JPS51149287A - Process for preparing 5-fluorouracil - Google Patents
Process for preparing 5-fluorouracilInfo
- Publication number
- JPS51149287A JPS51149287A JP50074109A JP7410975A JPS51149287A JP S51149287 A JPS51149287 A JP S51149287A JP 50074109 A JP50074109 A JP 50074109A JP 7410975 A JP7410975 A JP 7410975A JP S51149287 A JPS51149287 A JP S51149287A
- Authority
- JP
- Japan
- Prior art keywords
- fluorouracil
- preparing
- prepare
- followed
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002949 fluorouracil Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 2
- 230000003327 cancerostatic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229940035893 uracil Drugs 0.000 abstract 1
Abstract
PURPOSE: To prepare 5-fluorouracil, which is useful as carcinostatic agents, in high yield by reacting uracil with F2 gas in trifluoroacetic acid, followed by heat treatment.
COPYRIGHT: (C)1976,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP50074109A JPS51149287A (en) | 1975-06-17 | 1975-06-17 | Process for preparing 5-fluorouracil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP50074109A JPS51149287A (en) | 1975-06-17 | 1975-06-17 | Process for preparing 5-fluorouracil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS51149287A true JPS51149287A (en) | 1976-12-22 |
Family
ID=13537687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50074109A Pending JPS51149287A (en) | 1975-06-17 | 1975-06-17 | Process for preparing 5-fluorouracil |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS51149287A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS545985A (en) * | 1977-06-17 | 1979-01-17 | Asahi Glass Co Ltd | Preparation of 5-fluorouracil |
| JPS57154171A (en) * | 1981-03-18 | 1982-09-22 | Daikin Ind Ltd | Preparation of 5-fluorocytosine salt |
| US4631342A (en) * | 1984-03-09 | 1986-12-23 | Onoda Cement Company, Ltd. | Process for producing 5-fluorouracil |
| WO1989000560A1 (en) * | 1987-07-09 | 1989-01-26 | Allied Signal Inc | Direct fluorination of substituted pyridines |
-
1975
- 1975-06-17 JP JP50074109A patent/JPS51149287A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS545985A (en) * | 1977-06-17 | 1979-01-17 | Asahi Glass Co Ltd | Preparation of 5-fluorouracil |
| JPS57154171A (en) * | 1981-03-18 | 1982-09-22 | Daikin Ind Ltd | Preparation of 5-fluorocytosine salt |
| US4631342A (en) * | 1984-03-09 | 1986-12-23 | Onoda Cement Company, Ltd. | Process for producing 5-fluorouracil |
| WO1989000560A1 (en) * | 1987-07-09 | 1989-01-26 | Allied Signal Inc | Direct fluorination of substituted pyridines |
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