JPH11246332A - Uses of cinnamic acid or its derivatives in cosmetics - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an agent performing actions of stimulating the synthesis of total lipids of the skin, augmenting the barrier function of the skin, promoting the humectation of the skin, enhancing the pliability of the skin, etc., by formulation with a cosmetic by using a cinnamic acid (derivative) therein. SOLUTION: This agent for augmenting the barrier function of skin by application to a cosmetic is composed of cinnamic acid (derivative). The cinnamic acid is present in the transform in an essential oil of a cocoa leaf, Peruvian balsam and a cinnamon or a basil. The cis-form is present in an oil of Alpinia malacensis. For example, mono- and polyhydroxycinnamic acids or alcohols are cited as the cinnamic acid derivative. The cinnamic acid derivative may be a natural product or the one derived from synthesis however, the cinnamic acid is preferably used. The amount of the formulated cinammic acid is preferably 10<-6> to 10%, more preferably 10<-3> to 5% based on the total weight of the cosmetic.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to the use of cinnamic acid or a derivative thereof in at least one cosmetic composition as an agent for promoting the synthesis of skin lipids. In particular, the cosmetics of the invention are intended to stimulate the synthesis of total lipids of the skin, especially of the epidermis. The present invention also relates to a cosmetic containing an effective amount of at least one of cinnamic acid or a derivative thereof.

[0002]

BACKGROUND OF THE INVENTION Human skin consists of two compartments, the deep compartment, the dermis, and the superficial compartment, the epidermis. The dermis is a solid support for the epidermis. The dermis is also a trophic factor in the epidermis. The dermis is mainly composed of fibroblasts and extracellular matrix, and the extracellular matrix is mainly composed of collagen, elastin, and a substance known as a basal substance, and these components are synthesized by fibroblasts. In addition, leukocytes, mast cells or tissue macrophages are also found therein. Still further, the dermis also contains blood vessels and nerve fibers.

[0003] The epidermis comes into contact with the external environment. Its role is
The goal is to protect the body from external attacks and dehydration, whether it is chemical or mechanical, physical or infectious. The natural human epidermis is mainly composed of three types of cells: keratinocytes, which make up the majority,
Consists of melanocytes and Langerhans cells. Each of these cells, through its unique function, contributes to the essential role that the skin plays in the body.

[0004] The cells constituting the epidermis are linked by intercellular lipid domains. In differentiation, phospholipids, which play a role in expressing the fluid structure of the cell membrane in the living layer of the epidermis, are gradually replaced by a mixture consisting mainly of fatty acids, cholesterol and sphingolipids.

[0005] These lipids are organized into specific lamellar structures whose integrity depends not only on the quality of the existing fractions, but also on the respective proportions. Because the lipid has a lamellar structure in the intercellular lipid region of the epidermis,
It imparts fluidity to the skin and, consequently, flexibility. The lipids also have "barrier" properties in the epidermis, especially in the stratum corneum.

[0006] Epidermal lipids are mainly synthesized in living epidermis. They consist primarily of phospholipids, sphingolipids, cholesterol, free fatty acids, triglycerides, cholesterol esters and alkanes.

[0007] Phospholipids are essential for cell membrane formation. They play an important role in the formation of free aliphatic chains used to mediate extracellular signals and generate energy. They are stores of free fatty acids required for the production of sphingolipids.

[0008] Sphingolipids (or ceramides) are essential for maintaining the multilamellar structure of keratinocyte lipids. They are also essential for the "barrier" function of the epidermis and for moisture exchange.

Cholesterol plays a major role in the moisturizing of the skin and in the "barrier" function of the epidermis.

Free fatty acids play a major role in maintaining the lamellar structure of lipids in the stratum corneum, as well as in the formation of cell membranes, which result in membrane fluidity and physiological processes such as enzyme activity or receptor function. .

Therefore, the essential role played by skin lipids and the importance of their integrity are highly appreciated.

