JPH11199464A - External preparation for skin - Google Patents

Abstract

(57) [Summary] [Object] To provide an external preparation for skin characterized by containing an extract of Isomatsu. The present invention is an external preparation for skin characterized by containing an extract of Isomatsu, a plant belonging to the family Pinaceae. Isomatsu extract showed excellent anti-inflammatory and beautiful skin effects.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin characterized by containing an extract of Isomatsu.

[0002]

2. Description of the Related Art Isomatsu is used for treating arthritis by drinking its stem and leaves in the Nansei Islands and is cultivated for appreciation, but there is no example of it being used as an external preparation for skin. On the other hand, skin inflammation due to ultraviolet rays or the like is one of the causes of skin roughness, and external preparations for skin that reduce the inflammation and improve skin roughness are desired.
As one of the treatment methods, there is a method of suppressing release of histamine, which is a proinflammatory substance generated during inflammation. However, most conventional skin external preparations that have a histamine release inhibitory action contain substances obtained by chemical synthesis, such as steroids, and have the risk of side effects. There is a demand for an excellent skin external preparation derived from natural products.

[0003]

Therefore, when the application of Isomatsu extract as a natural product to an external preparation for skin was examined, it was found to be highly safe, have an excellent anti-inflammatory action (histamine release inhibitory action) and a beautiful skin action. And the present invention was completed because it can be formulated.

[0004]

The present invention is an external preparation for skin characterized by containing an extract of Isomatsu. The term “Isomatsu” ( Limonium wrightii O. Kuntze) as used in the present invention is a small shrub-like perennial plant of the dicotyledonous plant belonging to the genus Isomatsu, belonging to the family Pinus sylvestris. In addition, this pine is also called Kaifu in Taiwan.

The extract of Isomatsu used in the present invention is obtained by extracting from a part or whole of a plant of Isomatsu leaves, stems, flowers, fruits and roots. Preferably, it is obtained by extracting from one or both of the leaves and stems. The preparation method is not particularly limited, and may be, for example, one extracted by heating or one extracted at ordinary temperature. As the solvent to be extracted, for example,
Water, lower monovalent alcohols (methanol, ethanol,
1-propanol, 2-propanol, 1-butanol, 2-butanol, etc.), liquid polyhydric alcohols (1,3-butylene glycol, propylene glycol, etc.), esters (ethyl acetate, isopropyl myristate, etc.), hydrocarbons (Benzene, hexane, pentane, liquid paraffin, etc.), ketones (acetone, methyl ethyl ketone, etc.),
Ethers (ethyl ether, tetrahydrofuran, propyl ether, etc.), acetonitrile and the like.
These solvents may be used alone or as a mixture of two or more. Preferably, water or a water-soluble solvent (a solvent that can be mixed with water at any ratio, for example, ethanol, 1,3-
It is preferable to use one or more solvents among butylene glycol, propylene glycol, etc.).

[0006] The extract of Isomatsu may be used as it is as an extracted solution, or may be used after being subjected to a treatment such as concentration, dilution, or filtration as required.

The external preparation for skin of the present invention contains oils and fats, waxes, hydrocarbons, fatty acids, fatty acids, and the like which are commonly used in external preparations for skin, as long as the effects of the extract of Isomatsu are not impaired.
Alcohols, esters, surfactants, metal soaps, pH
Conditioners, preservatives, fragrances, humectants, powders, UV absorbers,
Components such as a thickener, a pigment, an antioxidant, a cosmetic component, and a chelating agent can be compounded.

The external preparation for skin of the present invention can be used for any of pharmaceuticals, quasi-drugs, and cosmetics. Examples of the dosage form include lotions, creams, emulsions, gels, aerosols, and the like. Ointments, cataplasms, pastes, plasters, essences, packs, detergents, baths, foundations
And those applied to the skin such as powder, powder and lipstick.

The amount of the extract of Isomatsu used in the present invention is as follows:
The total amount of the external preparation for skin of the present invention is preferably 0.0001% by weight or more, preferably 0.001 to 10% by weight in terms of dry matter.
If it is less than 0.001% by weight, a sufficient effect cannot be expected. 10% by weight
When the amount is more than the above, the effect is not enhanced and it is uneconomical. The method of addition may be added in advance or may be added during the production, and may be appropriately selected in consideration of workability.

