further applied to a nonwoven fabric, a synthetic resin film, or the like, and placed on the upper surface of the separating agent.

When assembling the blood collection container, the above-mentioned separating agent, medicine and the like are contained in the bottomed tube as required, or after being coated and dried,
It is completed by fitting a plug.

The method of using the blood collection container of the present invention will be described in detail below. That is, the blood collection container and the vein are communicated by inserting one end of the blood collection needle having both ends into the stopper and inserting the other end into the vein. At the same time, another hollow needle is pierced into the exhaust path to connect the blood collection container with the outside.

Thereafter, when the air in the blood collection container is sucked from the hollow needle, the inside of the blood collection container is reduced in pressure, a differential pressure from the blood pressure is generated, and the blood is sucked into the blood collection container. The suction is performed by a mechanical pump, a manual syringe, a manual pump having a check valve, or the like.

When a predetermined amount of blood has been collected, the blood collection needle and another hollow needle are removed from the blood collection container. If a drug such as a blood coagulation promoter or a blood anticoagulant is contained, gently invert and mix to mix the drug and blood. Thereafter, centrifugation may be performed to obtain serum or plasma. When a separating agent is contained, a centrifuging condition of about 1300 G for about 10 minutes is selected.

[0038]

The blood collection container of the present invention has the structure described above in detail, and is not a conventional vacuum blood collection container. Blood can be collected and occurrence of hemolysis can be suppressed without causing pain. Further, since the exhaust path is provided, blood does not leak outside during blood collection, so that a specified amount of blood can be reliably collected without interrupting blood collection. Furthermore, since blood can be directly collected in the test container without passing through a syringe, medical errors such as infection can be prevented.

[0039]

BEST MODE FOR CARRYING OUT THE INVENTION

(Embodiment 1) FIG. 1 is a sectional view showing an example of the blood collection container of the present invention, FIG. 2 is a top view of FIG. 1, and FIG.
It is AA sectional drawing of. In the blood collection container 10 of the present embodiment shown in FIGS. 1, 2 and 3, a bottomed tube 2 having an opening 21 at the upper end and a closed bottom 22 having a spherical lower end.
(Length 100 mm, outer diameter 16 mm) and an opening 2 of the bottomed tube 2 at the upper end along the tube axis direction of the inner wall surface of the bottomed tube 2.
An exhaust passage 3 having an opening 4 independent of the exhaust passage 1 is provided.

A plurality of ventilation holes 5 communicating with the inside of the bottomed tube 2 are provided at equal intervals in the exhaust path 3.

Further, the stopper 21 which can simultaneously seal the opening 21 of the bottomed tube 2 and the opening 4 of the exhaust passage 3 with the opening 21 of the bottomed tube 2 and has a self-closing property with respect to the piercing hole is provided. It is fitted. An elastic material is fixed to the back surface of the plug 6 by simultaneous molding, and piercing portions 7 are provided at two openings on the upper surface of the plug 6.

The stopper 6 is pivotally mounted on a hinge 8 provided at the edge of the upper end opening of the bottomed tube 2 and is attached so as to be openable and closable.

In the above embodiment, a high-density polyethylene resin (manufactured by Asahi Kasei Kogyo Co., Ltd.) was used as a raw material of the plug 6 except for the bottomed tube 2 and the piercing portion. As a raw material for the piercing portion of the plug 6, a styrene-based thermoplastic elastomer (ToughTech S2951 manufactured by Asahi Kasei Kogyo Co., Ltd.) was used.

The molding of each of the above members was performed simultaneously by combining an injection molding method using a slide mold and a two-color injection molding method.

The bottomed tube 2 was formed with seven vents having a diameter of 1 mm along the vertical axis direction.

(Embodiment 2) FIG. 4 is a cross-sectional view showing another example of the blood collection container of the present invention. FIG. 5 is a top view of FIG. 4, and FIG. 7, and FIG.
It is sectional drawing. Blood collection container 2 of the present embodiment shown in FIGS.
0, a bottomed tube 21 (length 100) having an opening 211 at the upper end and a closed bottom 212 with a spherical bottom at the lower end.
mm, an outer diameter of 16 mm), and an exhaust passage 31 having an opening 41 independent of the opening 211 of the bottomed tube 21 is provided at an upper end of the inner wall surface of the bottomed tube 21 along the tube axis direction. In addition, along the circumferential direction of the bottomed tube 21, the diameter is 1m.
Four m holes were formed by molding at a position 20 mm from the bottom of the tube.

The exhaust passage 31 is formed in a cylindrical shape inside the inner wall surface of the bottomed tube 21 as shown in the figure, and the hollow portion formed therebetween is the exhaust passage 31. In the vicinity of the upper end of the cylindrical exhaust passage 31, an exhaust passage 311 bulging out of the bottomed tube 21 and having a substantially circular cross section is formed. The exhaust passage 311 communicates with the exhaust passage 31. The upper end is the opening 41.