[0012] Unfortunately, lipids in the skin, especially the epidermis,
It is known to be affected by genetic factors, aging, dietary habits, seasons, environmental factors, external aggression and / or certain medical conditions (eg scurvy or nicotinic acid deficiency syndrome). As a result of all these factors, the composition of the lipids of the skin is adversely affected or denatured or reduced in quantity, which necessarily leads to dry skin. For example, it is known that a diet without a lipid component results in poorly healthy skin. The lack of lipids generally worsens the health and increases the loss of water through the epidermis, resulting in a skin with a particularly flaky appearance.
Thus, skin lipids are essential for maintaining the skin's moisture “barrier”.

It is also known that epidermal lipids affect the activity of certain skin enzymes associated with desquamation and maturation of the stratum corneum. Thus, changes in the type and level of lipids present in the stratum corneum affect the "barrier" function, moisture content and skin condition of the stratum corneum.

[0014] It is also known that during menopause, women develop discomfort when the skin develops a swelling sensation and presents a "dry skin" appearance, and even a dryness appearance. Also, without wishing to establish any particular theory, skin lipids play an important role in moisturizing the skin, and menopausal-related hormone deficiency is accompanied by a general delay in cellular metabolism Thus, it can be inferred that the dry skin or skin tonicity experienced by women is associated with a decrease in the amount of total lipids in the skin.

It is therefore important to be able to stimulate the synthesis of skin lipids and to fulfill the important role played by the cortex in order to maintain and / or restore integrity.

[0016]

SUMMARY OF THE INVENTION In this regard, the applicant has surprisingly and unexpectedly found that cinnamic acid or a derivative thereof is a lipid, especially a total lipid of the skin. Has the property of stimulating the synthesis of.

Cinnamic acid is present in trans form in the essential oils of cocoa leaves, Peruvian balsam, and cinnamon or basil. The cis form is present in the oil of the genus Alpinia malacensis.

Conventionally, cinnamic acid or a derivative thereof is used as a composition for preventing bedsore (Japanese Patent No. 0724255).
No. 8), an anti-UV activator (US Pat. No. 5,093,109)
No.), a composition for permanent wave (German Patent No. 33)
01515, German Patent No. 29124777 and European Patent No. 22996), a lotion for hair (Japanese Patent No. 7053401 and Japanese Patent No. 3041413).
No. 5), a composition for depigmentation (Japanese Patent No. 5221845)
And Japanese Patent No. 1 188 611) and antioxidants (European Patent 664 290).

To the applicant's knowledge, the use of cinnamic acid or a derivative thereof to stimulate the synthesis of total skin lipids has not previously been disclosed.

Thus, the subject of the present invention is that in the use of an effective amount of cinnamic acid or a derivative thereof in at least one cosmetic, the cinnamic acid or cosmetic stimulates the synthesis of total lipids in the skin. In its intended use.

The cinnamic acid or a derivative thereof may be natural or synthetic. Naturally derived refers to cinnamic acid or a derivative thereof prepared from plant material found in the natural state. Synthetic origin refers to cinnamic acid or a derivative thereof prepared by chemical synthesis or biotechnology. Therefore, in the following, the term cinnamic acid is understood to refer to a cinnamic acid of natural or synthetic origin or a derivative thereof in purified form or any preparation containing them. Is done.

The cinnamic acid derivatives usable in the present invention include, for example, mono- and polyhydroxycinnamic acids, alcohols, aldehydes, esters and derivatives. Cinnamic acid is preferably used in the present invention.

Needless to say, in the present invention, cinnamic acid or a derivative thereof can be used alone or as a mixture.

As noted above, lipids are involved, inter alia, in skin barrier function, skin moisturization, and skin softness. It is also known that menopause affects the skin, especially skin lipids. For this reason, one aspect of the invention is intended for cinnamic acid or cosmetics to enhance the barrier function of the skin in the use of an effective amount of cinnamic acid or a derivative thereof in at least one cosmetic. It is in proposing a use that is.

