JPH11100324A - Composition for treating acne - Google Patents

Abstract

(57) Abstract: A composition for treating acne, comprising a combination of an oil-soluble extract extracted from licorice and a keratolytic agent and / or an anti-inflammatory agent. EFFECTS OF THE INVENTION According to the present invention, it is possible to provide a composition for treating acne, which does not have the side effects of steroids and has an excellent acne treatment or prevention effect.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a composition for treating acne having an excellent effect of treating or preventing acne.

[0002]

2. Description of the Related Art Although there are still many unclear points about the mechanism of acne development, the main factors are the increase in sebum secretion, promotion of follicle keratinization, bacterial proliferation, and inflammation of the hair follicle wall. Is considered as a factor. Conventionally, for treatment of acne, creams, ointments, and the like containing an antibacterial agent, an anti-inflammatory agent, a sebum secretion inhibitor, and a keratin exfoliant have been generally used in response to these factors. However, there are various drawbacks in acne treatment drugs containing various existing drugs. For example, antibacterial agents include chlorhexidine gluconate, benzalkonium chloride, and the like, but they are extremely irritating such as extremely roughening of the skin, and cannot be sufficiently effective in actual use. Furthermore, female hormones are used as sebum secretion inhibitors, but there are serious problems with the side effects caused by hormonal agents.

[0003] It is conceivable that a combination of drugs having different action points may exert a synergistic effect on acne treatment.
No satisfactory synergistic effect has been obtained, or side effects have been synergistically developed, and no effective drug combination for acne treatment has yet been obtained.

Accordingly, it is an object of the present invention to provide a composition for treating acne which has no irritation or other side effects and which can effectively treat and prevent acne.

[0005]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies to achieve the above object, and as a result, the oil-soluble extract extracted from licorice was added to the exfoliating agent and / or Or by combining anti-inflammatory agents, there is no side effects such as skin irritation and steroids,
The inventors have found that excellent acne treatment or prevention effects can be obtained, and have completed the present invention.

[0006] Conventionally, it has been known to use an oil-soluble extract extracted from licorice as an active ingredient of a whitening agent (JP-A-5-201847 and JP-A-6-256152).
No. 6-271442, No. 6-271453, No. 8-12518, etc.), in which it is remarkable that an oil-soluble extract from licorice is used in combination with a keratolytic agent and an anti-inflammatory agent. Giving an effect is a new finding by the present inventors.

Hereinafter, the present invention will be described in more detail.
The composition for treating acne of the present invention comprises (A) an oil-soluble extract extracted from licorice, and (B) one or more of a keratolytic agent and (C) an anti-inflammatory agent as active ingredients. .

[0008] The oil-soluble extract (A) extracted from licorice in the composition for treating acne of the present invention is composed of Glycyrrhiza glabra and Glycyrrhiza uralen.
sis), Glycyrrhiza e
chnata), Glycyrrhiz
a pallidifra) or a root of a plant belonging to the same genus is dried or ground as it is and can be obtained by solvent extraction.

Examples of the extraction solvent include alcohols such as methanol, ethanol and butanol, aliphatic and alicyclic hydrocarbons such as hexane, heptane and cyclohexane.
Examples thereof include esters such as ethyl acetate, ketones such as acetone, and ethers, and one of these can be used alone or in combination of two or more. Usually, extraction treatment is performed at a temperature of about 3 to 70 ° C. Can be. The obtained extract may be used as it is, or may be used as a diluent, a dried powder by concentrating and drying, or prepared in a paste form. Further, the active ingredient can be separated and purified from the extract and used.

In this case, the extraction conditions are not limited to those described above. However, after extraction with absolute ethanol, concentration, extraction with ethyl acetate, and drying under reduced pressure to obtain a powder extract may be used. preferable.

[0011] Separation and purification can be achieved by purifying an extract with a solvent by column chromatography or liquid chromatography. For example, separation and purification of glabridine from Nankin licorice, Uralkanzo, Chinese licorice, and dog liquorice, the above-mentioned powdery dried extract is processed by normal-phase silica gel column chromatography and reverse-phase silica gel column chromatography, and then from a hexane-benzene mixed solvent system. Crystallization can be performed. The color and odor of the extract can be removed using activated carbon or an adsorption resin.

The amount of the oil-soluble extract extracted from the licorice is 0.005 to 10% by weight, preferably 0.05 to 1% by weight, based on the total composition for treating acne in the present invention. When the amount is less than 0.005% by weight, the effect is insufficient. When the amount exceeds 10% by weight, it is difficult to incorporate the compound into a preparation.