As shown in FIG. 7, vent holes 51 communicating with the inside of the bottomed tube 2 are equally divided in the circumferential direction at equal intervals and provided at four places on the wall surface of the exhaust passage 31. ing.

Further, the opening 211 of the bottomed tube 21 can be simultaneously sealed with the opening 211 of the bottomed tube 21 and the opening 41 of the exhaust passage 311 and the piercing portion 71 having a self-closing property with respect to the piercing hole. , 71 are fitted.

The stopper 61 is pivotally mounted on a hinge 81 provided at the edge of the upper end opening 211 of the bottomed tube 21 and is attached so as to be openable and closable.

Also in this embodiment, the raw materials used for each member were the same as those in the above-mentioned embodiment 1.

Each of the above members was molded by a two-color injection molding method.

In order to form an exhaust passage, a cylindrical member was fused near the upper end of the bottomed tube by a thermal fusion method using high-frequency induction heating.

(Embodiment 3) FIG. 8 is a sectional view showing a modification of the blood collection container of the present invention, and FIG. 9 is a top view of FIG. This blood collection container 30 is a modification of the blood collection container 10 shown in FIG. 1, and only different points from the blood collection container 10 will be described.

8 and 9, an exhaust passage 43 provided on the inner wall surface side of the bottomed pipe 42 (length 75 mm, outer diameter 13 mm) has a ventilation hole 44 communicating with the inside of the bottomed pipe 42.
Are provided at approximately one central portion and one near the upper and lower ends, respectively, for convenience. The bottomed pipe 42 was provided with three ventilation holes 1 mm in diameter along the vertical axis direction.

Further, a stopper 46 capable of simultaneously sealing the opening 421 of the bottomed tube 42 and the opening 45 of the exhaust passage 43 with the opening 421 of the bottomed tube 42 and having a self-closing property with respect to the piercing hole is provided. It is fitted. The plug 45 is formed of the elastic material itself without being combined with other synthetic resin molded parts. Two piercing portions 47 are formed on the upper surface of the plug 45. Also, unlike the blood collection container 10, the stopper 45 is not particularly mounted on a hinge, and the bottomed tube 42 is not provided.
It is made more detachable.

Also in this embodiment, the raw materials used for each member were the same as those in the above-mentioned first embodiment.

The above members were formed by an injection molding method using a slide mold.

[0059]

The blood collection container of the present invention has the structure described in detail above, and is not a conventional vacuum blood collection container. Blood can be collected and occurrence of hemolysis can be suppressed without giving extra pain. Further, since the exhaust path is provided, blood does not leak outside during blood collection, so that a specified amount of blood can be reliably collected without interrupting blood collection. Furthermore, since blood can be directly collected in the test container without passing through a syringe, medical errors such as infection can be prevented. Furthermore, since an exhaust path is provided, blood does not leak outside during blood collection,
It is possible to reliably collect a prescribed amount of blood without interrupting blood collection. Therefore, it is suitably used as a blood collection container.

[Brief description of the drawings]

FIG. 1 is a sectional view showing an example of a blood collection container of the present invention.

FIG. 2 is a top view of FIG. 1;

FIG. 3 is a sectional view taken along line AA of FIG. 1;

FIG. 4 is a cross-sectional view showing another example of the blood collection container of the present invention.

FIG. 5 is a top view of FIG. 4;

FIG. 6 is a sectional view taken along line BB of FIG. 4;

FIG. 7 is a sectional view taken along line CC of FIG. 4;

FIG. 8 is a sectional view showing a modified example of the blood collection container of the present invention.

FIG. 9 is a top view of FIG. 8;

FIG. 10 is a cross-sectional view of a conventional blood collection container.

[Explanation of symbols]

 10, 20, 30 blood collection container 2, 21, 42 bottomed tube 3, 31, 43, 311 exhaust path 4, 41, 45211, 421 opening 5, 51, 44 vent hole 6, 61, 46 plug 7, 47, 71 Piercing part 8, 81 Hinge 212 Bottom part 8 Blood 8a Serum or plasma 8b Blood clot or blood cell

Claims (1)

[Claims] An exhaust path having an independent opening is provided on the end side along an axial direction of an inner wall surface of a bottomed pipe having one end opened, and the exhaust path has a bottomed bottom. A ventilation hole communicating with the inside of the tube is provided, and further, at the opening of the bottomed tube,
The opening of the bottomed pipe and the opening of the exhaust path can be integrally sealed,
A blood collection container comprising a plug having a self-closing property fitted into a puncture hole.