In another aspect, the subject of the present invention contemplates that in the use of an effective amount of cinnamic acid or a derivative thereof in at least one cosmetic product, the cinnamic acid or cosmetic product promotes moisturizing the skin. The use is what you have done.

In another aspect, the subject of the present invention is:
In the use of an effective amount of cinnamic acid or a derivative thereof in at least one cosmetic product, the use is such that the cinnamic acid or cosmetic product is intended to enhance skin softness.

In yet another aspect, the subject of the present invention is the use of an effective amount of cinnamic acid or a derivative thereof in at least one cosmetic composition, wherein the cinnamic acid or cosmetic composition has a menopausal or menopausal effect on the skin. In use that is intended to resist.

Finally, in another aspect, the subject of the present invention is the use of an effective amount of cinnamic acid or a derivative thereof in at least one cosmetic product, wherein the cinnamic acid or cosmetic product is menopausal or climacteric to skin lipids. In use that is intended to resist the effects of.

It is clear that the amount of cinnamic acid or a derivative thereof that can be used in the present invention depends on the desired effect, but it must be an amount effective to stimulate the synthesis of skin lipids. No. For example, the amount of available cinnamic acid in the present invention, ¹⁰ with respect to the total weight of the cosmetic ^- 6% to 10%, preferably in the range of ¹⁰ -3% to 5%.

In the present invention, cinnamic acid or one of its derivatives can be used in combination with other products that stimulate lipogenesis. These other products that stimulate lipogenesis include plant hormones.

Examples of plant hormones include auxins such as 3-indoleacetic acid (IAA), 4-chloro-3-indoleacetic acid (4-Cl-IAA), and phenylacetic acid (P
AA), 3-indolebutyric acid (IBA), 2,4-dichlorophenoxyacetic acid (2,4-D), α-naphthaleneacetic acid (α-NAA), β-naphthoxyacetic acid, indoleethanol, indoleacetaldehyde ( indoleacetaldehyde) and indoleacetonitrile. In the present invention, β-naphthoxyacetic acid is preferably used.

Since skin is composed of many components other than lipids, when the synthesis of skin is promoted by cinnamic acid, it is advantageous to simultaneously promote the synthesis of these other components, for example, collagen. Thus, in the present invention, it is possible to use cinnamic acid or one of its derivatives, for example, in combination with other products that stimulate the synthesis of collagen. In this regard, plant hormones such as auxin,
Particularly, β-naphthoxyacetic acid is exemplified.

The subject of the present invention is also intended to promote the synthesis of skin total lipids containing an effective amount of cinnamic acid or one of its derivatives in a cosmetically acceptable medium. In cosmetics. The product that stimulates the synthesis of lipids and / or collagen is 10 ^{−6 based on} the total weight of the cosmetic.
% To 10%, preferably ^10-3 % to 5%.

Furthermore, a subject of the invention is a moisturizing cosmetic comprising an effective amount of cinnamic acid or one of its derivatives in a cosmetically acceptable medium.

Still a further subject of the invention is a cosmetic softening agent which contains an effective amount of cinnamic acid or one of its derivatives in a cosmetically acceptable medium.

The subject of the present invention is also a cosmetic composition intended to reinforce the "barrier" function of the skin, which comprises an effective amount of cinnamic acid or one of its derivatives in a cosmetically acceptable medium. In the fee.

Finally, the subject of the invention is a menopause or menopause on the skin, in particular a menopause on lipids of the skin, containing an effective amount of cinnamic acid or one of its derivatives in a cosmetically acceptable medium. In cosmetics intended to resist the effects of climacteric or climacteric.

The term cosmetically acceptable medium is:
Refers to a medium compatible with the skin, scalp, mucous membranes, nails and hair.

