JPH11508536A - アドレナリン性α▲下１ａ▼受容体アンタゴニスト - Google Patents

アドレナリン性α▲下１ａ▼受容体アンタゴニスト

Info

Publication number: JPH11508536A
Authority: JP; Japan
Prior art keywords: alkyl; dioxide; mono; oxo; piperidin
Prior art date: 1995-02-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP8525855A

Other languages

English (en)

Japanese (ja)

Inventor

エバンス，ベン・イー

ポンテイチエロ，ジエラルド・エス

ホフマン，ジエイコブ・エム

チヤン，レイモンド・エス・エル

Original Assignee

メルクエンドカンパニーインコーポレーテッド

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-02-23

Filing date

1996-02-23

Publication date

1999-07-27

1996-02-19 Priority claimed from GBGB9603457.4A external-priority patent/GB9603457D0/en

1996-02-23 Application filed by メルクエンドカンパニーインコーポレーテッド filed Critical メルクエンドカンパニーインコーポレーテッド

1999-07-27 Publication of JPH11508536A publication Critical patent/JPH11508536A/ja

Status Pending legal-status Critical Current

Links

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229940113178 5 Alpha reductase inhibitor Drugs 0.000 claims abstract description 17
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RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical group C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 claims description 19
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QUJXIMWUJGTUEG-CLKUPZDLSA-N 2-[2-[[[(2s,6s,9e,13s)-13-amino-2-[(4-hydroxyphenyl)methyl]-4,14-dioxo-1,5-diazacyclotetradec-9-ene-6-carbonyl]amino]methyl]phenyl]acetic acid Chemical compound C([C@H]1CC(=O)N[C@@H](CC/C=C/CC[C@@H](C(N1)=O)N)C(=O)NCC=1C(=CC=CC=1)CC(O)=O)C1=CC=C(O)C=C1 QUJXIMWUJGTUEG-CLKUPZDLSA-N 0.000 claims 1
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239000003765 sweetening agent Substances 0.000 description 1
230000002889 sympathetic effect Effects 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
230000002194 synthesizing effect Effects 0.000 description 1
238000007910 systemic administration Methods 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
230000008685 targeting Effects 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 1
HJKUNABSNYEGJB-UHFFFAOYSA-N tert-butyl 4-(2-hydroxyanilino)piperidine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCC1NC1=CC=CC=C1O HJKUNABSNYEGJB-UHFFFAOYSA-N 0.000 description 1
STEAYGPTLHZMJU-UHFFFAOYSA-N tert-butyl 4-(2-oxo-3h-benzimidazol-1-yl)piperidine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCC1N1C(=O)NC2=CC=CC=C21 STEAYGPTLHZMJU-UHFFFAOYSA-N 0.000 description 1
KAXDRALMRYZRCT-UHFFFAOYSA-N tert-butyl 4-(5-fluoro-2-oxo-3h-benzimidazol-1-yl)piperidine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCC1N1C(=O)NC2=CC(F)=CC=C21 KAXDRALMRYZRCT-UHFFFAOYSA-N 0.000 description 1
ROUYFJUVMYHXFJ-UHFFFAOYSA-N tert-butyl 4-oxopiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(=O)CC1 ROUYFJUVMYHXFJ-UHFFFAOYSA-N 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
IXZDIALLLMRYOU-UHFFFAOYSA-N tert-butyl hypochlorite Chemical compound CC(C)(C)OCl IXZDIALLLMRYOU-UHFFFAOYSA-N 0.000 description 1
210000001550 testis Anatomy 0.000 description 1
229940095585 testosterone-5-alpha reductase inhibitors for benign prostatic hypertrophy Drugs 0.000 description 1
125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
125000001113 thiadiazolyl group Chemical group 0.000 description 1
DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
125000006089 thiamorpholinyl sulfoxide group Chemical group 0.000 description 1
125000001984 thiazolidinyl group Chemical group 0.000 description 1
125000000335 thiazolyl group Chemical group 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
125000004568 thiomorpholinyl group Chemical group 0.000 description 1
VXUYXOFXAQZZMF-UHFFFAOYSA-N titanium(IV) isopropoxide Chemical compound CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C VXUYXOFXAQZZMF-UHFFFAOYSA-N 0.000 description 1
229940125725 tranquilizer Drugs 0.000 description 1
239000003204 tranquilizing agent Substances 0.000 description 1
230000002936 tranquilizing effect Effects 0.000 description 1
230000037317 transdermal delivery Effects 0.000 description 1
230000001960 triggered effect Effects 0.000 description 1
UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical compound ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
239000002753 trypsin inhibitor Substances 0.000 description 1
210000003954 umbilical cord Anatomy 0.000 description 1
201000002327 urinary tract obstruction Diseases 0.000 description 1
238000005292 vacuum distillation Methods 0.000 description 1
229940070710 valerate Drugs 0.000 description 1
NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
239000000052 vinegar Substances 0.000 description 1
235000021419 vinegar Nutrition 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000001993 wax Substances 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1
238000005303 weighing Methods 0.000 description 1
229930195724 β-lactose Natural products 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

