JPH11335231A - Skin lotion for slimming body - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin lotion for a slimming a body capable of imparting a feeling of use with tensity in use and further imparting a high feeling of slimming effects in aspects of not only sensation and but also actual effects. SOLUTION: This lotion for a slimming a body is obtained by formulating a vegetable extract selected from a lavandula, an angustifolia, a lavender, Lavandula angustifolia pyrenaica, a spike lavender, a lavandin fennel, a sweet fennel, a rosemary, Bupleurum root, a tea, a cacao, a hop, a beefsteak plant, a scarlet sage, a kola and a plant of the genus Coffea, especially the rosemary or hop and a film-forming agent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin having an excellent slimming action, and in particular, gives a slimy feeling when used, and gives a high slimming effect sensationally and practically. And a skin external preparation for slimming.

[0002]

2. Description of the Related Art Conventionally, in order to reduce excess fat on the face and body and maintain a firm body, in addition to various exercises and dietary restrictions, gels that promote metabolism in the body, It is known to use cosmetics such as creams. It is well known that such cosmetics contain certain plant extracts or xanthine derivatives for the purpose of promoting lipolysis of fat cells constituting fat and having a slimming effect. It is a fact.

[0003] However, the conventional lipolysis compositions focus on searching for and blending the lipolysis-promoting substance, and do not consider the effect at the time of application or have a very weak effect. Met.

Accordingly, it is an object of the present invention to provide a skin external preparation for slimming which, when used, has a feeling of swelling on the skin, has a high tightening effect and has a slimming effect.

[0005]

Means for Solving the Problems The present inventors have conducted intensive studies to find a composition that promotes lipid decomposition of adipocytes and has a feeling of effect after application. It has been found that the combination of the present invention has a lipolysis accelerating action, and enhances both the lipolysis effect and the use effect with the realization of a tightening feeling after application, thereby completing the present invention.

[0006] That is, the present invention relates to Laundula, Angustifolia, Lavender, Laundula Angustifolia Pyrenica, Spike Lavender, Lavandin Fennel, Italian Fennel, Rosemary, Psycho, Tea, Cacao, Hop, Perilla, Salvia, Cora And an external preparation for slimming, comprising one or more plant extracts selected from Cofia and a cofia, and a film-forming agent.

Further, according to the present invention, there is provided an external preparation for slimming skin, which further comprises a xanthine derivative in addition to the above components.

Hereinafter, the configuration of the present invention will be described in detail. The plant extract used in the present invention, laundula, angstifolia, lavender, laundula angstifolia pyrenica, spike lavender, lavandin fennel, Italian fennel, rosemary, psycho, tea, cacao, hops, perilla, One or more selected from salvia, kora and cofia. Here, examples of the psycho include Mishima Psycho, Manshu Mishima Psycho, Dafrica Psycho, and the like.
Examples of the tea include green tea and oolong tea. Of these, lavender, lavandin fennel, Italian fennel, rosemary, and hop are preferred, and rosemary or hop is particularly preferred because of their excellent effects. These can be used alone or in combination of two or more.

These plants include flowers, stems, fruits, seeds,
Roots, whole plants, etc. are used. The extraction method is not particularly limited. For example, water, a hydrophilic organic solvent such as alcohol, or a mixture thereof, or glycerin,
It is extracted with a polyhydric alcohol such as 3-butylene glycol or a mixture of water and a polyhydric alcohol. As an extraction method, for example, the following method is used. Add 500 ml of 30V / V% ethanol solution to 500 g of plant pieces, extract at 50 ° C. for 60 minutes, cool,
Filter naturally with filter paper and concentrate if necessary.

The amount of the above-mentioned plant extract in the external preparation for skin is 0.001 to 30.0% by weight, preferably 0.01 to 10.0% by weight in terms of dry matter. If the amount of the extract is less than 0.001% by weight, a sufficient lipolytic effect cannot be obtained, and if the amount exceeds 30.0% by weight, the lipolytic effect is not enhanced.

[0011] The coating agent used in the present invention, after coating,
A substance that forms a thin film on the skin and gives a sense of firmness.
For example, polyvinyl alcohol, an alkyl methacrylate copolymer, a carboxyvinyl polymer, a vinylpyrrolidone-alkene copolymer, preferably a vinylpyrrolidone-eicosene copolymer, and R ₃ SiO _1/2 units, R ₂ SiO units, and RSiO An average molecular weight of 1500 or more, which is composed of one or more siloxane units selected from organosiloxane units in the group consisting of _3/2 units and SiO ₂ units and satisfies the average formula: R _n SiO _{(4-n) / 2}
And an organopolysiloxane having a molecular weight of 10,000 or less (wherein, R represents a hydrocarbon group having a carbon number of 1 or more and 6 or less, and n represents a value of 1.0 or more and 1.8 or less). .