Needless to say, the cosmetic of the present invention can contain a cosmetically acceptable substrate (medium),
Any pharmaceutical dosage form commonly used for topical application, especially aqueous, aqueous-alcoholic or oily solutions, oil-in-water, water-in-oil or multiple emulsions, aqueous or oily gels, liquids, pastes or The oil is added to the aqueous phase using solid anhydrous products, polymeric micro (nano) particles such as nanospheres and nanocapsules, more preferably microspheres, which can be ionic and / or non-ionic lipid vesicles. It can be provided as dispersed.

The cosmetic may be more or less fluid and may be white or colored creams, ointments, milks,
It may have a lotion, serum, paste or mousse appearance. It can also be applied to the skin in the form of an aerosol, if desired. Further, it may be in a solid form, for example, a rod form. In addition,
It can also be used as a care product, a cleansing product, a makeup product or just a deodorant product.

In a known manner, the cosmetic preparations according to the invention can also be formulated with adjuvants customary in the cosmetic and dermatological fields, for example hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic active agents. , A preservative, an antioxidant, a solvent, a fragrance, a filler, a screen agent, a pigment, a chelating agent, an odor absorber and a dye. The amounts of these various adjuvants are those conventionally used in the fields under consideration, for example, 0.0%, based on the total weight of the cosmetic.
It is 1% to 20%. These adjuvants are, by their nature, incorporated into the fatty phase, aqueous phase, lipid vesicles and / or nanoparticles.

When the cosmetic of the present invention is an emulsion, the proportion of the fatty phase is 5% by weight based on the total weight of the cosmetic.
８０80% by weight, preferably 5% to 50% by weight. The oils, emulsifiers and co-emulsifiers used in cosmetics in the form of emulsions are selected from those conventionally used in the field under consideration. Emulsifiers and coemulsifiers are present in the cosmetic in an amount of from 0.3% by weight to 30% by weight,
% By weight, preferably in the range of 0.5% to 20% by weight.

The oils usable in the present invention include mineral oils, vegetable oils (apricot oil, sunflower oil), animal oils, synthetic oils, silicone oils and fluorinated oils (perfluoropolyether). it can. In addition, as the fatty substance, a fatty alcohol (cetyl alcohol), a fatty acid, and a wax (bee wax) can be used.

The emulsifiers and co-emulsifiers usable in the present invention include esters of polyethylene glycol and fatty acids,
Mention may be made, for example, of PEG-40 stearate and PEG-100 stearate, and esters of polyols and fatty acids, such as glyceryl stearate and sorbitan tristearate.

Examples of hydrophilic gelling agents include carboxyvinyl polymers (carbomers), acrylic copolymers such as acrylate / alkyl acrylate copolymers, polyacrylamides, polysaccharides, natural gums and the like. Clays may be mentioned, and lipophilic gelling agents include modified clays such as bentones, metal salts of fatty acids, hydrophobic silica and polyethylene.

Cosmetics are other hydrophilic activators, for example,
Protein or protein hydrolysate, amino acid, polyol, urea, allantoin, saccharide and saccharide derivative,
It may contain water-soluble vitamins, plant extracts and hydroxy acids.

As the lipophilic activator, retinol (vitamin A) and its derivatives, tocopherol (vitamin E) and its derivatives, essential fatty acids, ceramides, essential oils and salicylic acid and its derivatives can be used.

-Plant hormones;-antibacterial agents, such as macrolides, pyranosides and tetracyclines, especially erythromycin;-calcium antagonists, such as verapamil and diltiazem;-OH scavengers, such as dimethyl sulfoxide; A plant extract, such as an extract of the present invention, which may contain isoflavones, etc .;-a microbial extract, especially including a bacterial extract, for example a non-photosynthetic filamentous fungus; It can also be used in the present invention in combination with at least one of its derivatives.

In addition, the above list includes other compounds, such as potassium channel openers, such as diazoxide and minoxidil, spiroxazone,
Phospholipids such as lecithin, linoleic and linolenic acid, salicylic acid and the derivatives described in FR-A-2 581 542, e.g.
A salicylic acid derivative carrying an alkyl group having a carbon atom of, hydroxycarboxylic acid or ketocarboxylic acid and esters thereof, lactones and their corresponding salts, anthralin, carotenoid, eicosatetraenoic acid and eicosatrienoic acid or esters thereof And amides, and vitamin D and its derivatives can also be added.