[0010]

EXAMPLES Next, the present invention will be described in detail with reference to examples, but the present invention is not limited thereto. In the examples, “parts” and “%” indicate “parts by weight” and “%” by weight, respectively.

Production Example 1 Isomatsu hot water extract To 50 g of a mixture of stalks and leaves of Isomatsu, 1000 ml of water was added, and 95 to 10
After extraction at 0 ° C. for 2 hours, the mixture was filtered, and the filtrate was concentrated and dried to obtain 10.5 g of Isomatsu hot water extract.

Production Example 2 Isomatsu Ethanol Extract 1000 ml of ethanol was added to 50 g of Isomatsu leaves,
After extraction for days, filter and concentrate the filtrate to dryness,
4.0 g of Isomatsu ethanol extract was obtained.

Production Example 3 Isomatsu 1,3-butylene glycol extract To 50 g of dried whole isomatsu plant, 1,3-butylene glycol 10
After adding 10 g at room temperature, the mixture was filtered,
800 g of 3-butylene glycol extract was obtained.

Example 1 Lotion Formulation Formulation amount 1. Isomatsu hot water extract (Production example 1) 0.1 part 2. 1,3-butylene glycol 8.0 3. Glycerin 2.0 4. Xanthan gum 0.02 5. Citric acid 0.01 6. Citric acid Sodium acid salt 0.1 7. Ethanol 5.0 8. Methyl parahydroxybenzoate 0.1 9. Polyoxyethylene hydrogenated castor oil (40E.O.) 0.1 10. Perfume appropriate amount 11. Make the total amount 100 with purified water [Production method] Ingredient 1 6, 11 and the components 7 to 10 are uniformly dissolved, and both are mixed and filtered to obtain a product.

Comparative Example 1 A conventional lotion was prepared by replacing the Isomatsu hot water extract with purified water in Example 1 of the conventional lotion.

Example 2 Cream Formulation Formulation amount 1. Isomatsu ethanol extract (Production example 2) 0.05 part 2. Squalane 5.5 3. Olive oil 3.0 4. Stearic acid 2.0 5. Beeswax 2.0 6. Octyldodecyl myristate 3.5 7. Poly Oxyethylene cetyl ether (20E.O.) 3.0 8. Behenyl alcohol 1.5 9. Glycerin monostearate 2.5 10. 1,3-Butylene glycol 8.5 11. Methyl parahydroxybenzoate 0.2 12. Ethyl paraoxybenzoate 0.05 13. Fragrance 0.114 Adjust the total amount to 100 with purified water. [Production method] Heat and dissolve components 2 to 9 and mix. Ingredients 1, 10 to 12, and 14 are dissolved by heating and mixed, and the mixture is kept at 75 ° C. to form an aqueous phase. Add the water phase to the oil phase, emulsify, cool with stirring, add component 13 at 45 ° C,
Cool to 30 ° C to obtain a product.

Example 3 Emulsion Formulation Formulation amount 1. Isomatsu 1,3-butylene glycol extract (Production Example 3) 1.0 part 2. Squalane 5.0 3. Olive oil 5.0 4. Jojoba oil 5.0 5. Cetanol 1.5 6. Monostearic acid Glycerin 2.0 7. Polyoxyethylene cetyl ether (20E.O.) 3.0 8. Polyoxyethylene sorbitan monooleate (20E.O.) 2.0 9. Propylene glycol 1.0 10. Glycerin 2.0 11. Methyl paraoxybenzoate 0.2 12. Perfume 0.1 13. Make the total amount 100 with purified water. [Production method] Components 2 to 8 are dissolved by heating and mixed, and kept at 70 ° C to obtain an oil phase. Components 1, 9 to 11 and 13 are dissolved by heating and mixed, and the mixture is kept at 75 ° C. to form an aqueous phase. Add the water phase to the oil phase, emulsify, cool with stirring, add component 12 at 45 ° C,
Cool to 30 ° C to obtain a product.