In the case of a water-soluble coating agent, the amount of the coating agent in the external preparation for skin is preferably 0.01% by weight or more, particularly preferably 0.05 to 0.5% by weight. In the case of a water-insoluble coating agent, the content is preferably 0.1% by weight or more, particularly preferably 1.0 to 10.0% by weight. If the blending amount of the filming agent is too small, the effect of giving a peel to the skin is low, and if it is too large, the feeling of filming becomes too strong and the feeling of use is impaired.

In the present invention, the slimming effect can be further enhanced by further blending a xanthine derivative in addition to one or more of the above-mentioned plant extracts and a film-forming agent. As the xanthine derivative used in the present invention,
For example, caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, diprofylline, proxyphylline, oxtriphylline and the like can be mentioned. These can be used alone or in combination of two or more. In the present invention, it is desirable to use one or a combination of two or more selected from the group consisting of caffeine, aminophylline and theophylline.

The amount of the xanthine derivative in the external preparation for skin is preferably 0.001% by weight or more, more preferably 0.01 to 10.0% by weight.

The external preparation for skin of the present invention can contain various components generally used in cosmetics, pharmaceuticals and the like, if necessary, as long as the effects of the present invention are not impaired. Such components include the following.

Vitamin A such as vitamin oil, retinol, retinol acetate, riboflavin, riboflavin butyrate,
Vitamin B2 such as flavin adenine nucleotide, vitamin B6 such as pyridoxine hydrochloride and pyridoxine dioctanoate, L-ascorbic acid, L-ascorbic acid dipalmitate, L-ascorbic acid-2
-Vitamin Cs such as sodium sulfate, L-ascorbic acid phosphate, DL-α-tocopherol-L-ascorbic acid diester dipotassium, calcium pantothenate, D-pantothenyl alcohol, pantothenyl ethyl ether, acetyl pantothenyl Pantothenic acids such as ethyl ether, ergocalciferol,
Vitamin Ds such as cholecalciferol, nicotinic acid,
Nicotinic acids such as nicotinamide and benzyl nicotinate; vitamin Es such as α-tocopherol, tocopherol acetate, DL-α-tocopherol nicotinate, and DL-α-tocopherol succinate; and vitamins such as vitamin P and biotin. Can be

Liquid oils and fats include avocado oil, camellia oil, evening primrose oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil,
Castor oil, linseed oil, safflower oil, cottonseed oil, eno oil,
Soybean oil, peanut oil, teaseed oil, kaya oil, rice bran oil, cinnamon oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin, trioctanoic acid glycerin, triisopalmitic acid glycerin, etc. Fat, coconut oil, horse fat, hardened coconut oil, palm oil, tallow, sheep butter, hardened beef tallow, palm kernel oil, lard, beef tallow, moku kernel oil, hardened oil, beef tallow, mokuro, hardened castor oil Examples of waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ibotaro wax, whale wax, montan wax, nuka wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugar cane wax, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin , Jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether Examples of POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, etc., and hydrocarbon oils such as liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, etc. Oils.

The higher fatty acids include, for example, lauric acid, myristic acid, palmitic acid, stearic acid, behenic (behenic) acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tallic acid, isostearic acid, linoleic acid, linoleic acid. Acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and the like.

As the higher alcohol, for example, linear alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, monostearyl glycerin ether (bacyl alcohol), and 2-decyltetradecyl alcohol And branched-chain alcohols such as knol, lanolin alcohol, cholesterol, phytosterol, hexyldecanol, isostearyl alcohol, octyldodecanol, and the like.

Examples of synthetic ester oils include isopropyl myristate, cetyl octoate, octyl dodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate,
Decyl oleate, hexyl decyl dimethyl octoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate,
Cholesteryl 2-hydroxystearate, ethylene glycol di-2-ethylhexylate, fatty acid ester of dipentaerythritol, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, diisostearyl malate, glycerin di-2-heptylundecanoate Trimethylolpropane tri-2-ethylhexylate, trimethylolpropane triisostearate, pentaneerythritol tetra-2-ethylhexylate, glycerin tri-2-ethylhexylate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimmyristate, tri-2-
Heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleic oil, cetostearyl alcohol, acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, adipic acid Di-2-heptylundecyl, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate , Ethyl acetate, butyl acetate, amyl acetate, triethyl citrate and the like.

Examples of the silicone include linear polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane, decamethylcyclopolysiloxane, dodecamethylcyclopolysiloxane, and tetramethyltetrahydrogencyclopolysiloxane. Cyclic polysiloxane, silicone rubber, trimethylsiloxysilicate-octamethylcyclotetrasiloxane solution (50%), and the like.