In the present invention, it is also possible to combine other active agents intended particularly for the prevention and / or treatment of skin diseases with at least one of cinnamic acid or a derivative thereof. Such active agents include, for example: agents that modulate skin differentiation and / or proliferation and / or pigmentation, such as retinoic acid and its isomers, retinol and its esters, vitamin D and its derivatives, estrogens , E.g. estradiol, kojic acid or hydroquinone;-anthelmintics, in particular metronidazole, crotamiton or pyrethroids;-antifungal agents, in particular compounds belonging to the imidazoles,
For example, econazole, ketoconazole or miconazole or salts thereof, polyene compounds such as amphotericin B, compounds of allylamines such as terbinafine or octopirox; antiviral agents such as acyclovir; steroidal anti-inflammatory agents E.g. hydrocortisone, betamethasone valerate or clobetasol propionate, or non-steroidal anti-inflammatory agents such as ibuprofen and its salts, diclofenac and its salts, acetylsalicylic acid, acetaminophen or glycyrrhetinic acid; -Lidocaine hydrochloride and its derivatives;-antipruritics, such as tenaldine, trimeprazine or cyproheptadine;-keratolytic agents, such as α- and β-hydroxycarboxylic acids, or β-keto. Carboxylic acids, their salts, amides or esters, especially hydroxy acids, such as glycolic acid, lactic acid, salicylic acid, citric acid, and generally fruit acids and 5-n-octanoylsalicylic acid; anti-free radical agents, For example, α-tocopherol or its esters, superoxide-dismutase,
Certain metal chelators or ascorbic acid and its esters; antiseborrheic agents such as progesterone; antidandruff agents such as octopirox or zinc pyrithione; antiacne agents such as retinoic acid or peroxidation. Benzoyl;-an antagonist of substance P, CGRP or bradykinin or a NO-synthase inhibitor, active in the treatment of sensitive skin and described as having an anti-irritant effect, especially on irritating compounds which may be present in cosmetics. Compounds.

Thus, another object of the present invention is to provide an effective amount of at least one of cinnamic acid or a derivative thereof, an antibacterial agent, an anthelmintic agent, an antifungal agent, an antiviral agent, an anti-inflammatory agent, an antipruritic, an anesthetic agent. Agents, keratolytic agents, antifree radical agents, antiseborrheic agents, antidandruff agents, antiacne agents, agents that regulate skin differentiation and / or proliferation and / or pigmentation, substance P, CGRP
Or a cosmetic containing at least one drug selected from bradykinin antagonists or NO-synthase inhibitors.

As activators, in particular, humectants such as polyols (eg glycerol), vitamins (eg D
-Panthenol), anti-inflammatory agents, sedatives (calmatives)
(Allantoin, cornflower water), UVA and UVB
Screening agents, matting agents [eg, partially crosslinked polydimethylorganosiloxanes sold under the name KSG® by Shin-Etsu] and mixtures thereof can also be used.

Also, anti-wrinkle actives, especially tensioning products, such as plant proteins and their hydrolysates, especially Eleser from LSN.
yl) .RTM., a soy protein extract sold under the name of.RTM., or Reductin from Silab.
tine) (registered trademark) can be further added.

It goes without saying that at least one of the cinnamic acids or derivatives thereof can also be used in cosmetic and / or pharmaceutical compositions, especially dermatological compositions, intended to stimulate lipid synthesis.

[0055]

Other features and advantages of the present invention will become apparent from the following examples, which are intended to be illustrative and not limiting. In the following or the above description, unless otherwise specified, the ratio is a weight percentage. Example 1 Test of the Effect of Cinnamic Acid on the Synthesis of Total Lipids in the Skin This test was marketed by Skinethic and reconstituted human with a total lipid composition close to normal human epidermis. Was carried out by measuring the amount of carbon-14-labeled acetate introduced in the epidermis model of No. 1.

