JPH11514017A - 合成タンパク質折り触媒作用 - Google Patents

合成タンパク質折り触媒作用

Info

Publication number
JPH11514017A
JPH11514017A JP10509051A JP50905198A JPH11514017A JP H11514017 A JPH11514017 A JP H11514017A JP 10509051 A JP10509051 A JP 10509051A JP 50905198 A JP50905198 A JP 50905198A JP H11514017 A JPH11514017 A JP H11514017A
Authority
JP
Japan
Prior art keywords
protein
dithiol
catalyst
folding
protein folding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10509051A
Other languages
English (en)
Japanese (ja)
Inventor
テイー． ライネス，ロナルド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of JPH11514017A publication Critical patent/JPH11514017A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP10509051A 1996-07-25 1997-07-09 合成タンパク質折り触媒作用 Pending JPH11514017A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/687,276 US5910435A (en) 1996-07-25 1996-07-25 Method of folding proteins with synthetic dithiol catalysts
US08/687,276 1996-07-25
PCT/US1997/013210 WO1998004734A1 (fr) 1996-07-25 1997-07-09 Catalyse de la plicature des proteines synthetiques

Publications (1)

Publication Number Publication Date
JPH11514017A true JPH11514017A (ja) 1999-11-30

Family

ID=24759789

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10509051A Pending JPH11514017A (ja) 1996-07-25 1997-07-09 合成タンパク質折り触媒作用

Country Status (9)

Country Link
US (1) US5910435A (fr)
EP (1) EP0920528A4 (fr)
JP (1) JPH11514017A (fr)
KR (1) KR100337966B1 (fr)
AU (1) AU723104B2 (fr)
CA (1) CA2260795C (fr)
IL (1) IL128021A0 (fr)
NZ (1) NZ333712A (fr)
WO (1) WO1998004734A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2854569B1 (fr) * 2003-05-06 2006-07-28 Oreal Dithiols a fonction amide et leur utilisation pour la transformation de la forme du cheveu
US20050002886A1 (en) * 2003-05-06 2005-01-06 Michel Philippe Dithiols comprising at least one amide functional group and their use in transforming the shape of the hair
US20050019290A1 (en) * 2003-05-16 2005-01-27 Michel Philippe Dithiols and use thereof for strengthening the hair
FR2854797B1 (fr) * 2003-05-16 2006-07-28 Oreal Dithiols et leur utilisation pour le renforcement du cheveu
WO2005077319A2 (fr) * 2004-02-12 2005-08-25 Unilever Plc Compositions de traitement capillaire
US20090081145A1 (en) * 2005-12-23 2009-03-26 Aplagen Gmbh Process for forming disulphide bridges
WO2008077621A1 (fr) * 2006-12-23 2008-07-03 Aplagen Gmbh Procédé de formation de ponts disulfure
WO2013123382A1 (fr) 2012-02-15 2013-08-22 Wisconsin Alumni Research Foundation Agents réducteurs dithioamine
US9371521B2 (en) 2014-06-30 2016-06-21 Wisconsin Alumni Research Foundation Substituted pyrazinedithiol reducing agents
US9630916B2 (en) 2014-08-19 2017-04-25 Wisconsin Alumni Research Foundation Organocatalysts of oxidative protein folding
CN105260626B (zh) * 2015-09-25 2017-11-14 麦科罗医药科技(武汉)有限公司 蛋白质结构空间构象的全信息预测方法
KR20240174948A (ko) 2023-06-09 2024-12-18 단국대학교 산학협력단 단백질 발현 효율 증가를 위한 rna 압타머 또는 rna를 활용한 단백질 발현 벡터 시스템

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0208539A3 (fr) * 1985-07-11 1988-08-03 Repligen Corporation Protéines pliantes liées par pont disulfuré en croix
US5235043A (en) * 1990-04-06 1993-08-10 Synergen, Inc. Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins
US5460806A (en) * 1993-06-22 1995-10-24 President And Fellows Of Harvard College Bis(2-mercaptoethyl) sulfone

Also Published As

Publication number Publication date
EP0920528A4 (fr) 2001-01-31
CA2260795A1 (fr) 1998-02-05
WO1998004734A1 (fr) 1998-02-05
KR100337966B1 (ko) 2002-05-24
AU3740897A (en) 1998-02-20
US5910435A (en) 1999-06-08
KR20000029532A (ko) 2000-05-25
NZ333712A (en) 2000-10-27
AU723104B2 (en) 2000-08-17
EP0920528A1 (fr) 1999-06-09
CA2260795C (fr) 2004-05-25
IL128021A0 (en) 1999-11-30

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