Examples of the humectant include polyethylene glycol, propylene glycol, glycerin, 1,3-
Butylene glycol, hexylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile salts, dl-pyrrolidone carboxylate, Short-chain soluble collagen, adducts of diglycerin (EO) PO, extract of Iris osseum, extract of Achillea millefolium, extract of melilot and the like can be mentioned.

Examples of the ultraviolet absorber include para-aminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester
Benzoic acid ultraviolet absorbers such as N-dimethyl PABA ethyl ester and N, N-dimethyl PABA butyl ester; anthranilic acid ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; amyl salicylate;
Salicylic acid ultraviolet absorbers such as menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate , Ethyl-2,
4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl-p-methoxycinnamate (2- Ethylhexyl-p
-Methoxycinnamate), 2-ethoxyethyl-p-
Methoxy cinnamate, cyclohexyl-p-methoxy cinnamate, ethyl-α-cyano-β-phenyl cinnamate, 2-ethylhexyl-α-cyano-β-phenyl cinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxy Cinnamate, cinnamic acid-based ultraviolet absorbers such as 3,4,5-trimethoxycinnamate 3-methyl-4- [methylbis (trimethylsiloxy) silyl] butyl and the like, 2,4-dihydroxybenzophenone, 2,2 ′
-Dihydroxy-4-methoxybenzophenone, 2,
2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4′-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4′-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n
Benzophenone-based ultraviolet absorbers such as -octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, 3- (4'-methylbenzylidene) -d, 1-camphor, 3-benzylidene-d, 1-camphor, urocanic acid, Urocanic acid ethyl ester, 2-phenyl-5-methylbenzoxazole, 2,2′-hydroxy-5-methylphenylbenzotriazole, 2- (2 ′
-Hydroxy-5'-t-octylphenyl) benzotriazole, 2- (2'-hydroxy-5'-methylphenylbenzotriazole, dibenzarazine, dianisoylmethane, 4-methoxy-4'-t-butyldibenzoylmethane, 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one and the like.

Examples of the anionic surfactant include soap base, fatty acid soaps such as sodium laurate and sodium palmitate, higher alkyl sulfates such as sodium lauryl sulfate and potassium lauryl sulfate, POE lauryl sulfate triethanolamine, PO
E Alkyl ether sulfates such as sodium lauryl sulfate; N-acyl sarcosine acids such as sodium lauroyl sarcosine; sodium N-myristoyl-N-methyltaurine; higher fatty acids such as sodium coconut oil methyl tauride and sodium lauryl methyl tauride. Amidosulfonic acid salts, phosphate salts such as POE sodium oleyl ether phosphate, POE stearyl ether phosphoric acid, sodium di-2-ethylhexylsulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, lauryl polypropylene glycol sulfosuccinate Sulfosuccinates such as sodium, sodium linear dodecylbenzenesulfonate, triethanolamine linear dodecylbenzenesulfonate Alkylbenzenesulfonates such as linear dodecylbenzenesulfonic acid, monosodium N-lauroylglutamate, disodium N-stearoylglutamate, N-acylglutamate such as monosodium N-myristoyl-L-glutamate, and hydrogenated coconut oil fatty acid sodium glycerin sulfate Sulphate oils such as funnel oils, sulfated oils such as funnel oils, PO
E alkyl ether carboxylic acid, POE alkyl allyl ether carboxylate, α-olefin sulfonate,
Higher fatty acid ester sulfonate, secondary alcohol sulfate, higher fatty acid alkylolamide sulfate, sodium lauroyl monoethanolamidosuccinate, N-palmitoyl aspartate ditriethanolamine, sodium caseinate and the like.

Examples of the cationic surfactant include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride and lauryltrimethylammonium chloride, distearyldimethylammonium dialkyldimethylammonium salt, and poly (N, N'-dimethyl-3, Alkylpyridinium salts such as 5-methylenepiperidinium) and cetylpyridinium chloride, alkyl quaternary ammonium salts, alkyldimethylbenzylammonium salts, alkylisoquinolinium salts, dialkylmorphonium salts, POE alkylamines, alkylamine salts, Examples thereof include polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride, benzethonium chloride and the like.

Examples of the amphoteric surfactant include 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium and 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyl. Imidazoline surfactants such as roxy disodium salt, 2-heptadecyl-N-carboxymethyl-N-
Betaine-based surfactants such as hydroxyethylimidazolinium betaine, lauryl dimethylaminoacetate betaine, alkyl betaine, amido betaine, and sulfobetaine.

Examples of the lipophilic nonionic surfactant include sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, Sorbitan fatty acid esters such as penta-2-ethylhexyl diglycerol sorbitan, tetra-2-ethylhexyl diglycerol sorbitan, mono-cottonseed oil fatty acid glycerin, glycerin monoerucate, glycerin sesquioleate, glyceryl monostearate, α,
Glycerin polyglycerin fatty acids such as α'-oleic acid glycerol pyroglutamate, glyceryl monostearate, propylene glycol fatty acid esters such as propylene glycol monostearate, hydrogenated castor oil derivatives, glycerin alkyl ether, polyoxyethylene methyl And polysiloxane copolymers.