Reconstituted human epidermal cultures were prepared according to the supplier's instructions. After culturing the reconstituted human epidermis for 14 days under the conditions recommended by the supplier, 10
Contact with cinnamic acid at ^-5 , ^10-6 and ^10-7 M concentrations for 72 hours. After contacting the test product with the culture 2
During 4 hours, ie during the last 48 hours of culture,
¹⁴ C acetate (sodium [2- ¹⁴ C] -acetate sold by Amersham) was used and labeled at a rate of 0.5 μCi of ¹⁴ C acetate per culture.

At the end of the culture, after washing the epidermis with phosphate buffer (PBS), the epidermis was lysed and the cells were lysed on ice with 0.5 M perchloric acid. The lysate was then extracted with a mixture of methanol / chloroform (2: 1), centrifuged and the resulting pellet was extracted again under the same conditions as described above. Lipids were separated by adding PBS and chloroform [Bright-Bier method (Blight-B
yer technique)]. The organic phase containing the lipid was removed and the radioactivity introduced into this phase was measured by liquid scintillation. The organic phase was then dried under a stream of nitrogen. Thin-layer plate chromatography on Merck K60 plates was used to separate phospholipids using a mixture of chloroform / methanol / water (50/18 / 2.6) as eluent or hexane / ether / acetic acid The mixture (15 / 5.6 / 0.19) was used to separate neutral lipids. The plates were then autoradiographed for 24 hours and chromatograms analyzed with a densitometer using One-D-Scan software from Scanalytics.

The results were evaluated by comparison with a control consisting of cells not treated with cinnamic acid. A positive control (10 ⁻⁴ M trifluoroperazine) known to stimulate lipogenesis and a negative control (10 ⁻⁶ M retinoic acid) known to inhibit lipogenesis Included in the test for comparison.

The results of this test, expressed as a percentage of the degree of irritation, are shown in the following table.

[Table 1]

These results indicate that cinnamic acid significantly stimulates the introduction of ¹⁴ C acetate, which has an effect on lipogenesis.

Example 2 Specific Examples of the Cosmetic of the Present Invention These cosmetics were obtained by conventional techniques often used in cosmetics or pharmaceuticals. Cosmetic 1 : Care cream Beeswax 1.5% Apricot kernel oil 13.0% Preservative 0.3% Fragrance 0.4% β-naphthoxyacetic acid 0.01% Cinnamic acid 0.01% Xanthan 0.5% Cyclopentadimethylsiloxane 5.0% Sterile demineralized water 69.28% Sucrose-mono- and dipalmitostearate 3.0% Sesquistearate methylglucoside 3.0% Stearic acid 1.0% Cetyl alcohol 3.0%

Cosmetic 2 : Body oil Fluid Vaseline 47.98% Apricot kernel oil 6.0% Fragrance 1.0% β-Naphthoxyacetic acid 0.01% Cinnamic acid 0.01% Cyclopentadimethylsiloxane 45.0 %

Cosmetic 3 : Milk for removing makeup 2-ethylhexyl palmitate 10.5% Liquid fraction of karite butter 16.5% Preservative 0.3% Fragrance 0.15% β-Naphthoxyacetic acid 0.01% Kei Cinnamic acid 0.01% Sodium hydroxide 0.04% Carboxyvinyl polymer 0.2% Sterilized demineralized water 69.79% Mixture of cetyl stearyl glucoside with cetyl and stearyl alcohol 2.5%

Cosmetic 4 : Care cream Beeswax 1.5% Apricot kernel oil 13.0% Preservative 0.3% Fragrance 0.4% β-naphthoxyacetic acid 0.01% Cinnamic acid 0.01% Ethyl acid 0.01% Xanthan 0.5% Cyclopentadimethylsiloxane 5.0% Sterile demineralized water 69.27% Sucrose-mono- and dipalmitostearate 3.0% Methylglucoside sesquistearate 3.0% Stearin Acid 1.0% Cetyl alcohol 3.0%

