JPS4987677A - - Google Patents
Info
- Publication number
- JPS4987677A JPS4987677A JP14179773A JP14179773A JPS4987677A JP S4987677 A JPS4987677 A JP S4987677A JP 14179773 A JP14179773 A JP 14179773A JP 14179773 A JP14179773 A JP 14179773A JP S4987677 A JPS4987677 A JP S4987677A
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00315836A US3839346A (en) | 1972-12-18 | 1972-12-18 | N-substituted pyridone and general method for preparing pyridones |
| US38065573A | 1973-07-19 | 1973-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS4987677A true JPS4987677A (fr) | 1974-08-22 |
Family
ID=26980095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14179773A Pending JPS4987677A (fr) | 1972-12-18 | 1973-12-18 |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS4987677A (fr) |
| DE (2) | DE2362958C2 (fr) |
| ES (1) | ES421598A1 (fr) |
| FR (1) | FR2232316B1 (fr) |
| GB (2) | GB1458048A (fr) |
| NL (1) | NL7317316A (fr) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5350179A (en) * | 1976-10-15 | 1978-05-08 | Rikagaku Kenkyusho | Novel 2-pyridone compounds and their preparation |
| JP2004203795A (ja) * | 2002-12-26 | 2004-07-22 | Kdl Inc | ピリドン誘導体の溶液状医薬組成物 |
| WO2009022899A1 (fr) | 2007-08-14 | 2009-02-19 | Cell Therapy Technology, S.A. De C.V. | Gel à base de pirfénidone |
| JP2012121931A (ja) * | 2005-05-10 | 2012-06-28 | Intermune Inc | ストレス活性化蛋白質キナーゼ系をモジュレートするためのピリドン誘導体 |
| WO2013012307A1 (fr) | 2011-07-19 | 2013-01-24 | Cell Therapy And Techonology S.A. De C.V. | Procédé de fabrication d'une composition pharmaceutique sous forme de comprimés à libération prolongée contenant de la pirfenidone, utilisation pour faire régresser l'insuffisance rénale chronique, la contracture capsulaire mammaire et la fibrose hépatique chez l'homme |
| WO2013147577A1 (fr) | 2012-03-28 | 2013-10-03 | Cell Therapy and Technology S.A. DE C.V. | Composition topique semi-solide contenant de la pirfénidone et de l'oxyde de disulfure dialyle modifié (odd-m) pour éliminer ou prévenir l'acné |
| JP2017031192A (ja) * | 2011-01-31 | 2017-02-09 | ジェノア ファーマシューティカルズ，インク． | エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用 |
| WO2019035705A2 (fr) | 2017-08-15 | 2019-02-21 | Cell Therapy and Technology S.A. DE C.V. | Composition topique semi-solide contenant un agent antimicrobien et de la pirfénidone pour le traitement d'affections chroniques de la peau |
| JP2020530005A (ja) * | 2017-07-31 | 2020-10-15 | ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ | Ｂリンパ球活性の調節及び臓器保護のためのピルフェニドン誘導体 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1049411A (fr) * | 1972-12-18 | 1979-02-27 | Affiliated Medical Research | Pyridone n-substituee; methode generale de synthese des pyridones |
| CA2726588C (fr) | 2008-06-03 | 2019-04-16 | Karl Kossen | Composes et procedes de traitement des troubles inflammatoires et fibrotiques |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| MX382781B (es) | 2014-04-02 | 2025-03-13 | Intermune Inc | Piridinonas anti-fibroticas. |
| ITUB20154832A1 (it) | 2015-10-29 | 2017-04-29 | Procos Spa | Processo per la sintesi di pirfenidone |
| US12331021B2 (en) | 2020-09-10 | 2025-06-17 | Suzhou Fude Zhaofeng Biochemical Technology Co., Ltd | Total synthesis of pirfenidone |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2947755A (en) * | 1959-02-05 | 1960-08-02 | Wallace & Tiernan Inc | Substituted 1-m-aminophenyl-2-pyridones |
| US3655897A (en) * | 1971-01-25 | 1972-04-11 | Merck & Co Inc | Anti-inflammatory agents |
-
1973