Examples of the hydrophilic nonionic surfactant include POE such as POE sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate and the like.
Sorbitan fatty acid esters, POE-sorbit monolaurate, POE-sorbit monooleate, PO
POE sorbitol fatty acid esters such as E-sorbit pentaoleate and POE-sorbit monostearate; POE glycerin fatty acid esters such as POE-glycerin monostearate, POE-glycerin monoisostearate and POE-glycerin triisostearate , POE monooleate, POE distearate,
POE fatty acid esters such as POE monodioleate and ethylene glycol cysteate, POE lauryl ether, POE oleyl ether, POE stearyl ether, POE behenyl ether, POE alkyl ethers such as POE2-octyldodecyl ether, POE cholestanol ether, POE octyl POE alkyl phenyl ethers such as phenyl ether, POE nonyl phenyl ether, and POE dinonyl phenyl ether; pluronic type such as pluronic;
POE / POP alkyl ethers such as POP cetyl ether, POE / POP2-decyltetradecyl ether, POE / POP monobutyl ether, POE / POP hydrogenated lanolin, POE / POP glycerin ether, and tetraPOE / tetraPOP ethylenediamine such as Tetronic Condensates, POE castor oil, POE hardened castor oil, POE hardened castor oil monoisostearate,
POE-cured castor oil triisostearate, POE-cured castor oil monopyroglutamic acid monoisostearate diester, POE-casted oil-cured castor oil derivatives such as POE-cured castor oil maleic acid, POE beeswax lanolin derivatives such as POE sorbitol beeswax, coconut oil Fatty acid diethanolamide, lauric acid monoethanolamide,
Alkanolamides such as fatty acid isopropanolamide, POE propylene glycol fatty acid ester, PO
E alkylamine, POE fatty acid amide, sucrose fatty acid ester, POE nonylphenylformaldehyde condensate, alkylethoxydimethylamine oxide, trioleyl phosphoric acid and the like.

As amino acids, glycine, alanine,
Valine, leucine, isoleucine, phenylalanine,
Examples include tyrosine, threonine, serine, proline, hydroxyproline, tryptophan, methionine, cystine, aspartic acid, glutamic acid, glutamine, lysine, arginine, histidine and the like.

In addition, preservatives such as ethyl paraben and butyl paraben, anti-inflammatory agents such as glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, whitening agents such as placenta extract, glutathione, and yukinoshita extract, Oubak, Ouren,
Chicken, peonies, assembly, birch, sage, loquat, carrot, aloe, mallow, iris, grape, yokuinin, loofah, lily, saffron, senkyu, ginger, chrysanthemum, ononis, garlic, capsicum, chimpi, touki, seaweed, etc. Extract, royal jelly, photosensitizer, cholesterol derivative, activator such as juvenile blood extract, nonylate valenylamide, nicotinic acid benzyl ester, nicotinic acid β-butoxyethyl ester, capsaicin, zingerone, canthalis tincture, ictamol, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, cyclandate, cinnarizine, tolazoline,
There are blood circulation promoters such as acetylcholine, verapamil, cepharanthin, γ-oryzanol, antiseborrheic agents such as sulfur and thiantol, tranexamic acid, trimethylglycine, thiotaurine and hypotaurine.

Examples of natural water-soluble polymers include, for example, gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (quince), alge colloid (cassow extract), starch (rice, corn) , Potato, wheat), plant macromolecules such as glycyrrhizic acid, microbial macromolecules such as xanthan gum, dextran, succinoglucan, pullulan, collagen,
Animal-based polymers such as casein, albumin, and gelatin are exemplified.

As the semi-synthetic water-soluble polymer, for example,
Starch-based polymers such as carboxymethyl starch and methylhydroxypropyl starch, methylcellulose, nitrocellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, cellulose sodium sulfate, hydroxypropylcellulose, sodium carboxymethylcellulose (CM
C), cellulosic polymers such as crystalline cellulose and cellulose powder, and alginic acid polymers such as sodium alginate and propylene glycol alginate.

Examples of the synthetic water-soluble polymer include vinyl polymers such as polyvinyl methyl ether and polyvinyl pyrrolidone, and polyethylene glycols 2,000, 4,000,
Polyoxyethylene polymers such as 6,000, copolymer polymers such as polyoxyethylene polyoxypropylene copolymer, acrylic polymers such as sodium polyacrylate, polyethyl acrylate, polyacrylamide, polyethylene imine, and cationic polymer And the like.

Examples of the inorganic water-soluble polymer include bentonite, AlMg silicate (Vegum), laponite, hectorite, and silicic anhydride.