Claims (23)

[Claims] 1. An agent for reinforcing skin barrier function, which is used in cosmetics and comprises an effective amount of at least one of cinnamic acid or a derivative thereof. 2. An agent for promoting skin moisturization, which is used in cosmetics and comprises an effective amount of at least one of cinnamic acid or a derivative thereof. 3. An agent for enhancing skin softness, which is used in cosmetics and comprises an effective amount of at least one of cinnamic acid or a derivative thereof. 4. An agent for stimulating lipid synthesis, which is used in cosmetics and comprises an effective amount of at least one of cinnamic acid or a derivative thereof. 5. A medicament for use in cosmetics, comprising an effective amount of at least one of cinnamic acid or a derivative thereof for combating menopausal effects on the skin. 6. A medicament for use in cosmetics, comprising an effective amount of at least one of cinnamic acid or a derivative thereof for combating climacteric effects on total lipids in the skin. 7. The medicament according to claim 1, wherein the cosmetic is used by topical application to the skin. 8. The method according to claim 1, wherein the cinnamic acid derivative is selected from mono- and polyhydroxycinnamic acids, alcohols, aldehydes, esters and derivatives thereof. The drug according to the above. 9. Cinnamic acid is 10% based on the total weight of the cosmetic.
The medicament according to any one of claims 1 to 8, wherein the medicament is used in an amount ranging from ^-6 % to 10%. 10. Cinnamic acid is 1 to the total weight of the cosmetic.
0 ^-3% to 5% of the employed in amounts ranging claims 1, characterized in that to the drug according to any one of 9. 11. The method according to claim 1, wherein the cinnamic acid is combined with at least one other product for stimulating lipogenesis. 12. The agent according to claim 1, wherein cinnamic acid is combined with at least one other product for stimulating collagen synthesis. 13. The medicament according to claim 11, wherein the other product for stimulating the synthesis of lipids and / or collagen is selected from plant hormones. 14. The drug according to claim 13, wherein the plant hormone is auxin. 15. An auxin comprising 3-indoleacetic acid (IAA), 4-chloro-3-indoleacetic acid (4-C
1-IAA), phenylacetic acid (PAA), 3-indolebutyric acid (IBA), 2,4-dichlorophenoxyacetic acid (2,4-D), α-naphthaleneacetic acid (α-NAA),
15. The medicament according to claim 14, characterized in that it is selected from [beta] -naphthoxyacetic acid, indoleethanol, indoleacetaldehyde and indoleacetonitrile. 16. The method according to claim 15, wherein the auxin is β-naphthoxyacetic acid. 17. The other product for stimulating lipogenesis is used in an amount of 10 ^-6 % to 10%, preferably 10 ^-3 % to 5%, based on the total weight of the cosmetic. The drug according to any one of claims 11 to 16, characterized in that: 18. A cosmetic composition for combating climacteric effects on skin lipids, comprising at least an effective amount of cinnamic acid or one of its derivatives in a cosmetically acceptable medium. 19. A cosmetic composition for reinforcing the barrier function of the skin, comprising at least an effective amount of cinnamic acid or one of its derivatives in a cosmetically acceptable medium. 20. A moisturizing cosmetic comprising at least an effective amount of cinnamic acid or one of its derivatives in a cosmetically acceptable medium. 21. A cosmetic composition for softening the skin, comprising at least an effective amount of cinnamic acid or one of its derivatives in a cosmetically acceptable medium. 22. A cosmetic for combating climacteric effects on the skin, comprising at least an effective amount of cinnamic acid or one of its derivatives in a cosmetically acceptable medium. 23. A cosmetic composition for stimulating the synthesis of total skin lipids, comprising at least an effective amount of cinnamic acid or one of its derivatives in a cosmetically acceptable medium.