JP8525855A 1995-02-23 1996-02-23 アドレナリン性α▲下１ａ▼受容体アンタゴニスト Pending JPH11508536A (ja)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
US39269995A	1995-02-23	1995-02-23
US253495P	1995-08-18	1995-08-18
GB08/392,699		1996-02-19
GBGB9603457.4A GB9603457D0 (fr)	1996-02-19	1996-02-19
GB60/002,534		1996-02-19
GB9603457.4		1996-02-19
PCT/US1996/002534 WO1996025934A1 (fr)	1995-02-23	1996-02-23	ANTAGONISTES DU RECEPTEUR ALPHA-1a-ADRENERGIQUE

Publications (1)

Publication Number	Publication Date
JPH11508536A true JPH11508536A (ja)	1999-07-27

Family

ID=26308756

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP8525855A Pending JPH11508536A (ja)	1995-02-23	1996-02-23	アドレナリン性α▲下１ａ▼受容体アンタゴニスト

Country Status (4)

Country	Link
EP (1)	EP0812196A4 (fr)
JP (1)	JPH11508536A (fr)
AU (1)	AU700559B2 (fr)
CA (1)	CA2213192A1 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4110449A (en) *	1977-05-23	1978-08-29	E. R. Squibb & Sons, Inc.	2-substituted benzisothiazol-3-ones
RU2118322C1 (ru) *	1993-07-05	1998-08-27	Дюфар Интернэшнл Рисерч Б.В.	2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли
CA2187767A1 (fr) *	1994-04-14	1995-10-26	Joel R. Huff	Antagonistes du recepteur adrenergique alpha1c

1996
- 1996-02-23 CA CA002213192A patent/CA2213192A1/fr not_active Abandoned
- 1996-02-23 AU AU49301/96A patent/AU700559B2/en not_active Ceased
- 1996-02-23 JP JP8525855A patent/JPH11508536A/ja active Pending
- 1996-02-23 EP EP96905575A patent/EP0812196A4/fr not_active Ceased

Also Published As

Publication number	Publication date
CA2213192A1 (fr)	1996-08-29
EP0812196A4 (fr)	1998-05-20
EP0812196A1 (fr)	1997-12-17
AU4930196A (en)	1996-09-11
AU700559B2 (en)	1999-01-07

Publication	Publication Date	Title
US5661163A (en)	1997-08-26	Alpha-1a adrenergic receptor antagonists
US6075038A (en)	2000-06-13	Alpha 1a adrenergic receptor antagonists
JPH11504010A (ja)	1999-04-06	アドレナリン性α▲下１ａ▼受容体アンタゴニスト
US6096763A (en)	2000-08-01	α1a adrenergic receptor antagonists
US6358959B1 (en)	2002-03-19	Polyazanaphthalenone derivatives useful as alpha 1a adrenoceptor antagonists
US6316437B1 (en)	2001-11-13	Spirohydantoin compounds and uses thereof
JP2002511085A (ja)	2002-04-09	α１ａアドレナリン受容体拮抗薬
JP2002505685A (ja)	2002-02-19	α１ａアドレナリン受容体拮抗薬
US5807856A (en)	1998-09-15	Alpha 1a adrenergic receptor antagonist
AU705661B2 (en)	1999-05-27	Alpha 1a adrenergic receptor antagonists
JP2002511086A (ja)	2002-04-09	α１ａアドレナリン受容体拮抗薬
US5952351A (en)	1999-09-14	Alpha 1a adrenergic receptor antagonists
WO1996025934A1 (fr)	1996-08-29	ANTAGONISTES DU RECEPTEUR ALPHA-1a-ADRENERGIQUE
JPH11508536A (ja)	1999-07-27	アドレナリン性α▲下１ａ▼受容体アンタゴニスト
JPH11512710A (ja)	1999-11-02	アルファ１ｂアドレナリンレセプターアンタゴニスト
US5922722A (en)	1999-07-13	Alpha 1a adrenergic receptor antagonists
AU710337B2 (en)	1999-09-16	Alpha 1a adrenergic receptor antagonists
US5747490A (en)	1998-05-05	Alpha 1b adrenergic receptor antagonists
US6235759B1 (en)	2001-05-22	Dihydropyridinones and pyrrolinones useful as alpha 1A adrenoceptor antagonists
US6228870B1 (en)	2001-05-08	Oxazolidinones useful as alpha 1a adrenoceptor antagonists
WO1997018209A1 (fr)	1997-05-22	ANTAGONISTES DE RECEPTEURS ADRENERGIQUES ALPHA 1a
CA2235370A1 (fr)	1997-05-22	Antagonistes du recepteur adrenergique alpha 1a