Examples of the thickener include gum arabic, carrageenan, karaya gum, tragacanth gum, carob gum, quince seed (quince), casein, dextrin, gelatin, sodium pectate, sodium alginate, methylcellulose, ethylcellulose, C
MC, hydroxyethylcellulose, hydroxypropylcellulose, PVA, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, dialkyldimethylammonium cellulose sulfate, xanthan gum, aluminum magnesium silicate, bentonite,
Hectorite and the like.

The powder components include talc, kaolin, mica, sericite (sericite), muscovite, phlogopite, synthetic mica, mica, biotite, litthic mica, vermiculite,
Magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, zeolite, barium sulfate, calcined calcium sulfate (calcium gypsum), calcium phosphate, Fluoroapatite, hydroxyapatite, ceramic powder, metal soap (zinc myristate, calcium palmitate, aluminum stearate), inorganic powder such as boron nitride, polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene Powders, organic resin powders such as copolymer resin powder of styrene and acrylic acid, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, and inorganic white such as titanium dioxide and zinc oxide Fee, iron oxide (red iron oxide),
Inorganic red pigments such as iron titanate, inorganic brown pigments such as γ-iron oxide, inorganic yellow pigments such as yellow iron oxide and loess, and inorganic black pigments such as black iron oxide, carbon black and lower titanium oxide , Inorganic violet pigments such as chromium oxide, chromium hydroxide, cobalt titanate, etc., inorganic blue pigments such as ultramarine blue, navy blue, etc., titanium oxide coated mica, titanium oxide coated oxychloride Bismuth, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, pearl pigments such as fish scale foil, aluminum powder,
Metal powder pigments such as copper powder, Red No. 201, Red 2
02, Red 204, Red 205, Red 220, Red 226,
Red 228, Red 405, Orange 203, Orange 204, Yellow 20
Organic pigments such as No. 5, Yellow 401, Blue No. 404, Red No. 3,
Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 40
No. 1, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 2
Organic pigments such as zirconium, barium or aluminum lake such as 02, yellow 203, green 3 and blue 1, natural pigments such as chlorophyll, riboflavin, crocin, anthraquinone, β-carotene, fragrance, water, alcohol, Coloring agents such as titanium yellow, carthamine, and safflower red can be appropriately compounded as needed.

The dosage form of the external preparation for skin of the present invention is arbitrary, for example, an oily preparation, a solubilizing system for a lotion, an emulsifying system such as an emulsion or a cream, or a gel, paste, pack, or the like.
It can be in the form of plaster, sheet, ointment, dispersion, powder and the like.

[0038]

Next, the present invention will be described in more detail by way of examples. Note that the present invention is not limited by these examples. The compounding amount is% by weight. Prior to the examples, the effects of the present invention will be shown by experimental data.

1. Preparation of rosemary extract and hop extract Each plant extract was prepared by adding 500 g of water to 500 g of each plant shred.
After adding 00 ml, the mixture was extracted at 50 ° C. for 60 minutes, cooled, filtered naturally by a filter paper, and the obtained filtrate was freeze-dried, and water was added to prepare an extract of 10.0% by weight in terms of dry matter. .

Experimental Example 1 Lipolytic Effect [Evaluation Method] Isolation of fat cells from adipose tissue was performed using Rodbel.
According to the method of l (M. Rodbell, JBC, 239 (2), 1964). Human adipose tissue obtained by liposuction is 2-3 mm
And incubated in a 0.05% collagenase solution (Banks buffer, containing 4% glucose) (37 ° C., 45-60 minutes). Thereafter, the mixture was filtered to remove undigested adipose tissue, and centrifuged (1000 rpm).
m, 1 minute). Adipocytes have a specific gravity of less than 1 and float on top. The lower layer solution was removed, and the culture solution (199 medium, 1 medium) was removed.
Contains 0% newborn calf serum. ) Was added and redispersed. Centrifugation and medium addition were repeated twice to remove collagenase. Finally, 30 ml of the medium described in Table 1 was added, and the cells were dispersed. In each sample, the xanthine derivative was 0.2% by weight and the total concentration of the plant extract was 0.1%.
1% by weight. The lipid content of the adipocytes before and after the culture was quantified using Triglyceride-Test Wako (Wako Pure Chemical Industries, Ltd.) (color reagent for lipid determination) to determine the amount of degraded lipid (mg / tube). Table 1 shows the experimental results.

[0041]

[Table 1] ─────────────────────────── Sample amount of decomposed lipid (mg / tube) ────────── ───────────────── Not added 0.32 ± 0.08 Caffeine 1.75 ± 0.15 Rosemary extract 0.72 ± 0.12 Rosemary extract + caffeine 2.59 ± 0.19 Hop extract 0.66 ± 0.11 Hop extract + caffeine 2.55 ± 0.20 Hop extract + rosemary extract 1.62 ± 0.13 ───────────────────────────

From Table 1, it can be seen that the plant extract and the xanthine derivative promote lipid decomposition.

