JPH11246376A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for the oral cavity useful for preventing tooth decay, tartar and a foul breath, by formulating an abrasive material with a specific ratio of anethole and a polyhydric alcohol. SOLUTION: A pharmacologically acceptable zinc compound (e.g. zinc chloride, zinc citrate, zinc acetate or the like) is formulated with (B) preferably 0.01-1 wt.% of anethole, (C) a polyhydric alcohol (preferably sorbitol, xylitol, glycerol, a polyethylene glycol, maltitol, paratinose or the like) and preferably (D) 50-10,000 ppm calculated as fluorine of a fluoride (e.g. sodium fluoride, potassium fluoride or the like) to give the objective composition. The formulating ratio of the component B to the component C is 1:10 to 1:1,000 by weight. The composition can be in a dosage form such as a toothpaste, tooth powder, etc., and mixed with an abrasive material (e.g. silicic anhydride or the like) and a foaming agent (e.g. an anionic surfactant or the like), a preservative, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition containing a zinc compound for preventing dental caries, for preventing tartar and for preventing bad breath, which has improved astringency, bitterness and metallic taste of zinc, and has a good feeling in use. Oral compositions.

[0002]

2. Description of the Related Art Conventionally, it has been known that a zinc compound is added to an oral composition for the purpose of preventing bad breath and tartar. In addition, it is known that the zinc compound generally gives astringency, and JP-A-63-8324 discloses that the combined use of polyoxyethylene hydrogenated castor oil and l-menthol improves the astringency. Have been.

[0003]

However, the methods described so far do not have a sufficient effect of reducing astringency, and have the disadvantage that zinc has a bitterness and metallic taste unique to zinc, and the feeling of use is poor.

[0004]

Means for Solving the Problems The present inventors have conducted intensive studies in view of the above circumstances, and as a result, have found that a polyhydric alcohol and anethole can be contained in an oral composition containing a zinc compound at a certain ratio. It was surprisingly found that the metal taste of the zinc compound was unexpectedly improved by blending in the formula (1). An object of the present invention relates to an anti-caries, tartar-preventing, or bad breath-preventing oral composition containing zinc, which provides an oral composition having improved astringency, bitterness and metallic taste of zinc and a good feeling in use. Is to do.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The zinc compound used in the present invention is not particularly restricted but includes, for example, zinc chloride, zinc citrate,
Zinc acetate, zinc lactate, zinc salicylate, zinc sulfate, zinc stearate, zinc oxide, and the like can be used. These may be used alone or in combination of two or more.

[0006] The anethole used in the present invention may be of natural origin or synthetic.
1% by weight is preferred. If the amount is less than 0.01% by weight, no effect can be expected. If the amount is more than 1% by weight, the aroma of anethole is too strong to cause bitterness of the anethole itself, resulting in a good feeling of use when used. I can't get it.

The polyhydric alcohols include sorbitol, xylitol, glycerin and polyethylene glycol, maltitol, palatinose, etc.
One type or a combination of two or more types can be blended. The blending amount of the polyhydric alcohol is not particularly limited, but in the present invention, the ratio between anethole and the polyhydric alcohol is important, and the ratio is preferably from 1:10 to 1: 1000, particularly preferably from 1: 100 to 1: 1,000. 900 is preferred. Outside of that range, the effect of improving metal taste cannot be expected much,
If the amount of the polyhydric alcohol is too large, the burning sensation peculiar to the polyhydric alcohol at the time of use is so strong that the feeling of use is not preferable.

The fluoride used in the present invention includes sodium fluoride, potassium fluoride, ammonium fluoride, stannous fluoride, sodium monofluorophosphate and potassium monofluorophosphate. Sodium monofluorophosphate (more preferred fluorides and why) is more preferred.