Comparative Example 2 Conventional Emulsion A conventional emulsion was prepared by replacing the isomatsu 1,3-butylene glycol extract with 1,3-butylene glycol in Example 3.

Example 4 Gel formulation Formulation amount 1. Isomatsu 1,3-butylene glycol extract (Production Example 3) 5.0 parts 2. Ethanol 5.0 3. Methyl parahydroxybenzoate 0.1 4. Polyoxyethylene hydrogenated castor oil (60E) .O.) 0.1 5. Appropriate amount of perfume 6. 1,3-butylene glycol 5.0 7. Glycerin 5.0 8. Xanthan gum 0.1 9. Carboxyvinyl polymer 0.2 10. Potassium hydroxide 0.2 11. Make the total amount 100 with purified water [ Production method] Components 2 to 5 and components 1 and 6 to 11 are uniformly dissolved, and the both are mixed and filtered to obtain a product.

Example 5 Ointment Prescription Formulation amount 1. Isomatsu hot water extract (Production Example 1) 1.0 part 2. Polyoxyethylene cetyl ether (30E.O.) 2.0 3. Glycerin monostearate 10.0 4. Liquid paraffin 5.0 5. Cetanol 6.0 6. Methyl parahydroxybenzoate 0.1 7. Propylene glycol 10.0 8. Make the total amount up to 100 with purified water. [Production method] Heat and dissolve components 2 to 5 and maintain at 70 ° C to mix with the oil phase. I do. Ingredients 1, 6 to 8 heat and mix
Keep at ℃ and make water phase. Add the water phase to the oil phase, emulsify and cool to 30 ° C with stirring to obtain the product.

Example 6 Pack Formulation Compounding amount 1. Isomatsu hot water extract (Production Example 1) 0.5 part 2. Polyvinyl alcohol 12.0 3. Ethanol 5.0 4. 1,3-butylene glycol 8.0 5. Methyl paraoxybenzoate 0.26 Polyoxyethylene hydrogenated castor oil (20E.O.) 0.5 7. Citric acid 0.1 8. Sodium citrate 0.3 9. Flavor appropriate amount 10. Make the total amount 100 with purified water [Production method] Ingredients 1 to 10 are uniform Dissolved in the product.

Example 7 Foundation Prescription Formulation amount 1. Isomatsu 1,3-butylene glycol extract (Production Example 3) 1.0 part 2. Stearic acid 2.4 3. Polyoxyethylene sorbitan monostearate (20E.O.) 1.0 4 Polyoxyethylene cetyl ether (20E.O.) 2.0 5. Cetanol 1.0 6. Liquid lanolin 2.0 7. Liquid paraffin 3.0 8. Isopropyl myristate 6.5 9. Butyl paraoxybenzoate 0.1 10. Sodium carboxymethyl cellulose 0.1 11. Bentonite 0.5 12. Propylene glycol 4.0 13. Triethanolamine 1.1 14. Methyl parahydroxybenzoate 0.2 15. Titanium dioxide 8.0 16. Talc 4.0 17. Bengala 5.0 18. Perfume appropriate amount 19. Make the total amount to 100 with purified water. Swell the component 10 well in a part of the component 19, add a solution obtained by dissolving the component 13 in the remaining component 19, and then,
Components 1, 11 to 14 are added and uniformly mixed to obtain an aqueous phase. Ingredient 2
9 is heated and dissolved, and kept at 80 ° C. to obtain an oil phase. Ingredients 15-17
Pulverized with a pulverizer, added to the aqueous phase, and stirred with a homomixer.
Keep at 75 ° C. The oil phase is added to the aqueous phase with stirring, cooled, and the component 18 is added at 45 ° C, and cooled to 30 ° C with stirring to obtain a product.