Example 1 Cream (1) cetostearyl alcohol 3.5% by weight (2) squalane 40.0 (3) beeswax 3.0 (4) reduced lanolin 5.0 (5) ethylparaben 0.3 (6 ) Polyoxyethylene (20) sorbitan monopalmitate 2.0 (7) monoglyceride stearate 2.0 (8) sodium N-stearoyl glutamate 0.5 (9) 2-hydroxy-4-methoxybenzophenone 1.0 ( 10) Retinol acetate 2.0 (11) Evening primrose oil 0.05 (12) Fragrance 0.05 (13) Organopolysiloxane 3.0 (general formula R_nSiO_{(4-n) / 2}And R = CH_Three, N = 1.33, (CH_Three)_ThreeSiO_1/2Unit / SiO _Two (14) Rosemary extract 5.0 (15) Fennel extract 1.0 (16) Caffeine 0.1 (17) Green tea extract 3.0 (18) ) Sodium hexametaphosphate 0.02 (19) 1,3-butylene glycol 0.1 (20) Purified water Residue
500 ml of 30V / V% ethanol solution was added to
Extracted at 60 ° C for 60 minutes, cooled, and filtered naturally through filter paper.
After freeze-drying the obtained filtrate, 30V / V% ethanol solution
To prepare an extract of 10.0% by weight in terms of dry matter.
Was. (1) to (13) were dissolved by heating and heated to 70 ° C.
4) Add to (20) with stirring. Homomixer treatment
After finely emulsified particles, quench with stirring and cool.
Got a ream.

Experimental Example 2 Lipid Metabolism Promoting Effect [Evaluation Method] Ninety women in their twenties and thirties applied the cream of Example 1 on the face and whole body in the morning and evening, and were continuously used for three months. The body fat ratio (the ratio of fat to the whole body) before and after continuous use was measured by a measuring device (body fat meter BFT-2000, manufactured by Kett Kagaku) based on the principle of light reflection at an outside infrared wavelength. A control group was obtained by removing caffeine and a plant extract from 40 of 90 persons, and the average value of each body fat percentage was determined. Table 2 shows the results.

[0045]

[Table 2]

As is evident from the above results, when the product of the present invention, Example 1, was used, the body fat percentage was significantly reduced as compared with the control group.

Example 2 Lotion (1) Rosemary extract 0.5% by weight (2) Hop extract 0.5 (3) Theophylline 0.1 (4) Glycerin 4.0 (5) 1,3- Butylene glycol 4.0 (6) Tocopherol acetate 0.05 (7) Ethanol 7.0 (8) Polyvinyl alcohol 0.2 (9) Polyoxyethylene (18) Oleyl alcohol ether 0.5 (10) Methyl paraben 0 2 (11) Citric acid 0.05 (12) Sodium citrate 0.1 (13) Trisodium ethylenediaminetetraacetate 0.02 (14) Fragrance 0.05 (15) Purified water residue (Production method) , 500g of each plant shred
Was added at 500 ° C., extracted at 50 ° C. for 60 minutes, cooled, filtered naturally through filter paper, and the obtained filtrate was freeze-dried.
Water was added to prepare an extract of 10.0% by weight in terms of dry matter. Add (1)-(5), (11)-(13) to (15),
Dissolves (aqueous phase). (7) to (8) to (10),
(6) and (14) were added and dissolved, and this was added to the above-mentioned aqueous phase to solubilize and filtered to obtain a lotion.

Comparative Example 1 Lotion A lotion was prepared in the same manner as in Example 2 except that polyvinyl alcohol was replaced with purified water.

Example 3 Emulsion (1) Stearic acid 1.5% by weight (2) Cetyl alcohol 0.5 (3) Beeswax 2.0 (4) Polyoxyethylene (10) Monooleate 1.0 (5 ) Octyl methoxycinnamate 2.0 (6) Vinylpyrrolidone-eicosene copolymer 1.0 (7) Lavandin extract 0.2 (8) Italian Fennel extract 0.5 (9) Sodium hyaluronate 0.01 (10) Triethanolamine 0.75 (11) Glycerin 7.0 (12) Inosit 0.5 (13) Ginseng extract 0.5 (14) Caffeine 0.2 (15) Sodium ethylenediaminehydroxytriacetate 0.01 (16) Ethylparaben 0.3 (17) Fragrance 0.03 (18) Purified water residue (Preparation method) Plant extract is 500 g of each plant.
Was added at 500 ° C., extracted at 50 ° C. for 60 minutes, cooled, filtered naturally through filter paper, and the obtained filtrate was freeze-dried.
Water was added to prepare an extract of 10.0% by weight in terms of dry matter. (7) to (15) are added to (18) and the temperature is maintained at 70 ° C. (aqueous phase). The other components are mixed, dissolved by heating and kept at 70 ° C. (oil phase). Preliminary emulsification is performed by adding the oil phase to the water phase, and the mixture is uniformly emulsified with a homomixer. Thereafter, the mixture was rapidly cooled while stirring to obtain an emulsion.

