JPH1057449A - Tablet manufacturing method - Google Patents
Tablet manufacturing methodInfo
- Publication number
- JPH1057449A JPH1057449A JP24414996A JP24414996A JPH1057449A JP H1057449 A JPH1057449 A JP H1057449A JP 24414996 A JP24414996 A JP 24414996A JP 24414996 A JP24414996 A JP 24414996A JP H1057449 A JPH1057449 A JP H1057449A
- Authority
- JP
- Japan
- Prior art keywords
- tablet
- tablets
- coating
- air
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
Abstract
(57)【要約】
【課題】錠剤のコーティング等における転動時の錠剤の
摩損、欠け、割れの発生などのトラブルを生じさせるこ
となく、服用時には容易に分割できる錠剤の製造方法を
提供する。
【解決手段】錠剤を、相対湿度３０〜９５％の範囲の空
気中に放置し吸湿させ、必要に応じてさらに相対湿度０
〜５０％の範囲の空気中に放置して乾燥することを特徴
とする錠剤の製造方法。(57) [Problem] To provide a tablet manufacturing method which can be easily divided at the time of ingestion without causing troubles such as abrasion, chipping and cracking of the tablet during rolling in tablet coating and the like. A tablet is allowed to absorb moisture by leaving it in the air having a relative humidity of 30 to 95%.
What is claimed is: 1. A method for producing a tablet, wherein the tablet is dried by being allowed to stand in air in a range of 50% to 50%.
Description
【０００１】[0001]
【発明が属する技術分野】本発明は、容易に分割可能な
錠剤の製造方法に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for producing a tablet which can be easily divided.
【０００２】[0002]
【従来の技術】一般に、食品、医薬品等の分野では、投
与法や投与量から錠剤を２以上に分割することがしばし
ば行われている。その方法として、錠剤に溝をもうけて
分割できるようにしている。この種の分割を可能に構成
した錠剤には、例えば、特開平８−５３３４５号公報に
記載されたものが知られている。分割を容易にするため
には、錠剤の硬度を低くすればよく、従来より行われて
いるのは、圧縮成型する際の圧縮圧力を低くする方法
や、圧縮成型される粉末または顆粒の結合力を弱くする
方法がある。2. Description of the Related Art In the field of foods, pharmaceuticals and the like, it is common practice to divide tablets into two or more according to the administration method and dosage. As a method, a tablet is provided with a groove so that the tablet can be divided. As a tablet configured to be capable of this kind of division, for example, a tablet described in Japanese Patent Application Laid-Open No. 8-53345 is known. In order to facilitate the division, the hardness of the tablet may be lowered. Conventionally, a method of lowering the compression pressure at the time of compression molding, the bonding force of the powder or granules to be compression-molded, and the like. There is a way to make it weaker.
【０００３】また、錠剤が含有する成分によっては味、
臭いをマスクするためや安定性向上の面から、フィルム
コーティング等によって適当な剤皮を錠剤に施す場合が
ある。このような剤皮を施した錠剤においても錠剤を２
以上に分割する必要がある場合が多くなってきている。
このようなフィルムコーティングを施す工程では、多数
の錠剤をコーティング機に入れ、錠剤を転動させながら
コーティング液を錠剤に吹き付ける方法がとられるた
め、錠剤の摩損、欠け、割れが発生する。そこで錠剤硬
度を摩損、欠け、割れの生じない程度にする必要があ
り、適当な剤皮を施した錠剤において容易に分割可能な
ものはできなかった。[0003] In addition, depending on the components contained in the tablet, taste,
In order to mask the odor and to improve the stability, an appropriate coating may be applied to the tablet by film coating or the like. Even tablets coated with such a coating have 2 tablets.
There are many cases where it is necessary to divide as described above.
In the step of applying such a film coating, a method is employed in which a large number of tablets are put into a coating machine and a coating liquid is sprayed on the tablets while rolling the tablets, so that the tablets are worn, chipped, or cracked. Therefore, it is necessary to reduce the tablet hardness to such a degree that abrasion, chipping and cracking do not occur, and it has not been possible to obtain a tablet having an appropriate coating that can be easily divided.
【０００４】[0004]
【発明が解決しようとする課題】本発明の目的は、錠剤
のコーティング等における転動時に錠剤の摩損、欠け、
割れの発生などのトラブルを生じさせることなく、服用
に際しては容易に分割できる錠剤の製造方法を提供する
ことにある。SUMMARY OF THE INVENTION An object of the present invention is to provide a tablet with abrasion, chipping,
An object of the present invention is to provide a tablet manufacturing method which can be easily divided at the time of taking without causing troubles such as cracking.