[0013] The exfoliating agent (B) is an exfoliating accelerator, and is used for the purpose of treating hyperkeratosis, epithelial hyperplasia and associated skin diseases, removing hair, and cleaning the skin surface. .

Specifically, glycolic acid, lactic acid, citric acid, malic acid, salicylic acid, resorcinol, sulfur, urea,
Benzoyl peroxide, papain and the like can be mentioned. Of these, glycolic acid, salicylic acid and resorcin are preferred. The compounding amount of the exfoliating agent is 0.01 to 5% by weight, preferably 0.1 to 2% by weight. When the amount is less than 0.01% by weight, the effect is insufficient.
If it exceeds 5, it is difficult to mix it into the preparation.
It is desirable not to exceed by weight.

Further, specific examples of the anti-inflammatory agent (C) include:
Glycyrrhizic acid or a salt or ester thereof, glycyrrhetinic acid or a salt or ester thereof, allantoin, methyl salicylate and the like can be mentioned. The compounding concentration of the anti-inflammatory agent is 0.01 to 5% by weight, preferably 0.1 to 1% by weight. If it exceeds 5% by weight, it is difficult to mix it into a preparation.

In the present invention, the effect as a remedy for acne is enhanced by combining the above-mentioned exfoliating agent and anti-inflammatory agent into an oil-soluble extract from licorice.

The composition for treating acne of the present invention is in any form, and can be widely used for pharmaceuticals, quasi-drugs, cosmetics, toiletries and the like. For example, it can be used as an oily ointment, an aqueous ointment, a cream, a serum, a lotion, an emulsion, a lotion, a pack, a soap, a face wash, a makeup, a body cosmetic, and the like.

In the composition for treating acne of the present invention, in addition to the above-mentioned essential components, raw materials usually blended in the agent to be prepared, for example, surfactants, oils, alcohols, humectants, thickeners , Preservatives, antioxidants, chelating agents, pH
Conditioning agents, fragrances, pigments, ultraviolet absorbing / scattering agents, vitamins, amino acids, water and the like can be added.

By appropriately mixing the above essential components and optional components, various external preparations for skin, for example, serums, creams, emulsions, ointments, plasters, liniments, lotions, gels, plasters, packs , Spraying agent, bathing agent and the like.

The composition for treating acne prepared as described above varies depending on its dosage form and product form.
It can be administered once to several times a day by applying it to the affected area.

[0021]

According to the present invention, it is possible to provide a composition for treating acne having excellent acne treatment or prevention effects without the side effects of steroids.

[0022]

Next, the present invention will be described in detail with reference to examples and comparative examples, but the present invention is not limited to the following examples. In the following examples,% is% by weight. In addition, the total of the compounding amounts of the respective examples is 100.0%. In addition,
As the oil-soluble licorice extract in Tables 1 to 9, an oil-soluble licorice extract, which is a product listed in the specification of the compounding component for each cosmetic variety, was used.

Examples 1 to 11 and Comparative Examples 1 to 3
A composition for treating acne having the formulation shown in No. 2 was prepared. next,
Ninety-seven acne patients were used as test subjects, and the serums of Examples and Comparative Examples were continuously applied to the face several times a day, and the therapeutic effect on acne one month later was determined. Judgment is significantly improved (+
+), Improvement (+), unchanged (±), and deterioration (−). The determination results are shown in Tables 1 and 2.

In Examples 1 to 11, the therapeutic effect was confirmed in more than 80% of the subjects. On the other hand, in Comparative Examples 1 to 3, 60%
And the combined use of the oil-soluble licorice extract and the exfoliating agent and / or anti-inflammatory agent proved the excellent acne treatment effect of the present invention.

[0025]

[Table 1]

[0026]

[Table 2]

Examples 12 to 32 Tables 3 to 9 show formulation examples of the composition for treating acne.

[0028]

[Table 3]

[0029]

[Table 4]

[0030]

[Table 5]

[0031]

[Table 6]

[0032]

[Table 7]

[0033]

[Table 8]

[0034]

[Table 9]

 ──────────────────────────────────────────────────続 き Continuation of the front page (72) Inventor Yusuke Hakamada 1-7-3 Honjo, Sumida-ku, Tokyo Inside Lion Corporation

Claims (1)

[Claims] 1. A composition for treating acne, comprising a combination of an oil-soluble extract extracted from licorice and an exfoliant and / or an anti-inflammatory agent.