Comparative Example 2 Emulsion An emulsion was prepared in the same manner as in Example 3 except that the vinylpyrrolidone / eicosene copolymer was replaced with purified water.

Example 4 Foam Pack (1) Spike Lavender Extract 0.1% by Weight (2) Fennel Extract 1.0 (3) Aminophylline 0.2 (4) Sodium Metaphosphate 0.02 (5) 1 , 3-butylene glycol 5.0 (6) glycerin 7.0 (7) methyl paraben 0.1 (8) potassium hydroxide 0.15 (9) polyvinyl alcohol 0.1 (10) stearic acid 0.5 (11) Myristic acid 1.0 (12) Bacyl alcohol 1.5 (13) Polyoxyethylene (60) hydrogenated castor oil 3.0 (14) Fragrance 0.05 (15) Liquefied petroleum gas 6.0 (16) Dimethyl ether 3. 0 (17) Purified water residue (Preparation method) Plant extract is 500 g of shredded plant
500 ml of 1,3-butylene glycol solution was added to
The mixture was extracted at 50 ° C. for 60 minutes, cooled, filtered naturally with a filter paper, and the obtained filtrate was freeze-dried, and a 1,3-butylene glycol solution was added. Prepared. Add (1) to (9) to (17) and heat and dissolve at 70 ° C. Add (10) to (14) heated and stirred at 75 ° C, stir well, then cool. . This was filled in a container, and finally (15) and (16) were filled as a propellant to obtain a foam pack.

Comparative Example 3 Foam Pack A foam pack was prepared in the same manner as in Example 4 except that polyvinyl alcohol was replaced with purified water.

Example 5 Ointment (1) Angstifolia extract 10.0% by weight (2) Hop extract 1.0 (3) Caffeine 0.2 (4) Trimethylglycine 0.2 (5) Ethylenediaminehydroxy Sodium triacetate 0.01 (6) Polyvinyl alcohol 0.2 (7) Retinol palmitate 0.5 (8) Stearyl alcohol 18.0 (9) Mokurou 20.0 (10) Polyoxyethylene (20) Monooleic acid Ester 0.25 (11) Glycerin monostearate 0.3 (12) Vaseline 40.0 (13) Organopolysiloxane 2.0 (14) Purified water Residue (Production method) Cut 500g
Was added at 500 ° C., extracted at 50 ° C. for 60 minutes, cooled, filtered naturally through filter paper, and the obtained filtrate was freeze-dried.
Water was added to prepare an extract of 10.0% by weight in terms of dry matter. (1) to (6) are added to (14) and dissolved, and the mixture is maintained at 70 ° C (aqueous phase). The remaining components (7) to (13) are mixed and dissolved at 70 ° C. (oil phase). The oil phase was added to the aqueous phase, and the mixture was uniformly emulsified with a homomixer and then cooled to obtain an ointment.

Example 6 Emulsion for Massage (1) 1.5% by weight of stearic acid (2) Cetyl alcohol 0.5 (3) Polyoxyethylene (10) Monooleate 1.0 (4) Vaseline 3.0 (5) Squalane 10.0 (6) Liquid paraffin 5.0 (7) Organopolysiloxane 3.0 (general formula R_nSiO_{(4-n) / 2}And R = CH_Three, N = 1.33, (CH_Three)_ThreeSiO_1/2Unit / SiO _Two (8) glycerin 7.0 (9) 1,3-butylene glycol 5.0 (10) triethanolamine 0.75 (11) Lauandula angsifolia pyrenaica Extract 0.05 (12) Italian Fennel extract 1.0 (13) Caffeine 3.0 (14) Theophylline 2.0 (15) Sodium metaphosphate 0.02 (16) Sodium ethylenediaminehydroxy triacetate 0.01 (17) Ethylparaben 0.25 (18) Fragrance 0.02 (19) Purified water residue
500 ml of water, extract at 50 ° C for 60 minutes, cool
After that, the mixture was naturally filtered through filter paper, and the obtained filtrate was freeze-dried.
Add water to prepare an extract of 10.0% by weight in terms of dry matter
did. Add (8) to (16) to (19) and keep at 70 ° C
(Aqueous phase). Mix other ingredients, heat and dissolve and keep at 70 ° C
(Oil phase). Preliminary emulsification is performed by adding the oil phase to the aqueous phase,
Emulsify uniformly with a mixer. Then quench with stirring
To obtain a milky lotion for massage.