[0009] The oral composition of the present invention is appropriately formulated according to its use, and toothpaste, powdered toothpaste, liquid dentifrice, liquid dentifrice, moisturizing dentifrice, gels, creams, pasta, It can be in the form of mouthwash, spray, foam and the like. Other components are not particularly limited, and include known active ingredients, abrasives, wetting agents, binders, foaming agents, preservatives, flavoring agents, pH adjusters, and the like within a range that does not impair the effects of the present invention. Can be blended.

For example, the following are examples of the active ingredient other than the fluoride. Amylase, protease,
Lysozyme, enzymes such as dextranase, sanguinarine, allantoin, aminobenzoic acid derivatives, hexetidine, chlorhexidine salts, triclosan, antiplaque agents and antibacterial agents such as cetylpyridinium chloride, vitamin B,
Examples include vitamins such as C and E, and potassium, lithium, and sodium nitrates.

Examples of the abrasive include silicic anhydride, alumina, aluminosilicate, calcium hydrogen phosphate, calcium carbonate, calcium phosphate, aluminum hydroxide and the like. Examples of the binder include carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, xanthan gum, carrageenan, and gum arabic.

Examples of the foaming agent include anionic, nonionic, cationic and amphoteric surfactants. Examples of the anionic surfactant include alkylsulfuric acid surfactants, amino acid surfactants, and sulfosuccinic acid surfactants. Surfactants.
Examples of the nonionic surfactant include a pluronic surfactant which is a polyoxyethylene polyoxypropylene copolymer and a fatty acid dialkanolamide surfactant.

Examples of the preservative include methyl paraben, propyl paraben, benzoate, sodium benzoate, paraoxybenzoate, titanium dioxide and the like. Flavoring agents include saccharin salt, dextrose, aspartame, xylitol, stevia extract, peppermint oil, spearmint oil, hatsuka oil, orange oil, menthol, and winter green oil.

[0014] pH adjusters include citric acid and its salts, phosphoric acid and its salts, malic acid and its salts, gluconic acid and its salts, maleic acid and its salts, aspartic acid and its salts, succinic acid and its salts , Glucuronic acid and its salts, fumaric acid and its salts, glutamic acid and its salts, adipic acid and its salts, hydrochloric acid, alkali metal hydroxide and the like.

Next, the present invention will be described in more detail with reference to Test Examples and Examples, but the present invention is not limited to these. All of the compounding amounts in the examples mean% by weight.

Test Examples Flavor Evaluation According to the amounts shown in Tables 1 and 2, a dentifrice containing a zinc compound, anethole and a polyhydric alcohol was prepared according to a conventional method, and the flavor was evaluated by sensory evaluation.
The results are shown in Tables 1 and 2.

[0017]

[Table 1]

[0018]

[Table 2]

Example 9 A toothpaste was prepared according to a conventional method according to the following formulation. The above dentifrices had a good feeling of use.

Example 10 A water dentifrice was prepared according to the following formulation according to a conventional method. The above water dentifrices had a good feeling of use.

Example 11 A mouthwash was prepared according to the following formulation according to a conventional method. The above mouthwash had a good feeling of use.

[0022]

The oral composition according to the present invention improves the metallic taste of zinc salt by blending a zinc compound with anethole and a polyhydric alcohol and further limiting the ratio of anethole to the polyhydric alcohol. Thus, it is possible to provide an oral composition having an excellent feeling in use.

Claims (4)

[Claims] An oral composition comprising a pharmaceutically acceptable zinc compound, anethole and a polyhydric alcohol,
The mixing ratio of anethole and polyhydric alcohol is 1:10 by weight.
１ ： 1: 1000. 2. The oral composition according to claim 1, wherein the content of said anethole is 0.01 to 1% by weight. 3. The method according to claim 2, wherein the polyhydric alcohol is sorbitol, xylitol, glycerin and polyethylene glycol.
1 selected from the group consisting of maltitol and palatinose
The oral composition according to claim 1, wherein the composition is at least one species. 4. A fluorine compound of 50 to 10 as fluorine.
000 ppm, further comprising:
The oral composition according to the above item.