Example 8 Hair Cream Formulation Formulation Amount 1. Stearic acid 2.0 parts 2. Stearyl alcohol 2.0 3. Liquid paraffin 8.0 4. Glycerin monostearate 2.3 5. Sorbitan monooleate 2.5 6. Polyoxyethylene sorbitan monooleate (10E) .O.) 0.8 7. Isomatsu 1,3-butylene glycol extract (Production Example 3) 0.2 8. Glycerin 6.0 9. Methyl paraoxybenzoate 0.1 10. Appropriate amount of fragrance 11. Make the total amount 100 with purified water [Production Method] Components 1 to 6 are dissolved by heating and mixed, and the mixture is kept at 70 ° C. to obtain an oil phase. Heat and dissolve components 7 to 10 and mix at 75 ° C
Keep the water phase. Add the water phase to the oil phase, emulsify, cool with stirring, add component 10 at 45 ° C, and cool to 30 ° C to obtain the product.

Example 9 Bath agent Prescription Compounding amount 1. Sodium bicarbonate 50.0 parts 2. Isomatsu hot water extract (Production example 1) 0.5 3. Yellow 202 proper amount 4. Perfume proper amount 5. Total amount with sodium sulfate 100 [Production method] Components 1 to 5 are uniformly mixed to obtain a product.

[0025]

EFFECT OF THE INVENTION The extract of Isomatsu of the present invention has an excellent histamine release inhibitory action (anti-inflammatory action), and an external preparation for skin characterized by containing the extract of Isomatsu has an excellent skin beautiful action. showed that. Next, experimental examples will be described in order to explain the effects of the present invention in detail.

Experimental Example 1 Inhibitory Effect on Histamine Release (Anti-Inflammatory Activity) The inhibitory effect on histamine release was measured using mast cells collected from the intraperitoneal cavity of male Spraque-Dawley rats. That is, the effect of suppressing the release of histamine from mast cells by 1 μg / ml of Compound 48/80 was determined as the release inhibition rate. Mast cells were obtained by the method of Sullivan et al. (J. Immunology, 11
4 (5), 1473, 1975), and histamine was quantified by the method of May et al. (J. Allergy, 46, 12-20, 1970). Table 1 shows the results of the experiment. As a result, the extract of Isomatsu showed an excellent histamine release inhibitory action. As samples, freeze-dried extracts of the extracts of Production Examples 1 and 2 and evaporation residues of the extract of Production Example 3 were used.

[0027]

[Table 1] Table 1 Histamine release inhibition rate ────────────────────────────── Sample concentration Histamine release (mg / ml) Inhibition rate (%) ────────────────────────────── Isomatsu hot water extract 0.001 9 0.01 31 0.1 97 0.5 99 Isomatsu ethanol Extract 0.001 15 0.01 29 0.1 88 0.5 99 Isomatsu 1,3-butylene glycol extract 0.001 12 0.01 28 0.1 90 0.5 98 Indomethacin (positive control) 0.1 40 ──────────────── ──────────────

EXPERIMENTAL EXAMPLE 2 Skin Beautification Using the lotion of Example 1, the emulsion of Example 3, the conventional lotion of Comparative Example 1, and the conventional emulsion of Comparative Example 2, 15 women suffering from rough skin (21 to 21) A 46-year-old subject was subjected to a one-month use test. After use, the effect of improving skin roughness was determined by a questionnaire. The results are shown in Table 2. As a result, an external preparation for skin characterized by containing an extract of Isomatsu exhibited an excellent skin-beautifying effect.

[0029]

[Table 2] Table 2 Skin Beautification ───────────────────────────────── Number of people judgment ────── ─────────────────── Example 1 Comparative Example 1 Example 3 Comparative Example 2 Lotion of lotion ──────────────────────── Greatly improved 9 2 10 3 Improved 5 4 3 4 Not much improved 1 5 2 5 Improvement 0 4 0 3 た

The cream of Example 2, the gel of Example 4,
Example 5 Ointment, Example 6 Pack, Example 7 Foundation, Example 8 Hair Cream and Example 9
A similar use test was conducted with respect to the bathing agent, which showed an excellent beautifying effect. As described above, the extract of Isomatsu of the present invention has an excellent histamine release inhibitory action, and a skin external preparation characterized by containing the extract exhibits an excellent skin beautiful action. Was.

Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 7/50 A61K 7/50 9/06 9/06 G 9/107 9/107 S 35/78 ABE 35/78 ABEC

Claims (1)

[Claims] 1. An external preparation for skin comprising an extract of Isomatsu.