JPH11506770A - アダプタプロテイン／チロシンキナーゼ相互作用を阻害するための方法および組成物 - Google Patents
アダプタプロテイン／チロシンキナーゼ相互作用を阻害するための方法および組成物Info
- Publication number
- JPH11506770A JPH11506770A JP9501241A JP50124197A JPH11506770A JP H11506770 A JPH11506770 A JP H11506770A JP 9501241 A JP9501241 A JP 9501241A JP 50124197 A JP50124197 A JP 50124197A JP H11506770 A JPH11506770 A JP H11506770A
- Authority
- JP
- Japan
- Prior art keywords
- quinoline
- dihydroxy
- methylbut
- indol
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47613695A | 1995-06-07 | 1995-06-07 | |
| US476,136 | 1995-06-07 | ||
| PCT/US1996/008741 WO1996040115A1 (en) | 1995-06-07 | 1996-06-05 | Method and compositions for inhibition of adaptor protein/tyrosine kinase interactions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH11506770A true JPH11506770A (ja) | 1999-06-15 |
| JPH11506770A5 JPH11506770A5 (2) | 2004-07-22 |
Family
ID=23890650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9501241A Ceased JPH11506770A (ja) | 1995-06-07 | 1996-06-05 | アダプタプロテイン／チロシンキナーゼ相互作用を阻害するための方法および組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US5780496A (2) |
| EP (1) | EP0831809A4 (2) |
| JP (1) | JPH11506770A (2) |
| KR (1) | KR19990022369A (2) |
| CN (1) | CN1192680A (2) |
| AR (1) | AR003140A1 (2) |
| BR (1) | BR9609353A (2) |
| CA (1) | CA2224103A1 (2) |
| IL (1) | IL122427A0 (2) |
| MX (1) | MX9709442A (2) |
| WO (1) | WO1996040115A1 (2) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5593852A (en) * | 1993-12-02 | 1997-01-14 | Heller; Adam | Subcutaneous glucose electrode |
| CA2050057A1 (en) | 1991-03-04 | 1992-09-05 | Adam Heller | Interferant eliminating biosensors |
| US6376529B1 (en) | 1995-06-07 | 2002-04-23 | Peng Cho Tang | Mono- and bis-indolylquinones and prophylactic and therapeutic uses thereof |
| US5786488A (en) * | 1996-11-13 | 1998-07-28 | Sugen, Inc. | Synthetic methods for the preparation of indolyquinones |
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-
1996
- 1996-06-05 KR KR1019970708849A patent/KR19990022369A/ko not_active Withdrawn
- 1996-06-05 IL IL12242796A patent/IL122427A0/xx unknown
- 1996-06-05 WO PCT/US1996/008741 patent/WO1996040115A1/en not_active Ceased
- 1996-06-05 CA CA002224103A patent/CA2224103A1/en not_active Abandoned
- 1996-06-05 CN CN96196106A patent/CN1192680A/zh active Pending
- 1996-06-05 US US08/658,337 patent/US5780496A/en not_active Expired - Fee Related
- 1996-06-05 EP EP96917126A patent/EP0831809A4/en not_active Withdrawn
- 1996-06-05 JP JP9501241A patent/JPH11506770A/ja not_active Ceased
- 1996-06-05 MX MX9709442A patent/MX9709442A/es not_active IP Right Cessation
- 1996-06-05 BR BR9609353A patent/BR9609353A/pt not_active Application Discontinuation
- 1996-06-11 AR ARP960103099A patent/AR003140A1/es unknown
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1998
- 1998-06-04 US US09/090,737 patent/US6090838A/en not_active Expired - Fee Related
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2000
- 2000-05-05 US US09/565,855 patent/US6239161B1/en not_active Expired - Fee Related
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2001
- 2001-05-14 US US09/854,424 patent/US20020016353A1/en not_active Abandoned
Also Published As
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|---|---|
| AU5979996A (en) | 1996-12-30 |
| AU697120B2 (en) | 1998-09-24 |
| US5780496A (en) | 1998-07-14 |
| WO1996040115A1 (en) | 1996-12-19 |
| AR003140A1 (es) | 1998-07-08 |
| IL122427A0 (en) | 1998-06-15 |
| EP0831809A4 (en) | 2001-11-28 |
| KR19990022369A (ko) | 1999-03-25 |
| BR9609353A (pt) | 1999-05-11 |
| EP0831809A1 (en) | 1998-04-01 |
| MX9709442A (es) | 1998-02-28 |
| US20020016353A1 (en) | 2002-02-07 |
| US6239161B1 (en) | 2001-05-29 |
| US6090838A (en) | 2000-07-18 |
| CA2224103A1 (en) | 1996-12-19 |
| CN1192680A (zh) | 1998-09-09 |
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