【０００５】[0005]
【課題を解決するための手段】本発明は、コーティング
等における転動に耐え得る錠剤硬度で打錠し、問題とな
るコーティング等の工程をトラブルを生じさせることな
く実施した後に、錠剤を吸湿させて錠剤硬度を低下させ
る方法である。According to the present invention, tablets are tableted with a tablet hardness that can withstand rolling in a coating or the like, and after performing the steps of coating or the like without causing any trouble, the tablets are absorbed. This is a method of reducing tablet hardness.
【０００６】吸湿は相対湿度３０〜９５％、望ましくは
相対湿度５０〜９０％の空気中に、目的の吸湿量になる
まで放置して行う。このときの空気の温度は任意である
が、望ましくは室温〜５０℃で行う。錠剤中に含まれる
成分が水分に対して不安定であるときは吸湿後に乾燥さ
せてもよい。乾燥は相対湿度０〜５０％、望ましくは相
対湿度０〜３０％の空気中に放置して行う。吸湿および
乾燥は通気型の装置を使用してもよい。通気型の装置と
して、棚型の装置を用いて錠剤を静置して行ってもよ
く、コーティング機を使用して錠剤を静置または転動さ
せながら行うことができるが、これらに限られるわけで
はない。[0006] The moisture absorption is carried out in air at a relative humidity of 30 to 95%, desirably 50 to 90%, until the target moisture absorption is reached. At this time, the temperature of the air is arbitrary, but desirably the temperature is from room temperature to 50 ° C. When the components contained in the tablet are unstable to moisture, they may be dried after absorbing moisture. Drying is carried out by leaving it in air at a relative humidity of 0 to 50%, preferably 0 to 30%. Moisture absorption and drying may use a ventilation type apparatus. As a ventilation type device, the tablets may be left standing by using a shelf type device, or the tablets can be left standing or rolling using a coating machine, but this is not a limitation. is not.
【０００７】本発明は、コーティングを行って適当な剤
皮を施した錠剤に適用して良好な結果を与えるが、剤皮
を施さない錠剤に適用することもできる。本発明は、服
用時の錠剤の分割を容易にするためのものであり、錠剤
の形状はどのようなものでもよいが、望ましくは、容易
に２以上に分割できるよう割線を施した錠剤である。以
下に実施例を記載するが、これらの実施例は本発明を制
限するためのものではない。The present invention provides good results when applied to coated and suitably coated tablets, but can also be applied to uncoated tablets. The present invention is intended to facilitate the division of tablets at the time of ingestion, and the tablet may have any shape, but is preferably a tablet with a score line so that it can be easily divided into two or more. . Examples are described below, but these examples are not intended to limit the present invention.
【０００８】[0008]
〔実施例１〕素錠は、打錠機CORRECT12HUK（菊水製作所
製）により、結晶セルロース６５．５重量％、無水リン
酸水素カルシウム３１.５重量％、カルボキシメチルス
ターチナトリウム２重量％、ステアリン酸マグネシウム
１重量％を含む直径８ｍｍ（割線入り）、重量２００ｍ
ｇの素錠として直接圧縮法によって錠剤硬度が７〜８ｋ
ｇとなるように調製した。[Example 1] Uncoated tablets were prepared using a tableting machine CORRECT12HUK (manufactured by Kikusui Seisakusho) with 65.5% by weight of crystalline cellulose, 31.5% by weight of anhydrous calcium hydrogen phosphate, 2% by weight of sodium carboxymethyl starch, magnesium stearate. 8mm in diameter including 1% by weight (with split lines), weight 200m
tablet hardness 7-8k by direct compression method
g.
【０００９】コーティング皮膜剤としてヒドロキシプロ
ピルメチルセルロース（ＨＰＭＣ）を５重量％、顔料と
して酸化チタン及びタルクを、それぞれＨＰＭＣの２０
重量％および１０重量％配合したものを水・エタノール
混液に溶解・分散したものを調製しコーティング液とし
た。ドリアコーターＤＲＣ−５００（パウレック社製）
を用いて、上記コーティング液を１錠あたり膜量６.５
ｍｇとなるよう、素錠にフィルムコーティングを行いフ
ィルムコート錠（ＦＣ錠）を調製した。上記ＦＣ錠を、
４０℃、相対湿度７５％に調湿した室内に７時間静置し
て放置して吸湿させた後、通気型の棚型乾燥機を用いて
５０℃、相対湿度１０％以下で乾燥した。5% by weight of hydroxypropylmethylcellulose (HPMC) as a coating film agent, titanium oxide and talc as pigments, and 20% of HPMC, respectively.