- 1973-12-18 ES ES421598A patent/ES421598A1/es not_active Expired
- 1973-12-18 FR FR7345342A patent/FR2232316B1/fr not_active Expired
- 1973-12-18 DE DE19732362958 patent/DE2362958C2/de not_active Expired
- 1973-12-18 DE DE19732366349 patent/DE2366349C2/de not_active Expired
- 1973-12-18 GB GB5864273A patent/GB1458048A/en not_active Expired
- 1973-12-18 GB GB4107475A patent/GB1458049A/en not_active Expired
- 1973-12-18 JP JP14179773A patent/JPS4987677A/ja active Pending
- 1973-12-18 NL NL7317316A patent/NL7317316A/xx not_active Application Discontinuation
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5350179A (en) * | 1976-10-15 | 1978-05-08 | Rikagaku Kenkyusho | Novel 2-pyridone compounds and their preparation |
| JP2004203795A (ja) * | 2002-12-26 | 2004-07-22 | Kdl Inc | ピリドン誘導体の溶液状医薬組成物 |
| JP2012121931A (ja) * | 2005-05-10 | 2012-06-28 | Intermune Inc | ストレス活性化蛋白質キナーゼ系をモジュレートするためのピリドン誘導体 |
| EP2591784A1 (fr) | 2005-05-10 | 2013-05-15 | Intermune, Inc. | Dérives de la pyridin-2-one comme modulateur du système de proteine kinase activé par le stress |
| WO2009022899A1 (fr) | 2007-08-14 | 2009-02-19 | Cell Therapy Technology, S.A. De C.V. | Gel à base de pirfénidone |
| JP2025060674A (ja) * | 2011-01-31 | 2025-04-10 | アヴァリン ファーマ インク． | エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用 |
| JP2017031192A (ja) * | 2011-01-31 | 2017-02-09 | ジェノア ファーマシューティカルズ，インク． | エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用 |
| JP2025108419A (ja) * | 2011-01-31 | 2025-07-23 | アヴァリン ファーマ インク． | エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用 |
| WO2013012307A1 (fr) | 2011-07-19 | 2013-01-24 | Cell Therapy And Techonology S.A. De C.V. | Procédé de fabrication d'une composition pharmaceutique sous forme de comprimés à libération prolongée contenant de la pirfenidone, utilisation pour faire régresser l'insuffisance rénale chronique, la contracture capsulaire mammaire et la fibrose hépatique chez l'homme |
| EP2907506A1 (fr) | 2011-07-19 | 2015-08-19 | Cell Therapy And Technology, S.A. De C.V. | Procédé de fabrication d'une composition pharmaceutique sous forme de comprimés à libération prolongée contenant de la pirfénidone et leur utilisation dans la régression de l'insuffisance rénale chronique, la contracture capsulaire du sein et de la fibrose hépatique chez l'homme |
| WO2013147577A1 (fr) | 2012-03-28 | 2013-10-03 | Cell Therapy and Technology S.A. DE C.V. | Composition topique semi-solide contenant de la pirfénidone et de l'oxyde de disulfure dialyle modifié (odd-m) pour éliminer ou prévenir l'acné |
| JP2020530005A (ja) * | 2017-07-31 | 2020-10-15 | ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ | Ｂリンパ球活性の調節及び臓器保護のためのピルフェニドン誘導体 |
| US12365651B2 (en) | 2017-07-31 | 2025-07-22 | Washington University | Use of pirfenidone and derivatives for modulation of B lymphocyte activity and organ protection from acute tissue damage |
| WO2019035705A2 (fr) | 2017-08-15 | 2019-02-21 | Cell Therapy and Technology S.A. DE C.V. | Composition topique semi-solide contenant un agent antimicrobien et de la pirfénidone pour le traitement d'affections chroniques de la peau |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2232316A1 (fr) | 1975-01-03 |
| AU6374673A (en) | 1975-06-19 |
| ES421598A1 (es) | 1977-01-01 |
| DE2362958A1 (de) | 1974-06-27 |
| FR2232316B1 (fr) | 1978-03-24 |
| GB1458048A (en) | 1976-12-08 |
| NL7317316A (fr) | 1974-06-20 |
| DE2366349C2 (de) | 1986-03-27 |
| DE2362958C2 (de) | 1984-06-14 |
| GB1458049A (en) | 1976-12-08 |