Example 7 Massage Gel (1) Caffeine 2.0% by weight (2) Rosemary Extract 5.0 (3) Hop Extract 3.0 (4) Glycerin 50.0 (5) Trimethylglycine 0.2 (6) Carboxyvinyl polymer 0.4 (7) Polyethylene glycol 400 30.0 (8) Sodium ethylenediaminehydroxy triacetate 0.1 (9) Polyvinyl alcohol 0.1 (10) Polyoxyethylene (10) methyl Polysiloxane copolymer 2.0 (11) Squalane 1.0 (12) Fragrance 0.12 (13) Potassium hydroxide 0.15 (14) Purified water residue (Production method) Cut 500g
500 ml of a 20 V / V% methanol solution was added to
Extracted at 60 ° C. for 60 minutes, cooled, filtered naturally by filter paper, freeze-dried the obtained filtrate, and added a 20 V / V% methanol solution to prepare an extract of 10.0% by weight in terms of dry matter. . Dissolve (1) to (9) in (14). Separately (10) ~
After adding the mixture of (12), add (13),
A massage gel was obtained.

Example 8 Serum (1) Rosemary extract 10.0% by weight (2) Lavender extract 10.0 (3) Tranexamic acid 1.0 (4) Caffeine 0.1 (5) L- Arginine L-aspartate 0.1 (6) Sodium hyaluronate 0.01 (7) Glycerin 10.0 (8) 1,3-butylene glycol 5.0 (9) Carboxyvinyl polymer 0.3 (10) Ethylenediamine Sodium hydroxytriacetate 0.01 (11) Ethanol 7.0 (12) Vinylpyrrolidone-eicosene copolymer 2.0 (13) Polyoxyethylene (18) Oleyl alcohol ether 0.8 (14) Macadamia nut oil 0.1 (15) Evening primrose oil 0.01 (16) Tocopherol acetate 0.01 (17) Methyl paraben 0.15 (18) Fragrance 0.1 (19) Potassium hydroxide 0.08 (20) Purified water Residue (Preparation method) Plant extract is 500 g of shredded plant
Was added at 500 ° C., extracted at 50 ° C. for 60 minutes, cooled, filtered naturally through filter paper, and the obtained filtrate was freeze-dried.
Water was added to prepare an extract of 10.0% by weight in terms of dry matter. Dissolve (1) to (10) in (20) and add (12) to (11) in (11). Then (1
9) was added to obtain a serum.

Experimental Example 3 Actual feeling of tightening effect at the time of application [Evaluation method]
The cosmetics obtained in Comparative Examples 1 to 3 were used, and the tightness was evaluated according to the following criteria. Table 3 shows the results.

Evaluation criteria A: Out of 30 persons, 24 or more persons answered that there was a sense of tightness. ：: Of the 30 people, 18 or more and less than 24 answered that they felt tight. Δ: Of the 30 people, 12 or more and less than 18 answered that there was a sense of tightening. ×: Out of 30, 6 or more and less than 12 answered that there was a sense of tightening.

[0059]

[Table 3]

As is clear from the above results, it was revealed that the cosmetics of Examples 2 to 8, which are the products of the present invention, are excellent in tightness at the time of application.

[0061]

As described above, the external preparation for slimming skin of the present invention has an excellent effect of accelerating the decomposition of lipids and has a high tightening effect when applied.

──────────────────────────────────────────────────の Continued on front page (51) Int.Cl. ⁶ Identification code FI A61K 35/78 ACN A61K 35/78 ACNC

Claims (4)

[Claims] 1. From Laundula, Angustifolia, Lavender, Laundula Angsifolia Pyreneica, Spike Lavender, Lavandin Fennel, Italian Fennel, Rosemary, Psycho, Tea, Cacao, Hops, Perilla, Salvia, Cola and Kofia An external preparation for slimming skin, comprising one or more selected plant extracts and a film-forming agent. 2. The external preparation for slimming skin according to claim 1, wherein the plant extract is rosemary or hop. 3. A coating agent comprising polyvinyl alcohol, an alkyl methacrylate copolymer, a carboxyvinyl polymer, a vinylpyrrolidone-alkene copolymer or an average formula: R _n SiO _{(4-n) / 2} (wherein R represents a hydrocarbon group having 1 or more and 6 or less carbon atoms, and n represents 1.0 or more and 1.
8 or less. Average molecular weight satisfying 1500)
Not less than 10,000 and R ₃ SiO _1/2 unit, R ₂ Si
O unit, slimming skin external preparation according to claim 1, wherein the organopolysiloxane consisting of one or two or more siloxane units selected from the organosiloxane units of the group consisting of RSiO _3/2 units and SiO ₂ units. 4. The external preparation for slimming skin according to claim 1, further comprising a xanthine derivative.