By weight and 10% by weight were dissolved and dispersed in a water / ethanol mixture to prepare a coating solution. Doria Coater DRC-500 (made by Powrex)
The above coating solution is applied to a tablet in a film amount of 6.5.
The uncoated tablet was coated with a film so as to obtain the amount in mg, and a film-coated tablet (FC tablet) was prepared. The above FC tablet,
After leaving it to stand for 7 hours in a room conditioned at 40 ° C. and a relative humidity of 75% to allow it to absorb moisture, it was dried at 50 ° C. and a relative humidity of 10% or less using a ventilated shelf dryer.
【００１０】 ・コーティング時の摩損、欠け、割れ： 認めなかっ
た。[0010] ・ Abrasion, chipping and cracking during coating: not recognized.
【００１１】〔比較例１〕素錠を実施例１の方法に従っ
て、錠剤硬度が約６ｋｇとなるように調製し、これに実
施例１の方法に従ってフィルムコーティングを行いＦＣ
錠とした。 ・コーティング時の摩損、欠け、割れ： 摩損傾向がみ
られ、欠け錠が発生した。Comparative Example 1 An uncoated tablet was prepared according to the method of Example 1 so as to have a tablet hardness of about 6 kg.
Tablets. -Abrasion, chipping and cracking during coating: Abrasion tendency was observed, and chipped tablets were generated.
【００１２】[0012]
【発明の効果】本発明による製造方法により、コーティ
ング等における錠剤の転動時の錠剤の摩損、欠け、割れ
の発生などのトラブルを生じさせることなく、分割が容
易な錠剤を製造することが可能となる。According to the manufacturing method of the present invention, tablets which can be easily divided can be manufactured without causing troubles such as abrasion, chipping and cracking of the tablets when rolling the tablets in coating or the like. Becomes
Claims (5)
空気中に放置し吸湿させることを特徴とする錠剤の製造
方法。1. A method for producing a tablet, comprising leaving the tablet in air having a relative humidity of 30 to 95% to absorb the moisture.
さらに相対湿度０〜５０％の範囲の空気中に放置して乾
燥することを特徴とする錠剤の製造方法。2. A tablet prepared by the method according to claim 1,
A method for producing a tablet, further comprising drying in air having a relative humidity of 0 to 50%.
用いる請求項１または２記載の錠剤の製造方法。3. The method for producing a tablet according to claim 1, wherein the method of leaving in the air uses a ventilated apparatus.
１、２または３記載の錠剤の製造方法。4. The method for producing a tablet according to claim 1, wherein the tablet is a coated tablet.
施した錠剤である請求項１、２、３または４記載の錠剤
の製造方法。5. The method for producing a tablet according to claim 1, wherein the tablet is a tablet which is divided so as to be divided into two or more.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24414996A JP4557313B2 (en) | 1996-08-26 | 1996-08-26 | Tablet manufacturing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24414996A JP4557313B2 (en) | 1996-08-26 | 1996-08-26 | Tablet manufacturing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH1057449A true JPH1057449A (en) | 1998-03-03 |
| JP4557313B2 JP4557313B2 (en) | 2010-10-06 |
Family
ID=17114497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP24414996A Expired - Lifetime JP4557313B2 (en) | 1996-08-26 | 1996-08-26 | Tablet manufacturing method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4557313B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007145733A (en) * | 2005-11-25 | 2007-06-14 | Ohara Yakuhin Kogyo Kk | Sarpogrelate hydrochlolide-containing tablet |
| JP2010532362A (en) * | 2007-07-05 | 2010-10-07 | ダウ グローバル テクノロジーズ インコーポレイティド | In-situ liquid activated film-coated tablet and method for producing the same |
-
1996
- 1996-08-26 JP JP24414996A patent/JP4557313B2/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007145733A (en) * | 2005-11-25 | 2007-06-14 | Ohara Yakuhin Kogyo Kk | Sarpogrelate hydrochlolide-containing tablet |
| JP2010532362A (en) * | 2007-07-05 | 2010-10-07 | ダウ グローバル テクノロジーズ インコーポレイティド | In-situ liquid activated film-coated tablet and method for producing the same |
| US8778399B2 (en) | 2007-07-05 | 2014-07-15 | Dow Global Technologies Llc | In situ, liquid-activated film coated tablets and a process for making the same |
Also Published As
| Publication number | Publication date |
|---|---|
| JP4557313B2 (en) | 2010-10-06 |
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